Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T65864 | Target Info | |||
| Target Name | Stress-activated protein kinase 2a (p38 alpha) | ||||
| Synonyms |
SAPK2A; P38 mitogen activatedprotein kinase; P38 Mitogen-activatedprotein kinase alpha; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; MXI2; MAX-interacting protein 2; MAPK 14; MAP kinase p38alpha; MAP kinase p38 alpha; MAP kinase MXI2; MAP kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; Cytokine suppressive anti-inflammatory drug binding protein; CSPB1; CSBP2; CSBP1; CSBP; CSAID-binding protein; CSAID binding protein; CRK1
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| Target Type | Clinical trial Target | ||||
| Gene Name | MAPK14 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 198 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Imatinib
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|
Approved | Compound Info | ||
| Synonyms |
Cgp 57148; Glamox; Glamox (TN); Gleevec (TN); Glivec (TN); Imatinib (INN); Imatinib (STI571); Imatinib Methansulfonate; Imatinib [INN:BAN]; 112GI019; 152459-95-5; BKJ8M8G5HI; CCRIS 9076; CGP-57148; CHEMBL941; Imatinib free base; STI; UNII-BKJ8M8G5HI
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Pirfenidone
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Approved | Compound Info | ||
| Synonyms |
Deskar; Esbriet; Pirespa; Pirfenidona; Pirfenidonum; AMR 69; P 2116; AMR-69; F-647; KS-5041; Pirfenidona [INN-Spanish]; Pirfenidone (Deskar); Pirfenidone [USAN:INN]; Pirfenidonum [INN-Latin]; S-7701; Pirfenidone (JAN/USAN/INN); 5-Methyl-1-phenyl-1H-pyridin-2-one; 5-Methyl-1-phenyl-2(1H)-pyridone; 5-Methyl-1-phenyl-2-(1H)-pyridone; 5-methyl-1-phenylpyridin-2(1H)-one; 5-methyl-1-phenylpyridin-2-one
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| Activity |
IC50 = 165400 nM
|
[2] | |||
| Compound Name |
PMID25991433-Compound-P6
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Patented | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
PMID25991433-Compound-P5
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Patented | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
PMID19364658C33
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|
Investigative | Compound Info | ||
| Synonyms |
GTPL8163; BDBM50259563
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
HTS-466284
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Investigative | Compound Info | ||
| Synonyms |
4-(3-Pyridin-2-YL-1H-pyrazol-4-YL)quinoline; 396129-53-6; LY-364947; LY364947; 4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)quinoline; 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE; TbetaR-I Inhibitor; LY 364947; ALK5 Inhibitor I; TGF-beta RI Kinase Inhibitor; 4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline; CHEMBL261454; Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor; 4-(3-pyridin-2-yl)(1h)-pyrazol-4-yl quinoline; 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline; [3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole; 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
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| Activity |
IC50 = 51000 nM
|
[6] | |||
| Compound Name |
U0126
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Investigative | Compound Info | ||
| Synonyms |
U0126; 109511-58-2; U-0126; U 0126; 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene; UNII-8027P94HLL; CHEBI:64208; 8027P94HLL; (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile; FT-1069-1; 218601-62-8; Succinonitrile, bis(amino(o-aminophenylthio)methylene)-; Butanedinitrile, bis(amino((2-aminophenyl)thio)methylene)-; C18H16N6S2; (2z)-Bis{amino[(2-Aminophenyl)sulfanyl]methylidene}butanedinitrile; (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylene}succinonitrile
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| Activity |
IC50 = 55000 nM
|
[7] | |||
| Compound Name |
8-chloro-quinoline-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL436817; Cyanoquinoline, 11; SCHEMBL6071997; BDBM21898; CHEBI:94979; BRD-K00088062-001-01-3; 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(1H-imidazole-5-ylmethyl)amino]-8-chloro-3-quinolinecarbonitrile
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
PMID16451062C46
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Investigative | Compound Info | ||
| Synonyms |
GTPL8355; GSK-623906A; BDBM50181532
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
PMID17480064C16
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Investigative | Compound Info | ||
| Synonyms |
724711-21-1; 3fhr; 2jbp; 2jbo; P4O; Pyrrolopyridine, 16; Kinome_3179; 3r2y; GTPL8177; BDBM30185; ZINC16052855; AKOS027322581; DB08358; KB-19275; DB-013997; FT-0745988
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-{[2-(3-Thienyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL481248; BDBM50259638
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-(Naphthalen-2-yl)-3-(2-(thiazol-2-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644627; BDBM50333991
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
N-[4-Bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(6,7-difluoro-2-oxoquinolin-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1822145; SCHEMBL3783987; US9796706, Compound 44; BDBM351600; BDBM50352614; n-(4-bromo-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6,7-difluoro-2-oxoquinolin-1(2h)-yl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-(Naphthalen-2-yl)-3-(2-(pyridin-3-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644626; BDBM50333993
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
4-(Naphthalen-2-yl)-3-(pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644617; BDBM50334009
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
N-(4,4''-Bithiazol-5-yl)-2-(isoquinolin-5-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288160; SCHEMBL3713725; BDBM50332091; 2-isoquinolin-5-yl-N-[4-(1,3-thiazol-4-yl)-1,3-thiazol-5-yl]acetamide
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
4-Methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3-yl]-N-(5-methyl-1,3-thiazol-2-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2031243; BDBM50384388
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
CID 46179972
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163016; BDBM50378568
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
4-(6-Bromonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644634; BDBM50334002
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
N-[4-Cyano-3-(1h-1,2,4-Triazol-5-Yl)thiophen-2-Yl]-2-(2-Oxo-3,4-Dihydroquinolin-1(2h)-Yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682015; SCHEMBL3784549; US9796706, Compound 36; BDBM351592; BDBM50338293; Q27453534
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
WYE-354; WYE 354; pyrazolo pyrimidine, 19; cc-506; MLS006011008; SCHEMBL300431; CHEMBL561708; GTPL9361; WYE354; BDBM35587; DTXSID00657912; C24H29N7O5; HMS3654N09; BCP02898; ZINC43013490; CCG-264882; CS-0183; SB19260; NCGC00242484-01; NCGC00242484-02; NCGC00242484-09; AC-28454; AS-55957; HY-12034; SMR004702806; BCP0726000260; DB-059456; FT-0675866; S1266; SW219671-1; X7422; W-5702; J-001552; J-514253; BRD-K77008974-001-01-6; Q27166532; mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5
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| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
Schembl22388257
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1822151; SCHEMBL3780453; BDBM351666; US9796706, Compound 110; BDBM50352620; N-(4-bromo-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(6-cyano-2-oxoquinolin-1(2H)-yl)acetamide; n-(4-bromo-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-cyano-2-oxoquinolin-1(2h)-yl)acetamide; N-[4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(6-cyano-2-oxoquinolin-1-yl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-(Isoquinolin-5-yl)-n-(4-(1-methyl-1h-1,2,4-triazol-5-yl)thiazol-5-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288129; SCHEMBL3783552; BDBM50332089; 2-isoquinolin-5-yl-N-[4-(2-methyl-1,2,4-triazol-3-yl)-1,3-thiazol-5-yl]acetamide
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
N-(4-(1H-1,2,4-Triazol-3-yl)thiazol-5-yl)-2-(isoquinolin-5-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288128; SCHEMBL3783463; US9796706, Compound 67; BDBM351623; BDBM50332088; n-(4-(1h-1,2,4-triazol-5-yl)thiazol-5-yl)-2-(isoquinolin-5-yl)acetamide; 2-isoquinolin-5-yl-N-[4-(1H-1,2,4-triazol-5-yl)-1,3-thiazol-5-yl]acetamide
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080994; SCHEMBL2934634; BDBM50311953
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| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
4-(8-Aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644636; BDBM50334004
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-(Isoquinolin-5-yl)-n-(4-(pyrazin-2-yl)thiazol-5-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288159; SCHEMBL3713088; BDBM50332090; 2-isoquinolin-5-yl-N-(4-pyrazin-2-yl-1,3-thiazol-5-yl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
N-[4-Cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-quinolin-5-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682021; SCHEMBL3778052; BDBM50338267; N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 4-(2-(naphthalen-1-yl)acetamido)-1H-pyrazole-3-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1287886; BDBM50332065
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
N-(2-(5-Amino-1H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288039; n-(2-(3-amino-1h-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide; N-[2-(3-amino-1H-1,2,4-triazol-5-yl)thiophen-3-yl]-2-(4-methoxyphenyl)acetamide; SCHEMBL3788513; US9796706, Compound 17; BDBM351573; BDBM50332080
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
4-(8-Fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644635; BDBM50333998
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3-(2-(Cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1-(pyridin-4-ylmethyl)-1H-1,2,4-triazol-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644642; BDBM50333980
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
N-(4-Cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682018; SCHEMBL3781602; US9796706, Compound 35; BDBM351591; BDBM50338264; N-[4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-isoquinolin-5-ylacetamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(2-(Cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644618; BDBM50334008
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
4-(Naphthalen-2-yl)-1-(piperidin-4-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644643; BDBM50333988
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3-{[(1R)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466496; SCHEMBL4365652; BDBM50259376; DB07234; Q27096459; 3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-cyclobut-3-ene-1,2-dione
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-[4-(4-Naphthalen-2-yl-5-oxo-1H-1,2,4-triazol-3-yl)pyridin-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644629; BDBM50333999; N-(4-(4-(naphthalen-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2-yl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
N-[4-Methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3-yl]phenyl]-1,3-thiazole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029367; BDBM50384384
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477817; SCHEMBL5520662; SCHEMBL5520668; BDBM50263132
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| Activity |
IC50 ~ 50000 nM
|
[18] | |||
| Compound Name |
3-(2-(Cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-1,2,4-triazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644638; BDBM50334000
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
N-[4-(4-Naphthalen-2-yl-5-oxo-1H-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644631; BDBM50334005; N-(4-(4-(naphthalen-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamide
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
4-(6-Aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644633; BDBM50334006
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
NC=1C=C(C=CC=1OC)C1=NNC(=N1)NCC1=C(C=CC=C1F)Cl
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064000; SCHEMBL19356051; BDBM50241731
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| Activity |
IC50 ~ 50000 nM
|
[19] | |||
| Compound Name |
n-(4-Bromo-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682016; SCHEMBL3783151; US9796706, Compound 32; BDBM351588; BDBM50338262; N-[4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-isoquinolin-5-ylacetamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 4-(4-(naphthalen-2-yl)-5-oxo-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)piperidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644646; BDBM50333997
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
4-(Naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644620; BDBM50333994
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
n-(4-Methyl-3-(3-methyl-1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682010; SCHEMBL3782459; US9796706, Compound 26; BDBM351582; BDBM50338287; N-[4-methyl-3-(5-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl]-2-quinolin-5-ylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(4-Methoxyphenyl)-N-(2-(5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl)thiophen-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288038; 2-(4-methoxyphenyl)-N-[2-[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]thiophen-3-yl]acetamide; SCHEMBL2229021; US9796706, Compound 13; BDBM351569; BDBM50332079; 2-(4-methoxyphenyl)-n-(2-(3-(trifluoromethyl)-1h-1,2,4-triazol-5-yl)thiophen-3-yl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
N-(4-Methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682012; SCHEMBL3784527; US9796706, Compound 15; BDBM351571; BDBM50338289
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[4-(4-Naphthalen-2-yl-5-oxo-1H-1,2,4-triazol-3-yl)pyridin-2-yl]cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644630; BDBM50333984
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3-{[2-(2-Furyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519113; SCHEMBL4366875; BDBM50259637; 3-[[2-(furan-2-yl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
ClC1=C(CNC2=NC(=NN2)C2=CC(=CC=C2)NC)C(=CC=C1)F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073371; SCHEMBL19356084; BDBM50241733
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[19] | |||
| Compound Name |
Methyl 5-(2-(isoquinolin-5-yl)acetamido)thiazole-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288127; SCHEMBL3712075; BDBM50332087; methyl 5-[(2-isoquinolin-5-ylacetyl)amino]-1,3-thiazole-4-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
N-[4-Methyl-3-(1h-1,2,4-Triazol-5-Yl)thiophen-2-Yl]-2-(2-Oxo-3,4-Dihydroquinolin-1(2h)-Yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1614820; n-(4-methyl-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2h)-yl)acetamide; SCHEMBL3783179; US9796706, Compound 14; BDBM351570; BDBM50338290; Q27456956; N-[4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1-yl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095627; SCHEMBL3991434; BDBM50316253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[20] | |||
| Compound Name |
6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080995; SCHEMBL2934911; BDBM50311954
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
N-(4-Bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1822138; SCHEMBL3784982; SCHEMBL21216180; US9796706, Compound 99; BDBM351655; BDBM50352607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl]amino}-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467079; SCHEMBL4379540; BDBM50259532; 2-[[3,4-dioxo-2-(pyridin-4-ylamino)cyclobuten-1-yl]amino]-2-phenylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
n-(4-Bromo-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682019; SCHEMBL3783257; US9796706, Compound 33; BDBM351589; BDBM50338265; N-[4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-quinolin-5-ylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(2-(Cyclopropylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644623; BDBM50333986
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
5-[2-(Cyclohexylamino)pyridin-4-Yl]-4-Naphthalen-2-Yl-2-(Tetrahydro-2h-Pyran-4-Yl)-2,4-Dihydro-3h-1,2,4-Triazol-3-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644639; BDBM50334001; Q27455545
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
N-[4-Methyl-3-[2-methyl-6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3-yl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2031223; BDBM50384379
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
4-(Naphthalen-2-yl)-3-(2-(pyridin-2-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644625; SCHEMBL16573741; BDBM50333982
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
n-(4-Chloro-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2h)-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682014; SCHEMBL3782279; US9796706, Compound 18; BDBM351574; BDBM50338292; N-[4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1-yl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
n-(4-Chloro-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682020; SCHEMBL3782088; US9796706, Compound 21; BDBM351577; BDBM50338266; N-[4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-quinolin-5-ylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[21] | |||
| Compound Name |
Methyl 3-(2-(isoquinolin-5-yl)acetamido)thiophene-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288215; BDBM50332050
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
4-(Naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644640; BDBM50333996
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-(4-Methoxyphenyl)-N-(2-(2-methyl-1H-imidazol-4-yl)thiophen-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288069; SCHEMBL3782262; BDBM50332083; 2-(4-methoxyphenyl)-N-[2-(2-methyl-1H-imidazol-5-yl)thiophen-3-yl]acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
2-(4-Methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288098; SCHEMBL3713053; BDBM50332084; 2-(4-methoxyphenyl)-N-(2-pyrazin-2-ylthiophen-3-yl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
2-(Isoquinolin-5-yl)-N-(2-(thiazol-4-yl)thiophen-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288100; SCHEMBL3713199; BDBM50332086; 2-isoquinolin-5-yl-N-[2-(1,3-thiazol-4-yl)thiophen-3-yl]acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
4-(Naphthalen-2-yl)-1-(pyridin-2-ylmethyl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644615; BDBM50334007
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
n-(4-Methyl-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682011; SCHEMBL3776306; US9796706, Compound 23; BDBM351579; BDBM50338288; N-[4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-quinolin-5-ylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(Benzyloxy)-1-(3-fluorobenzyl)-3-(trifluoromethyl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078404; SCHEMBL4381953; BDBM50310959; 1-[(3-fluorophenyl)methyl]-4-phenylmethoxy-3-(trifluoromethyl)pyridin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[22] | |||
| Compound Name |
4-(Naphthalen-2-yl)-3-(2-(phenylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644624; BDBM50334003
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
4-(6-Fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644632; BDBM50333990
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
Methyl 3-[2-(2-thienyl)acetamido]thiophene-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288895; Methyl 3-[(Thiophen-2-Ylacetyl)amino]thiophene-2-Carboxylate; Oprea1_862132; ZINC82427; HMS3745A11; methyl 3-[(2-thiophen-2-ylacetyl)amino]thiophene-2-carboxylate; BDBM50332040; CCG-45435; AKOS001327224; MCULE-1255934042; SR-01000635201-1; Q27162609; methyl3-[(thiophen-2-ylacetyl)amino]thiophene-2-carboxylate; methyl 3-(2-(thiophen-2-yl)acetamido)thiophene-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(2-(Cyclopentylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644621; BDBM50333985
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3-(2-(Cyclobutylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644622; BDBM50333992
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-(4-Methoxyphenyl)-N-(2-(1-methyl-1H-imidazol-4-yl)thiophen-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288067; SCHEMBL3782326; BDBM50332081; 2-(4-methoxyphenyl)-N-[2-(1-methylimidazol-4-yl)thiophen-3-yl]acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
4-(Naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-3-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644619; BDBM50333987
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
4-(Naphthalen-2-yl)-1-(pyridin-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644641; BDBM50333981
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
4',3''-Di-O-methylapocynin-B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651277; BDBM50335606; 4'',3''''-Di-O-methylapocynin-B; Q27138600
Click to Show/Hide
|
||||
| Activity |
IC50 = 50800 nM
|
[23] | |||
| Compound Name |
(NE)-N-[(5-amino-1-phenylpyrazol-4-yl)-phenylmethylidene]hydroxylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202863
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[24] | |||
| Compound Name |
N-[3-[[7-(2-Morpholin-4-ylethoxy)-11-oxo-6H-benzo[c][1]benzoxepin-3-yl]amino]phenyl]furan-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3087474; BDBM50494260
Click to Show/Hide
|
||||
| Activity |
IC50 = 51380 nM
|
[25] | |||
| Compound Name |
8-(2-Aminophenylamino)-1-methoxy-10,11-dihydrodibenzo[a,d]cyclohepten-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152971; SCHEMBL2315119; BDBM50392200; 3-(2-aminoanilino)-7-methoxy-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 52100 nM
|
[26] | |||
| Compound Name |
5-Methyl-1-[4-(2-piperidin-1-ylethoxy)phenyl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099806; BDBM50005208
Click to Show/Hide
|
||||
| Activity |
IC50 = 54310 nM
|
[2] | |||
| Compound Name |
4-Benzoyl-1-(3-nitrophenyl)-1H-pyrazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
aminopyrazole 10; CHEMBL202684; BDBM15719; [5-amino-1-(3-nitrophenyl)pyrazol-4-yl]-phenylmethanone; [5-amino-1-(3-nitrophenyl)-1H-pyrazol-4-yl]phenylmethanone
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 56000 nM
|
[24] | |||
| Compound Name |
Ethyl 2-[5-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120991; BDBM50496068
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[27] | |||
| Compound Name |
N-(5-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-4-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450161; BDBM50255227
Click to Show/Hide
|
||||
| Activity |
EC50 = 57800 nM
|
[28] | |||
| Compound Name |
3-(2-Aminoanilino)-8-(2-morpholin-4-ylethoxy)-6H-benzo[c][1]benzoxepin-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086701; BDBM50494272
Click to Show/Hide
|
||||
| Activity |
IC50 = 58730 nM
|
[25] | |||
| Compound Name |
3-(2-Aminoanilino)-8-methoxy-6H-benzo[c][1]benzoxepin-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086699; BDBM50494249
Click to Show/Hide
|
||||
| Activity |
IC50 = 71790 nM
|
[25] | |||
| Compound Name |
3-(2,4-Difluoroanilino)-8-(2-morpholin-4-ylethoxy)-6H-benzo[c][1]benzoxepin-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086700; BDBM50494248
Click to Show/Hide
|
||||
| Activity |
IC50 = 71790 nM
|
[25] | |||
| Compound Name |
1-Benzyl-4-(benzyloxy)-3-vinylpyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1077396; SCHEMBL4385439; BDBM50310956; DB-087500; 1-benzyl-3-ethenyl-4-phenylmethoxypyridin-2-one; 1-Benzyl-4-(benzyloxy)-3-vinylpyridine-2(1H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[22] | |||
| Compound Name |
8-(2,4-Difluorophenylamino)-1-methoxy-10,11-dihydrodibenzo[a,d]cyclohepten-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152965; SCHEMBL2315309; BDBM50392195; 3-(2,4-difluoroanilino)-7-methoxy-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 78700 nM
|
[26] | |||
| Compound Name |
(R)-8-(2-Aminophenylamino)-1-(2,3-dihydroxypropoxy)-10,11-dihydrodibenzo[a,d]cyclo-hepten-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152973; SCHEMBL2318029; BDBM50392202; 3-(2-aminoanilino)-7-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 78800 nM
|
[26] | |||
| Compound Name |
7-Methoxy-2-(2,3,4-trifluorophenylamino)-10,11-dihydrodibenzo[a,d]-cyclo-hepten-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152790; SCHEMBL2318112; BDBM50392160; 9-methoxy-3-(2,3,4-trifluoroanilino)-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[26] | |||
| Compound Name |
4-[2-(4-Ethynylphenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-methylsulfanylpyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314286; BDBM50045571
Click to Show/Hide
|
||||
| Activity |
IC50 = 82100 nM
|
[29] | |||
| Compound Name |
2-[2-(2-Fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Pyrrolopyridine, 23; Kinome_2487; CHEMBL226471; SCHEMBL15508853; BDBM30192; DB07728; Q27096944
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[10] | |||
| Compound Name |
6-(2,4-Difluoroanilino)-12-(oxan-4-yl)tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaen-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152967; BDBM50392197
Click to Show/Hide
|
||||
| Activity |
IC50 = 87200 nM
|
[26] | |||
| Compound Name |
3-(2,4-Difluoroanilino)-7-[(2S)-2,3-dihydroxypropoxy]-6H-benzo[c][1]benzoxepin-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086109; BDBM50494251
Click to Show/Hide
|
||||
| Activity |
IC50 = 90410 nM
|
[25] | |||
| Compound Name |
3-(2,4-Difluoroanilino)-8-[[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-6H-benzo[c][1]benzoxepin-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3087481; BDBM50494286
Click to Show/Hide
|
||||
| Activity |
IC50 = 91190 nM
|
[25] | |||
| Compound Name |
Unii-O5YT36mst0
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
EF-24; O5YT36MST0; CHEMBL379849; SCHEMBL8119310; BDBM50431030; ZINC34009101; EF-24, >=98% (HPLC); 3,5-bis(2-flurobenzylidene) piperidin-4-one; (3E,5E)-3,5-Bis((2-fluorophenyl)methylene)-4-piperidinone; 4-Piperidinone, 3,5-bis((2-fluorophenyl)methylene)-, (3E,5E)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 92000 nM
|
[30] | |||
| Compound Name |
(S)-2-(2-Aminophenylamino)-8-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-10,11-dihydrodibenzo[a,d]cyclohepten-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152963; SCHEMBL2313572; BDBM50392193
Click to Show/Hide
|
||||
| Activity |
IC50 = 93600 nM
|
[26] | |||
| Compound Name |
3-(2-Amino-4-fluoroanilino)-8-(2-morpholin-4-ylethoxy)-6H-benzo[c][1]benzoxepin-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086702; BDBM50494281
Click to Show/Hide
|
||||
| Activity |
IC50 = 94800 nM
|
[25] | |||
| Compound Name |
CID 25181471
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059862; BDBM50388721; N-[5-(1,5-dimethylimidazol-2-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[31] | |||
| Compound Name |
[(2R,3S,4R,5R,6R)-3,4,6-Triacetyloxy-5-[4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-oxazol-2-yl]triazol-1-yl]oxan-2-yl]methyl acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121003; BDBM50496093
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-[2-Methyl-5-[5-(trifluoromethyl)-1H-pyrazol-3-yl]phenyl]-4-(pyridin-2-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059871; BDBM50388704
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[31] | |||
| Compound Name |
ClC=1C=C(C=C(C1O)Cl)C1=CN=C2C(=N1)N=C(C=C2)NC(=O)NCC
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695651; SCHEMBL14506634; BDBM142693; US8937068, 186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Ethyl-3-[3-(3-propan-2-yloxyanilino)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695647; SCHEMBL14506631; BDBM142689; US8937068, 182
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Ethyl-3-[3-(3-hydroxy-phenyl)-pyrido[2,3-b]pyrazine-6-yl]-urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
US8937068, 1; SCHEMBL5445423; CHEMBL3695657; BDBM47096; US8937068, 151; 1-ethyl-3-[3-(3-hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213923; BDBM50323916; 4-((4-methylpiperazin-1-yl)methyl)-N-(4-(2-morpholinoethoxy)naphthalen-1-yl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Ethyl-3-[3-[(6-methoxypyridin-3-yl)amino]pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695655; SCHEMBL14506629; BDBM142697; US8937068, 190
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-(2-Hydroxy-2-methylpropyl)-N-(5-((7-methoxyquinolin-4-yl)oxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AMG-458; AMG 458; AMG458; UNII-4535RW5Y3A; 4535RW5Y3A; C30H29N5O5; Substituted Pyrazolone, 17; cc-602; MLS006010963; SCHEMBL197714; CHEMBL460472; BDBM24466; AMG-458,AMG458; DTXSID80238521; SYN1144; AMG458/AMG-458/; HMS3656H21; BCP01917; EX-A2447; 2209AH; ABP000135; s2747; ZINC43194549; AKOS027422876; CCG-269954; SB19374; NCGC00346670-01; NCGC00346670-05; AS-16283; HY-14723; SMR004702767; AMG-458(AMG458;AMG 458); CS-0003527; FT-0752842; SW220166-1; Z-3256; Q27258802
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[33] | |||
| Compound Name |
N-(2-Methoxyethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611079; BI-90H9; BDBM50310148
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
1-Ethyl-3-[3-(pyrazin-2-ylamino)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5456517; CHEMBL3695646; BDBM142688; US8937068, 181
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
Triazole, 7b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472074; BDBM29302
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
N-(3,4-Dimethoxyphenethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599111; BI-90H10; BDBM50310146
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
N-Methyl-4-(4-(4-((4-methylpiperazin-1-yl)methyl)benzamido)phenoxy)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213922; BDBM50323915
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-[3-(4-Chloroanilino)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5477088; CHEMBL3695630; BDBM142671; US8937068, 159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Ethyl-3-[3-(4-fluoroanilino)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5449855; CHEMBL3695637; BDBM142678; US8937068, 167
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
5-N-(4-Aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163999; BDBM50395262
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
[4-[6-(Ethylcarbamoylamino)pyrido[2,3-b]pyrazin-3-yl]-2-methoxyphenyl] 4-methylbenzenesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695648; SCHEMBL16673921; BDBM142690; US8937068, 183
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-(3-Hydroxypropyl)-3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5449460; CHEMBL3695622; BDBM142661; US8937068, 147
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
4-(2-Cyanophenoxy)-N-(pyrimidin-4-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393063; BDBM50059170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N-[2-Methyl-5-(5-methyl-1H-imidazol-4-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059868; BDBM50388710
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[31] | |||
| Compound Name |
1-Ethyl-3-[3-[(5-methylpyridin-2-yl)amino]pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695635; SCHEMBL14506618; BDBM142676; US8937068, 165
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL609039; BI-90H6; BDBM50310142
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223203; BDBM50325369; 4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(2-(dimethylamino)ethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
1-Ethyl-3-[3-[(1-methylpyrazol-3-yl)amino]pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695636; SCHEMBL14506617; BDBM142677; US8937068, 166
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(3Z,5Z)-3,5-Bis(pyridin-2-ylmethylidene)thian-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036343; SCHEMBL10062873; BDBM50431027
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Disodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314275
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
[(2R,3S,4R,5R,6R)-3,4,6-Triacetyloxy-5-[4-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]oxan-2-yl]methyl acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121002; BDBM50496057
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
1-Ethyl-3-[3-(4-hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5441456; CHEMBL3695617; BDBM142655; US8937068, 43; 1-ethyl-3-[3-(4-oxocyclohexa-2,5-dien-1-ylidene)-4H-pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
ClC1=C(CNC2=NC(=NN2)C2=CC(=C(C=C2)OC)OC)C(=CC=C1)F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091764; SCHEMBL19356073; BDBM50241732
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
CCNC(=O)Nc1ccc2ncc(Nc3cc(Cl)c(O)c(Cl)c3)nc2n1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695650; SCHEMBL14506633; BDBM142692; US8937068, 185
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
N-Methyl-4-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)ureido)phenoxy)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213975; BDBM50323920
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-[3-(4-Hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl]-3-prop-2-enylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4679766; CHEMBL3695615; BDBM142653; US8937068, 25
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
7-Methoxy-3,4,5,10-tetrahydro-1H-2,5-methanoazepino[3,4-b]indole-1-carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392876; SCHEMBL1655459; BDBM50215481
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
1-[3-[(2-Chloropyridin-4-yl)amino]pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695649; SCHEMBL14506638; BDBM142691; US8937068, 184
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
4-Benzoyl-5-methyl-2-phenyl-1H-pyrazol-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-phenyl-3-methyl-4-benzoyl-5-pyrazolone; 4-benzoyl-5-methyl-2-phenyl-1H-pyrazol-3-one; (5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(phenyl)methanone; pyrazole 3; Maybridge1_004190; ACMC-209k2y; MLS000850531; SCHEMBL9288406; CHEMBL3144705; SCHEMBL12438890; BDBM15716; HMS553G12; 4-benzoyl-5-methyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one; HMS2806N07; HMS3401G15; KS-000010HZ; ZINC6483269; ANW-30296; CCG-52686; MFCD03147230; SBB044929; STK008663; STL367904; TD8140; ZINC95628204; AKOS000275124; AKOS015998989; MCULE-5968028548; NE19364; 1-phenyl-3-methyl-4-benzoylpyrazol-5-ol; SMR000456549; FT-0617632; W6369; 4-benzoyl-3-methyl-1-phenyl-1H-pyrazol-5-ol; 4-Benzoyl-3-methyl-1-phenyl-5(2H)-pyrazolone; SR-01000641901-1; BRD-K40293218-001-07-1; 5-hydroxy-3-methyl-1-phenylpyrazol-4-yl phenyl ketone; (5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)phenylmethanone; (5-hydroxy-3-methyl-1-phenyl-pyrazol-4-yl)-phenyl-methanone; 5-methyl-2-phenyl-4-(phenylcarbonyl)-1,2-dihydro-3H-pyrazol-3-one; Methanone, (5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)phenyl-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
4-Benzoyl-1-phenyl-1H-pyrazole-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazole 2; CHEMBL203735; BDBM15715; HMS3401M11; 4-benzoyl-2-phenylpyrazole-3-carbonitrile; 4-benzoyl-2-phenyl-2H-pyrazole-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
N-Sec-Butyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599518; BI-98A10; BDBM50310147
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
1-(4-Hydroxybutyl)-3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5445107; CHEMBL3695621; BDBM142660; US8937068, 146
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Ethyl-3-[3-(1-methylpyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695642; SCHEMBL14506622; BDBM142683; US8937068, 173
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395157; 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid; 6-METHOXY-1H,2H,3H,4H,9H-PYRIDO[3,4-B]INDOLE-1-CARBOXYLIC ACID; SCHEMBL608164; SCHEMBL12660570; CTK0H2172; DTXSID00397280; BDBM50215483; MFCD00010826; STL525685; AKOS015894383; MCULE-5714246217; ST065834; 952M635; J-011460; Z2216905627; 6-methoxy-1,2,3,4-tetrahydrobeta-carbolinecarboxylic acid; 6-Methoxy-1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acid; 6-methoxy-2,3,4,9-tetrahydro-1h-beta-carboline-1-carboxylic acid; 1H-Pyrido[3,4-b]indole-1-carboxylic acid, 2,3,4,9-tetrahydro-6-methoxy-; 1H-Pyrido[3,4-b]indole-1-carboxylicacid, 2,3,4,9-tetrahydro-6-methoxy-; 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-2-ium-1-carboxylate; 6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid, 97%
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
3-[6-(Ethylcarbamoylamino)pyrido[2,3-b]pyrazin-3-yl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4687454; CHEMBL3695625; BDBM142665; US8937068, 152
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
Triazole, 3j
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL448771; SCHEMBL4789242; BDBM29292
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
Thiourea, N-(3-(4-hydroxyphenyl)pyrido(2,3-b)pyrazin-6-yl)-N'-2-propenyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
D-87503; UNII-AED3R32X41; AED3R32X41; N-[3-(4-HYDROXYPHENYL)PYRIDO[2,3-B]PYRAZIN-6-YL]-N'-2-PROPEN-1-YL-THIOUREA; 1-allyl-3-[3-(4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-thiourea; SCHEMBL4680272; CHEMBL3695616; BDBM142654; BCP27634; ZINC6717518; ABP000090; BCP9000574; Thiourea, N-(3-(4-hydroxyphenyl)pyrido(2,3-b)pyrazin-6-yl)-N'-2-propen-1-yl-; DB-075639; FT-0704801; US8937068, 30; D 87503; D 87503;D87503; D-87503/D87503; Q27273894; 1-Allyl-3-(3-(4-hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl)thiourea; 1-[3-(4-hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl]-3-(prop-2-en-1-yl)thiourea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
[4-[6-(Ethylcarbamoylamino)pyrido[2,3-b]pyrazin-3-yl]-2-methoxyphenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4342106; CHEMBL3695660; BDBM47099; US8937068, 169
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Ethyl-3-[3-(4-methoxyanilino)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5452117; CHEMBL3695629; BDBM142670; US8937068, 158
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Ethyl-3-[3-(3-hydroxy-4-methylanilino)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695653; SCHEMBL14506635; BDBM142695; US8937068, 188
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-[3-(4-Chloro-2-methoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695640; SCHEMBL14506624; BDBM142681; US8937068, 171
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
Halicin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU 3327; SU3327; 5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazol-2-amine; SU-3327; 2-Amino-5-[(5-nitro-2-thiazolyl)thio]-1,3,4-thiadiazole; 5-(5-Nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine; 5-[(5-nitro-1,3-thiazol-2-yl)thio]-1,3,4-thiadiazol-2-amine; CHEMBL510038; SCHEMBL8044196; BDBM29315; CTK8G3223; GTPL10703; DTXSID70474254; 2-amino-1,3,4-thiadiazole, 9; HMS3414C07; HMS3678C07; BCP32078; ZINC8716875; AKOS016368573; compound 9 [PMID: 19271755]; DB15624; SU3327; SU-3327; HY-107597; B7444; CS-0028934; EC-000.2369; JNK Inhibitor XIII - CAS 40045-50-9; 5-(5-Nitrothiazole-2-ylthio)-1,3,4-thiadiazole-2-amine; 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
ClC=1C=C(C=C(C1O)OC)C1=CN=C2C(=N1)N=C(C=C2)NC(=O)NCC
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
US8937068, 156; SCHEMBL4686470; CHEMBL3695661; BDBM47100; US8937068, 175
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
3-[[6-(Ethylcarbamoylamino)pyrido[2,3-b]pyrazin-3-yl]amino]-5-(trifluoromethyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4684758; CHEMBL3695654; BDBM142696; US8937068, 189
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Ethyl-3-[3-(pyridin-3-ylamino)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5458507; CHEMBL3695631; BDBM142672; US8937068, 161
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
4-[2-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-5-(4-fluorophenyl)-3-methylimidazol-4-yl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120969; BDBM50045578
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
1-[3-(4-Cyanoanilino)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5452102; CHEMBL3695656; BDBM142698; US8937068, 192
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Ethyl-3-[3-(4-ethylanilino)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5456518; CHEMBL3695632; BDBM142673; US8937068, 162
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
N-[2-Methyl-5-(1,3,5-trimethylpyrazol-4-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059870; BDBM50388712
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[31] | |||
| Compound Name |
1-Ethyl-3-[3-(3-methylanilino)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5458922; CHEMBL3695658; BDBM47097; US8937068, 157
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
N-Benzyl-4-(2-cyanophenoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393294; BDBM50059173
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338335; BDBM50431025
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
1-[3-(4-Aminophenyl)pyrido[2,3-b]pyrazin-6-yl]-3-methylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5452959; CHEMBL3695618; BDBM142656; US8937068, 44
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Methyl-3,5-bis-pyridin-2-ylmethylene-piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338333; SCHEMBL8120726; UBS-109; BDBM50431028; (3E,5E)-1-methyl-3,5-bis(2-pyridylmethylene)piperidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
N=1C2=NC(NC(=S)Ncc)=CC=C2N=CC=1C1=CC=C(O)C=C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5441469; CHEMBL3695624; BDBM142663; US8937068, 149
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
5-Methoxy-2-(5-nitrothiazol-2-ylthio)benzo[d]thiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL474804; BI-87D11; BDBM50257103
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
1-N-[3-Chloro-4-[(2-methylphenyl)methyl]phenyl]-4-fluorobenzene-1,2-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153795; BDBM50136894; N*1*-[3-Chloro-4-(2-methyl-benzyl)-phenyl]-4-fluoro-benzene-1,2-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
4-[6-[(3,4-Dichlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-(2-pyrrolidin-1-ylethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222474; BDBM50325373; 4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
1-Ethyl-3-[3-(3-methoxy-4-methylanilino)pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695633; SCHEMBL14506619; BDBM142674; US8937068, 163
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338334; BDBM50431026
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
N-[5-(1,2-Dimethylimidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059869; BDBM50388711
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[31] | |||
| Compound Name |
N-(2-Methyl-5-phenylmethoxyphenyl)-1-phenyl-5-propylpyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393300; BDBM50059179
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
4-[6-[(3-Chlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222992; BDBM50325368; (S)-4-(6-(3-chlorobenzylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
Occccnc(=O)NC=1C=CC=2C(=NC(=CN2)C2=CC(=C(C=C2)O)OC)N1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695638; SCHEMBL14506632; BDBM142679; US8937068, 168
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-[3-(3,5-Dimethoxyanilino)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695645; SCHEMBL14506641; BDBM142687; US8937068, 180
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
N=1C2=NC(NC(=O)Ncc)=CC=C2N=CC=1NC1=CC=C(O)C=C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5445286; CHEMBL3695634; BDBM142675; US8937068, 164
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Ethyl-3-[3-[4-(3-morpholin-4-ylpropoxy)phenyl]pyrido[2,3-b]pyrazin-6-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695623; SCHEMBL14506616; BDBM142662; US8937068, 148
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-[3-(3-Chloro-4-methoxyanilino)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695644; SCHEMBL14506620; BDBM142685; US8937068, 177
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(S)-4-(6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222990; BDBM50325375
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
Chembl4276946
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[42] | |||
| Compound Name |
2-Benzyl-5-(benzyloxy)-4-bromopyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094166; SCHEMBL6232624; CTK1F4502; DTXSID30677007; BDBM50318051; 2-benzyl-4-bromo-5-phenylmethoxypyridazin-3-one; 3(2H)-Pyridazinone, 4-bromo-5-(phenylmethoxy)-2-(phenylmethyl)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
2-(5-Nitrothiazol-2-ylthio)benzo[d]thiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BI-87G3; CHEMBL493539; JNK Inhibitor XI; JNK Inhibitor XI, BI-87G3; SCHEMBL20142744; BDBM50257184; ZINC40429498; BI-87G3, >=98% (HPLC); J-014468; 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
1-[3-(3,5-Dimethyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695641; SCHEMBL14506623; BDBM142682; US8937068, 172
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
4-[6-[(3,4-Dichlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222565; BDBM50325374; (S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
1-[3-(3,4-Dimethoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5447864; CHEMBL3695626; BDBM142666; US8937068, 153
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
Dithioether 1,3,4-thiadiazole, 8f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL503022; SCHEMBL11430427; BDBM29313; 2,5-bis[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
C(C)NC(=O)NC=1C=CC=2C(=NC(=CN2)C2=CC(=C(C=C2)O)OC)N1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
US8937068, 124; CHEMBL3695663; SCHEMBL14506608; BDBM47103; US8937068, 193
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(R)-8-(2,4-Difluorophenylamino)-1-(2,3-dihydroxypropoxy)-10,11-dihydrodibenzo-[a,d]cyclohepten-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152969; SCHEMBL2320856; BDBM50392198; 3-(2,4-difluoroanilino)-7-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[26] | |||
| Compound Name |
3-[6-(Ethylcarbamoylamino)pyrido[2,3-b]pyrazin-3-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4684786; CHEMBL3695628; BDBM142668; US8937068, 155
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
6-(2,4-Difluoroanilino)-13-[[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152959; BDBM50392189
Click to Show/Hide
|
||||
| Activity |
IC50 = 123000 nM
|
[26] | |||
| Compound Name |
2-(1-Benzyltriazol-4-yl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120962; BDBM50496091
Click to Show/Hide
|
||||
| Activity |
IC50 = 158000 nM
|
[27] | |||
| Compound Name |
(S)-8-(2-Aminophenylamino)-1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-10,11-dihydrodibenzo[a,d]cyclohepten-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152972; SCHEMBL2320814; BDBM50392201
Click to Show/Hide
|
||||
| Activity |
IC50 = 158000 nM
|
[26] | |||
| Compound Name |
(S)-2-(2,4-Difluorophenylamino)-8-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-10,11-dihydrodibenzo[a,d]cyclohepten-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152957; SCHEMBL2316044; BDBM50392187
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[26] | |||
| Compound Name |
2,4-Bis(1,3-benzodioxol-5-yl)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2000337; NSC162496; SCHEMBL16211954; CTK5G1373; BDBM50392853; 2,3]dioxol-5-yl)-4-oxobutanoic acid; NSC-162496; FT-0627100; Butanoic acid,4-bis[1,3-benzodioxol-5-yl]-4-oxo-
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| Activity |
IC50 = 197000 nM
|
[44] | |||
| Compound Name |
3-(2,4-Difluoroanilino)-7-(2-morpholin-4-ylethoxy)-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152970; SCHEMBL2316236; BDBM50392199; 8-(2,4-Difluorophenylamino)-1-(2-morpholin-4-yl-ethoxy)-10,11-dihydrodibenzo[a,d]cyclo-hepten-5-one
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| Activity |
IC50 = 200000 nM
|
[26] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4290513
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Investigative | Compound Info | ||
| Synonyms |
BDBM50468570
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| Activity |
IC50 > 200000 nM
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[45] | |||
| Compound Name |
Chembl4277125
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Investigative | Compound Info | ||
| Synonyms |
BDBM50468565
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| Activity |
IC50 > 200000 nM
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[45] | |||
| Compound Name |
Chembl4294787
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Investigative | Compound Info | ||
| Synonyms |
BDBM50468557
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| Activity |
IC50 > 200000 nM
|
[45] | |||
| Compound Name |
d-Epigalbacin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2151191; (?)-Zuonin A; BDBM50392850
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| Activity |
IC50 = 252000 nM
|
[44] | |||
| Compound Name |
N-Phenylpyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
N-phenyl-2-pyrimidinamine; 2-Anilinopyrimidine; 2-(N-Anilino)pyrimidine; 2-Anilinopyrirmidine; 2-(Phenylamino)pyrimidine; anilinopyrimidine; MFCD01646270; CHEMBL1650061; Phenyliminopyrimidin; 2-phenylaminopyrimidine; PubChem23552; SCHEMBL911; 2-Pyrimidinamine, N-phenyl-; KSC497S9P; SCHEMBL21389617; CTK3J7997; DTXSID90469905; ACT06630; ZINC6665770; 1-benzyl-3-carboxypyridiniumchloride; BDBM50350909; AKOS006242256; CM14290; MCULE-8162084400; AS-58598; BR-51553; SY031633; AB0006887; DB-072288; FT-0651865; X0168; S-3664; A831405; J-506511; Z54888538
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| Activity |
IC50 > 630957.34 nM
|
[46] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
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| Activity |
Ki > 1000000 nM
|
[47] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 1 | The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796. Bioorg Med Chem. 2010 Aug 1;18(15):5738-48. | ||||
| REF 2 | Synthesis and biological evaluation of the pirfenidone derivatives as antifibrotic agents. Bioorg Med Chem Lett. 2014 Jan 1;24(1):220-3. | ||||
| REF 3 | Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1838-43. | ||||
| REF 4 | Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5521-7. | ||||
| REF 5 | Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. | ||||
| REF 6 | Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolines. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3585-8. | ||||
| REF 7 | Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. | ||||
| REF 8 | Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. 2007 Nov 16;282(46):33295-304. | ||||
| REF 9 | Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J Med Chem. 2006 Feb 9;49(3):955-70. | ||||
| REF 10 | Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54. | ||||
| REF 11 | Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. Bioorg Med Chem Lett. 2011 Jan 1;21(1):315-9. | ||||
| REF 12 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
| REF 13 | Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7303-7. | ||||
| REF 14 | The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38alpha MAP kinase inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3879-83. | ||||
| REF 15 | Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance. J Med Chem. 2010 Feb 11;53(3):1238-49. | ||||
| REF 16 | ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. | ||||
| REF 17 | Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6575-7. | ||||
| REF 18 | 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4420-3. | ||||
| REF 19 | In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery. J Med Chem. 2017 Oct 26;60(20):8552-8564. | ||||
| REF 20 | Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. | ||||
| REF 21 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 22 | Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5851-6. | ||||
| REF 23 | Catechin derivatives from Parapiptadenia rigida with in vitro wound-healing properties. J Nat Prod. 2010 Dec 27;73(12):2035-41. | ||||
| REF 24 | Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highl... J Med Chem. 2006 Mar 9;49(5):1562-75. | ||||
| REF 25 | Metabolically stable dibenzo[b,e]oxepin-11(6H)-ones as highly selective p38 MAP kinase inhibitors: optimizing anti-cytokine activity in human whole blood. J Med Chem. 2013 Nov 14;56(21):8561-78. | ||||
| REF 26 | Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem. 2012 Jun 28;55(12):5868-77. | ||||
| REF 27 | Syntheses and structure-activity relationships for some triazolyl p38alpha MAPK inhibitors. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1352-7. | ||||
| REF 28 | 2-Aminoimidazoles inhibitors of TGF-beta receptor 1. Bioorg Med Chem Lett. 2009 Feb 1;19(3):912-6. | ||||
| REF 29 | Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38alpha MAPK, CK1 and JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3412-8. | ||||
| REF 30 | Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties. J Med Chem. 2013 May 9;56(9):3456-66. | ||||
| REF 31 | Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4907-11. | ||||
| REF 32 | US patent application no. 8937068B2, Pyridopyrazine derivatives and their use | ||||
| REF 33 | Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series. J Med Chem. 2012 Mar 8;55(5):1868-97. | ||||
| REF 34 | Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors. Bioorg Med Chem. 2010 Jan 15;18(2):590-6. | ||||
| REF 35 | Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase. J Med Chem. 2009 Apr 9;52(7):1943-52. | ||||
| REF 36 | Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. J Med Chem. 2012 Aug 9;55(15):6700-15. | ||||
| REF 37 | Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors. J Med Chem. 2015 Jan 8;58(1):278-93. | ||||
| REF 38 | Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5113-8 | ||||
| REF 39 | Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett. 2007 Aug 15;17(16):4657-63. | ||||
| REF 40 | Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors. Bioorg Med Chem. 2009 Apr 1;17(7):2712-7. | ||||
| REF 41 | Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J Med Chem. 2003 Dec 18;46(26):5651-62. | ||||
| REF 42 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 43 | Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett. 2010 May 15;20(10):3146-9. | ||||
| REF 44 | From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules. ACS Med Chem Lett. 2012 Aug 6;3(9):721-725. | ||||
| REF 45 | Design and biological evaluation of novel triaryl pyrazoline derivatives with dioxane moiety for selective BRAF V600E inhibition. Eur J Med Chem. 2018 Jul 15;155:725-735. | ||||
| REF 46 | Selectivity of kinase inhibitor fragments. J Med Chem. 2011 Jul 28;54(14):5131-43. | ||||
| REF 47 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
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