Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T63846 | Target Info | |||
| Target Name | IL-1 receptor-associated kinase 1 (IRAK1) | ||||
| Synonyms |
Interleukin-1 receptor-associated kinase 1; IRAK-1; IRAK
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| Target Type | Patented-recorded Target | ||||
| Gene Name | IRAK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-[6-(Piperidin-4-ylamino)pyridin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL255873; SCHEMBL18427750; BDBM50377168
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| Activity |
IC50 = 96000 nM
|
[1] | |||
| Compound Name |
2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098682; BDBM50242512
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
6-(6-Chloroimidazo[1,2-a]pyridin-3-yl)-N-piperidin-3-ylpyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256961; SCHEMBL19900101; BDBM50377179
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| Activity |
IC50 = 175000 nM
|
[1] | |||
| Compound Name |
N-(Azetidin-3-yl)-6-(6-chloroimidazo[1,2-a]pyridin-3-yl)pyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256963; NCGC00241410; SCHEMBL19900090; BDBM50377181; NCGC00241410-01; NCGC00241410-02
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| Activity |
IC50 = 195000 nM
|
[1] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Schembl22145730
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402629; BDBM50377169
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| Activity |
IC50 = 293000 nM
|
[1] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
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| Activity |
Ki > 1000000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3656-60. | ||||
| REF 2 | Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2708-2712. | ||||
| REF 3 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
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