Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | E3 ubiquitin-protein ligase UHRF1 (UHRF1) | ||||
| UniProt ID | UHRF1_HUMAN | ||||
| Gene Name | UHRF1 | ||||
| Gene ID | 29128 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Target Info | PPI Info | [1] | |
| Interacting Patented-recorded Target(s) | DNA [cytosine-5]-methyltransferase 3A (DNMT3A) | Target Info | PPI Info | [2] | |
| Interacting Preclinical Target(s) | Herpesvirus ubiquitin-specific protease (HAUSP) | Target Info | PPI Info | [3] | |
| Histone-lysine N-methyltransferase EHMT2 (EHMT2) | Target Info | PPI Info | [4] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression. Oncogene. 2008 Apr 3;27(15):2187-97. | ||||
| REF 2 | Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep. 2009 Nov;10(11):1259-64. | ||||
| REF 3 | The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res. 2011 Oct;39(19):8355-65. | ||||
| REF 4 | UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res. 2009 Feb;37(2):493-505. | ||||
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