Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) | ||||
| UniProt ID | P55G_HUMAN | ||||
| Gene Name | PIK3R3 | ||||
| Gene ID | 8503 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
| Insulin-like growth factor I receptor (IGF1R) | Target Info | PPI Info | [2] | ||
| Interacting Clinical trial Target(s) | Erbb3 tyrosine kinase receptor (Erbb-3) | Target Info | PPI Info | [1] | |
| Insulin receptor substrate-1 (IRS1) | Target Info | PPI Info | [4] | ||
| Interacting Literature-reported Target(s) | Proto-oncogene c-Crk (c-Crk) | Target Info | PPI Info | [3] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74. | ||||
| REF 2 | Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins. Mol Endocrinol. 1997 Dec;11(13):1911-23. | ||||
| REF 3 | Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9. | ||||
| REF 4 | Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation. Biochem J. 1999 Aug 1;341 ( Pt 3):831-7. | ||||
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