Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T26203 | Target Info | |||
| Target Name | Intercellular adhesion molecule ICAM-1 (ICAM1) | ||||
| Synonyms |
Major group rhinovirus receptor; Intercellular adhesion molecule 1; ICAM-1; CD54
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| Target Type | Successful Target | ||||
| Gene Name | ICAM1 | ||||
| Biochemical Class | Immunoglobulin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-Benzyl-6-ethylthieno[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL6430; Oprea1_061553; Oprea1_653654; SCHEMBL5429540; ZINC187679; BDBM50098477; AKOS016523460; MCULE-3319004424; AG-690/40146950; Benzyl-(6-ethyl-thieno[2,3-d]pyrimidin-4-yl)-amine; Z57088564
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| Activity |
IC50 = 56000 nM
|
[1] | |||
| Compound Name |
6-Ethyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)thieno[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL269495; SCHEMBL7056184; BDBM50098519; (6-Ethyl-thieno[2,3-d]pyrimidin-4-yl)-(5-methyl-[1,3,4]thiadiazol-2-yl)-amine
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| Activity |
IC50 = 92000 nM
|
[1] | |||
| Compound Name |
4-Benzylsulfanyl-6-ethylthieno[2,3-d]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL266064; SCHEMBL7053638; ZINC572863; BDBM50098497; MCULE-6275361121; 4-Benzylsulfanyl-6-ethyl-thieno[2,3-d]pyrimidine
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| Activity |
IC50 = 99000 nM
|
[1] | |||
| Compound Name |
N-(4-Chlorophenyl)-4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL6417; SCHEMBL7059677; BDBM50098489; 4-p-Tolylsulfanyl-thieno[2,3-c]pyridine-2-carboxylic acid (4-chloro-phenyl)-amide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
6-Ethylthieno[2,3-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
6-ethylthieno[2,3-d]pyrimidin-4-ol; 6-ethyl-3H-thieno[2,3-d]pyrimidin-4-one; 6-Ethyl-thieno[2,3-d]pyrimidin-4-ol; CHEMBL6215; MLS000029626; 6-ethyl-3H,4H-thieno[2,3-d]pyrimidin-4-one; SMR000009585; 6-ethylthiopheno[2,3-d]pyrimidin-4-ol; Maybridge3_001404; ChemDiv2_002305; Cambridge id 5313227; cid_645569; SCHEMBL3108511; SCHEMBL10325022; BDBM37871; CTK8C0316; DTXSID90349410; HMS1375I17; HMS1434P18; HMS1673P03; HMS2289E05; ALBB-019867; ANW-64489; BDBM50500488; MFCD00457520; QC-140; SBB014493; STK674212; STK827908; ZINC18193916; AKOS000265733; AKOS000541118; 6-ethyl thieno[2,3-d]pyrimidin-4-ol; MCULE-8942412555; IDI1_012791; AS-64355; DB-065548; ST4037528; FT-0741237; Z2902; 4-Oxo-(3H)-6-ethylthieno[2,3-d]pyrimidine; C-1220; thieno[2,3-d]pyrimidin-4(3H)-one, 6-ethyl-; SR-01000519447; 6-Ethyl-3,4-dihydrothieno[2,3-d]pyrimidine-4-one; SR-01000519447-1; Z94601204
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Chloro-6-ethylthieno[2,3-d]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
4-Chloro-6-ethyl-thieno[2,3-d]pyrimidine; CHEMBL269056; PubChem14877; Enamine_005558; SCHEMBL3799246; CTK5E8489; DTXSID00358795; HMS1409M14; ZINC502269; ANW-57940; BDBM50098495; CC0227; MFCD01950152; QC-857; RW2839; STK744870; AKOS000122829; MCULE-7765736940; VP50232; 4-Chloro-6-ethylthieno[2,3-D]pyrimide; BS-13597; DB-019107; 4-chloro-6-ethylthiopheno[2,3-d]pyrimidine; A9978; FT-0646575; Thieno[2,3-d]pyrimidine,4-chloro-6-ethyl-; Z2857; EN300-13897; M-8987; 136C427; J-515092; F3027-0208
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J Med Chem. 2001 Mar 15;44(6):988-1002. | ||||
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