Protein-Protein Interaction Details
Protein General Information | Top | ||||
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Full Name | E3 ubiquitin-protein ligase UHRF1 (UHRF1) | ||||
UniProt ID | UHRF1_HUMAN | ||||
Gene Name | UHRF1 | ||||
Gene ID | 29128 |
Interacting TTD Target Information | Top | ||||
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Interacting Clinical trial Target(s) | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Target Info | PPI Info | [1] | |
Interacting Patented-recorded Target(s) | DNA [cytosine-5]-methyltransferase 3A (DNMT3A) | Target Info | PPI Info | [2] | |
Interacting Preclinical Target(s) | Herpesvirus ubiquitin-specific protease (HAUSP) | Target Info | PPI Info | [3] | |
Histone-lysine N-methyltransferase EHMT2 (EHMT2) | Target Info | PPI Info | [4] |
References | Top | ||||
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REF 1 | The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression. Oncogene. 2008 Apr 3;27(15):2187-97. | ||||
REF 2 | Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep. 2009 Nov;10(11):1259-64. | ||||
REF 3 | The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res. 2011 Oct;39(19):8355-65. | ||||
REF 4 | UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res. 2009 Feb;37(2):493-505. |
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