Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40694 | Target Info | |||
| Target Name | Polo-like kinase 1 (PLK1) | ||||
| Synonyms |
Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; Serine-threonine protein kinase 13; STPK13; Plk1; PLK-1; PLK; Mitoticserine-threonine kinase polo-like kinase 1
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| Target Type | Clinical trial Target | ||||
| Gene Name | PLK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 102 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Erlotinib
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Approved | Compound Info | ||
| Synonyms |
Erlotinin; Tarceva; Erlotinib Base; OSI 744; R 1415; CP 358,774; CP-358774; Erlotinib(Tarceva); Tarceva (TN); CP-358,774; Erlotinib, OS-774; N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-Quinazolinamine; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; 4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Lapatinib
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Approved | Compound Info | ||
| Synonyms |
FMM; Tycerb; Lapatinib Ditosylate; Lapatinib [INN]; Lapatinib tosilate hydrate; GSK 572016; GSK572016; GW 572016; GW 572016X; GW572016; Lapatinib (INN); Tykerb (TN); Lapatinib, Tykerb, GW572016; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine; N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine; N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine; 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline; Lapatinib (ERBB2 inhibitor)
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Staurosporine
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Phase 2 | Compound Info | ||
| Synonyms |
staurosporine; Staurosporin; (+)-Staurosporine; Antibiotic 230; 62996-74-1; Antibiotic AM 2282; CCRIS 3272; AM-2282; UNII-H88EPA0A3N; Alkaloid AM-2282 from Streptomyces; H88EPA0A3N; CHEMBL388978; CHEBI:15738; CGP 39360; 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
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| Activity |
IC50 = 129000 nM
|
[3] | |||
| Compound Name |
MLN8054
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Phase 1 | Compound Info | ||
| Synonyms |
ZZL; MLN-8054
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| Activity |
IC50 = 53000 nM
|
[4] | |||
| Compound Name |
Flavonoid derivative 4
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Patented | Compound Info | ||
| Synonyms |
PMID26394986-Compound-48
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| Activity |
IC50 = 64000 nM
|
[5] | |||
| Compound Name |
KENPAULLONE
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Patented | Compound Info | ||
| Synonyms |
kenpaullone; 142273-20-9; 9-Bromopaullone; NSC 664704; 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; NSC-664704; NSC664704; MLS002702152; CHEMBL296586; 9-Bromo-7,12-dihydroindolo(3,2-d)(1)benzazepin-6(5H)-one; Indolo[3,2-d][1]benzazepin-6(5H)-one,9-bromo-7,12-dihydro-; QQUXFYAWXPMDOE-UHFFFAOYSA-N; 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one; 9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one; 9-Bromo-7,12-dihydro-indolo-[3,2-d]-[1]benzazepin-6(5H)-one
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitrophenyl)acryloyl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242482; SCHEMBL3193921; SCHEMBL3193924; BDBM50326061; 4-[(E)-2-[(4-bromophenyl)methylsulfanyl]-3-(4-fluoro-3-nitrophenyl)prop-2-enoyl]benzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
6-(3-Methylphenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL263902; BDBM50376350
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
2-(Dimethylamino)-2-(2-ethylphenyl)-N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CFI-400936; CHEMBL3330409; BDBM50053305; N-[3-[3-(Aminosulfonyl)phenyl]-1H-indazole-5-yl]-2-(dimethylamino)-2-(2-ethylphenyl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
2-Pyrrolidin-1-yl-N-[3-(3-sulfamoylphenyl)-1H-indazol-5-yl]-2-thiophen-3-ylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330410; BDBM50053304; N-[3-[3-(Aminosulfonyl)phenyl]-1H-indazole-5-yl]-2-(pyrrolidine-1-yl)-2-(3-thienyl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
CID 58405741
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2401970; SCHEMBL2049271; BDBM50436722; (7R)-7-ethyl-2-[2-(4-fluorophenyl)imidazol-1-yl]-5-methyl-8-(oxetan-3-yl)-7H-pteridin-6-one
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
4-[2-Amino-5-[4-[(dimethylamino)methyl]thiophen-2-yl]pyridin-3-yl]-2-[(Z,2S)-5,5,5-trifluoropent-3-en-2-yl]oxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042042; BDBM50385914
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
4-{5-[(1-Methylpiperidin-4-YL)oxy]-1H-benzimidazol-1-YL}-2-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1615277; BDBM50339801; Q27467275
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| Activity |
IC50 = 51300 nM
|
[13] | |||
| Compound Name |
9-Chloro-2-[[5-[3-(dimethylamino)propyl]pyridin-3-yl]amino]-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945803; SCHEMBL3113248; BDBM50362976
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| Activity |
EC50 = 53000 nM
|
[14] | |||
| Compound Name |
4-(4-Hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598633; BDBM50308202; 2-(4-Hydroxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one
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| Activity |
IC50 = 55000 nM
|
[6] | |||
| Compound Name |
(7-Nitro-3-oxy-5-trifluoromethyl-benzothiazol-2-yl)-pyrrolidin-1-yl-methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL523487; SCHEMBL5171055; BDBM50263745
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| Activity |
IC50 = 56000 nM
|
[5] | |||
| Compound Name |
4-(1-Methylbenzimidazol-2-yl)-N-phenylpyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036725; BDBM50385171
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| Activity |
IC50 = 60000 nM
|
[15] | |||
| Compound Name |
9-Chloro-2-[5-[3-(dimethylamino)propyl]-2-methylanilino]-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945171; BDBM50362981
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| Activity |
EC50 = 64000 nM
|
[14] | |||
| Compound Name |
Benzamide, 4-ethoxy-N-methyl-
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Investigative | Compound Info | ||
| Synonyms |
4-ethoxy-N-methylbenzamide; ACMC-20m5zk; SCHEMBL2528973; CHEMBL3929778; CTK0G7239; DTXSID20355009; BDBM190260; AKOS008933456; US9175357, 5786
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| Activity |
IC50 = 64700 nM
|
[16] | |||
| Compound Name |
(R)-3-(1-(2-Chloro-4-((isopropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL560808; BDBM50297970
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| Activity |
EC50 = 68000 nM
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[17] | |||
| Compound Name |
2-(2-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL599844; BDBM50308185
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| Activity |
IC50 = 73000 nM
|
[6] | |||
| Compound Name |
Norlichexanthone
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Investigative | Compound Info | ||
| Synonyms |
1,3,6-Trihydroxy-8-methyl-9H-xanthen-9-one; 9H-xanthen-9-one, 1,3,6-trihydroxy-8-methyl-; CHEMBL466154; 1,3,6-trihydroxy-8-methylxanthen-9-one; 1,3,6-trihydroxy-8-methyl-xanthen-9-one; 3,6,8-Trihydroxy-1-methylxanthone; Fusarindin; AC1NQYTV; Xanthen-9-one, 1,3,6-trihydroxy-8-methyl-; C10087; ACon0_000599; ACon1_001113; CTK4E4931; DTXSID20174777; 1,3,6-trihydroxy-8-methylxanthone; ZINC5765089; BDBM50350423; AKOS000365318; MCULE-8777096541; NCGC00169665-01; W2650; 1,3,6-Trihydroxy-8-methyl-9H-xanthen-9-one #; BRD-K97951054-001-01-6; Q27107546; NCGC00169665-03!1,3,6-trihydroxy-8-methylxanthen-9-one
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| Activity |
IC50 = 75700 nM
|
[18] | |||
| Compound Name |
(R)-3-(1-(4-((Tert-butylamino)methyl)-2-(difluoromethyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL551078; SCHEMBL2516429; BDBM50297984
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| Activity |
EC50 = 82000 nM
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[17] | |||
| Compound Name |
(+/-)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1689165; BDBM50339800
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| Activity |
IC50 = 87900 nM
|
[13] | |||
| Compound Name |
N-[(2,6-Dibromo-4-sulfamoylphenyl)carbamothioyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894239; BDBM50206451
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| Activity |
IC50 = 95000 nM
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[19] | |||
| Compound Name |
4-Methoxy-N-methylnaphthalene-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2005312; CHEMBL3943963; SCHEMBL11962157; BDBM190258; US9175357, 5756
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| Activity |
IC50 = 99000 nM
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[16] | |||
| Compound Name |
Tert-Butyl 6-((2-Chloro-4-(Dimethylcarbamoyl)phenyl)amino)-2-(1-Methyl-1h-Pyrazol-4-Yl)-1h-Pyrrolo[3,2-C]pyridine-1-Carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109933; SCHEMBL12526414; BDBM50446431; Q27456769
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| Activity |
IC50 ~ 100000 nM
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[20] | |||
| Compound Name |
2-(4-Methylanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL605324; BDBM50308230
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-Methyl-4-(2-phenoxyacetamido)-1H-thieno[2,3-c]pyrazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL199759; BDBM50175252
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| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[4-(3-bromoanilino)quinazolin-6-yl]oxymethyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3663540; CHEMBL3217993
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
6-Phenyl-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL262623; Kinome_3598; BDBM50376344
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456294; Calicoferol I; USFQLAVWHQCNDG-AYEIPMSGSA-; BDBM50358248; LMST03020180
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Calicoferol E
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456936; (8S)-3-hydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one; BDBM50358246; LMST03020157
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
2-(4-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL596807; BDBM50308228
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-(1-Methylbenzimidazol-2-yl)-N-(4-methylphenyl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036726; BDBM50385172
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
3,8,13,15,17,18-Hexazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL608427; BDBM50308215; 6,8-Dihydro-7H-pyrido[3,2-b][1,2,4]triazolo[5'',1'':2,3]pyrimido[4,5-d]azepin-7-one
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
6-Phenyl-7,8-dihydro-9H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL259380; BDBM50376351
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
4-(1-Methylbenzimidazol-2-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036728; BDBM50385170
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
4-(4-Ethoxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598837; BDBM50308204; 2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3361128; BDBM50038423; ZINC16052822; (E)-2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one
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| Activity |
IC50 = 100000 nM
|
[23] | |||
| Compound Name |
2-Anilino-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL603255; SCHEMBL10309999; BDBM50308225
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
7-[[(1R,2S,4Ar,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-5-methoxy-2-methyl-1,3-benzoxazol-6-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109402; BDBM50446565
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| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
N-(4-Chlorophenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036727; BDBM50385173
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-(4-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL597586; BDBM50308232
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-(4-Methoxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL606255; BDBM50308203; 2-(4-Methoxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-Methoxy-8,13,17,18-tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL599248; BDBM50308209; 10-Methoxy-6,8-dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[5,4-d][1]benzazepin-7-one
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[4-(3-ethynylanilino)quinazolin-6-yl]oxymethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4082796; CHEMBL3218000
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(2-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599027; BDBM50308186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL610512; BDBM50308222; 7,12-Dihydro-5H-pyrido[3,2-b]pyrimido[5'',4'':5,6]pyrido[2,3-d]azepine-6,9,11(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-(3-Chloro-4-hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598431; BDBM50308206; 2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Methyl 3-(piperidin-1-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200348; BDBM50175233
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
16-Phenyl-3,8,13,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598435; BDBM50308213; 2-Phenyl-6,8-dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[4,5-d]pyrido[3,2-b]azepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606119; BDBM50308220; 7,12-Dihydro-5H-pyrido[4,3-b]pyrimido[5'',4'':5,6]pyrido[2,3-d]azepine-6,9,11(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
8,15,17,19-Tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597207; BDBM50308216; 7,12-Dihydro-5H-pyrimido[5'',4'':5,6]pyrido[3,2-d][1]benzazepine-6,9,11(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Calicoferol C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515982; BDBM50358249
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201511; SCHEMBL1155440; BDBM47167; CTK3C7420; DTXSID40468140; US8957103, Z1; 1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-; 3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606410; BDBM50308224
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
16-Phenyl-4,8,13,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598434; BDBM50308211; 2-Phenyl-6,8-dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[4,5-d]pyrido[4,3-b]azepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
6-(3-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407532; BDBM50376348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Calicoferol B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL464351; BDBM50358250
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
8,13,17,18-Tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590769; BDBM50308207; 6,8-Dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[5,4-d][1]benzazepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(4-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605841; BDBM50308231
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Astrogorgiadiol B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ASTROGORGIADIOL; (8S,9R)-9,10-seco-1,3,5(10)-cholestatriene-3,9-diol; LMST03020242; CHEMBL517956; SCHEMBL4865385; BDBM50358247
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
6-(4-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407265; BDBM50376347
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
15,17-Dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603481; BDBM50308217; 10,12-Dimethyl-7,12-dihydro-5H-pyrimido[5'',4'':5,6]pyrido[3,2-d][1]benzazepine-6,9,11-(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N8-[(2S)-3,3-Dimethylbutan-2-yl]-N2-[2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CCT-271850; compound 34h [PMID: 27055065]; GTPL9169; CHEMBL3809829; SCHEMBL15515099; BDBM241235; MFCD28963915; ZINC207617458; example 77 [WO2014037750]; KS-0000054Y; AS-53277; CS-0012732; J3.605.544H; US9409907, 77; Q27076574
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
(E)-3-[1-[4-(3-Ethynylanilino)quinazolin-6-yl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4080295; CHEMBL3218002
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
15,17-Dimethyl-4,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599055; BDBM50308221
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-Methoxy-15,17-dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596598; BDBM50308219
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-[2-(4-Fluorophenyl)imidazol-1-yl]-5,7,7-trimethyl-8-propan-2-ylpteridin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2401961; SCHEMBL2046905; BDBM50436723
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-(4-Nitroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596808; BDBM50308229
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
15,17-Dimethyl-3,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599056; BDBM50308223
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
6-(3-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259381; BDBM50376346
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
6-(4-Methylphenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL405233; BDBM50376349
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Calicoferol A
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(22E)-(8S)-3-hydroxy-9,10-seco-1,3,5(10),22-cholestatetraen-9-one; LMST03020605; CHEMBL518060; BDBM50358244
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
4-(3-Hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606185; BDBM50308205; 2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
6-(4-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260620; BDBM50376345
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
3-Methyl-4-(thiophene-2-carboxamido)-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL382070; BDBM50175246
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
4-(3-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199657; BDBM50175253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
3,8,13,17,18-Pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591896; BDBM50308212; 6,8-Dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[4,5-d]pyrido[3,2-b]azepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-Methoxy-8,13,15,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597005; BDBM50308214; 10-Methoxy-6,8-dihydro-7H-[1,2,4]triazolo[5'',1'':2,3]pyrimido[5,4-d][1]benzazepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-Methoxy-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599666; BDBM50308218; 3-Methoxy-7,12-dihydro-5H-pyrimido[5'',4'':5,6]pyrido[3,2-d][1]benzazepine-6,9,11-(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-(4-Ethoxyphenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036867; BDBM50385176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
Chembl4276946
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Methyl 3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200586; SCHEMBL14163466; BDBM50175248; ZINC28564886
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
1,3-Dimethyl-7-(1-methylbenzimidazol-2-yl)pyrido[2,3-d]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036871; BDBM50385180
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
4-(4-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199658; BDBM50175244
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
Rel-Astrogorgol F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1922224; BDBM50358243
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
16-Phenyl-8,13,17,18-tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599247; BDBM50308208; 2-Phenyl-6,8-dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[5,4-d][1]benzazepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
3-[(E)-[3-[(E)-2-Pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407749; SCHEMBL12795185; BDBM50437838
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
24-Exomethylenecalicoferol E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1922225; BDBM50358245
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[22] | |||
| Compound Name |
N-Methyl-1-naphthalenecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Methyl-1-naphthamide; N-methylnaphthalene-1-carboxamide; 1-Naphthamide, N-methyl-; 1-Naphthalenecarboxamide, N-methyl-; NSC100670; N-Methyl-a-naphthamide; NCIOpen2_002067; N-Methyl-.alpha.-naphthamide; SCHEMBL1150424; SCHEMBL8191199; CHEMBL3972485; CTK4H1585; DTXSID00187608; BDBM190256; ZINC1662340; MFCD12974517; AKOS008933206; MCULE-1279856802; NSC-100670; SB18511; Naphtalene-1-carboxylic acid methylamide; AS-50965; naphthalene-1-carboxylic acid methyl amide; DB-068922; CS-0048785; FT-0747112; KS-00000690; US9175357, 5753
Click to Show/Hide
|
||||
| Activity |
IC50 = 104000 nM
|
[16] | |||
| Compound Name |
(R)-3-(1-(2-Chloro-4-((1-hydroxy-2-methylpropan-2-ylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563411; SCHEMBL2522130; BDBM50297976
Click to Show/Hide
|
||||
| Activity |
EC50 = 120000 nM
|
[17] | |||
| Compound Name |
(R)-3-(1-(2-Chloro-4-((4-methylpiperazin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557126; BDBM50297978
Click to Show/Hide
|
||||
| Activity |
EC50 = 120000 nM
|
[17] | |||
| Compound Name |
(R)-3-(1-(2-Chloro-4-((cyclopentylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564529; SCHEMBL2517106; BDBM50297972
Click to Show/Hide
|
||||
| Activity |
EC50 = 121000 nM
|
[17] | |||
| Compound Name |
4-Methoxy-N-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-methoxy-N-methyl-benzamide; (4-methoxyphenyl)-N-methylcarboxamide; NSC404038; N-Methyl-p-anisolcarbamid; N-Methyl 4-methoxybenzamide; SCHEMBL837307; CHEMBL3932992; CTK6I4237; DTXSID60323449; BDBM190257; ZINC336924; KS-00000R3U; 4042AB; BBL003667; MFCD00522600; SBB087913; STK395612; AKOS005433986; DS-6230; MCULE-3249852999; NSC-404038; AK120611; DA-06686; CS-0061778; FT-0715146; ST50450559; T7720; AP-065/34563049; US9175357, 5754; 2,8-Diazaspiro[5.5]undecane-2-carboxylic acid 1,1-dimethylethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[16] | |||
| Compound Name |
9-Chloro-2-[5-[3-(dimethylamino)propyl]-2-methoxyanilino]-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945173; BDBM50362979
Click to Show/Hide
|
||||
| Activity |
EC50 = 130000 nM
|
[14] | |||
| Compound Name |
4-[2-(2-Hydroxyethoxy)-5-methyl-3-[4-(2H-tetrazol-5-yl)phenyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2324036; BDBM50426930
Click to Show/Hide
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||||
| Activity |
IC50 = 139000 nM
|
[3] | |||
| Compound Name |
9-Chloro-2-[3-chloro-5-[3-(dimethylamino)propyl]anilino]-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945500; BDBM50362988
Click to Show/Hide
|
||||
| Activity |
EC50 = 150000 nM
|
[14] | |||
| Compound Name |
(R)-3-(1-(2-Chloro-4-((2-hydroxyethylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563363; BDBM50297974
Click to Show/Hide
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||||
| Activity |
EC50 = 184000 nM
|
[17] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 23 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(R)-3-(1-(2-Chloro-4-((3-hydroxypropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552084; BDBM50297975
Click to Show/Hide
|
||||
| Activity |
EC50 = 219000 nM
|
[17] | |||
| Compound Name |
(R)-3-(1-(2-Chloro-4-((cyclopropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561286; BDBM50297971
Click to Show/Hide
|
||||
| Activity |
EC50 = 220000 nM
|
[17] | |||
| Compound Name |
3-((1R)-1-(2-Chloro-4-((3-hydroxypyrrolidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562735; BDBM50297980
Click to Show/Hide
|
||||
| Activity |
EC50 = 227000 nM
|
[17] | |||
| Compound Name |
N-Methyl-2-[5-(4-methylphenyl)-2-oxopyrazin-1-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944580; SCHEMBL11962156; BDBM190253; US9175357, 5603
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[16] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
Click to Show/Hide
|
||||
| Activity |
IC50 = 271000 nM
|
[30] | |||
| Compound Name |
(R)-3-(1-(4-((Tert-butylamino)methyl)-2-fluorophenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559888; BDBM50297983
Click to Show/Hide
|
||||
| Activity |
EC50 = 290000 nM
|
[17] | |||
| Compound Name |
5-Methoxy-N-methyl-2,3-dihydro-1,4-benzodioxine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967183; SCHEMBL11962155; BDBM190254; US9175357, 5604
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[16] | |||
| Compound Name |
Schembl20920285
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2207846; SCHEMBL464377; BDBM50403017
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[31] | |||
| Compound Name |
N~1~-Methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3977826; SCHEMBL11962152; BDBM190249; ZINC64543272; MCULE-4582606313; US9175357, 5598; N~1~-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 320000 nM
|
[16] | |||
| Compound Name |
N~1~-Methyl-2-(6-methyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908492; SCHEMBL11962150; BDBM190246; ZINC64552856; MCULE-9273640208; US9175357, 5594; N~1~-methyl-2-(6-methyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000 nM
|
[16] | |||
| Compound Name |
1-(Benzenesulfonyl)-N-methylindole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8999130; CHEMBL3987050; BDBM190244; US9175357, 5591
Click to Show/Hide
|
||||
| Activity |
IC50 = 375000 nM
|
[16] | |||
| Compound Name |
3-(3-Methoxyphenyl)-N-methyl-1H-pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961841; SCHEMBL11962149; ZINC75337258; MCULE-6226816390
Click to Show/Hide
|
||||
| Activity |
IC50 = 380000 nM
|
[16] | |||
| Compound Name |
(R)-3-(1-(2-Chloro-4-((4-hydroxypiperidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564067; BDBM50297979
Click to Show/Hide
|
||||
| Activity |
EC50 = 390000 nM
|
[17] | |||
| Compound Name |
(R)-3-(1-(2-Chloro-4-((4-fluoropiperidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563469; BDBM50297977
Click to Show/Hide
|
||||
| Activity |
EC50 = 400000 nM
|
[17] | |||
| Compound Name |
3-[(1R)-1-[2-Chloro-4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]ethoxy]-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552348; BDBM50297982
Click to Show/Hide
|
||||
| Activity |
EC50 = 400000 nM
|
[17] | |||
| Compound Name |
N-Methylquinoline-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3895334; SCHEMBL11962154; 6-Quinolinecarboxamide, N-methyl-; BDBM190252; AKOS011591437; US9175357, 5601
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[16] | |||
| Compound Name |
9-Chloro-2-[2-chloro-5-[3-(dimethylamino)propyl]anilino]-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945172; BDBM50362980
Click to Show/Hide
|
||||
| Activity |
EC50 = 440000 nM
|
[14] | |||
| Compound Name |
N-Methyl-2-(6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3978875; SCHEMBL11962151; BDBM190247; US9175357, 5595
Click to Show/Hide
|
||||
| Activity |
IC50 = 475000 nM
|
[16] | |||
| Compound Name |
N-Methyl-4-phenyl-5-(trifluoromethyl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4108316; BDBM190248; US9175357, 5597
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[16] | |||
| Compound Name |
N,5-Dimethyl-2-(3-morpholin-4-ylpropyl)-1-phenyl-2H-pyrrol-1-ium-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4115250; BDBM190251; US9175357, 5600
Click to Show/Hide
|
||||
| Activity |
IC50 = 550000 nM
|
[16] | |||
| Compound Name |
N,2-Dimethyl-1,5-diphenylpyrrole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3910546; SCHEMBL11962153; BDBM190250; US9175357, 5599
Click to Show/Hide
|
||||
| Activity |
IC50 = 600000 nM
|
[16] | |||
| Compound Name |
3-Amino-N-methyl-4-phenyl-5-(trifluoromethyl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111245; BDBM190255; US9175357, 5607
Click to Show/Hide
|
||||
| Activity |
IC50 > 600000 nM
|
[16] | |||
| Compound Name |
(R)-3-(1-(2-Chloro-4-((3-oxopiperazin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550475; BDBM50297981
Click to Show/Hide
|
||||
| Activity |
EC50 = 1700000 nM
|
[17] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases. Medchemcomm. 2012;3:829-35. | ||||
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| REF 3 | Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton. Bioorg Med Chem. 2013 Feb 1;21(3):608-17. | ||||
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| REF 6 | Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation. J Med Chem. 2010 Mar 25;53(6):2433-42. | ||||
| REF 7 | Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase. Bioorg Med Chem. 2010 Mar 15;18(6):2317-2326. | ||||
| REF 8 | Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2691-5. | ||||
| REF 9 | Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. Bioorg Med Chem. 2014 Sep 1;22(17):4968-97. | ||||
| REF 10 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 11 | Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors. Bioorg Med Chem Lett. 2013 May 1;23(9):2743-9. | ||||
| REF 12 | Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem. 2012 Apr 12;55(7):3228-41. | ||||
| REF 13 | Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship. J Med Chem. 2011 Mar 24;54(6):1626-39. | ||||
| REF 14 | Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905). J Med Chem. 2012 Jan 12;55(1):197-208. | ||||
| REF 15 | 2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines. Eur J Med Chem. 2012 Jul;53:254-63. | ||||
| REF 16 | US patent application no. 9175357B2, Fragment ligated inhibitors selective for the polo box domain of PLK1 | ||||
| REF 17 | Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4673-8. | ||||
| REF 18 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. Bioorg Med Chem. 2011 Aug 1;19(15):4644-51. | ||||
| REF 19 | Identification of acylthiourea derivatives as potent Plk1 PBD inhibitors. Eur J Med Chem. 2016 Nov 29;124:229-236. | ||||
| REF 20 | Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). J Med Chem. 2013 Dec 27;56(24):10045-65. | ||||
| REF 21 | Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors. Bioorg Med Chem Lett. 2006 Jan 1;16(1):96-9. | ||||
| REF 22 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. Bioorg Med Chem. 2011 Nov 15;19(22):6873-80. | ||||
| REF 23 | In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor. Eur J Med Chem. 2015 Jan 7;89:310-9. | ||||
| REF 24 | Cytotoxic and protein kinase inhibiting nakijiquinones and nakijiquinols from the sponge Dactylospongia metachromia. J Nat Prod. 2014 Feb 28;77(2):218-26. | ||||
| REF 25 | Profile and molecular modeling of 3-(indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) as a highly selective VEGF-R2/3 inhibitor. J Med Chem. 2006 Dec 14;49(25):7549-53. | ||||
| REF 26 | Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach. J Med Chem. 2016 Apr 28;59(8):3671-88. | ||||
| REF 27 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 28 | Optimization of potent DFG-in inhibitors of platelet derived growth factor receptor (PDGF-R) guided by water thermodynamics. J Med Chem. 2015 Jan 8;58(1):170-82. | ||||
| REF 29 | The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3'[3H]indol]-2'(1'H)-ones as Orally Bioavailable Antitumor Agents. J Med Chem. 2015 Jan 8;58(1):130-46. | ||||
| REF 30 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
| REF 31 | Application of oxime-diversification to optimize ligand interactions within a cryptic pocket of the polo-like kinase 1 polo-box domain. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5009-12. | ||||
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