Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T63505 Target Info
Target Name Tyrosine-protein kinase ABL1 (ABL)
Synonyms p150; Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Target Type Successful Target
Gene Name ABL1
Biochemical Class Kinase
UniProt ID
ABL1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 3 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [3]
4 Far Western [3]
5 Reconstituted Complex [4]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Biochemical Activity [5]
3 Fluorescence Resonance Energy Transfer [6]
4 Reconstituted Complex [5]
Interacting Protein Name E3 ubiquitin-protein ligase parkin (PRKN) Interacting Protein Interacting Protein Info
UniProt ID
PRKN_HUMAN 
Synonyms AR.JP; LPRS2; PDJ; PRKN
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [7]
3 Reconstituted Complex [8]
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [10]
4 Yeast two hybrid [10]
Interacting Target Name NCK adaptor protein 1 (NCK1) Clinical trial Target Interacting Protein Info
UniProt ID
NCK1_HUMAN 
Synonyms SH2/SH3 adaptor protein NCK-alpha; SH2/SH3 adaptor protein NCKalpha; Nck-1; Nck1; NCK; Cytoplasmic protein NCK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [10]
3 Yeast two hybrid [10]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [12]
3 Co-localization [12]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Reconstituted Complex [14]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Protein Name MutS protein homolog 5 (MSH5) Interacting Protein Interacting Protein Info
UniProt ID
MSH5_HUMAN 
Synonyms G7; MUTSH5; NG23
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Biochemical Activity [15]
3 Yeast two hybrid [16]
Interacting Protein Name Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) Interacting Protein Interacting Protein Info
UniProt ID
SHIP2_HUMAN 
Synonyms OPSMD; SHIP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [17]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [18]
2 Affinity Capture-Western [19]
Kinases [+] 8 Kinases +
Interacting Target Name ATM serine/threonine kinase (ATM) Clinical trial Target Interacting Protein Info
UniProt ID
ATM_HUMAN 
Synonyms Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Biochemical Activity [21]
3 Reconstituted Complex [22]
4 Yeast two hybrid [22]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [23]
2 Yeast two hybrid [24]
Interacting Target Name Erbb2 tyrosine kinase receptor (HER2) Successful Target Interacting Protein Info
UniProt ID
ERBB2_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER2; Tyrosine kinase receptor ErbB2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; P185erbB2; NGL; NEU proto-oncogene; NEU; MLN19; MLN 19; Metastatic lymph node gene 19 protein; HER2/neu; HER2 (erbB2/neu); HER-2; Erb2; Epidermal growth factor receptor 2; C-erbB-2 oncoprotein; C-erbB-2; CD340
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [25]
2 Reconstituted Complex [26]
Interacting Target Name Tropomyosin-related kinase A (TrkA) Successful Target Interacting Protein Info
UniProt ID
NTRK1_HUMAN 
Synonyms Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; NGF-trk receptor type A; Neurotrophic tyrosine kinase receptor type 1; MTC; High affinity nerve growth factor receptor; gp140trk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Yeast two hybrid [28]
Interacting Target Name Serine/threonine-protein kinase ATR (FRP1) Clinical trial Target Interacting Protein Info
UniProt ID
ATR_HUMAN 
Synonyms FRAP-related protein 1; Ataxia telangiectasia and Rad3-related protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Protein-peptide [30]
Interacting Target Name Tyrosine-protein kinase ABL2 (ABL2) Literature-reported Target Interacting Protein Info
UniProt ID
ABL2_HUMAN 
Synonyms Tyrosine-protein kinase ARG; ARG; ABLL; Abelson-related gene protein; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Reconstituted Complex [31]
Interacting Protein Name Breakpoint cluster region protein (BCR) Interacting Protein Interacting Protein Info
UniProt ID
BCR_HUMAN 
Synonyms ALL; BCR1; CML; D22S11; D22S662; PHL
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Reconstituted Complex [33]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [34]
Proteins 14-3-3 [+] 5 Proteins 14-3-3 +
Interacting Target Name AS1 14-3-3 protein eta (YWHAH) Literature-reported Target Interacting Protein Info
UniProt ID
1433F_HUMAN 
Synonyms YWHA1; Protein AS1; 14-3-3 protein eta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [12]
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [12]
Interacting Protein Name 14-3-3 protein epsilon (YWHAE) Interacting Protein Interacting Protein Info
UniProt ID
1433E_HUMAN 
Synonyms 14.3.3E; HEL2; KCIP.1; MDCR; MDS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [12]
Interacting Protein Name 14-3-3 protein gamma (YWHAG) Interacting Protein Interacting Protein Info
UniProt ID
1433G_HUMAN 
Synonyms 14.3.3GAMMA; PPP1R170
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [12]
Interacting Protein Name 14-3-3 protein theta (YWHAQ) Interacting Protein Interacting Protein Info
UniProt ID
1433T_HUMAN 
Synonyms 14.3.3; 1C5; HS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [12]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Tumor protein p73 (TP73) Interacting Protein Interacting Protein Info
UniProt ID
P73_HUMAN 
Synonyms P73
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Reconstituted Complex [35]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Biochemical Activity [36]
3 Protein-peptide [37]
Other proteins [+] 7 Other proteins +
Interacting Target Name Proto-oncogene c-Crk (c-Crk) Literature-reported Target Interacting Protein Info
UniProt ID
CRK_HUMAN 
Synonyms P38; Adapter molecule crk
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [38]
3 Biochemical Activity [12]
4 Reconstituted Complex [39]
5 Yeast two hybrid [40]
Interacting Protein Name Crk-like protein (CRKL) Interacting Protein Interacting Protein Info
UniProt ID
CRKL_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [41]
3 Yeast two hybrid [41]
Interacting Protein Name Docking protein 1 (DOK1) Interacting Protein Interacting Protein Info
UniProt ID
DOK1_HUMAN 
Synonyms P62DOK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Biochemical Activity [43]
3 Reconstituted Complex [44]
Interacting Target Name DNA repair protein RAD51 homolog 1 (RAD51) Clinical trial Target Interacting Protein Info
UniProt ID
RAD51_HUMAN 
Synonyms RECA; RAD51A; RAD51 homolog A; HsRAD51; HRAD51
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Reconstituted Complex [20]
Interacting Protein Name Abl interactor 1 (ABI1) Interacting Protein Interacting Protein Info
UniProt ID
ABI1_HUMAN 
Synonyms ABI.1; ABLBP4; E3B1; NAP1BP; SSH3BP; SSH3BP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [45]
2 Biochemical Activity [46]
Interacting Protein Name Abl interactor 2 (ABI2) Interacting Protein Interacting Protein Info
UniProt ID
ABI2_HUMAN 
Synonyms ABI.2; ABI2B; AIP.1; AblBP3; SSH3BP2; argBP1; argBPIA; argBPIB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Yeast two hybrid [47]
Interacting Protein Name SHC-transforming protein 1 (SHC1) Interacting Protein Interacting Protein Info
UniProt ID
SHC1_HUMAN 
Synonyms SHC; SHCA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [32]
References  Top
REF 1 Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9.
REF 2 Detection in primary chronic myeloid leukaemia cells of p210BCR-ABL1 in complexes with adaptor proteins CBL, CRKL, and GRB2. Genes Chromosomes Cancer. 2006 Dec;45(12):1121-9.
REF 3 Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor. Oncogene. 2001 Jul 5;20(30):4058-69.
REF 4 Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J Biol Chem. 1996 Apr 5;271(14):8435-42.
REF 5 Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation. Mol Cell Biol. 2002 Jun;22(12):4020-32.
REF 6 Detection of transient protein-protein interactions by bimolecular fluorescence complementation: the Abl-SH3 case. Proteomics. 2007 Apr;7(7):1023-36.
REF 7 Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16691-6.
REF 8 Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease. J Neurosci. 2011 Jan 5;31(1):157-63.
REF 9 The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr. J Biol Chem. 1997 Dec 26;272(52):33260-70.
REF 10 Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev. 1994 Apr 1;8(7):783-95.
REF 11 Requirement of multiple SH3 domains of Nck for ligand binding. Cell Signal. 1999 Apr;11(4):253-62.
REF 12 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol. 2005 Mar;7(3):278-85.
REF 13 Interaction of BCR-ABL with the retinoblastoma protein in Philadelphia chromosome-positive cell lines. Int J Hematol. 1997 Feb;65(2):115-21.
REF 14 Disruption of retinoblastoma protein function by coexpression of its C pocket fragment. Genes Dev. 1995 Jan 1;9(1):31-46.
REF 15 Physical and functional interaction between hMSH5 and c-Abl. Cancer Res. 2006 Jan 1;66(1):151-8.
REF 16 Evidence for a direct involvement of hMSH5 in promoting ionizing radiation induced apoptosis. Exp Cell Res. 2009 Aug 15;315(14):2420-32.
REF 17 A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. Blood. 1999 Apr 15;93(8):2707-20.
REF 18 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001.
REF 19 Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. Blood. 2011 Mar 17;117(11):3151-62.
REF 20 Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J Biol Chem. 1999 Apr 30;274(18):12748-52.
REF 21 Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res. 2007 Apr 1;67(7):3010-7.
REF 22 Interaction between ATM protein and c-Abl in response to DNA damage. Nature. 1997 May 29;387(6632):520-3.
REF 23 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 24 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 25 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74.
REF 26 Reciprocal regulation of Abl and receptor tyrosine kinases. Cell Signal. 2009 Jul;21(7):1143-50.
REF 27 Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor. J Neurosci Res. 2000 Feb 1;59(3):356-64.
REF 28 Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop. FEBS Lett. 2000 Mar 3;469(1):72-6.
REF 29 A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell Death Differ. 2011 Jan;18(1):5-15.
REF 30 Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem. 1999 Dec 31;274(53):37538-43.
REF 31 Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response. J Biol Chem. 2003 Apr 11;278(15):12961-7.
REF 32 Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J. 1994 Feb 15;13(4):764-73.
REF 33 BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell. 1991 Jul 12;66(1):161-71.
REF 34 Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. J Biol Chem. 1994 Jan 21;269(3):1927-33.
REF 35 p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature. 1999 Jun 24;399(6738):814-7.
REF 36 Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. EMBO J. 2002 Jul 15;21(14):3715-27.
REF 37 Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1749-54.
REF 38 Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk. Immunity. 2008 Oct 17;29(4):578-88.
REF 39 c-Abl kinase regulates the protein binding activity of c-Crk. EMBO J. 1994 May 15;13(10):2341-51.
REF 40 The SH2-containing adapter protein GRB10 interacts with BCR-ABL. Oncogene. 1998 Aug 27;17(8):941-8.
REF 41 Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation. Blood. 1997 Jan 1;89(1):297-306.
REF 42 A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice. PLoS One. 2009 Oct 13;4(10):e7439.
REF 43 Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell. 1997 Jan 24;88(2):205-11.
REF 44 Interactions of p62(dok) with p210(bcr-abl) and Bcr-Abl-associated proteins. J Biol Chem. 1998 Nov 27;273(48):32360-8.
REF 45 Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. Oncogene. 1997 Jan 16;14(2):233-41.
REF 46 Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1. Biochim Biophys Acta. 2008 May;1783(5):737-47.
REF 47 Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. BMC Cancer. 2016 May 26;16:335.

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