Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T36121 | Target Info | |||
| Target Name | Proto-oncogene c-Myc (MYC) | ||||
| Synonyms |
Transcription factor p64; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; BHLHE39
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| Target Type | Literature-reported Target | ||||
| Gene Name | MYC | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Resveratrol
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Phase 3 | Compound Info | ||
| Synonyms |
Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
(Z)-3,4,3',5'-Tetramethoxystilbene
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Investigative | Compound Info | ||
| Synonyms |
(Z)-3,5,30,40-Tetramethoxystilbene; CHEMBL1172104; BDBM50431277; ZINC13340303; (Z)-3,3',4,5'-Tetramethoxystilbene; (Z)-3,4,3'''',5''''-Tetramethoxystilbene; (Z)-3,4,3'',5''-TETRAMETHOXYSTILBENE
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
Chembl4241092
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463137
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Chembl4250683
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463132
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Chembl4240576
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463133
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4248050
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463124
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4248116
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463136
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4242611
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463125
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-7-amine
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Investigative | Compound Info | ||
| Synonyms |
10074-G5; CHEMBL2312756; N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-amine; Oprea1_158245; MLS006012602; SCHEMBL2689577; DTXSID60385481; HMS3743K15; BCP09223; EX-A4226; KS-00000UC6; ZINC3879010; BDBM50423921; s8426; CCG-267830; CS-6372; NCGC00346825-01; AK687962; BS-16819; SMR004704145; HY-100996; c-Myc Inhibitor II - CAS 413611-93-5; 10074-G5, >=98% (HPLC)
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| Activity |
IC50 = 146000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. J Nat Prod. 2013 Apr 26;76(4):679-84. | ||||
| REF 2 | Synthetic molecules for disruption of the MYC protein-protein interface. Bioorg Med Chem. 2018 Aug 7;26(14):4234-4239. | ||||
| REF 3 | Pharmacophore identification of c-Myc inhibitor 10074-G5. Bioorg Med Chem Lett. 2013 Jan 1;23(1):370-4. | ||||
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