Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T42658 Target Info
Target Name Herpesvirus ubiquitin-specific protease (HAUSP)
Synonyms Ubiquitin-specific-processing protease 7; Ubiquitin thioesterase 7; Ubiquitin carboxyl-terminal hydrolase 7; Herpesvirus-associated ubiquitin-specific protease; Deubiquitinating enzyme 7
Target Type Preclinical Target
Gene Name USP7
Biochemical Class Peptidase
UniProt ID
UBP7_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name DNA replication licensing factor MCM4 (MCM4) Interacting Protein Interacting Protein Info
UniProt ID
MCM4_HUMAN 
Synonyms CDC21; CDC54; NKCD; NKGCD; P1.CDC21; hCdc21
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Acyltransferases [+] 9 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase UHRF1 (UHRF1) Interacting Protein Interacting Protein Info
UniProt ID
UHRF1_HUMAN 
Synonyms ICBP90; Np95; RNF106; hNP95; hUHRF1; huNp95
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [6]
5 Biochemical Activity [7]
6 Co-crystal Structure [8]
7 Reconstituted Complex [4]
8 Reconstituted Complex [8]
Interacting Protein Name E3 ubiquitin-protein ligase RING2 (RNF2) Interacting Protein Interacting Protein Info
UniProt ID
RING2_HUMAN 
Synonyms BAP.1; BAP1; DING; HIPI3; RING1B; RING2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Affinity Capture-Western [11]
4 Biochemical Activity [11]
5 Reconstituted Complex [9]
6 Reconstituted Complex [11]
Interacting Protein Name E3 ubiquitin-protein ligase RING1 (RING1) Interacting Protein Interacting Protein Info
UniProt ID
RING1_HUMAN 
Synonyms RING1A; RNF1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [11]
Interacting Protein Name E3 ubiquitin-protein ligase RNF169 (RNF169) Interacting Protein Interacting Protein Info
UniProt ID
RN169_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Biochemical Activity [12]
3 Co-crystal Structure [12]
Interacting Protein Name E3 ubiquitin-protein ligase RNF220 (RNF220) Interacting Protein Interacting Protein Info
UniProt ID
RN220_HUMAN 
Synonyms C1orf164
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [13]
3 Yeast two hybrid [14]
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [15]
2 Reconstituted Complex [16]
Interacting Target Name E3 ubiquitin-protein ligase TRIP12 (TRIP12) Literature-reported Target Interacting Protein Info
UniProt ID
TRIPC_HUMAN 
Synonyms ULF; TRIP12; TRinteracting protein 12; Thyroid receptorinteracting protein 12; E3 ubiquitinprotein ligase TRIP12; E3 ubiquitinprotein ligase for Arf
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [17]
Interacting Target Name Zinc finger protein RFP (TRIM27) Literature-reported Target Interacting Protein Info
UniProt ID
TRI27_HUMAN 
Synonyms Tripartite motif-containing protein 27; RNF76; RING-type E3 ubiquitin transferase TRIM27; RING finger protein 76; Ret finger protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Yeast two hybrid [18]
Interacting Protein Name E3 ubiquitin-protein ligase HUWE1 (HUWE1) Interacting Protein Interacting Protein Info
UniProt ID
HUWE1_HUMAN 
Synonyms ARF.BP1; HECTH9; HSPC272; Ib772; LASU1; MULE; URE.B1; UREB1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [19]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TNF receptor-associated factor 4 (TRAF4) Interacting Protein Interacting Protein Info
UniProt ID
TRAF4_HUMAN 
Synonyms CART1; MLN62; RNF83
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Reconstituted Complex [16]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Protein Name Protein phosphatase 1G (PPM1G) Interacting Protein Interacting Protein Info
UniProt ID
PPM1G_HUMAN 
Synonyms PP2CG; PP2CGAMMA; PPP2CG
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [21]
3 Reconstituted Complex [21]
Interacting Target Name Phosphatase and tensin homolog (PTEN) Literature-reported Target Interacting Protein Info
UniProt ID
PTEN_HUMAN 
Synonyms TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatidylinositol 3,4,5trisphosphate 3phosphatase and dualspecificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; MMAC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Biochemical Activity [23]
FAM proteins [+] 1 FAM proteins +
Interacting Protein Name BRISC complex subunit Abraxas 2 (ABRAXAS2) Interacting Protein Interacting Protein Info
UniProt ID
ABRX2_HUMAN 
Synonyms ABRO1; KIAA0157
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [24]
Histones [+] 1 Histones +
Interacting Protein Name Histone H2A type 2-C (HIST2H2AC) Interacting Protein Interacting Protein Info
UniProt ID
H2A2C_HUMAN 
Synonyms H2A; H2A.GL101; H2A/q; H2AFQ
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Biochemical Activity [25]
Kinases [+] 1 Kinases +
Interacting Target Name Checkpoint kinase-1 (CHK1) Clinical trial Target Interacting Protein Info
UniProt ID
CHK1_HUMAN 
Synonyms Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Chk1; Cell cycle checkpoint kinase
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Affinity Capture-Western [27]
3 Biochemical Activity [27]
4 Biochemical Activity [28]
Ligases [+] 1 Ligases +
Interacting Target Name Glutamine amidotransferase (GMPS) Literature-reported Target Interacting Protein Info
UniProt ID
GUAA_HUMAN 
Synonyms GMP synthetase; GMP synthase [glutamine-hydrolyzing]
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [29]
4 Affinity Capture-Western [30]
5 Affinity Capture-Western [31]
6 Affinity Capture-Western [6]
7 Co-purification [30]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name DNA [cytosine-5]-methyltransferase 1 (DNMT1) Clinical trial Target Interacting Protein Info
UniProt ID
DNMT1_HUMAN 
Synonyms MCMT; M.HsaI; Dnmt1; DNMT; DNA MTase HsaI; DNA methyltransferase HsaI; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine5)methyltransferase 1; CXXC-type zinc finger protein 9; CXXCtype zinc finger protein 9; CXXC9; AIM
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [4]
4 Affinity Capture-Western [32]
5 Biochemical Activity [7]
6 Biochemical Activity [32]
7 Biochemical Activity [33]
8 Reconstituted Complex [4]
9 Reconstituted Complex [33]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 17 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [31]
3 Affinity Capture-Western [35]
4 Affinity Capture-Western [36]
5 Affinity Capture-Western [37]
6 Affinity Capture-Western [38]
7 Affinity Capture-Western [39]
8 Affinity Capture-Western [26]
9 Affinity Capture-Western [40]
10 Affinity Capture-Western [20]
11 Biochemical Activity [34]
12 Biochemical Activity [20]
13 Co-crystal Structure [41]
14 Protein-peptide [41]
15 Protein-peptide [42]
16 Protein-peptide [43]
17 Reconstituted Complex [37]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Zinc finger E-box-binding homeobox 1 (ZEB1) Interacting Protein Interacting Protein Info
UniProt ID
ZEB1_HUMAN 
Synonyms AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Affinity Capture-Western [44]
3 Reconstituted Complex [27]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [45]
2 Yeast two hybrid [46]
Interacting Protein Name BCL-6 corepressor (BCOR) Interacting Protein Interacting Protein Info
UniProt ID
BCOR_HUMAN 
Synonyms ANOP2; MAA2; MCOPS2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Yeast two hybrid [14]
Ubiquitin related proteins [+] 2 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [47]
2 Affinity Capture-Western [48]
3 Affinity Capture-Western [31]
4 Affinity Capture-Western [35]
5 Affinity Capture-Western [49]
6 Affinity Capture-Western [50]
7 Affinity Capture-Western [38]
8 Affinity Capture-Western [40]
9 Affinity Capture-Western [51]
10 Co-crystal Structure [41]
11 Protein-peptide [41]
12 Protein-peptide [42]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 11 Experimental Evidences +
1 Biochemical Activity [15]
2 Biochemical Activity [52]
3 Biochemical Activity [43]
4 Biochemical Activity [53]
5 Biochemical Activity [54]
6 Biochemical Activity [55]
7 Biochemical Activity [56]
8 Co-crystal Structure [55]
9 Protein-peptide [57]
10 Protein-peptide [58]
11 Reconstituted Complex [59]
Other proteins [+] 5 Other proteins +
Interacting Target Name Polycomb complex protein BMI-1 (BMI1) Clinical trial Target Interacting Protein Info
UniProt ID
BMI1_HUMAN 
Synonyms RNF51; RING finger protein 51; Polycomb group RING finger protein 4; PCGF4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Reconstituted Complex [9]
4 Reconstituted Complex [11]
Interacting Protein Name Sex comb on midleg-like protein 2 (SCML2) Interacting Protein Interacting Protein Info
UniProt ID
SCML2_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [10]
4 Reconstituted Complex [10]
Interacting Protein Name Mini-chromosome maintenance complex-binding protein (MCMBP) Interacting Protein Interacting Protein Info
UniProt ID
MCMBP_HUMAN 
Synonyms C10orf119; MCM.BP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-crystal Structure [60]
3 Reconstituted Complex [60]
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [61]
3 Co-localization [62]
Interacting Protein Name Thymopoietin isoform alpha (TMPO) Interacting Protein Interacting Protein Info
UniProt ID
LAP2A_HUMAN 
Synonyms CMD1T; LAP2; LEMD4; PRO0868; TP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Yeast two hybrid [14]
References  Top
REF 1 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 2 USP7 is a SUMO deubiquitinase essential for DNA replication. Nat Struct Mol Biol. 2016 Apr;23(4):270-7.
REF 3 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 4 The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res. 2011 Oct;39(19):8355-65.
REF 5 M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4828-33.
REF 6 Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7. PLoS Pathog. 2015 Jun 5;11(6):e1004950.
REF 7 Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1. J Cell Biochem. 2011 Feb;112(2):439-44.
REF 8 An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Rep. 2015 Sep 1;12(9):1400-6.
REF 9 Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J. 2010 Aug 4;29(15):2553-65.
REF 10 USP7 cooperates with SCML2 to regulate the activity of PRC1. Mol Cell Biol. 2015 Apr;35(7):1157-68.
REF 11 Regulation of the Polycomb protein RING1B ubiquitination by USP7. Biochem Biophys Res Commun. 2010 Sep 24;400(3):389-95.
REF 12 Dual-utility NLS drives RNF169-dependent DNA damage responses. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2872-E2881.
REF 13 The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of -catenin. Mol Cell Biol. 2014 Dec 1;34(23):4355-66.
REF 14 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell. 2006 May 19;125(4):801-14.
REF 15 Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol. 2010 Aug;17(8):939-47.
REF 16 A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J Biol Chem. 2001 Jun 29;276(26):24242-52.
REF 17 Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response. FEBS Lett. 2016 Dec;590(23):4213-4222.
REF 18 Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. J Biol Chem. 2012 Dec 14;287(51):43007-18.
REF 19 Quantitative Lys--Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. J Biol Chem. 2014 Oct 17;289(42):28942-55.
REF 20 SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 1;27(3):274-87.
REF 21 ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol Cell. 2012 Mar 30;45(6):801-13.
REF 22 Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec;15(12):1486-1494.
REF 23 Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat Cell Biol. 2015 Sep;17(9):1169-81.
REF 24 ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53. Nat Commun. 2014 Oct 6;5:5059.
REF 25 USP11 Is a Negative Regulator to H2AX Ubiquitylation by RNF8/RNF168. J Biol Chem. 2016 Jan 8;291(2):959-67.
REF 26 USP7 regulates the stability and function of HLTF through deubiquitination. J Cell Biochem. 2011 Dec;112(12):3856-62.
REF 27 ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Sep;16(9):864-75.
REF 28 USP7 controls Chk1 protein stability by direct deubiquitination. Cell Cycle. 2014;13(24):3921-6.
REF 29 EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PLoS Pathog. 2009 Oct;5(10):e1000624.
REF 30 GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. Mol Cell. 2005 Mar 4;17(5):695-707.
REF 31 Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization. Mol Cell. 2014 Feb 6;53(3):458-70.
REF 32 DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci Signal. 2010 Nov 2;3(146):ra80.
REF 33 Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun. 2015 May 11;6:7023.
REF 34 Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature. 2002 Apr 11;416(6881):648-53.
REF 35 Critical role for Daxx in regulating Mdm2. Nat Cell Biol. 2006 Aug;8(8):855-62.
REF 36 Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. Cell Death Differ. 2007 Jul;14(7):1350-60.
REF 37 The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP. Oncogene. 2007 Nov 8;26(51):7262-6.
REF 38 HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response. Sci Rep. 2015 Aug 4;5:12793.
REF 39 FAM188B enhances cell survival via interaction with USP7. Cell Death Dis. 2018 May 24;9(6):633.
REF 40 STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation. Oncotarget. 2015 Oct 27;6(33):34718-31.
REF 41 Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol. 2006 Feb;4(2):e27.
REF 42 Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nat Struct Mol Biol. 2006 Mar;13(3):285-91.
REF 43 Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. J Biol Chem. 2003 Nov 28;278(48):47753-61.
REF 44 USP51 promotes deubiquitination and stabilization of ZEB1. Am J Cancer Res. 2017 Oct 1;7(10):2020-2031.
REF 45 Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. J Cell Biochem. 2008 Oct 1;105(2):596-611.
REF 46 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 47 Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Mol Cell Biol. 2006 Sep;26(18):6819-31.
REF 48 Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Sci Signal. 2017 Feb 14;10(466). pii: eaai8026.
REF 49 The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell. 2007 Oct;12(4):342-54.
REF 50 USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation. Cell Rep. 2016 Mar 22;14(11):2528-37.
REF 51 WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway. Cell Death Dis. 2017 Apr 13;8(4):e2743.
REF 52 Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes. Biochemistry. 2016 Aug 23;55(33):4708-19.
REF 53 The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types. Chem Biol. 2011 Dec 23;18(12):1550-61.
REF 54 Subunit-Specific Labeling of Ubiquitin Chains by Using Sortase: Insights into the Selectivity of Deubiquitinases. Chembiochem. 2016 Aug 17;17(16):1525-31.
REF 55 USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538.
REF 56 Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. Structure. 2018 Jan 2;26(1):72-84.e7.
REF 57 A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 1;339(6119):590-5.
REF 58 Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation. Structure. 2016 Aug 2;24(8):1335-1345.
REF 59 USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms. Cell Chem Biol. 2017 Dec 21;24(12):1501-1512.e5.
REF 60 A role for USP7 in DNA replication. Mol Cell Biol. 2014 Jan;34(1):132-45.
REF 61 Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies. J Virol. 2010 Nov;84(21):11113-23.
REF 62 The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies. PLoS One. 2011 Jan 31;6(1):e16598.

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