Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T68334 | Target Info | |||
| Target Name | Follicle-stimulating hormone receptor (FSHR) | ||||
| Synonyms |
LGR1; Follitropin receptor; FSH-R
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|
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| Target Type | Successful Target | ||||
| Gene Name | FSHR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 12 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(3R)-1-Hexyl-4-methyl-3-[[4-(3,4,5-trimethoxyphenyl)phenyl]methyl]piperazine-2,5-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL300634; BDBM50142679; (R)-1-Hexyl-4-methyl-3-(3'',4'',5''-trimethoxy-biphenyl-4-ylmethyl)-piperazine-2,5-dione
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Cyclopropyl-N-[5-[[(1R,2S,3R)-2,3-dihydroxycyclohexyl]carbamoyl]-2-[4-(2-methylphenyl)piperazin-1-yl]phenyl]-1,3-oxazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263692; SCHEMBL14652088; BDBM50012121
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| Activity |
EC50 = 53000 nM
|
[2] | |||
| Compound Name |
N-[2-[4-(2-Methylphenyl)piperazin-1-yl]-5-[3-(oxolan-3-yl)propylcarbamoyl]phenyl]furan-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263687; SCHEMBL14651693; BDBM50012116
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|
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| Activity |
EC50 = 88000 nM
|
[2] | |||
| Compound Name |
2-Cyclopropyl-N-[2-[4-(2-methylphenyl)piperazin-1-yl]-5-[3-(2H-tetrazol-5-yl)propylcarbamoyl]phenyl]-1,3-oxazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263691; SCHEMBL14651957; BDBM50012120
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|
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| Activity |
EC50 = 89000 nM
|
[2] | |||
| Compound Name |
2-Cyclopropyl-N-[2-[4-(2-methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]-1,3-oxazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263667; SCHEMBL14651603; BDBM50012105
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|
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| Activity |
EC50 = 99000 nM
|
[2] | |||
| Compound Name |
N-[5-(2-Cyclopentylethylcarbamoyl)-2-[4-(2-methylphenyl)piperazin-1-yl]phenyl]furan-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263686; SCHEMBL14651722; BDBM50012115
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|
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| Activity |
EC50 = 129000 nM
|
[2] | |||
| Compound Name |
5-Methyl-N-[2-[4-(2-methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]furan-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263663; SCHEMBL14651506; BDBM50012101
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|
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| Activity |
EC50 = 129000 nM
|
[2] | |||
| Compound Name |
2-Cyclopropyl-N-[2-[4-(2-methylphenyl)piperazin-1-yl]-5-(3-pyridin-4-ylpropylcarbamoyl)phenyl]-1,3-oxazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263688; SCHEMBL14651773; BDBM50012117
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|
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| Activity |
EC50 = 153000 nM
|
[2] | |||
| Compound Name |
2-Cyclopropyl-N-[2-[4-(2-methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]-1,3-thiazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263668; SCHEMBL14651768; BDBM50012106
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|
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| Activity |
EC50 = 184000 nM
|
[2] | |||
| Compound Name |
N-[5-[3-(2,5-Dioxopyrrolidin-1-yl)propylcarbamoyl]-2-[4-(2-methylphenyl)piperazin-1-yl]phenyl]furan-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263690; SCHEMBL14651677; BDBM50012119
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|
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| Activity |
EC50 = 184000 nM
|
[2] | |||
| Compound Name |
N-[2-[4-(2-Methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]pyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263671; SCHEMBL14651534; BDBM50012109
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|
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| Activity |
EC50 = 185000 nM
|
[2] | |||
| Compound Name |
3-(Cyclopropanecarbonylamino)-4-[4-(2-methylphenyl)piperazin-1-yl]-N-[3-(2-oxopyrrolidin-1-yl)propyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263669; SCHEMBL14633890; BDBM50012107
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|
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| Activity |
EC50 = 199000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 9 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Methyl-N-[2-[4-(2-methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]-1,3-oxazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263666; SCHEMBL14651571; BDBM50012104
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|
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| Activity |
EC50 = 250000 nM
|
[2] | |||
| Compound Name |
N-[2-[4-(2-Methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]furan-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263660; SCHEMBL14651510; BDBM50012099
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|
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| Activity |
EC50 = 494000 nM
|
[2] | |||
| Compound Name |
3-Methyl-N-[2-[4-(2-methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]furan-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263664; SCHEMBL14651513; BDBM50012102
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|
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| Activity |
EC50 = 508000 nM
|
[2] | |||
| Compound Name |
3-Benzamido-4-[4-(2-methylphenyl)piperazin-1-yl]-N-[3-(2-oxopyrrolidin-1-yl)propyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263670; SCHEMBL14633865; BDBM50012108
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|
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| Activity |
EC50 = 554000 nM
|
[2] | |||
| Compound Name |
2-Cyclopropyl-N-[5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]-2-[4-[2-(trifluoromethyl)phenyl]piperazin-1-yl]phenyl]-1,3-oxazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263674; SCHEMBL14651789; BDBM50012110
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|
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| Activity |
EC50 = 1001000 nM
|
[2] | |||
| Compound Name |
2-Cyclopropyl-N-[2-[4-(3-methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]-1,3-oxazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263676; SCHEMBL14651788; BDBM50012111
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|
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| Activity |
EC50 = 1440000 nM
|
[2] | |||
| Compound Name |
N-[5-(2-Aminoethylcarbamoyl)-2-[4-(2-methylphenyl)piperazin-1-yl]phenyl]furan-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263684; SCHEMBL14651729; BDBM50012113
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|
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| Activity |
EC50 = 1850000 nM
|
[2] | |||
| Compound Name |
N-Methyl-N-[2-[4-(2-methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]-1H-pyrrole-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263665; BDBM50012103
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|
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| Activity |
EC50 = 4900000 nM
|
[2] | |||
| Compound Name |
N-Methyl-N-[2-[4-(2-methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]furan-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263661; SCHEMBL14634151; BDBM50012100
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|
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| Activity |
EC50 = 8820000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1717-20. | ||||
| REF 2 | Discovery of substituted benzamides as follicle stimulating hormone receptor allosteric modulators. Bioorg Med Chem Lett. 2014 May 1;24(9):2168-72. | ||||
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