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| Protein General Information |
Top |
| Full Name |
F-box/WD repeat-containing protein 8 (FBXW8)
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| UniProt ID |
FBXW8_HUMAN
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| Gene Name |
FBXW8
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| Gene ID |
26259
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| Interacting TTD Target Information |
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| Interacting Literature-reported Target(s) |
Cullin-7 (CUL-7) |
Target Info
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PPI Info
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[1] |
| Interacting Clinical trial Target(s) |
Insulin receptor substrate-1 (IRS1) |
Target Info
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PPI Info
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[2] |
| References |
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| REF 1 |
Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination. J Biol Chem. 2012 Nov 23;287(48):40758-66.
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| REF 2 |
The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol Cell. 2008 May 23;30(4):403-14.
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