Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | Axin-1 (AXIN1) | ||||
| UniProt ID | AXIN1_HUMAN | ||||
| Gene Name | AXIN1 | ||||
| Gene ID | 8312 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Beta-catenin (CTNNB1) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Glycogen synthase kinase-3 beta (GSK-3B) | Target Info | PPI Info | [1] | |
| Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [2] | ||
| MAPK/ERK kinase kinase 1 (MAP3K1) | Target Info | PPI Info | [3] | ||
| LDL receptor related protein-6 (LRP-6) | Target Info | PPI Info | [4] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. Genes Cells. 1998 Jun;3(6):395-403. | ||||
| REF 2 | AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation. Oncogene. 2011 Mar 10;30(10):1194-204. | ||||
| REF 3 | Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/-catenin signaling. Hum Mol Genet. 2014 Feb 15;23(4):1073-83. | ||||
| REF 4 | Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev Cell. 2006 Aug;11(2):213-23. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.