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Protein General Information |
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Full Name |
E3 ubiquitin-protein ligase parkin (PRKN)
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UniProt ID |
PRKN_HUMAN
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Gene Name |
PARK2
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Gene ID |
5071
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References |
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REF 1 |
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16691-6.
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REF 2 |
Transglutaminase-mediated intramolecular cross-linking of membrane-bound alpha-synuclein promotes amyloid formation in Lewy bodies. J Biol Chem. 2009 Oct 2;284(40):27252-64.
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REF 3 |
Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015 Apr 13;209(1):111-28.
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REF 4 |
Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease. Protein Cell. 2016 Feb;7(2):114-29.
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