Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02702 | Target Info | |||
| Target Name | Bacterial Dihydrofolate reductase (Bact DHFR) | ||||
| Synonyms |
Bact Dihydrofolate reductase
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| Target Type | Clinical trial Target | ||||
| Gene Name | Bact DHFR | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5,6,7,8,9,10,11,12,13,14-Decahydro-15-thia-1,3-diaza-cyclododeca[a]indene-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL104770; PY831; BDBM50041927; 3-(3,4,5,-Trimethoxyphenyl)-2-propanone; 2,4-Diamino-5,6-decamrthylenethieno[2,3-d]pyrimidine; 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca[[?]:[?]]thieno[[?]]pyrimidine-2,4-diamine; 5,6,7,8,9,10,11,12,13,14-Decahydrocyclododeca[4,5]thieno[2,3-d]pyrimidine-2,4-diamine #
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
5-[3-(2,5-Dimethoxyphenyl)propyl]thieno[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL104379; BDBM50041938; 2,4-Diamino-5-[3-(2',3'-dimethoxyphenyl)propyl]thieno-[2,3-d]pyrimidine; 5-[3-(2,5-Dimethoxy-phenyl)-propyl]-thieno[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 = 55000 nM
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[1] | |||
| Compound Name |
5-(4-Chlorophenyl)-6-methyl-thieno[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107079; PY 826; BDBM50041930; 2,4-Diamino-5-(4'-chlorophenyl)-6-methylthieno[2,3-d]pyrimidine; 5-(4-Chloro-phenyl)-6-methyl-thieno[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 ~ 70000 nM
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[1] | |||
| Compound Name |
3-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1-yl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL266734; BDBM50291776; 3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl)-benzenesulfonamide; 3-[(1,2-Dihydro-2,2-dimethyl-4,6-diamino-1,3,5-triazin)-1-yl]benzenesulfonamide; Benzenesulfonamide, 3-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)-
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| Activity |
Ki = 70794.58 nM
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[2] | |||
| Compound Name |
6-[(N-Methylanilino)methyl]pyrido[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL146622; BDBM50135140; ZINC13529615; 2,4-Diamino-6-[(N-methylanilino)methyl]pyrido[2,3-d]-pyrimidine; 6-[(Methyl-phenyl-amino)-methyl]-pyrido[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 = 100000 nM
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[3] | |||
| Compound Name |
2,4-Diamino-5-benzyl-6-methylthieno[2,3-d]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL321826; 5-Benzyl-6-methyl-thieno[2,3-d]pyrimidine-2,4-diamine; 5-Benzyl-6-methylthieno[2,3-d]pyrimidine-2,4-diamine; BDBM50041937; AKOS015916977; 5-benzyl-6-methylthieno[3,2-e]pyrimidine-2,4-diamine; 5-Benzyl-6-methylthieno[2,3-d]pyrimidine-2,4-diamine #
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem. 1993 Oct 15;36(21):3103-12. | ||||
| REF 2 | Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines. J Med Chem. 1995 Mar 17;38(6):967-72. | ||||
| REF 3 | Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents. J Med Chem. 2003 Nov 6;46(23):5074-82. | ||||
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