Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40097 | Target Info | |||
| Target Name | Stress-activated protein kinase JNK1 (JNK1) | ||||
| Synonyms |
Stress-activated protein kinase 1c; SAPK1c; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | MAPK8 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 62 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Niclosamide
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|
Approved | Compound Info | ||
| Synonyms |
niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
PMID16451062C46
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|
Investigative | Compound Info | ||
| Synonyms |
GTPL8355; GSK-623906A; BDBM50181532
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(Pyridin-4-yl)-4-(quinolin-6-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784648; BDBM50345615
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(Naphthalen-2-yl)-3-(2-(thiazol-2-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644627; BDBM50333991
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-(5-(Naphthalen-2-yl)-1H-tetrazol-1-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784662; BDBM50345603
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(Naphthalen-2-yl)-3-(pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644617; BDBM50334009
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Methyl 5-(2-(naphthalen-1-yl)acetamido)-1,2,3-thiadiazole-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288271; BDBM50332057
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-(2-(Pyren-1-yl)acetamido)thiophene-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767245; BDBM50342374
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-(4-Methylpyridin-3-yl)-2-(naphthalen-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288299; BDBM50332062
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(2-Methylpyridin-4-yl)-4-(quinolin-3-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784645; BDBM50345612
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(2-Methylpyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784644; BDBM50345611
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Ac-RPTTLNL-OH
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL504550; BDBM50270671
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
Methyl 4-(2-(naphthalen-1-yl)acetamido)thiazole-5-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288297; BDBM50332060
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-(2-Morpholinoacetamido)thiophene-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767291; BDBM50342377; ZINC23995395; AKOS034384183; MCULE-3817555677; AB00987573-01; Z46180400; 2-[2-(morpholin-4-yl)acetamido]thiophene-3-carboxamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Ethyl 3-methyl-5-(2-(naphthalen-1-yl)acetamido)isothiazole-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288273; BDBM50332059
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(2-(Cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784650; BDBM50345617
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(4-(Naphthalen-2-yl)-4H-1,2,4-triazol-3-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784653; BDBM50345620
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(Naphthalen-2-yl)-5-(pyridin-4-yl)pyrimidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784667; BDBM50345608
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(2-(Perfluorophenyl)acetamido)thiophene-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767287; BDBM50342375; MCULE-9662613302; AB00985854-01
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-(4-Chloro-5-(naphthalen-2-yl)-1H-1,2,3-triazol-1-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784658; BDBM50345599
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(5-(Naphthalen-2-yl)-1H-1,2,3-triazol-1-yl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784659; BDBM50345600
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[4-(4-Naphthalen-2-yl-5-oxo-1H-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644631; BDBM50334005; N-(4-(4-(naphthalen-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(Pyridin-4-yl)-4-(quinolin-3-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784643; BDBM50345610
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(3-Fluoropyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784646; BDBM50345613
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(5-Chloro-4-(naphthalen-2-yl)-4H-1,2,4-triazol-3-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784656; BDBM50345597
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(3-Aminopropyl)-4-(1H-indazol-3-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1822311; SCHEMBL2194204; BDBM50352633
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
4-(5-Hydrazono-4-(naphthalen-2-yl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784657; BDBM50345598
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(1-(Naphthalen-2-yl)-1H-1,2,3-triazol-5-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784664; BDBM50345605
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(4-(Naphthalen-2-yl)-5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784652; BDBM50345619
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(1-(Naphthalen-2-yl)-1H-tetrazol-5-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784655; BDBM50345622
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(2-(Biphenyl-4-yl)acetamido)thiophene-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767289; ZINC2664217; BDBM50342376; AKOS034078132; MCULE-5382003402; Z29084339; 2-(2-{[1,1'-biphenyl]-4-yl}acetamido)thiophene-3-carboxamide
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-(2-(Cyclopropylmethylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784651; BDBM50345618
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 2-(2-(naphthalen-1-yl)acetamido)nicotinate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288298; BDBM50332061
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Methyl 4-(2-(naphthalen-1-yl)acetamido)-1,2,5-oxadiazole-3-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288272; BDBM50332058
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
4-(1-(Naphthalen-2-yl)-1H-imidazol-2-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784663; BDBM50345604
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(5-Methyl-4-(naphthalen-2-yl)-4H-1,2,4-triazol-3-yl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784654; BDBM50345621
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(1-(Naphthalen-2-yl)-1H-pyrazol-5-yl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784661; BDBM50345602
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(4-Methoxyphenyl)-N-(2-(2-oxooxazolidin-3-yl)thiophen-3-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288037; SCHEMBL3718818; BDBM50332078; 2-(4-methoxyphenyl)-N-[2-(2-oxo-1,3-oxazolidin-3-yl)thiophen-3-yl]acetamide
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(2-(Cyclopentylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644621; BDBM50333985
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(2-Bromopyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784647; BDBM50345614
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(2-(2,6-Dimethylmorpholino)acetamido)thiophene-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767292; BDBM50342350; AKOS034383488; MCULE-9722796239; Z46163978; 2-[2-(2,6-dimethylmorpholin-4-yl)acetamido]thiophene-3-carboxamide
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| Activity |
IC50 = 65300 nM
|
[6] | |||
| Compound Name |
4-(2,5-Dihydro-1H-imidazo[1,2-a]quinoxalin-4-ylideneamino)cyclohexan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420584
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|
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| Activity |
IC50 = 73000 nM
|
[9] | |||
| Compound Name |
2-(2-(4-(2-(Trifluoromethyl)phenylsulfonyl)piperazin-1-yl)acetamido)thiophene-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1734241; MLS002166283; HMS3053F09; BDBM50342351; ZINC35963748; AKOS034150207; MCULE-7093763854; NCGC00241095-01; SMR001248633; Z31017859
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| Activity |
IC50 = 75100 nM
|
[6] | |||
| Compound Name |
2-(2-(4-(Cyclopropanecarbonyl)piperazin-1-yl)acetamido)thiophene-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767294; BDBM50342352; ZINC35286955; AKOS034394758; MCULE-2184809978; AB00985050-01; Z46520127; 2-[2-(4-cyclopropanecarbonylpiperazin-1-yl)acetamido]thiophene-3-carboxamide
Click to Show/Hide
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| Activity |
IC50 = 83500 nM
|
[6] | |||
| Compound Name |
Chembl4294787
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Investigative | Compound Info | ||
| Synonyms |
BDBM50468557
Click to Show/Hide
|
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| Activity |
IC50 = 88900 nM
|
[10] | |||
| Compound Name |
Chembl4290513
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468570
Click to Show/Hide
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| Activity |
IC50 = 93600 nM
|
[10] | |||
| Compound Name |
4-Amino-2-ethoxy-6-(2-phenylethylamino)pyridine-3-carbonitrile
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2089252; BDBM50420398
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-(2-(Naphthalen-1-yl)acetamido)thiophene-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767128; BDBM50342354
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-(Pyrrolo[1,2-a]quinoxalin-4-ylamino)cyclohexan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420583
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-(3-Phenylpropanamido)thiophene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1567347; 2-(3-phenylpropanoylamino)thiophene-3-carboxamide; MLS001007941; HMS2835J23; ZINC4749838; BDBM50342358; STK470466; AKOS003375080; MCULE-8438747713; SMR000498234; ST50862928; 2-[(3-phenylpropanoyl)amino]-3-thiophenecarboxamide; 2-[(3-phenylpropanoyl)amino]thiophene-3-carboxamide; Z29084301
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
7-Chloro-1-(3,4-dichlorophenyl)-6-methoxy-3,4-dihydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1087421; BDBM50415616
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
N-(3-Cyanothiophen-2-yl)-2-(naphthalen-1-yl)acetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767130; ZINC2692899; BDBM50342356; AKOS001132356; MCULE-4612942200; SR-01000012351; SR-01000012351-1; Z29082124; F1385-0103
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-{[2-(Diethylamino)pyrimidin-4-yl]amino}benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-anilinopyrimidine 7e; CHEMBL394870; BDBM15990
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-Ethyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599519; BI-90G12; BDBM50310145
Click to Show/Hide
|
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| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
2-Cinnamamidothiophene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767239; HMS1427B03; ZINC4275728; BDBM50342359; AKOS024605330; IDI1_010708; SR-01000011718; SR-01000011718-1; F1358-0283
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-(2-(Naphthalen-1-yl)acetamido)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767235; BDBM50342357
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
7-Chloro-1-(3-chlorophenyl)-6-methoxy-3,4-dihydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088633; BDBM50415620
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-(2-Naphthylacetylamino)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767127; 2-[(1-naphthylacetyl)amino]benzamide; Oprea1_570132; ARONIS007799; KS-00003ZSD; ZINC486646; BDBM50342353; STK947862; AKOS000497412; MCULE-6378157538; 2-[(naphthalen-1-ylacetyl)amino]benzamide; 2-(2-(naphthalen-1-yl)acetamido)benzamide; ST45044551; AG-670/36669027
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-{[2-(Hexyloxy)pyrimidin-4-yl]amino}benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
4-anilinopyrimidine 6d; CHEMBL396730; BDBM15982
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| Activity |
IC50 ~ 100000 nM
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[13] | |||
| Compound Name |
Methyl 2-(2-(naphthalen-1-yl)acetamido)thiophene-3-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767129; ZINC4275682; BDBM50342355; AKOS024605288; MCULE-9338151739; F1358-0090
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| Activity |
IC50 ~ 100000 nM
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[6] | |||
| Compound Name |
4-(4-(4-Fluorophenyl)-2-(4-methylcyclohexyl)-1H-imidazol-5-yl)pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL523938; BDBM50260229
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| Activity |
IC50 = 175000 nM
|
[15] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4277125
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Investigative | Compound Info | ||
| Synonyms |
BDBM50468565
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| Activity |
IC50 > 200000 nM
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[10] | |||
| Compound Name |
N-Methyl-4-(2-(piperidin-4-yl)-5-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL489344; SCHEMBL4936886; BDBM50260228; N-methyl-4-[2-piperidin-4-yl-4-[3-(trifluoromethyl)phenyl]-1H-imidazol-5-yl]pyrimidin-2-amine
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| Activity |
IC50 = 385000 nM
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[15] | |||
| Compound Name |
7-Azaindole
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Investigative | Compound Info | ||
| Synonyms |
1H-Pyrrolo[2,3-b]pyridine; 1,7-Diazaindene; 7H-Pyrrolo[2,3-b]pyridine; 7-Aza-1-pyrindine; 1,7-Dideazapurine; 1H-PYRROLO(2,3-b)PYRIDINE; MFCD00005606; pyrrolo[2,3-b]pyridine; 7-aza-indole; UNII-QX4465NR9T; 7H-Pyrrolo(2,3-b)pyridine; 7-Azaindole, 98%; 1 h-pyrrolo[2,3:b]pyridine; QX4465NR9T; Pyrrolo(2,3-b)pyridine; WLN: T56 BM INJ; EINECS 205-981-0; NSC 67063; 7-azaindol; 7-aza indole; pyrrolo[b]pyridine; zlchem 221; PubChem7679; ACMC-20lk5f; ACMC-1CKM0; pyrrolo[2,3-b]-pyridine; NCIOpen2_000707; SCHEMBL17837; KSC202K2D; 1-H-pyrrolo[2,3-b]pyridine; 1H-pyrrolo(2,3-b)-pyridine; CHEMBL389685; DTXSID3075046; BDBM16223; CTK1A2521; CTK2J8336; ZLC0029; WT674; ACN-S002680; ACT02468; ALBB-006259; BCP26852; CS-B0516; KS-000002OI; NSC67063; NSC77951; STR01850; ANW-26142; BBL008683; HTS000456; MFCD00075874; NSC-67063; NSC-77951; SBB004295; SC1771; STK503791; ZINC15442276; AKOS000446848; AC-1215; AS07114; CM14215; LS21042; MCULE-6621126582; PB32078; PS-4533; QC-3424; NCGC00188278-01; AK-26735; BR-26735; SC-03043; SY001940; AB0005988; DB-016106; AM20070247; FT-0604377; P1117; ST51044413; EN300-25796; A-9500; C-8859; Z-9562; 38720-EP2272517A1; 38720-EP2292615A1; 38720-EP2295433A2; 38720-EP2303879A1; 38720-EP2311837A1; 72278-EP2272517A1; 72278-EP2308867A2; 72278-EP2308870A2; 271A636; 271-63-6 7-azaindole; Q27287542; F0001-0881
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| Activity |
IC50 > 630957.34 nM
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[16] | |||
| References | Top | ||||
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| REF 1 | Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9. | ||||
| REF 2 | Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J Med Chem. 2006 Feb 9;49(3):955-70. | ||||
| REF 3 | Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3726-9. | ||||
| REF 4 | Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. Bioorg Med Chem Lett. 2011 Jan 1;21(1):315-9. | ||||
| REF 5 | Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7303-7. | ||||
| REF 6 | Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase. Bioorg Med Chem. 2011 Apr 15;19(8):2582-8. | ||||
| REF 7 | Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. J Med Chem. 2011 Sep 22;54(18):6206-14. | ||||
| REF 8 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 9 | Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5217-22. | ||||
| REF 10 | Design and biological evaluation of novel triaryl pyrazoline derivatives with dioxane moiety for selective BRAF V600E inhibition. Eur J Med Chem. 2018 Jul 15;155:725-735. | ||||
| REF 11 | Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med Chem Lett. 2012 Jun 6;3(7):560-4. | ||||
| REF 12 | 1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2230-4. | ||||
| REF 13 | Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. | ||||
| REF 14 | Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors. Bioorg Med Chem. 2010 Jan 15;18(2):590-6. | ||||
| REF 15 | Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors. J Biol Chem. 2007 Feb 23;282(8):5536-44. | ||||
| REF 16 | Selectivity of kinase inhibitor fragments. J Med Chem. 2011 Jul 28;54(14):5131-43. | ||||
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