Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17967 | Target Info | |||
| Target Name | Pyruvate dehydrogenase kinase 2 (PDHK2) | ||||
| Synonyms |
PDKII; PDK2; PDH kinase 2; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial
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| Target Type | Literature-reported Target | ||||
| Gene Name | PDK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 11 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2,7-Dichloro-9-(trifluoromethyl)fluoren-9-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671599; SCHEMBL13127996; BDBM137421; US8871934, 14
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| Activity |
IC50 = 56574 nM
|
[1] | |||
| Compound Name |
4-Ethoxy-9-(trifluoromethyl)fluoren-9-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671651; SCHEMBL13128033; BDBM137473; US8871934, 66
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| Activity |
IC50 = 66305 nM
|
[1] | |||
| Compound Name |
4-(Methoxymethyl)-9-(trifluoromethyl)fluoren-9-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671667; SCHEMBL12460625; BDBM137489; US8871934, 82
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| Activity |
IC50 = 67348 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-9-(trifluoromethyl)fluorene-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671626; SCHEMBL13128017; BDBM137448; US8871934, 41
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| Activity |
IC50 = 68593 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-N-methyl-N-phenyl-9-(trifluoromethyl)fluorene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671641; SCHEMBL13128027; BDBM137463; US8871934, 56
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-N-methoxy-N-methyl-9-(trifluoromethyl)fluorene-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671650; SCHEMBL13128032; BDBM137472; US8871934, 65
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-N,N-dimethyl-9-(trifluoromethyl)fluorene-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671620; SCHEMBL12460176; BDBM137442; US8871934, 35
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[9-Hydroxy-9-(trifluoromethyl)fluoren-4-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671604; SCHEMBL13128001; BDBM137426; US8871934, 19
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-9-(trifluoromethyl)fluorene-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671617; SCHEMBL13128009; BDBM137439; US8871934, 32
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-9-(trifluoromethyl)fluorene-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671609; SCHEMBL12459972; BDBM137431; US8871934, 24
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-N,N-dimethyl-9-(trifluoromethyl)fluorene-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671629; SCHEMBL13128020; BDBM137451; US8871934, 44
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dichloroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
2,2-Dichloroacetic acid; Dichloracetic acid; Acetic acid, dichloro-; Dichloroethanoic acid; Urner's liquid; Dichlorethanoic acid; Bichloracetic acid; Acetic acid, 2,2-dichloro-; DCA (acid); DICHLORO-ACETIC ACID; Kyselina dichloroctova; UNII-9LSH52S3LQ; NSC 2654; MFCD00004223; 9LSH52S3LQ; NSC-2654; NCGC00091444-02; DSSTox_CID_428; Dichloroacetic acid, 99+%; DSSTox_RID_75580; DSSTox_GSID_20428; C2H2Cl2O2; Dichloroacetic acid (IUPAC); SMR000059158; Kyselina dichloroctova [Czech]; CCRIS 4016; HSDB 6894; EINECS 201-207-0; UN1764; BRN 1098596; AI3-18370; Dichloressigsaeure; DKhUK; dichloro acetic acid; WLN: QVYGG; ACMC-1BLM2; 2,2-dichloro-acetic acid; SCHEMBL7777; 4-02-00-00498 (Beilstein Handbook Reference); KSC377O2D; MLS000028893; MLS001074861; MLS001424165; CHEMBL13960; DTXSID2020428; CTK2H7721; KS-00000VOI; NSC2654; BDBM227588; HMS2051P22; HMS2232H11; HMS3370D12; HMS3393P22; ZINC3830689; Dichloroacetic acid, puriss., 99%; Tox21_111133; Tox21_202363; Tox21_300419; Acetic acid, dichloro- (8CI,9CI); ANW-37297; BBL011449; LMFA01090070; STL146561; AKOS005720869; Tox21_111133_1; CCG-101070; DB08809; MCULE-1246638159; NC00320; NE10301; UN 1764; Dichloroacetic acid, analytical standard; NCGC00091444-01; NCGC00091444-03; NCGC00091444-04; NCGC00167845-02; NCGC00254261-01; NCGC00259912-01; AS-14228; SC-18205; DB-056364; D0308; Dichloroacetic acid [UN1764] [Corrosive]; Dichloroacetic acid, biotech. grade, >=98%; FT-0624700; Dichloroacetic acid, ReagentPlus(R), >=99%; EN300-20014; C11149; 11029-EP2269610A2; 11029-EP2289510A1; 11029-EP2316457A1; 11029-EP2316458A1; 11029-EP2316825A1; 11029-EP2316826A1; 11029-EP2316827A1; 11029-EP2316828A1; 12408-EP2277848A1; 12408-EP2277878A1; 12408-EP2295503A1; 12408-EP2298772A1; 12408-EP2301918A1; 12408-EP2305649A1; 12408-EP2316974A1; Q412845; F2191-0226
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| Activity |
IC50 = 504000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 8871934B2, Fluorene compound and pharmaceutical use thereof | ||||
| REF 2 | Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors. J Med Chem. 2017 Mar 23;60(6):2227-2244. | ||||
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