Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57278 | Target Info | |||
| Target Name | Ephrin type-A receptor 2 (EPHA2) | ||||
| Synonyms |
Tyrosine-protein kinase receptor ECK; Epithelial cell kinase; EphA2receptor; ECK
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| Target Type | Clinical trial Target | ||||
| Gene Name | EPHA2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 24 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Bevacizumab + Trastuzumab
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Phase 3 | Compound Info | ||
| Synonyms |
Lithocholic acid; LITHOCHOLIC ACID; 434-13-9; Lithocolic acid; Lithocholate; 3alpha-Hydroxy-5beta-cholanic acid; 3alpha-Hydroxy-5beta-cholan-24-oic acid; 3-Hydroxycholan-24-oic acid; 3alpha-Hydroxycholanic acid; 3-alpha-Hydroxycholanic acid; 5beta-Cholanic acid-3alpha-ol; NCI-C03861; 3alpha-Hydroxy-5beta-cholanoic acid; (3alpha,5beta)-3-hydroxycholan-24-oic acid; 3-alpha-Hydroxy-5-beta-cholanic acid; CCRIS 363; UNII-5QU0I8393U; 3alpha-Hydroxy-5beta-cholanate; 5-beta-Cholanic acid, 3-alpha-hydroxy-; Cholan-24-oic acid, 3-hydroxy-,
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949788; SCHEMBL12134179; BDBM50364832; CH-4932748
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086065; SCHEMBL959662; BDBM50443366
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949789; SCHEMBL12134185; BDBM50364833; CH-4932750
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL600795; BDBM50306683
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(2S)-2-[[(4R)-4-[(3S,8S,9S,10R,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-3-phenoxypropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735472
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| Activity |
IC50 = 50118.72 nM
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[6] | |||
| Compound Name |
N-(3alpha-Hydroxy-24-oxo-5beta-cholane-24-yl)-L-tyrosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323556; BDBM50428060
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| Activity |
IC50 = 50118.72 nM
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[1] | |||
| Compound Name |
(2R)-3-Hydroxy-2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322997; BDBM50027864
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| Activity |
IC50 = 60255.96 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]propanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2336574; BDBM50428220
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| Activity |
IC50 = 71000 nM
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[7] | |||
| Compound Name |
N-(3alpha-Hydroxy-24-oxo-5beta-cholane-24-yl)-L-valine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322994; BDBM50428064
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| Activity |
IC50 = 71000 nM
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[1] | |||
| Compound Name |
N-(3alpha-Hydroxy-24-oxo-5beta-cholane-24-yl)-L-alanine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322992; BDBM50428065
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| Activity |
IC50 = 79000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(4R)-4-[(3S,8S,9S,10R,13R,14S,17R)-3-Acetyloxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736006
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| Activity |
IC50 = 89125.09 nM
|
[6] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2336582; BDBM50428230
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| Activity |
IC50 = 94000 nM
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[7] | |||
| Compound Name |
(2S)-2-[[(4R)-4-[(3S,8S,9S,10R,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735198
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| Activity |
IC50 ~ 100000 nM
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[6] | |||
| Compound Name |
(2R)-2-[[(4R)-4-[(3S,8S,9S,10R,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736288
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2336579; BDBM50428231
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2336577
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S)-3-Hydroxy-2-[[(4R)-4-[(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734875
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2336581
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2336580
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
N-(3alpha-Hydroxy-24-oxo-5beta-cholane-24-yl)-D-tyrosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322988; BDBM50027863
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(3alpha-Hydroxy-24-oxo-5beta-cholane-24-yl)-L-serine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322996; BDBM50428063
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| Activity |
IC50 = 101000 nM
|
[1] | |||
| Compound Name |
Glycolithocholic acid
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Investigative | Compound Info | ||
| Synonyms |
Lithocholylglycine; Glycolithocholate; Lithocholic acid glycine conjugate; UNII-Q53GV75CJG; Q53GV75CJG; N-(3a-hydroxy-5b-cholan-24-oyl)-Glycine; CHEMBL258818; N-((3-alpha,5-beta)-3-Hydroxy-24-oxocholan-24-yl)glycine; Glycine, N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-; lithocholoyglycine; Glykolithocholsaure; Glycolithocholic acid (6CI,7CI); 3a-Hydroxy-5b-cholanic acid glycine ester; Glycine, N-((3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl)-; BIDD:PXR0159; SCHEMBL736797; 3a-Hydroxy-5b-cholanoylglycine; CTK1D6430; DTXSID00963828; Glycine, N-((3-alpha,5-beta)-3-hydroxy-24-oxocholan-24-yl)-; ZINC6036201; N-(3a-Hydroxy-5b-cholanoyl)glycine; BDBM50375588; LMST05030009; PDSP2_001234; Lithocholic acid glycine conjugic acid; AKOS030240641; N-(3,24-Dihydroxycholan-24-ylidene)glycine; C15557; N-(3alpha-hydroxy-5beta-cholan-24-oyl)glycine; N-(3alpha-hydroxy-5beta-cholan-24-oyl)-glycine; 3a-Hydroxy-N-(carboxymethyl)-5b-cholan-24-amide; N-(carboxymethyl)-3a-hydroxy-5b-Cholan-24-amide; 5beta-Cholanic acid-3alpha-ol N-(carboxymethyl)-amide; Q27117337; 3alpha-hydroxy-5beta-cholan-24-oic acid N-(carboxymethyl)amide; Glycine, N-(3-alpha-hydroxy-5-beta-cholan-24-oyl)- (8CI); Lithocholylglycine; Glycholithocholic acid 3 sulfate intermediate
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| Activity |
IC50 = 138000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-N-(2-oxopropyl)pentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322991; BDBM50027861
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| Activity |
IC50 > 316227.77 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]butanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323551; BDBM50027859
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| Activity |
IC50 > 316227.77 nM
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[1] | |||
| Compound Name |
(2R)-4-Amino-2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323549; BDBM50027865
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| Activity |
IC50 > 316227.77 nM
|
[1] | |||
| Compound Name |
N-(24-Oxo-3alpha-hydroxy-5beta-cholane-24-yl)aspartic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323550; BDBM50027857
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| Activity |
IC50 > 316227.77 nM
|
[1] | |||
| Compound Name |
(2S)-4-Amino-2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323548; BDBM50027866
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| Activity |
IC50 > 316227.77 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. | ||||
| REF 2 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
| REF 3 | Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation. Bioorg Med Chem. 2012 Feb 15;20(4):1442-60. | ||||
| REF 4 | The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6223-7. | ||||
| REF 5 | Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. | ||||
| REF 6 | (5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system. Eur J Med Chem. 2015 Oct 20;103:312-24. | ||||
| REF 7 | Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor. ACS Med Chem Lett. 2013 Feb 5;4(3):344-348. | ||||
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