Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62449 | Target Info | |||
| Target Name | Checkpoint kinase-1 (CHK1) | ||||
| Synonyms |
Serine/threonine-protein kinase Chk1; Chk1; Cell cycle checkpoint kinase; CHK1 checkpoint homolog
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CHEK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 128 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
MLN8054
Click to Show/Hide
|
Phase 1 | Compound Info | ||
| Synonyms |
ZZL; MLN-8054
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
NSC-73306
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
PMID20936789C31
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GTPL8180; BDBM50330575
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Naphthalen-2-yl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2442310; SCHEMBL4595641; BDBM50442672; SR-01000383791; SR-01000383791-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-(2,3-Dihydro-1-benzofuran-5-yl)-N-(2-morpholin-4-ylphenyl)-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2037088; SCHEMBL14328467; BDBM50384670
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
WYE-354; WYE 354; pyrazolo pyrimidine, 19; cc-506; MLS006011008; SCHEMBL300431; CHEMBL561708; GTPL9361; WYE354; BDBM35587; DTXSID00657912; C24H29N7O5; HMS3654N09; BCP02898; ZINC43013490; CCG-264882; CS-0183; SB19260; NCGC00242484-01; NCGC00242484-02; NCGC00242484-09; AC-28454; AS-55957; HY-12034; SMR004702806; BCP0726000260; DB-059456; FT-0675866; S1266; SW219671-1; X7422; W-5702; J-001552; J-514253; BRD-K77008974-001-01-6; Q27166532; mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095626; SCHEMBL3984085; BDBM50316252; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2-(2,3-Dihydro-1-benzofuran-5-yl)-N-[2-(3-oxopiperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2037023; SCHEMBL14328471; BDBM50384665
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-((3-Bromo-5-(2-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1643465; BDBM50334914
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080994; SCHEMBL2934634; BDBM50311953
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
Ethyl 7-amino-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1643239; BDBM50334881
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2-(4-Chlorophenyl)-5-[(1-methylpiperidin-4-yl)amino]imidazo[1,2-c]pyrimidine-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381609; BDBM50433772
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
4-(2,3-Dihydro-1-benzofuran-5-yl)-N-(2-piperazin-1-ylphenyl)-1,3-thiazole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2037090; BDBM50384672
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(5-Fluoro-6-Iodo-1-Methyl-1h-Indol-3-Yl)-4-(7-Methoxy-1-Benzofuran-3-Yl)-1h-Pyrrole-2,5-Dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523435; SCHEMBL3142971; BDBM50267521; Q27466736; 3-(5-Fluoro-6-iodo-1-methyl-1H-indol-3-yl)-4-(7-methoxybenzofuran-3-yl)pyrrole-2,5-dione; 3-(5-fluoro-6-iodo-1-methylindol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)pyrrole-2,5-dione; 3-(5-Fluoro-6-iodo-1-methyl-1H-indol-3-yl )-4-(7-methoxy benzofuran-3-yl)-pyrrole-2,5-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-(4-Chlorophenyl)-5-(piperidin-3-ylmethylamino)imidazo[1,2-c]pyrimidine-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381610; BDBM50433771
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
2-[Benzyl(methyl)amino]-N-(2-piperazin-1-ylphenyl)-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381231; SCHEMBL11886218; BDBM50433517
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477817; SCHEMBL5520662; SCHEMBL5520668; BDBM50263132
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
9-Hydroxy-4-(3-piperidinyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL211306; BDBM50192431; 9-hydroxy-4-(piperidin-3-yl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
5H-Dibenzo[b,e]azepine-6,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5H-Dibenz[b,e]azepine-6,11-dione; 5H-benzo[c][1]benzazepine-6,11-dione; 5H-Dibenzo(B,E)azepine-6,11-dione; 5H-Dibenz(b,e)azepine-6,11-dione; 6,11(5H)-Morphanthridinedione; NSC144965; UNII-T0WI39HQ1R; T0WI39HQ1R; MLS002920641; CHEMBL242201; 5H-dibenz(b,e]-azepine-6,11-dione; 5H-dibenz[b,e]-azepine-6,11-dione; EINECS 214-539-6; NSC 144965; PubChem17365; Oprea1_353454; SCHEMBL3224273; CTK0H7934; KS-00000FBE; DTXSID80150693; ZINC406214; 5H-dibenz[b,e]azepin-6,11-dione; 5h-dibenzo[b,e]azepin-6,11-dione; ANW-48629; BDBM50218705; MFCD00612476; AKOS015899932; NSC-144965; AK-41415; BR-41415; DS-13842; SMR001798228; AB0034858; DB-024370; AM20120609; FT-0688216; X9082; S-7390; 143D506; 9-azatricyclo[9.4.0.0(3),?]pentadeca-1(15),3,5,7,11,13-hexaene-2,10-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
(3Z)-3-[(2,3-Dimethoxyphenyl)methylidene]-6-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
indolinone analog 16; CHEMBL200933; BDBM14652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
2-(2,3-Dihydro-1-benzofuran-5-yl)-N-[2-(2-oxopiperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2037022; SCHEMBL14328472; BDBM50384664
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
9-Hydroxy-4-[2-(methylsulfanyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215506; SCHEMBL5828162; BDBM50192363; 9-hydroxy-4-(2-methylsulfanylphenyl)-6H-pyrrolo[3,4-c]carbazole-1,3-dione; 9-hydroxy-4-(2-(methylthio)phenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
(3Z)-5-(4-Hydroxy-3-methoxyphenyl)-3-(1H-indol-3-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
indolinone analog 10; CHEMBL372771; BDBM14646
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
2-(4-Phenoxyphenyl)-N-(2-piperazin-1-ylphenyl)-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2037096; SCHEMBL14206457; BDBM50384650
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095627; SCHEMBL3991434; BDBM50316253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080995; SCHEMBL2934911; BDBM50311954
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
9-Hydroxy-4-[2-(methylsulfinyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209785; 9-hydroxy-4-(2-(methylsulfinyl)phenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione; SCHEMBL5829291; BDBM50192342; 9-hydroxy-4-(2-methylsulfinylphenyl)-6H-pyrrolo[3,4-c]carbazole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
11-Hydroxy-5,11-dihydro-dibenzo[b,e]azepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242418; SCHEMBL7513257; BDBM50218726; AKOS005064463; 11-Hydroxy-5H-dibenzo[b,e]azepin-6(11H)-one; 11-hydroxy-5,11-dihydrobenzo[c][1]benzazepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
11,11-Dioxo-5H-benzo[b][1,4]benzothiazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242417; SCHEMBL5710957; BDBM50218739; dibenzo[b,f][1,4]thiazepin-11(10H)-one 5,5-dioxide; Dibenzo[b,f][1,4]thiazepine-11(10H)-one 5,5-dioxide; 5,5-dioxo-5,10-dihydro-5lambda*6*-dibenzo[b,f][1,4]thiazepin-11-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
(3Z)-3-[(2,3-Dimethoxyphenyl)methylidene]-5-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
indolinone analog 12; CHEMBL373004; BDBM14648
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
5-[(4-Aminocyclohexyl)amino]-2-(4-chlorophenyl)imidazo[1,2-c]pyrimidine-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381607; BDBM50433764
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
5-(Piperidin-3-yl)-3-(thiazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1643251; SCHEMBL11930904; BDBM50334894
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2-[4-[(Dimethylamino)methyl]phenyl]-N-(2-piperazin-1-ylphenyl)-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2037098; SCHEMBL14328551; BDBM50384680
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
6-Bromoquinazolin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-bromoquinazolin-4(3H)-one; 6-Bromo-4-hydroxyquinazoline; 6-Bromo-3H-quinazolin-4-one; 6-Bromo-4-quinazolone; 6-bromo-1H-quinazolin-4-one; 6-BROMOQUINAZOLIN-4(1H)-ONE; 4(1H)-Quinazolinone, 6-bromo-; CHEMBL562488; 6-Bromo-4(3H)-quinazolinone; 6-Bromo-3,4-dihydro-4-oxoquinazoline; 4(3H)-Quinazolinone, 6-bromo-; Kinome_3257; PubChem18575; ACMC-209hqp; 6-bromo-4-quinazolinol; 6-Bromo-4-quinazolinone; Maybridge1_006260; Cambridge id 5585489; SCHEMBL182871; 6-bromo-4-hydroxy-quinazoline; 6-bromo-4(1H)-quinazolinone; 6-Bromoquinazoline-4(3H)-one; 4(3H)-Quinazolinone,6-bromo-; CTK4G8190; CTK5I7924; CTK5I8095; HMS559E12; 6-bromo-3-hydroquinazolin-4-one; DTXSID00351423; HMS1583H20; ACN-S003253; ACT03903; ALBB-024135; BCP23046; CS-D1073; ZINC8647743; AB1142; ANW-27263; ANW-50724; BBL029209; BDBM50414218; MFCD00115131; MFCD01219541; SBB054720; STK929158; STL382233; STL511999; 6-bromo-1,4-dihydroquinazolin-4-one; 6-bromo-3,4-dihydroquinazolin-4-one; AKOS000126969; AKOS005659209; AKOS022177712; AB21786; AS-3007; CCG-248929; FS-2625; GS-4275; LS40887; MCULE-3795655880; PS-3451; QC-9872; KS-000009A7; AK-22089; AM803687; BC004388; BR-22089; RH 00197; SC-24154; SY006403; 6-bromoquinazolin-4(3H)-one, AldrichCPR; AB0028245; AB0073530; AB0085565; DB-001815; DB-013151; B4328; FT-0649965; ST45003547; X0299; S-2276; X-1407; 084B596; SR-01000415022; J-518466; SR-01000415022-1; F1967-9986
Click to Show/Hide
|
||||
| Activity |
Ki = 50118.72 nM
|
[18] | |||
| Compound Name |
3-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N,N-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395775; BDBM50218733
Click to Show/Hide
|
||||
| Activity |
EC50 = 51900 nM
|
[15] | |||
| Compound Name |
5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(1)Benzothieno(2,3-d)pyrimidin-4(1H)-one, 5,6,7,8-tetrahydro-; 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-ol; 5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(1H)-one; 5,6,7,8-Tetrahydro-3H-benzo[4,5]thieno[2,3-d]-pyrimidin-4-one; 5,6,7,8-Tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one; 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one; 5,6,7,8-Tetrahydro-(1)benzothieno(2,3-d)pyrimidin-4(1H)-one; [1]Benzothieno[2,3-d]pyrimidin-4(1H)-one,5,6,7,8-tetrahydro-; 8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),5-trien-3-one; 5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ol; 3,5,6,7,8-pentahydrobenzo[b]thiopheno[2,3-d]pyrimidin-4-one; 5,6,7,8-Tetrahydro-[1]-benzothieno[2,3-d]pyrimidin-4(H)-one; [1]Benzothieno[2,3-d]pyrimidin-4(1H)-one, 5,6,7,8-tetrahydro-; SR-01000392225; NSC153324; 5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-4-one; Maybridge1_003809; benzothienopyrimidinone, 6; Cambridge id 5175548; Oprea1_037290; Oprea1_129421; Oprea1_667048; CBDivE_004950; MLS000058839; SCHEMBL736600; CHEMBL539906; BDBM33207; CTK4C3655; CTK7H0291; HMS552F03; KS-00003KGE; DTXSID70162427; HMS1579A20; HMS2399G06; HMS3604I16; ALBB-019439; BCP22667; BBL005273; MFCD00463623; SBB009540; STK104676; STK508759; STL512066; ZINC17920988; AKOS000265156; AKOS003268859; AKOS003326267; BCP9000171; DB08777; FS-1648; MCULE-6377092041; NSC-153324; DA-38320; SC-49408; SMR000069105; ST027014; ST037473; ST037707; AB0077749; EU-0033810; FT-0729980; R3209; AB00074915-01; AG-205/14488061; SR-01000530918; J-007818; SR-01000392225-1; SR-01000392225-2; SR-01000530918-1; Q27097957; Z56757191; 5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi; 4-oxo-3,4,5,6,7,8-hexahydrobenzothieno[2,3-d]pyrimidine; 5,6,7,8-tetrahydrobenzo[b]thiopheno[2,3-d]pyrimidin-4-ol; 5,6,7,8-Tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one; 1,5,6,7,8-pentahydrobenzo[b]thiopheno[2,3-d]pyrimidin-4-one; 3,4,5,6,7,8-Hexahydro[1]benzothieno[2,3-d]pyrimidine-4-one; 5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ol; Benzothieno[2,3-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-; [1]benzothieno[2,3-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-; 3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-one; 5,6,7,8-Tetrahydro[1]benzothieno-[2,3-d]pyrimidin-4(3H)-one; 5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4 (3H)-one; 5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one #; Pirimido[4,5-b]benzothiophen-4(3H)-one, 5,6,7,8-tetrahydro-; 5,6,7,8-TETRAHYDRO-[1]-BENZOTHIENO[2,3-D]PYRIMIDIN-4(1H)-ONE; 8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1(9),2(7),3,5-tetraen-3-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[19] | |||
| Compound Name |
3-Phenyl-6-(pyridin-4-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170317; BDBM50321657
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[20] | |||
| Compound Name |
(3S,4R)-Ethyl 4-(2-(5-fluoro-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650116; SCHEMBL9966939; BDBM50335668
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[21] | |||
| Compound Name |
4-[6-[[(4-Hydroxycyclohexyl)amino]methyl]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242521; SCHEMBL4816342; SCHEMBL4816352; BDBM50204698; 4-{6-[(trans-4-hydroxy-cyclohexylamino)-methyl]-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-benzoic acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59000 nM
|
[22] | |||
| Compound Name |
4-(6-(Morpholinomethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389780; SCHEMBL4810299; BDBM50204696; 4-[6-(morpholin-4-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]benzoic acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59000 nM
|
[22] | |||
| Compound Name |
4-(6-((4-Hydroxypiperidin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242949; 4-[6-[(4-hydroxypiperidin-1-yl)methyl]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]benzoic acid; SCHEMBL4818180; BDBM50204703
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59000 nM
|
[22] | |||
| Compound Name |
3-[4-(4-Hydroxyphenyl)phenyl]-N-(pyridin-4-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazole-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242753; SCHEMBL6794625; BDBM50204693
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59000 nM
|
[22] | |||
| Compound Name |
3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438485; SCHEMBL4809259; SCHEMBL4809267; BDBM91830; BDBM50204694; ZINC100469705; ZINC253994709; Q27456666
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59000 nM
|
[22] | |||
| Compound Name |
4-(6-(Morpholinomethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390626; SCHEMBL4811512; BDBM50204700; 4-[6-(morpholin-4-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59000 nM
|
[22] | |||
| Compound Name |
4-(6-(((1r,4r)-4-Hydroxycyclohexyl)carbamoyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242523; SCHEMBL4816604; SCHEMBL4816612; BDBM50204719
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59000 nM
|
[22] | |||
| Compound Name |
3-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243499; BDBM50218712
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59300 nM
|
[15] | |||
| Compound Name |
9-(4-Amino-3-methoxyphenyl)-3-hydroxy-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243491; BDBM50218711; 8-hydroxy-3-(3-methoxy-4-nitrophenyl)-5H-dibenzo[b,e][1,4]-diazepin-11(10H)-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59300 nM
|
[15] | |||
| Compound Name |
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-2-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387787; BDBM50218703
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59300 nM
|
[15] | |||
| Compound Name |
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389745; BDBM50218709
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59300 nM
|
[15] | |||
| Compound Name |
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395080; BDBM50218700
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59300 nM
|
[15] | |||
| Compound Name |
9-(4-Amino-3-methoxyphenyl)-3-methoxy-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396060; BDBM50218719; 8-methoxy-3-(3-methoxy-4-nitrophenyl)-5H-dibenzo[b,e][1,4]-diazepin-11(10H)-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 59300 nM
|
[15] | |||
| Compound Name |
6-(1-Methyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170531; BDBM50321659
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[20] | |||
| Compound Name |
2-[(Z)-[6-(4-Fluoro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910606; NSC-747108
Click to Show/Hide
|
||||
| Activity |
IC50 = 78500 nM
|
[23] | |||
| Compound Name |
6-(3-Bromophenoxy)-3-[(E)-2-phenylethenyl]-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5252256; CHEMBL3980816
Click to Show/Hide
|
||||
| Activity |
Ki = 82000 nM
|
[24] | |||
| Compound Name |
4-({5-[(4-Aminocyclohexyl)amino][1,2,4]triazolo[1,5-A]pyrimidin-7-YL}amino)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL380331; triazolo[1,5-a]pyrimidine 14; SCHEMBL14367517; BDBM11452; DB07687; 4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}amino)benzene-1-sulfonamide; Q27096906; 4-({5-[(trans-4-aminocyclohexyl)amino][1,2,4]triazolo[1,5-a]pyrimidin-7-yl}amino)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[25] | |||
| Compound Name |
(4-(6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)phenyl)methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170124; BDBM50321674
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[20] | |||
| Compound Name |
2-({5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl}amino)propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
furanopyrimidine compound 15; CHEMBL365383; BDBM14813
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-(2-methoxyethyl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
furanopyrimidine compound 14; CHEMBL191396; BDBM14812; N-(2-methoxyethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
2-[(E)-[2-(4-Chloro-3-nitrophenyl)imidazo[1,2-a]pyridin-3-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-734179; CHEMBL1910627; NSC734179
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(Z)-[6-(4-Fluorophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910605; NSC-747107
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-Cyclohexyl-2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL518175; BDBM50277025
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910753; NSC-730327
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[2-(2,5-Dimethoxy-4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910614; NSC-745255
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[2-Chloro-6-(4-fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910373; NSC-747109
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[2-(2,5-Dichlorothiophen-3-yl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910616; NSC-745256
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
3-Phenyl-6-(1H-pyrrol-2-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170533; BDBM50321661
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-[(E)-[6-(4-Nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-723552; CHEMBL1910754; NSC723552
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-720142; CHEMBL1910635; NSC722864; NSC720142; NSC-722864
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(Z)-[2-Bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910608; NSC-748103
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
6-(1H-Pyrazol-4-yl)-3-(pyridin-3-yl)imidazo[1,2-a]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171531; BDBM50321665
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-[(Z)-[6-(4-Fluoro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910602; NSC-747112
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[2-(4-Chloro-3-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-732182; CHEMBL1910745; NSC732182
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(Z)-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910597; NSC-747111
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[2-Methyl-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-720137; CHEMBL1910626; NSC720137
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[6-(2,5-Dimethoxy-4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-725093; CHEMBL1910630; NSC725093
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-723549; CHEMBL1910744; NSC723549
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-Amino-1-[(E)-[6-(4-chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910751; NSC-730326
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
1-(2-(3-(3-Chlorophenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)-3-methylbutanoyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461051; BDBM50277030
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-Tert-butyl-2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459794; BDBM50276994
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
3-(6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170921; BDBM50321671
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
6-(1H-Indol-3-yl)-3-phenylimidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170534; BDBM50321662
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
3-(6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1169926; BDBM50321672
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-{5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}benzamide; ChemDiv3_002739; furanopyrimidine compound 11; Oprea1_638665; CHEMBL362935; BDBM14809; HMS1480M11; ZINC1300613; STK805167; AKOS001655765; MCULE-7083487365; SR-01000471709; SR-01000471709-1; BRD-K64893827-001-01-5; N-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
N-(2-Aminoethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
furanopyrimidine compound 13; CHEMBL447783; BDBM14811; N-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-ethane-1,2-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
2-[(E)-[6-(2,5-Dichlorothiophen-3-yl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-732181; CHEMBL1910757; NSC732181
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
1-(2-(3-(3-Chlorophenyl)-5-methyl-4-oxo-3,4-dihydroquinazolin-2-ylthio)hexanoyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461057; BDBM50277033
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2-[(E)-[2-Chloro-6-(2,5-dichlorothiophen-3-yl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910371; NSC-745252
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[6-(4-Nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-709136; CHEMBL1910633; NSC709136
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-(3-Methyl-6-pyridin-3-ylimidazo[2,1-b][1,3]thiazol-5-yl)methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-728902; CHEMBL1910762; NSC728902
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-2-phenyl-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
furanopyrimidine compound 12; CHEMBL190396; BDBM14810; 2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}amino)-2-phenylethan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-723550; CHEMBL1910636; NSC723550
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
1-(3-Amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl)piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1277019; BDBM50330574
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[(E)-[6-(3-Nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-723551; CHEMBL1910747; NSC723551
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[6-(3-Nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910752; NSC-722875
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(Z)-[6-(4-Bromo-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1909651; NSC-747420
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[2-(2,5-Dimethoxy-4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910623; NSC-745849
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-(1-Adamantyl)-2-(4-oxo-3-phenylquinazolin-2-yl)sulfanylhexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459793; BDBM50276993; 2-(4-Oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-hexanoic acid adamantan-1-ylamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2-[(E)-[2-Chloro-6-(4-fluoro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910374; NSC-747110
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
5,6-Diphenylfuro[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
DFP-4A; 4-amino-5,6-diphenylfuro[2,3-d]pyrimidine; 5,6-diphenylfurano[2,3-d]pyrimidine-4-ylamine; NSC153298; ChemDiv1_028993; furanopyrimidine compound 8; MixCom3_000226; Oprea1_778350; CBDivE_005803; CHEMBL189977; SCHEMBL2965887; BDBM14806; CTK4J5366; DTXSID40302737; ZINC188651; ALBB-006589; 4837AE; MFCD00407207; SBB041134; STK387532; AKOS000266657; CCG-108961; MCULE-8163452124; NSC-153298; FT-0679229; R2881; ST45141138; 4-Amino-5,6-diphenyl-furo[2,3-d]pyrimidine; 5,6-diphenylfuro[2,3-d]pyrimidin-4-ylamine; 5,6-Diphenylfuro[2,3-d]pyrimidin-4-amine #; Furo[2,3-d]pyrimidin-4-amine,5,6-diphenyl-; 5,6-Diphenyl-furo[2,3-d]pyrimidin-4 -ylamine; Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-; AG-690/36538016; SR-01000461476; SR-01000461476-1; F0311-0239
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
3-Phenyl-6-(1H-pyrazol-3-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170750; BDBM50321658
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
1-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]piperidine-4-Carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1231522; 1-(3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylic acid; BDBM50330578; Q27458562; BX1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[(E)-[6-(4-Chloro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-709138; CHEMBL1910629; NSC709138
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
3,5-Dimethyl-4-phenyl-1H-pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540487; Phenyldimethylpyrazol; SCHEMBL873114; ZINC3091263; BDBM50414214; AKOS004902401; F2198-8628
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[18] | |||
| Compound Name |
2-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-720136; CHEMBL1910631; NSC720136
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[2-Chloro-6-(4-chloro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-722868; CHEMBL1910634; NSC722868
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[2-Chloro-6-(4-cyanophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910375; NSC-748104
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[2-Chloro-6-(3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910637; NSC-722874
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
4-(6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172645; BDBM50321670
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-[(E)-[6-(4-Chloro-3-nitrophenyl)-3-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-720138; CHEMBL1910756; NSC720138
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[6-(4-Chloro-3-nitrophenyl)-2,3-dimethylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-720143; CHEMBL1910748; NSC720143
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-Benzyl-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
furanopyrimidine compound 10; Oprea1_737599; CHEMBL434732; BDBM14808; ZINC1815102; STK061062; AKOS001641039; MCULE-3111887616; SR-01000474973; 4-(Benzylamino)-5,6-diphenylfuro[2,3-d]pyrimidine; SR-01000474973-1; Benzyl-(5,6-diphenyl-furo[2,3-d]pyrimidin-4-yl)-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
2-[(E)-[6-(4-Aminophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910628; NSC-709139
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-(2,3-Dimethyl-6-pyridin-3-ylimidazo[2,1-b][1,3]thiazol-5-yl)methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-726886; CHEMBL1910761; NSC726886
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-722870; CHEMBL1910632; NSC722870
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
3-(4-Phenoxyphenyl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171698; BDBM50321666
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-[(E)-[2-Chloro-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-720135; CHEMBL1910625; NSC720135
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
3-Phenyl-6-(pyridin-2-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170741; BDBM50321663
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-[(E)-[2-Methyl-6-(3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-722871; CHEMBL1910750; NSC722871
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
3-[(5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl)amino]propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
DFP-4AP; 3-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}amino)propan-1-ol; CBKinase1_000503; CBKinase1_012903; furanopyrimidine compound 9; MLS001173386; CHEMBL190698; SCHEMBL2241568; BDBM14807; HMS1587E14; HMS2872F14; ZINC1796853; STK860233; AKOS003359184; MCULE-5812462527; SMR000538951; EU-0009379; SR-01000474976; SR-01000474976-1; BRD-K55032308-001-01-9; 3-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-propan-1-ol; 3-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)propan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
2-[(E)-[6-(2,5-Dichlorothiophen-3-yl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-732180; CHEMBL1910755; NSC732180
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
3,9-Dimethyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403133; BDBM50220909
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
1,3-Bis[(E)-[2-chloro-6-(2,5-dimethoxy-4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-734184; CHEMBL1910746; NSC734184
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(Z)-[2-Fluoro-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910607; NSC-748105
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
1-(2-(3-(4-Chlorophenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)hexanoyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461264; BDBM50277032
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2R,4S)-Methyl 4-(2-o-tolylquinazolin-4-ylamino)pyrrolidine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650112; BDBM50335664
Click to Show/Hide
|
||||
| Activity |
IC50 = 104000 nM
|
[21] | |||
| Compound Name |
6-N-(Piperidin-4-ylmethyl)-4-N-pyridin-3-ylpyrimidine-4,6-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1928683; BDBM50359828
Click to Show/Hide
|
||||
| Activity |
IC50 = 122000 nM
|
[29] | |||
| Compound Name |
3-Phenyl-6-(pyridin-3-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170316; BDBM50321664
Click to Show/Hide
|
||||
| Activity |
IC50 = 139000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 23 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-(1-Benzyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170532; BDBM50321660
Click to Show/Hide
|
||||
| Activity |
IC50 = 208000 nM
|
[20] | |||
| Compound Name |
1-[(E)-[2-Chloro-6-(4-chlorophenyl)imidazo[2,1-b]thiazol-5-yl]methyleneamino]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC698274; NSC-698274; CHEMBL1910749
Click to Show/Hide
|
||||
| Activity |
IC50 > 7900000 nM
|
[23] | |||
| Compound Name |
6-(1H-Pyrazol-4-yl)-3-pyridin-3-ylimidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2235317; BDBM50486721
Click to Show/Hide
|
||||
| Activity |
IC50 = 10000000 nM
|
[30] | |||
| Compound Name |
3-(4-Phenoxyphenyl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2235319; BDBM50486719
Click to Show/Hide
|
||||
| Activity |
IC50 = 10000000 nM
|
[30] | |||
| Compound Name |
[3-[6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2235320; BDBM50486722
Click to Show/Hide
|
||||
| Activity |
IC50 = 21877616.24 nM
|
[30] | |||
| Compound Name |
6-(1H-Pyrazol-4-yl)-3-(1H-pyrrol-2-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170125; BDBM50321675
Click to Show/Hide
|
||||
| Activity |
IC50 = 23442288.15 nM
|
[30] | |||
| Compound Name |
(4-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170749; BDBM50321651
Click to Show/Hide
|
||||
| Activity |
IC50 = 25703957.83 nM
|
[30] | |||
| Compound Name |
3-Phenyl-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172464; 2xf0; BDBM50321652; Q27454997
Click to Show/Hide
|
||||
| Activity |
IC50 = 33113112.15 nM
|
[30] | |||
| Compound Name |
(3-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170748; BDBM50321656
Click to Show/Hide
|
||||
| Activity |
IC50 = 34673685.05 nM
|
[30] | |||
| Compound Name |
3-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170293; BDBM50321680
Click to Show/Hide
|
||||
| Activity |
IC50 = 35481338.92 nM
|
[30] | |||
| Compound Name |
4-(6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1169927; BDBM50321673
Click to Show/Hide
|
||||
| Activity |
IC50 = 38904514.5 nM
|
[30] | |||
| Compound Name |
3-(1H-Pyrazol-4-yl)-6-(pyridin-4-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170728; BDBM50321676
Click to Show/Hide
|
||||
| Activity |
IC50 = 39810717.06 nM
|
[30] | |||
| Compound Name |
4-[[3-[6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methyl]morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2235321; BDBM50486718
Click to Show/Hide
|
||||
| Activity |
IC50 = 43651583.22 nM
|
[30] | |||
| Compound Name |
4-[[4-[6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methyl]morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2235322; BDBM50486717
Click to Show/Hide
|
||||
| Activity |
IC50 = 45708818.96 nM
|
[30] | |||
| Compound Name |
3-(1-Methylpyrazol-4-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2235318; BDBM50486720
Click to Show/Hide
|
||||
| Activity |
IC50 = 45708818.96 nM
|
[30] | |||
| Compound Name |
6-Phenyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172089; BDBM50321677
Click to Show/Hide
|
||||
| Activity |
IC50 = 58884365.54 nM
|
[30] | |||
| Compound Name |
6-(5-Methyl-1H-pyrazol-4-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172090; BDBM50321678
Click to Show/Hide
|
||||
| Activity |
IC50 = 66069344.8 nM
|
[30] | |||
| Compound Name |
4-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172286; BDBM50321679
Click to Show/Hide
|
||||
| Activity |
IC50 = 66069344.8 nM
|
[30] | |||
| Compound Name |
3-(1H-Indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170126; 2xey; BDBM50321655; Q27467828
Click to Show/Hide
|
||||
| Activity |
IC50 = 154881661.9 nM
|
[30] | |||
| Compound Name |
3,6-Bis(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2235323; BDBM50486715
Click to Show/Hide
|
||||
| Activity |
IC50 = 199526231.5 nM
|
[30] | |||
| Compound Name |
(3-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1169754; BDBM50321681
Click to Show/Hide
|
||||
| Activity |
IC50 = 288403150.3 nM
|
[30] | |||
| Compound Name |
(4-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170747; BDBM50321650
Click to Show/Hide
|
||||
| Activity |
IC50 = 501187233.6 nM
|
[30] | |||
| Compound Name |
6-(1h-Pyrazol-3-Yl)-3-(1h-Pyrazol-4-Yl)imidazo[1,2-A]pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1236804; 2xez; BDBM50486716; Q27467532; 3-(1H-pyrazol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine
Click to Show/Hide
|
||||
| Activity |
IC50 = 660693448 nM
|
[30] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4106-11. | ||||
| REF 2 | Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. J Med Chem. 2009 May 28;52(10):3191-204. | ||||
| REF 3 | Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem. 2010 Nov 11;53(21):7682-98. | ||||
| REF 4 | Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6178-82. | ||||
| REF 5 | Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode. ACS Med Chem Lett. 2012 Jan 20;3(2):123-8. | ||||
| REF 6 | ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. | ||||
| REF 7 | Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. | ||||
| REF 8 | Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 1. Bioorg Med Chem Lett. 2011 Jan 1;21(1):467-70. | ||||
| REF 9 | Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6575-7. | ||||
| REF 10 | Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors. Bioorg Med Chem Lett. 2013 May 15;23(10):2863-7. | ||||
| REF 11 | From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells. J Med Chem. 2009 Apr 9;52(7):1853-63. | ||||
| REF 12 | Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. Bioorg Med Chem Lett. 2013 May 1;23(9):2590-4. | ||||
| REF 13 | 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4420-3. | ||||
| REF 14 | 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modific... J Med Chem. 2006 Aug 10;49(16):4896-911. | ||||
| REF 15 | Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem. 2007 Aug 23;50(17):4162-76. | ||||
| REF 16 | Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):421-6. | ||||
| REF 17 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 18 | Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes. J Med Chem. 2009 May 28;52(10):3159-65. | ||||
| REF 19 | Identification of inhibitors of checkpoint kinase 1 through template screening. J Med Chem. 2009 Aug 13;52(15):4810-9. | ||||
| REF 20 | Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4045-9. | ||||
| REF 21 | Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90. | ||||
| REF 22 | Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem. 2007 Apr 1;15(7):2759-67. | ||||
| REF 23 | Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors. Eur J Med Chem. 2011 Sep;46(9):4311-23. | ||||
| REF 24 | US patent application no. 6531491B1, Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | ||||
| REF 25 | Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1353-7. | ||||
| REF 26 | Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity. J Med Chem. 2005 Jun 30;48(13):4332-45. | ||||
| REF 27 | Development of thioquinazolinones, allosteric Chk1 kinase inhibitors. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1240-4. | ||||
| REF 28 | Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5989-94. | ||||
| REF 29 | Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. J Med Chem. 2011 Dec 22;54(24):8328-42. | ||||
| REF 30 | Docking and quantitative structure-activity relationship studies for imidazo[1,2-a]pyrazines as inhibitors of checkpoint kinase-1. Med Chem Res. 2011 Jul 06;21:1912-20. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.