Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T44991 | Target Info | |||
| Target Name | Vascular cell adhesion protein 1 (VCAM1) | ||||
| Synonyms |
Vascular cell adhesion molecule 1; VCAM-1; V-CAM 1; INCAM-100; CD106 antigen; CD106
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| Target Type | Literature-reported Target | ||||
| Gene Name | VCAM1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Probucol
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Approved | Compound Info | ||
| Synonyms |
Biphenabid; Bisbid; Bisphenabid; Lesterol; Lorelco; Lursell; Lurselle; Panavir; Probucolum; Sinlestal; Superlipid; Almirall Brand of Probucol; Aventis Brand of Probucol; Hoechst Brand of Probucol; DH 581; DH581; DE-3872; DH-581; LORELCO (TN); Probucolum [INN-Latin]; ZERO/001429; Probucol (JAN/USP/INN); Probucol [USAN:BAN:INN:JAN]; Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; Acetone, bis (3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; Acetone, bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol; 4,4'-(Isopropylidenedithio)bis(2, 6-di-tert-butylphenol); 4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol); 4,4'-(Isopropylidenedithio)bis[2, 6-di-tert-butylphenol]; 4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol]; 4,4'-(propane-2,2-diyldisulfanediyl)bis(2,6-di-tert-butylphenol); 4,4'-[(1-Methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Probucol Disuccinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313325; SCHEMBL8100563; BCP32627; BDBM50117531; Probucoldisuccinate;Probucol disuccinyl ester
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Oxalic acid 1-[2,6-di-tert-butyl-4-[1-methyl-1-(3,5-di-tert-butyl-4-hydroxyphenylthio)ethylthio]phenyl] ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL82014; BDBM50117533
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Hydroxyvaleric acid 2,6-di-tert-butyl-4-[1-methyl-1-(3,5-di-tert-butyl-4-hydroxyphenylthio)ethylthio]phenyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL85477; BDBM50117537
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
N-Benzyl-6-ethylthieno[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL6430; Oprea1_061553; Oprea1_653654; SCHEMBL5429540; ZINC187679; BDBM50098477; AKOS016523460; MCULE-3319004424; AG-690/40146950; Benzyl-(6-ethyl-thieno[2,3-d]pyrimidin-4-yl)-amine; Z57088564
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| Activity |
IC50 = 59000 nM
|
[2] | |||
| Compound Name |
4-(2-Pyridinylthio)thieno[2,3-c]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL263080; SCHEMBL7060049; BDBM50098492; 4-pyridin-2-ylsulfanylthieno[2,3-c]pyridine-2-carboxamide; 4-(Pyridin-2-ylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid amide
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| Activity |
IC50 = 65000 nM
|
[2] | |||
| Compound Name |
Hexafluoropentanedioic acid 1-[2,6-di-tert-butyl-4-[1-methyl-1-(3,5-di-tert-butyl-4-hydroxyphenylthio)ethylthio]phenyl] ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313781; BDBM50117540
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(4-Chlorophenyl)-4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL6417; SCHEMBL7059677; BDBM50098489; 4-p-Tolylsulfanyl-thieno[2,3-c]pyridine-2-carboxylic acid (4-chloro-phenyl)-amide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
6-Ethylthieno[2,3-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
6-ethylthieno[2,3-d]pyrimidin-4-ol; 6-ethyl-3H-thieno[2,3-d]pyrimidin-4-one; 6-Ethyl-thieno[2,3-d]pyrimidin-4-ol; CHEMBL6215; MLS000029626; 6-ethyl-3H,4H-thieno[2,3-d]pyrimidin-4-one; SMR000009585; 6-ethylthiopheno[2,3-d]pyrimidin-4-ol; Maybridge3_001404; ChemDiv2_002305; Cambridge id 5313227; cid_645569; SCHEMBL3108511; SCHEMBL10325022; BDBM37871; CTK8C0316; DTXSID90349410; HMS1375I17; HMS1434P18; HMS1673P03; HMS2289E05; ALBB-019867; ANW-64489; BDBM50500488; MFCD00457520; QC-140; SBB014493; STK674212; STK827908; ZINC18193916; AKOS000265733; AKOS000541118; 6-ethyl thieno[2,3-d]pyrimidin-4-ol; MCULE-8942412555; IDI1_012791; AS-64355; DB-065548; ST4037528; FT-0741237; Z2902; 4-Oxo-(3H)-6-ethylthieno[2,3-d]pyrimidine; C-1220; thieno[2,3-d]pyrimidin-4(3H)-one, 6-ethyl-; SR-01000519447; 6-Ethyl-3,4-dihydrothieno[2,3-d]pyrimidine-4-one; SR-01000519447-1; Z94601204
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3,3-Dimethyl-4-hydroxybutyric acid 2,6-di-tert-butyl-4-[1-methyl-1-(3,5-di-tert-butyl-4-hydroxyphenylthio)ethylthio]phenyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL85705; BDBM50117535
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| Activity |
IC50 = 110000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2545-8. | ||||
| REF 2 | Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J Med Chem. 2001 Mar 15;44(6):988-1002. | ||||
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