Protein-Protein Interaction Details
Protein General Information | Top | ||||
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Full Name | Axin-1 (AXIN1) | ||||
UniProt ID | AXIN1_HUMAN | ||||
Gene Name | AXIN1 | ||||
Gene ID | 8312 |
Interacting TTD Target Information | Top | ||||
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Interacting Successful Target(s) | Beta-catenin (CTNNB1) | Target Info | PPI Info | [1] | |
Interacting Clinical trial Target(s) | Glycogen synthase kinase-3 beta (GSK-3B) | Target Info | PPI Info | [1] | |
Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [2] | ||
MAPK/ERK kinase kinase 1 (MAP3K1) | Target Info | PPI Info | [3] | ||
LDL receptor related protein-6 (LRP-6) | Target Info | PPI Info | [4] |
References | Top | ||||
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REF 1 | Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. Genes Cells. 1998 Jun;3(6):395-403. | ||||
REF 2 | AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation. Oncogene. 2011 Mar 10;30(10):1194-204. | ||||
REF 3 | Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/-catenin signaling. Hum Mol Genet. 2014 Feb 15;23(4):1073-83. | ||||
REF 4 | Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev Cell. 2006 Aug;11(2):213-23. |
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