Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53251 | Target Info | |||
| Target Name | Histone-lysine N-methyltransferase EHMT2 (EHMT2) | ||||
| Synonyms |
Protein G9a; NG36; Lysine N-methyltransferase 1C; KMT1C; Histone H3-K9 methyltransferase 3; HLA-B-associated transcript 8; H3-K9-HMTase 3; G9A; Euchromatic histone-lysine N-methyltransferase 2; C6orf30; BAT8
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| Target Type | Preclinical Target | ||||
| Gene Name | EHMT2 | ||||
| Biochemical Class | Methyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 40 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Glutathione
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Approved | Compound Info | ||
| Synonyms |
glutathione; 70-18-8; Glutathion; Isethion; Tathion; Glutathione-SH; Glutinal; reduced glutathione; Neuthion; Deltathione; Copren; L-Glutathione reduced; Glutide; Tathione; Triptide; Ledac; Glutatione; GSH; Glutatiol; Panaron; gamma-L-Glutamyl-L-cysteinylglycine; Glutathione SH; L-Glutatione; Glutathione (reduced); Agifutol S; L-gamma-glutamyl-L-cysteinylglycine; gamma-L-glutamyl-L-cysteinyl-glycine; 5-L-Glutamyl-L-cysteinylglycine; Glutathione [JAN]; glutathione red; gamma-L-Glutamylcysteinylglycine; red. glutathione
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
GSK343
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Investigative | Compound Info | ||
| Synonyms |
compound 6 [PMID 24900432]; GSK 343
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
ANTHRAQUINONE
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Investigative | Compound Info | ||
| Synonyms |
84-65-1; 9,10-Anthraquinone; anthracene-9,10-dione; 9,10-Anthracenedione; Anthradione; Hoelite; 9,10-Dioxoanthracene; Corbit; Morkit; 9,10-Anthrachinon; Anthra-9,10-quinone; Anthrapel; 9,10-quinone; Anthrachinon; Caswell No. 052A; Anthraquinone [BSI:ISO]; UNII-030MS0JBDO; NSC 7957; Bis-alkylamino anthraquinone; 9,10-Anthrachinon [Czech]; CCRIS 649; 9,10-Anthracendion; Anthracene, 9,10-dihydro-9,10-dioxo-; CHEBI:40448; HSDB 2074; EINECS 201-549-0; Anthracene-9,10-quinone; EPA Pesticide Chemical Code 122701
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(1S,4S,7S,9S)-4-(Hydroxymethyl)-9-[(1S,4S,7S,9S)-4-(hydroxymethyl)-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-trien-9-yl]-5-methyl-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-3,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2315527; BDBM50425312
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Chembl4283782
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL15280263
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
Chembl4281110
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
7-[3-(4,4-Difluoropiperidin-1-yl)propoxy]-6-methoxy-2-(oxan-4-yl)-N-(1-propan-2-ylpiperidin-4-yl)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441074; BDBM50442108
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
(1R,4R,7R,9R)-4-(Hydroxymethyl)-9-[(1R,4R,7R,9R)-4-(hydroxymethyl)-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-trien-9-yl]-5-methyl-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-3,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222848; BDBM50396028
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-[3-[methyl(propyl)amino]propoxy]quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213902; BDBM50323807; NCGC00187796-01
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| Activity |
IC50 = 51000 nM
|
[6] | |||
| Compound Name |
7-[3-(Diethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213901; BDBM50323806; NCGC00187784-01
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| Activity |
IC50 = 52000 nM
|
[6] | |||
| Compound Name |
Ninhydrin
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Investigative | Compound Info | ||
| Synonyms |
Ninhydrine; Ninhydrin hydrate; 1H-Indene-1,3(2H)-dione, 2,2-dihydroxy-; 2,2-Dihydroxy-1H-indene-1,3(2H)-dione; 2,2-Dihydroxy-1,3-indandione; Triketohydrindene hydrate; 2,2-Dihydroxy-1,3-indanedione; 1,2,3-Indantrione, 2-hydrate; 2,2-Dihydroxyindane-1,3-dione; 2,2-dihydroxyindene-1,3-dione; Ninhydrin Spray; Trioxohydrindene monohydrate; UNII-HCL6S9K23A; MFCD00003791; Ninhydrin, ACS reagent; 1,3-Indandione, 2,2-dihydroxy-; 2,2-dihydroxy-2,3-dihydro-1H-indene-1,3-dione; HCL6S9K23A; CHEMBL1221925; Ninhydrin, spectrophotometric grade; CCRIS 4849; EINECS 207-618-1; BRN 1910963; 2,2-dihydroxy-2-hydrocyclopenta[1,2-a]benzene-1,3-dione; Ningidrin; nin-hydrin; AI3-04464; ninhydrin monohydrate; Ninhydrin ACS grade; zlchem 153; DSSTox_CID_5716; DSSTox_RID_77890; DSSTox_GSID_25716; Ninhydrin, AR, >=99%; SCHEMBL17986; 4-07-00-02786 (Beilstein Handbook Reference); MLS002454421; DTXSID7025716; CTK7H1849; ZLB0142; Ninhydrin, >=95.0% (UV); ZINC388306; ACT05788; ALBB-033740; HY-D0908; Tox21_200705; 1,2,3-Triketohydrindene Monohydrate; BBL012206; BDBM50324901; Ninhydrin, puriss. p.a., >=99%; SBB009147; STL163548; AKOS004906785; 1H-Indene-1,2,3, trione Monohydrate; 1H-Indene-1,2,3-trione, 2-hydrate; CS-W018489; MCULE-8190517984; NE10279; NCGC00091114-01; NCGC00091114-02; NCGC00091114-03; NCGC00258259-01; AC-11764; AS-14832; BP-11883; Ninhydrin, p.a., ACS reagent, 99.0%; SMR001372015; ST094931; Ninhydrin spray reagent, 0.2% in ethanol; Ninhydrin, SAJ special grade, >=98.0%; DB-051560; Ninhydrin, ACS reagent, >=98.0% (UV); FT-0632202; I0015; N0094; N0719; Ninhydrin, suitable for amino acid detection; 27828-EP2292592A1; 27828-EP2292628A2; 27828-EP2298767A1; 27828-EP2305671A1; 27828-EP2305808A1; 27828-EP2311842A2; 27828-EP2314587A1; AQ-911/40896973; Q421098; J-610068; Q-201472; Ninhydrin, ozone friendly ready to use spray for TLC; F0001-2517; Ninhydrin, >=98.0%, suitable for amino acid analysis
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| Activity |
IC50 = 54000 nM
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[1] | |||
| Compound Name |
6-Deoxy-5a,6-didehydrogliotoxin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950960; BDBM50364109
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| Activity |
IC50 = 55000 nM
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[7] | |||
| Compound Name |
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-[2-(2-pyrrolidin-1-ylethoxy)ethoxy]quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214067; BDBM50323814; NCGC00188558-01
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| Activity |
IC50 = 57000 nM
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[6] | |||
| Compound Name |
7-[3-(Dimethylamino)propoxy]-6-Methoxy-2-(4-Methyl-1,4-Diazepan-1-Yl)-N-(1-Methylpiperidin-4-Yl)quinazolin-4-Amine
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Investigative | Compound Info | ||
| Synonyms |
UNC0224; UNC 0224; UNC-0224; CHEMBL576781; C26H43N7O2; SCHEMBL15280266; DTXSID50658050; BCP13205; EX-A2274; 4141AH; BDBM50300041; ZINC36382580; AKOS024457835; CCG-208709; NCGC00185956-01; AK547076; BS-14469; HY-10929; J-004184; Q27459780; N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX 01294
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| Activity |
IC50 = 57000 nM
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[6] | |||
| Compound Name |
Dehydrobis(methylthio)gliotoxin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088849; BDBM50364110; 5a,6-Dehydrobisdethio-3,10a-bis(methylthio)gliotoxin
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| Activity |
IC50 = 58000 nM
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[7] | |||
| Compound Name |
N-(4-((2-Amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
SGI-1027; DNA Methyltransferase Inhibitor II; SGI 1027; CHEMBL2336409; GTPL8891; SCHEMBL3655385; C27H23N7O; AOB6458; SGI1027; HMS3653O06; HMS3748A21; BCP09928; EX-A2160; BDBM50430056; FD5030; MFCD27937047; s7276; ZINC95591603; AKOS024458519; CCG-269354; SB19043; KS-00000T67; NCGC00381561-65; AC-33115; AK175455; AS-74078; DA-48337; HY-13962; FT-0755513; SGI-1027, >=98% (HPLC); SW220204-1; Y1873; A14120; J-000537; Q27088794
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| Activity |
IC50 = 59000 nM
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[8] | |||
| Compound Name |
5'-[(R)-1-Amino-2-cyclopropylethyl]-5'-deoxyadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103578; BDBM50260388; J3.657.506I
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| Activity |
IC50 = 67200 nM
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[9] | |||
| Compound Name |
7-[5-(Dimethylamino)pentoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213828; BDBM50323803; NCGC00187798-01
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| Activity |
IC50 = 95000 nM
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[6] | |||
| Compound Name |
(2S)-2-Amino-5-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methyl-(2-iodoethyl)amino]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172427; BDBM50396017
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| Activity |
IC50 ~ 100000 nM
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[10] | |||
| Compound Name |
6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
UNC0379; UNC-0379; CHEMBL3318285; UNC 0379; 6,7-Dimethoxy-2-pyrrolidin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine; C23H35N5O2; CS-3345; HY-12335; SCHEMBL22568439; AOB6365; EX-A461; SYN5081; BCP10429; KS-00000T5A; 3362AH; BDBM50051117; MFCD28167817; s7570; ZINC98214604; AKOS025404942; UNC 0379;UNC-0379; CCG-268809; SB19349; NCGC00384189-06; NCGC00384189-10; AK174945; AS-16447; DA-43617; B8009; FT-0699830; A14320; UNC0379 trifluoroacetate salt, >=98% (HPLC)
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| Activity |
IC50 ~ 100000 nM
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[11] | |||
| Compound Name |
(1S,3R,11R,14R)-14-(Hydroxymethyl)-3-[(1S,3R,11R,14R)-14-(hydroxymethyl)-15-methyl-13,16-dioxo-17-thia-10,12,15-triazapentacyclo[12.2.1.01,12.03,11.04,9]heptadeca-4,6,8-trien-3-yl]-15-methyl-17-thia-10,12,15-triazapentacyclo[12.2.1.01,12.03,11.04,9]heptadeca-4,6,8-triene-13,16-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2315524; BDBM50425309
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| Activity |
IC50 ~ 100000 nM
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[12] | |||
| Compound Name |
Bisdethiobis(methylthio)gliotoxin
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Investigative | Compound Info | ||
| Synonyms |
bis(methylthio)gliotoxin; FR-49175; CHEMBL1088981; dimethylgliotoxin; AC1L4YI4; Bis(methylthio)gliotoxin(fr-49175); S,S-Dimethyl gliotoxin; FR 49175; bis(methylsulfanyl)gliotoxin; Bis(methylthio)gliotoxin, 99%; GTPL3150; SCHEMBL18652994; CTK5D9420; DTXSID70995590; 3R,10Ar-Dithiomethyl Gliotoxin A; ZINC5599818; BDBM50315535; MFCD00133146; MCULE-1105801460; NCGC00380667-01; Q27077740
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
(2S)-2-Amino-5-[[(2R,3S,4R,5R)-5-[6-(benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl-(2-iodoethyl)amino]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2169918; BDBM50396016
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| Activity |
IC50 ~ 100000 nM
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[10] | |||
| Compound Name |
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
GSK926; CHEMBL2204998; SCHEMBL2590353; BDBM50400779
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204997; SCHEMBL12180659; BDBM50400781
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Cysteamine
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Investigative | Compound Info | ||
| Synonyms |
2-Aminoethanethiol; Mercaptamine; Thioethanolamine; Becaptan; Mercamine; Cysteinamine; beta-Mercaptoethylamine; 2-Mercaptoethylamine; Cysteamin; Lambraten; Lambratene; beta-Aminoethanethiol; Cystagon; Riacon; Decarboxycysteine; Mercaptoethylamine; 2-Amino-1-ethanethiol; Ethanethiol, 2-amino-; Cisteamina; 2-Aminoethyl mercaptan; beta-Aminoethylthiol; 2-Mercaptoethanamine; Mercaptamin; (2-Mercaptoethyl)amine; MEA (mercaptan); Ethanethiolamine; 2-AMINO-ETHANETHIOL; beta-MEA; Aminoethyl mercaptan; Mercaptamina; Mercaptaminum; Cysteamide; Mecramine; Mercamin; Merkamin; Cisteamina [Italian]; Cystaran; Mercaptaminum [INN-Latin]; Mercaptamina [INN-Spanish]; 1-Amino-2-mercaptoethylamine; L-1573; Cysteamine (USAN); WR 347; 2-aminoethane-1-thiol; UNII-5UX2SD1KE2; NSC 647528; Cysteamine [USAN]; Mercaptamine (INN); .beta.-Mercaptoethylamine; 5UX2SD1KE2; 2-aminoethane-1-thiol; Cysteamine; Mercaptamine [INN]; NSC647528; NSC-647528; NCGC00015691-03; 2-Aminoethanethiol, 95%; Cysteamine [USAN:BAN]; C2H7NS; Cysteamine bitartate; CCRIS 3083; HSDB 7353; EINECS 200-463-0; L 1573; Cystagone; b-Aminoethylthiol; 2-aminoethanethio; b-Aminoethanethiol; mercapto ethylamine; b-Mercaptoethylamine; MFCD00008196; 2-amino-ethyl thiol; .beta.-MEA; Cysteamine, ~95%; Cysteamine, free base; .beta.-Aminoethylthiol; Spectrum_001755; .beta.-Aminoethanethiol; ACMC-1AVBC; SpecPlus_000654; (Mercaptoethyl)ammonium toluene-p-sulphonate; Lopac-M-6500; DSSTox_CID_2875; bmse000388; CHEMBL602; C-9500; DSSTox_RID_76770; DSSTox_GSID_22875; KBioSS_002235; KSC490G2L; DivK1c_006750; 2-$l^{1}-sulfanylethanamine; BDBM7968; GTPL7440; 2,3-DESHYDROLANTHIONINE; DTXSID3022875; CTK3J0325; KBio1_001694; KBio2_002235; KBio2_004803; KBio2_007371; KS-00000WES; Cysteamine, >=98.0% (RT); BCP15015; ZINC8034121; EINECS 221-235-7; Tox21_113092; ANW-33452; HY-77591A; s6402; STK315355; AKOS003793343; CCG-204834; DB00847; MCULE-1838427828; NE18622; SDCCGSBI-0050727.P004; NCGC00015691-01; NCGC00015691-02; NCGC00015691-04; NCGC00015691-14; NCGC00162236-01; NCGC00162236-02; AS-56218; BP-13401; NCI60_002000; SC-18413; SBI-0050727.P003; AB0020070; DB-053562; A0648; FT-0611243; V0810; C01678; D03634; AB00053754_09; AB00053754_10; 106791-EP2292597A1; 106791-EP2295407A1; 106791-EP2298736A1; 213515-EP2371809A1; Q617563; F0001-1576; 2DFDA1F8-7010-4225-8280-AB1C4C43F546
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Bis(dethio)-10a-methylthio-3a-deoxy-3,3a-didehydrogliotoxin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950959; BDBM50364108
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-pentyloxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263624; SCHEMBL16486895; BDBM50010378
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| Activity |
IC50 = 103000 nM
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[13] | |||
| Compound Name |
7-[2-(Dimethylamino)ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213766; BDBM50323801; NCGC00186580-01
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| Activity |
IC50 = 110000 nM
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[6] | |||
| Compound Name |
7-[4-(Dimethylamino)butoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213827; BDBM50323802; NCGC00187797-01
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| Activity |
IC50 = 110000 nM
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[6] | |||
| Compound Name |
7-(5-Aminopentoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214015; BDBM50323812; NCGC00187790-01
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| Activity |
IC50 = 110000 nM
|
[6] | |||
| Compound Name |
6-Methoxy-7-[3-(methylamino)propoxy]-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213830; BDBM50323805; NCGC00187781-01
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| Activity |
IC50 = 120000 nM
|
[6] | |||
| Compound Name |
6,7-Dimethoxy-2-(4-methylpiperazin-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572373; BDBM50300030; NCGC00185858-01; 6,7-Dimaethoxy-2-(4-methylpiperazin-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
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| Activity |
IC50 = 150000 nM
|
[6] | |||
| Compound Name |
1-((2-(1H-Indol-3-yl)ethyl)amino)-3-(9H-carbazol-9-yl)-propan-2-ol
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Investigative | Compound Info | ||
| Synonyms |
DC_05; DC-05; CHEMBL3358015; C25H25N3O; AOB6967; SYN5082; BDBM50031317; AKOS002242638; AKOS016316322; NCGC00402253-02; AS-16448; DC_05, >=98% (HPLC); HY-12746; ST50753266; 1-carbazol-9-yl-3-[(2-indol-3-ylethyl)amino]propan-2-ol; 1-carbazol-9-yl-3-[2-(1H-indol-3-yl)ethylamino]propan-2-ol; 1-(9H-Carbazole-9-yl)-3-[[2-(1H-indole-3-yl)ethyl]amino]-2-propanol
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| Activity |
IC50 ~ 150000 nM
|
[14] | |||
| Compound Name |
(2R,3S,4R,5R)-2-[2-Amino-3-(3,4-dimethoxyphenyl)propyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263627; SCHEMBL16487123; BDBM50010381
Click to Show/Hide
|
||||
| Activity |
IC50 = 157000 nM
|
[13] | |||
| Compound Name |
(2R,3S,4R,5R)-2-[(2S)-2-Amino-3-cyclobutylpropyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074394; BDBM50260387
Click to Show/Hide
|
||||
| Activity |
IC50 = 169000 nM
|
[9] | |||
| Compound Name |
N'-[2-[6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-[(1-methylpiperidin-4-yl)amino]quinazolin-7-yl]oxyethyl]-N,N,N'-trimethylethane-1,2-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214068; BDBM50323815; NCGC00187787-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 173000 nM
|
[6] | |||
| Compound Name |
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(3-phenylpropyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263625; SCHEMBL16487371; BDBM50010379
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[13] | |||
| Compound Name |
(2R,3S,4R,5R)-2-[(2S)-2-Amino-3-cyclopentylpropyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089220; BDBM50260383
Click to Show/Hide
|
||||
| Activity |
IC50 = 191300 nM
|
[9] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 23 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sinefungin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
sinefungin; ADENOSYL-ORNITHINE; Sinefunginum; Sinefungina; Sinefungine; Antibiotic A 9145; Compound 57926; Adenosylornithine; 58944-73-3; A 9145; Antibiotic 32232 RP; Sinefungin [USAN:INN]; Sinefungine [INN-French]; Sinefunginum [INN-Latin]; UNII-W2U467CIIL; Sinefungina [INN-Spanish]; 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxydecofuranuronic acid; 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuronic acid; BRN 3574678; W2U467CIIL; RP 32232; LY 57926; CHEBI:45453; Decofuranuronic
Click to Show/Hide
|
||||
| Activity |
IC50 = 509000 nM
|
[13] | |||
| Compound Name |
6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL578227; BDBM50300029; NCGC00185860-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[6] | |||
| Compound Name |
6,7-Dimethoxy-N-(1-methylpiperidin-4-yl)-2-(piperidin-1-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL570120; SCHEMBL15280595; BDBM50300031; NCGC00185859-01; 6,7-Dimethoxy-N-(1-methylpiperidin-4-yl)-2-(piperidin-1-yl)-quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 510000 nM
|
[6] | |||
| Compound Name |
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213958; BDBM50323810; NCGC00187788-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 780000 nM
|
[6] | |||
| Compound Name |
6,7-Dimethoxy-N-(1-Methylpiperidin-4-Yl)-2-(Morpholin-4-Yl)quinazolin-4-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL571717; MS0124; 6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-morpholinoquinazolin-4-amine; SCHEMBL15280520; BDBM50300032; NCGC00185861-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 810000 nM
|
[6] | |||
| Compound Name |
6,7-Dimethoxy-N2,N2-dimethyl-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL576260; BDBM50300034; NCGC00185941-01; 6,7-Dimethoxy-N2,N2-dimethyl-N4-(1-methylpiperidin-4-yl)-quinazoline-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 900000 nM
|
[6] | |||
| Compound Name |
N2,N2-Diethyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL585180; BDBM50300033; NCGC00185942-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 910000 nM
|
[6] | |||
| Compound Name |
6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpyrrolidin-3-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214630; BDBM50323800; NCGC00187782-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 910000 nM
|
[6] | |||
| Compound Name |
CID 46901936
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214145; BDBM50323816; NCGC00188550-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 1500000 nM
|
[6] | |||
| Compound Name |
7-[6-(Dimethylamino)hexoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213829; BDBM50323804; NCGC00187786-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 3200000 nM
|
[6] | |||
| Compound Name |
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(4-methylpentoxy)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213959; BDBM50323811; NCGC00187785-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 3400000 nM
|
[6] | |||
| Compound Name |
N-Cyclopropyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL568964; BDBM50300038; NCGC00185855-01; N-Cyclopropyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 5100000 nM
|
[6] | |||
| Compound Name |
N-Isopropyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL570799; BDBM50300039; NCGC00185865-01; N-Isopropyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 5800000 nM
|
[6] | |||
| Compound Name |
2-Chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL571951; SCHEMBL15280254; BDBM50300040; NCGC00185857-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 9100000 nM
|
[6] | |||
| Compound Name |
CID 46902073
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214628; BDBM50323817; NCGC00187783-01; 6,7-dimethoxy-N-methyl-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[6] | |||
| Compound Name |
Tert-Butyl 4-(6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-(1-methylpiperidin-4-ylamino)quinazolin-7-yloxy)butylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214014; BDBM50323821; NCGC00187791-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[6] | |||
| Compound Name |
5-(6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-(1-methylpiperidin-4-ylamino)quinazolin-7-yloxy)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214016; BDBM50323822; NCGC00185951-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[6] | |||
| Compound Name |
6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(tetrahydro-2H-pyran-4-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL583046; BDBM50300036; NCGC00186582-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[6] | |||
| Compound Name |
N-Cyclohexyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL568963; BDBM50300037; NCGC00186583-01; N-Cyclohexyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[6] | |||
| Compound Name |
6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(piperidin-4-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL570119; BDBM50300035; NCGC00186581-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[6] | |||
| Compound Name |
CID 46901785
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213960; BDBM50323820; NCGC00185954-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[6] | |||
| Compound Name |
6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-(1-methylpiperidin-4-yloxy)quinazoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214629; BDBM50323818; NCGC00187780-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[6] | |||
| Compound Name |
6,7-Dimethoxy-N-methyl-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213706; BDBM50323819; NCGC00185944-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II). Bioorg Med Chem Lett. 2018 Apr 15;28(7):1234-1238. | ||||
| REF 2 | Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6. | ||||
| REF 3 | Selective inhibitors of protein methyltransferases. J Med Chem. 2015 Feb 26;58(4):1596-629. | ||||
| REF 4 | Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti- Plasmodium activity. Medchemcomm. 2017 May 1;8(5):1069-1092. | ||||
| REF 5 | Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-42. | ||||
| REF 6 | Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57. | ||||
| REF 7 | Gliotoxin analogues from a marine-derived fungus, Penicillium sp., and their cytotoxic and histone methyltransferase inhibitory activities. J Nat Prod. 2012 Jan 27;75(1):111-4. | ||||
| REF 8 | Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy. J Med Chem. 2018 Aug 9;61(15):6518-6545. | ||||
| REF 9 | Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors. Bioorg Med Chem. 2017 Sep 1;25(17):4579-4594. | ||||
| REF 10 | Oncoepigenomics: making histone lysine methylation count. Eur J Med Chem. 2012 Oct;56:179-94. | ||||
| REF 11 | Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem. 2014 Aug 14;57(15):6822-33. | ||||
| REF 12 | Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification. Bioorg Med Chem Lett. 2013 Feb 1;23(3):733-6. | ||||
| REF 13 | Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2. ACS Med Chem Lett. 2014 Jan 31;5(4):293-7. | ||||
| REF 14 | Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57(21):9028-41. | ||||
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