Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T54771 | Target Info | |||
| Target Name | Sodium/glucose cotransporter 1 (SGLT1) | ||||
| Synonyms |
Solute carrier family 5 member 1; Na(+)/glucose cotransporter 1; NAGT; High affinity sodium-glucose cotransporter
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| Target Type | Clinical trial Target | ||||
| Gene Name | SLC5A1 | ||||
| Biochemical Class | Solute:sodium symporter | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 59 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
phloretin
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|
Investigative | Compound Info | ||
| Synonyms |
phloretin; 60-82-2; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one; Dihydronaringenin; Phloretol; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone; NSC 407292; UNII-S5J5OE47MK; 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-; CCRIS 7459; beta-(p-Hydroxyphenyl)phloropropiophenone; 2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone; 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone; EINECS 200-488-7; NSC407292; S5J5OE47MK; beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone
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| Activity |
Ki = 86000 nM
|
[1] | |||
| Compound Name |
(2S,3R,4R,5R)-2-[4-Chloro-3-[(6-methoxynaphthalen-2-yl)methyl]phenyl]-5-[(1R)-1,2-dihydroxyethyl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440378; BDBM50442477
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5R)-2-[4-Chloro-3-[(4-methylsulfanylphenyl)methyl]phenyl]-5-[(1R)-1,2-dihydroxyethyl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440376; BDBM50442478
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5R)-2-[4-Chloro-3-[(4-methoxyphenyl)methyl]phenyl]-5-[(1R)-1,2-dihydroxyethyl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440371; BDBM50442479
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5S)-2-[(1R)-1,2-Dihydroxyethyl]-5-[3-[(4-ethoxyphenyl)methyl]-4-methylphenyl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440365; BDBM50442476
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5S)-2-[(1R)-1,2-Dihydroxyethyl]-5-[3-[(4-ethylphenyl)methyl]-4-methylphenyl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440367; BDBM50442474
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5R)-2-[4-Chloro-2-methoxy-5-[(4-propan-2-ylphenyl)methyl]phenyl]-5-[(1R)-1,2-dihydroxyethyl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440369; BDBM50442472
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5R)-2-[4-Chloro-5-[(4-ethoxyphenyl)methyl]-2-methoxyphenyl]-5-[(1R)-1,2-dihydroxyethyl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440368; BDBM50442473
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5S)-2-[(1R)-1,2-Dihydroxyethyl]-5-[4-methyl-3-[(4-propan-2-ylphenyl)methyl]phenyl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440366; BDBM50442475
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Methyl (14E)-14-ethylidene-6-hydroxy-2-methyl-19-{[(3,4,5-trihydroxyphenyl)carbonyloxy]methyl}-18-oxa-2,12-diazahexacyclo[9.6.1.1^{9,15}.0^{1,9}.0^{3,8}.0^{12,17}]nonadeca-3(8),4,6-triene-19-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL602442; BDBM50308530
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
2',4',6'-Trihydroxy-4-methoxychalcone
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Investigative | Compound Info | ||
| Synonyms |
Isosakuranetin chalcone; 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one; CHEMBL133588; SCHEMBL11349226; BDBM50235135; LMPK12120265; 4-METHOXYL-2',4',6'-TRIHYDROXYCHALCONE; 4-METHOXYL-2'',4'',6''-TRIHYDROXYCHALCONE
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| Activity |
IC50 = 50900 nM
|
[4] | |||
| Compound Name |
(E)-3-(4-Phenylmethoxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071789; SCHEMBL18976296; BDBM50235133
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| Activity |
IC50 = 52600 nM
|
[4] | |||
| Compound Name |
(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[[4-(trifluoromethyl)phenyl]methyl]phenoxy]cyclohexane-1,2,3-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819496; SCHEMBL12152989; BDBM50351443
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| Activity |
IC50 = 57000 nM
|
[5] | |||
| Compound Name |
(2S,3R,4R,5S,6R)-2-(4-Chloro-5-(4-ethylbenzyl)-2-((2-hydroxypropoxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163823; SCHEMBL3687902; BDBM50321297
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| Activity |
IC50 = 60000 nM
|
[6] | |||
| Compound Name |
6-Chloro-2-[[2-chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2462721; CHEMBL3288738; BDBM104496; US8575114, I-8
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| Activity |
IC50 = 61159 nM
|
[7] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-6-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2461643; CHEMBL3288740; BDBM104490; US8575114, I-2
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| Activity |
IC50 = 67442 nM
|
[7] | |||
| Compound Name |
5-[[2-Chloro-5-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]furo[3,2-c]pyridin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660001; SCHEMBL12308588; BDBM104505; US8575114, II-2
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| Activity |
IC50 = 71535 nM
|
[7] | |||
| Compound Name |
CID 11596174
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048490; SCHEMBL2577306; BDBM50386881
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| Activity |
IC50 = 73000 nM
|
[8] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-[1,2,4]triazolo[4,3-a]pyridine-3-thione
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2464298; CHEMBL3659996; BDBM104495; US8575114, I-7
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| Activity |
IC50 ~ 73192 nM
|
[7] | |||
| Compound Name |
(2R,3R,4R,5S,6R)-2-[3-[[4-[[(1R,5S)-3-Bicyclo[3.1.0]hexanyl]oxy]phenyl]methyl]-4-chlorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4112382; CHEMBL4113665; SCHEMBL16871767; SCHEMBL16871769; SCHEMBL16871770; BDBM221895; BDBM221896; US9315438, Compound represented by formula (V); US9315438, Compound represented by formula (IV)
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| Activity |
IC50 = 75465.18 nM
|
[9] | |||
| Compound Name |
4-[[(3S,3'R,4'S,5'S,6'R)-3',4',5'-Trihydroxy-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-5-yl]methyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172382; SCHEMBL13201803; BDBM50396772
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| Activity |
IC50 = 81487 nM
|
[10] | |||
| Compound Name |
CID 53468203
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288754; SCHEMBL2462197; BDBM50019138
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| Activity |
IC50 = 83060 nM
|
[11] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-7-methoxy-[1,2,4]triazolo[4,3-a]pyridin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288747; BDBM50019132
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| Activity |
IC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-7-(hydroxymethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2466441; CHEMBL3659998; BDBM104502; US8575114, I-14
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| Activity |
IC50 ~ 90000 nM
|
[7] | |||
| Compound Name |
6-Bromo-2-[[2-chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2465025; CHEMBL3288739; BDBM104498; US8575114, I-10
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| Activity |
IC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-6-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2464228; CHEMBL3288742; BDBM104499; US8575114, I-11
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| Activity |
IC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
CID 53468204
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288757; SCHEMBL2461896; BDBM50019141
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| Activity |
IC50 = 90000 nM
|
[11] | |||
| Compound Name |
6-Chloro-2-[[2-chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2461868; CHEMBL3288752; BDBM104500; US8575114, I-12
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| Activity |
IC50 ~ 90000 nM
|
[7] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-5-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288749; BDBM50019134
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| Activity |
IC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
8-Chloro-2-[[2-chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288750; BDBM50019135
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| Activity |
IC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
1-[2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-3-oxo-[1,2,4]triazolo[4,3-a]pyridin-6-yl]cyclopropane-1-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2465140; CHEMBL3659997; BDBM104501; US8575114, I-13
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| Activity |
IC50 ~ 90000 nM
|
[7] | |||
| Compound Name |
7-Chloro-2-[[2-chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2465037; CHEMBL3288744; BDBM104492; US8575114, I-4
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| Activity |
IC50 ~ 90000 nM
|
[7] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-6-(hydroxymethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2466136; CHEMBL3288741; BDBM104494; US8575114, I-6
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| Activity |
IC50 ~ 90000 nM
|
[7] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2465222; CHEMBL3288745; BDBM104497; US8575114, I-9
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| Activity |
IC50 = 90000 nM
|
[7] | |||
| Compound Name |
US8575114, III-5
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660005; SCHEMBL12308595; BDBM104510
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| Activity |
IC50 ~ 90000 nM
|
[7] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-6-(2-hydroxyethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2463836; CHEMBL3659999; BDBM104503; US8575114, I-15
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| Activity |
IC50 ~ 90000 nM
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[7] | |||
| Compound Name |
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-([1,2,4]triazolo[1,5-a]pyridin-6-ylmethyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2465478; CHEMBL3660000; BDBM104504; US8575114, II-1
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| Activity |
IC50 ~ 90000 nM
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[7] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-7-(2,2,2-trifluoroethoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288748; BDBM50019133
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| Activity |
IC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2462743; CHEMBL3288743; BDBM104493; US8575114, I-5
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| Activity |
IC50 ~ 90000 nM
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[7] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-7-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2467462; CHEMBL3288746; BDBM104491; US8575114, I-3
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| Activity |
IC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-8-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288751; BDBM50019136
Click to Show/Hide
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| Activity |
IC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2465012; CHEMBL3288737; BDBM104489; US8575114, I-1
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| Activity |
IC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
(2S,3R,4R,5S,6R)-2-(2-(Allyloxymethyl)-4-chloro-5-(4-ethylbenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1164445; SCHEMBL3685515; BDBM50321289
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| Activity |
IC50 = 91000 nM
|
[6] | |||
| Compound Name |
1-[3,5-Dibromo-2,4-dihydroxy-6-[(2S,3S,4S,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(3,5-dibromo-4-hydroxyphenyl)propan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2303982; BDBM50422345
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| Activity |
Ki = 93100 nM
|
[1] | |||
| Compound Name |
N-[5-[3-[2,4-Dihydroxy-6-[(2S,3S,4S,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-oxopropyl]-2-hydroxyphenyl]-5-(dimethylamino)naphthalene-1-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2303994; BDBM50422358
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| Activity |
Ki = 94300 nM
|
[1] | |||
| Compound Name |
Methyl (14E)-14-ethylidene-6-methoxy-2-methyl-19-[(propanoyloxy)methyl]-18-oxa-2,12-diazahexacyclo[9.6.1.1^{9,15}.0^{1,9}.0^{3,8}.0^{12,17}]nonadeca-3(8),4,6-triene-19-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL601712; BDBM50308535
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| Activity |
IC50 = 97000 nM
|
[3] | |||
| Compound Name |
CID 11718001
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048495; SCHEMBL2575158; BDBM50386891
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
CID 11704386
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048493; SCHEMBL2574081; BDBM50386889
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Methyl (14E)-19-[(acetyloxy)methyl]-14-ethylidene-6-methoxy-2-methyl-18-oxa-2,12-diazahexacyclo[9.6.1.1^{9,15}.0^{1,9}.0^{3,8}.0^{12,17}]nonadeca-3(8),4,6-triene-19-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590530; BDBM50308534
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3S,3'R,4'S,5'S,6'R)-6'-(Aminomethyl)-6-chloro-7-[(4-ethylphenyl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566413; BDBM50303236
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(1R,2R,3S,4S,6R)-4-[2-Ethoxy-5-(4-ethylbenzyl)phenyl]-6-(hydroxymethyl)cyclohexane-1,2,3-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048492; SCHEMBL2579264; BDBM50386882
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
CID 11509608
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048491; SCHEMBL2575326; BDBM50386888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Methyl (14E)-19-[(benzyloxy)methyl]-14-ethylidene-6-methoxy-2-methyl-18-oxa-2,12-diazahexacyclo[9.6.1.1^{9,15}.0^{1,9}.0^{3,8}.0^{12,17}]nonadeca-3(8),4,6-triene-19-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590772; BDBM50308536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxyphenyl]-1-thio-D-glucitol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091948; SCHEMBL12257501; BDBM50315434
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|
||||
| Activity |
IC50 = 100000 nM
|
[13] | |||
| Compound Name |
(2S,3R,4R,5S,6R)-2-(4-Chloro-5-(4-ethylbenzyl)-2-((3-hydroxypropoxy)methyl)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163753; SCHEMBL3684776; BDBM50321295
Click to Show/Hide
|
||||
| Activity |
IC50 = 103000 nM
|
[6] | |||
| Compound Name |
4-[5-[3-[2,4-Dihydroxy-6-[(2S,3S,4S,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-oxopropyl]-2-hydroxyanilino]-4-oxobutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2303993; BDBM50422354
Click to Show/Hide
|
||||
| Activity |
Ki = 116000 nM
|
[1] | |||
| Compound Name |
(2S,3R,4R,5S,6R)-2-(4-Chloro-5-(4-ethylbenzyl)-2-((2,2,2-trifluoroethoxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163592; SCHEMBL3690214; BDBM50321294
Click to Show/Hide
|
||||
| Activity |
IC50 = 134000 nM
|
[6] | |||
| Compound Name |
(2S,3R,4R,5S,6R)-2-(4-Chloro-2-((2,2-difluoropropoxy)methyl)-5-(4-ethylbenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163692; SCHEMBL3679468; BDBM50321298
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[6] | |||
| Compound Name |
3-Amino-5-[3-[2,4-dihydroxy-6-[(2S,3S,4S,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-oxopropyl]-2-hydroxybenzenesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2303992; BDBM50422347
Click to Show/Hide
|
||||
| Activity |
Ki = 152000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(Z)-1-[2,4-Dihydroxy-6-[(2S,3S,4S,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029165; BDBM50409196
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Probing the conformation of the sugar transport inhibitor phlorizin by 2D-NMR, molecular dynamics studies, and pharmacophore analysis. J Med Chem. 2000 May 4;43(9):1692-8. | ||||
| REF 2 | Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors. Bioorg Med Chem. 2013 Nov 1;21(21):6282-91. | ||||
| REF 3 | Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. | ||||
| REF 4 | Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation. J Med Chem. 2017 Jan 26;60(2):568-579. | ||||
| REF 5 | 5a-Carba--D-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem. 2011 Sep 15;19(18):5334-41. | ||||
| REF 6 | ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Bioorg Med Chem. 2010 Jun 15;18(12):4422-32. | ||||
| REF 7 | US patent application no. 8575114B2, SGLT-2 inhibitors, methods of making them, and uses thereof | ||||
| REF 8 | C-Aryl 5a-carba-beta-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem. 2012 Jul 1;20(13):4117-27. | ||||
| REF 9 | US patent application no. 9315438B2, Optically pure benzyl-4-chlorophenyl-C-glucoside derivative | ||||
| REF 10 | Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem. 2012 Sep 13;55(17):7828-40. | ||||
| REF 11 | The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties. Bioorg Med Chem. 2014 Jul 1;22(13):3414-22. | ||||
| REF 12 | Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6877-81. | ||||
| REF 13 | (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotrans... J Med Chem. 2010 Apr 22;53(8):3247-61. | ||||
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