Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T69375 | Target Info | |||
| Target Name | Stress-activated protein kinase JNK2 (JNK2) | ||||
| Synonyms |
Stress-activated protein kinase 1a; SAPK1a; PRKM9; Mitogen-activated protein kinase 9; Mitogen-activated protein kinase 8-interacting protein 2; MAPK 9; MAP kinase 9; Jun-N-terminal kinase 2; JNK-interacting protein 2; JNK-55; JNK MAP kinase scaffold protein 2; JIP-2; Islet-brain-2; IB-2; C-jun-amino-terminal kinase interacting protein 2; C-Jun N-terminal kinase 2
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|
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| Target Type | Preclinical Target | ||||
| Gene Name | MAPK9 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 42 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
AM7
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|
Investigative | Compound Info | ||
| Synonyms |
pyrimidone, 22; AM 7; AM-7
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(Pyridin-4-yl)-4-(quinolin-6-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784648; BDBM50345615
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-(5-(Naphthalen-2-yl)-1H-tetrazol-1-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784662; BDBM50345603
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Methyl 5-(2-(naphthalen-1-yl)acetamido)-1,2,3-thiadiazole-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288271; BDBM50332057
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(2-Phenylacetamido)thiophene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288993; BDBM50332055
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(2-(1-Methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1287945; SCHEMBL3787324; BDBM50332072; N-[2-(1-methylpyrazol-3-yl)thiophen-3-yl]-2-naphthalen-1-ylacetamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(4-Methylpyridin-3-yl)-2-(naphthalen-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288299; BDBM50332062
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(2-Methylpyridin-4-yl)-4-(quinolin-3-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784645; BDBM50345612
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Methyl 4-(2-(naphthalen-1-yl)acetamido)thiazole-5-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288297; BDBM50332060
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Ethyl 3-methyl-5-(2-(naphthalen-1-yl)acetamido)isothiazole-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288273; BDBM50332059
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 3-(2-(pyridin-4-yl)acetamido)thiophene-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288931; BDBM50332042
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(2-(1H-1,2,4-Triazol-1-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288005; SCHEMBL3781251; BDBM50332076; 2-(4-methoxyphenyl)-N-[2-(1,2,4-triazol-1-yl)thiophen-3-yl]acetamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(Pyridin-4-yl)-4-(quinolin-3-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784643; BDBM50345610
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(3-Methylpyrazin-2-yl)-2-(naphthalen-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1287857; BDBM50332093
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(5-Chloro-4-(naphthalen-2-yl)-4H-1,2,4-triazol-3-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784656; BDBM50345597
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Methyl 3-(2-(4-(pyridin-4-yl)phenyl)acetamido)thiophene-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288157; BDBM50332044
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Ethyl 2-(2-(4-methoxyphenyl)acetamido)-4-(trifluoromethyl)thiophene-3-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681995; BDBM50338271
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(2-Acetylthiophen-3-yl)-2-phenylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288932; BDBM50332052
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 3-(2-(naphthalen-2-yl)acetamido)thiophene-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288187; BDBM50332047; ZINC15606685; AKOS008057378; MCULE-7266220057
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(4-(Naphthalen-2-yl)-5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784652; BDBM50345619
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(2-(1H-Pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1287915; SCHEMBL3782571; BDBM50332069; 2-naphthalen-1-yl-N-[2-(1H-pyrazol-5-yl)thiophen-3-yl]acetamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 3-(2-(4-(1H-imidazol-1-yl)phenyl)acetamido)thiophene-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288158; BDBM50332045
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(1-(Naphthalen-2-yl)-1H-tetrazol-5-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784655; BDBM50345622
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Methyl 2-(2-(naphthalen-1-yl)acetamido)nicotinate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288298; BDBM50332061
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 3-(2-(4-(trifluoromethyl)phenyl)acetamido)thiophene-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288186; BDBM50332046; AKOS001207770
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[2-(2,5-Dimethyl-1,2,4-triazol-3-yl)thiophen-3-yl]-2-naphthalen-1-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1287975; SCHEMBL3788557; BDBM50332074; n-(2-(1,3-dimethyl-1h-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 4-(2-(naphthalen-1-yl)acetamido)-1,2,5-oxadiazole-3-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288272; BDBM50332058
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(4-Methoxyphenyl)-N-(2-(2-methyl-1H-imidazol-4-yl)thiophen-3-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288069; SCHEMBL3782262; BDBM50332083; 2-(4-methoxyphenyl)-N-[2-(2-methyl-1H-imidazol-5-yl)thiophen-3-yl]acetamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(2-Methoxyethyl)-3-(2-phenylacetamido)thiophene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288244; BDBM50332056
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(4-Methoxyphenyl)-N-(2-(2-oxooxazolidin-3-yl)thiophen-3-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288037; SCHEMBL3718818; BDBM50332078; 2-(4-methoxyphenyl)-N-[2-(2-oxo-1,3-oxazolidin-3-yl)thiophen-3-yl]acetamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(2-(1H-Imidazol-1-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1287914; SCHEMBL3782221; BDBM50332068; N-(2-imidazol-1-ylthiophen-3-yl)-2-naphthalen-1-ylacetamide; N-(2-(1H-imidazol-1-yl)thiophen-3-yl)2-(naphthalen-1-yl)acetamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(2-Methoxyethyl)-N-methyl-3-(2-phenylacetamido)thiophene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288245; BDBM50332092
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(4-Methoxyphenyl)-N-(2-(1-methyl-1H-imidazol-4-yl)thiophen-3-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288067; SCHEMBL3782326; BDBM50332081; 2-(4-methoxyphenyl)-N-[2-(1-methylimidazol-4-yl)thiophen-3-yl]acetamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(2-Bromopyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784647; BDBM50345614
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(2-Hydroxy-2-methylpropyl)-N-(5-((7-methoxyquinolin-4-yl)oxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
AMG-458; AMG 458; AMG458; UNII-4535RW5Y3A; 4535RW5Y3A; C30H29N5O5; Substituted Pyrazolone, 17; cc-602; MLS006010963; SCHEMBL197714; CHEMBL460472; BDBM24466; AMG-458,AMG458; DTXSID80238521; SYN1144; AMG458/AMG-458/; HMS3656H21; BCP01917; EX-A2447; 2209AH; ABP000135; s2747; ZINC43194549; AKOS027422876; CCG-269954; SB19374; NCGC00346670-01; NCGC00346670-05; AS-16283; HY-14723; SMR004702767; AMG-458(AMG458;AMG 458); CS-0003527; FT-0752842; SW220166-1; Z-3256; Q27258802
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| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
5-[3-Fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
AMG-51; pyrimidone, 51; AMG51; CHEMBL453737; SCHEMBL2868963; AMG-51;AMG 51; BDBM24769; SYN1111; C34H33F2N5O5; BCP21618; ZINC43178754; NCGC00263201-01; NCGC00263201-02; AS-16255
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(3-(6-(2,4-Difluorophenylamino)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-4-methoxyphenyl)-2-methylbut-3-yn-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370156; SCHEMBL3256859; BDBM50175998
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-(5-(3-Amino-3-methylbut-1-ynyl)-2-methoxyphenyl)-N-(2,4-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-6-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200820; SCHEMBL3257122; BDBM50176007
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|
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| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
N-{4-[(6,7-Dimethoxyquinolin-4-Yl)oxy]-3-Fluorophenyl}-1,5-Dimethyl-3-Oxo-2-Phenyl-2,3-Dihydro-1h-Pyrazole-4-Carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2031893; 03X; BDBM50383191; Q27449828
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|
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| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
4-(4-(4-Fluorophenyl)-2-(4-methylcyclohexyl)-1H-imidazol-5-yl)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523938; BDBM50260229
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|
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| Activity |
IC50 = 166000 nM
|
[7] | |||
| Compound Name |
3-((3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1077414; SCHEMBL4374167; BDBM50310965; 3-[[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]methyl]benzamide
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| Activity |
IC50 = 167000 nM
|
[8] | |||
| Compound Name |
3-Bromo-4-(2,4-difluorobenzyloxy)-1-(4-((dimethylamino)methyl)benzyl)-6-methylpyridin-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078665; PHA-745052; SCHEMBL4382841; BDBM50310984
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|
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| Activity |
IC50 ~ 171000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 62 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
VX-745
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|
Phase 2 | Compound Info | ||
| Synonyms |
5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one; 209410-46-8; Neflamapimod; VX 745; VX745; VRT-031745; UNII-TYL52QM320; TYL52QM320; CHEBI:90528; 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one; 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one; Neflamapimod (USAN); Neflamapimod [USAN]; AK-44905; C19H9Cl2F2N3OS; 5-(2,6-Dichlorophenyl)-2-[(2,4-Difluorophenyl)sulfanyl]-6h-Pyrimido[1,6-B]pyridazin-6-One; VX745, VX-745; 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido(1,6-b)pyridazin-6-one; Vertex 745 (VX745)
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
PH-797804
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Phase 2 | Compound Info | ||
| Synonyms |
PH-797804; 586379-66-0; PH797804; PH 797804; 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide; UNII-SI09I1V827; UNII-GEL7GRJ3R6; GEL7GRJ3R6; CHEMBL1088751; CHEBI:82715; SI09I1V827; 3-{3-Bromo-4-[(2,4-Difluorobenzyl)oxy]-6-Methyl-2-Oxopyridin-1(2h)-Yl}-N,4-Dimethylbenzamide; PHA-797804; 1358027-80-1; 3-Bromo-4-((2,4-difluorobenzyl)oxy)-1-(5-((methylamino)carbonyl)-2-methylphenyl)-6-methylpyridin-2(1H)-one; 3hll; KCAJXIDMCNPGHZ-UHFFFAOYSA-N
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| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
PMID17480064C16
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|
Investigative | Compound Info | ||
| Synonyms |
724711-21-1; 3fhr; 2jbp; 2jbo; P4O; Pyrrolopyridine, 16; Kinome_3179; 3r2y; GTPL8177; BDBM30185; ZINC16052855; AKOS027322581; DB08358; KB-19275; DB-013997; FT-0745988
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| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
N-(4-((3-Chloro-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)benzyl)-2-hydroxyacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078667; SCHEMBL4386740; BDBM50310986
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|
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
4-((3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078678; SCHEMBL4376488; BDBM50310963; 4-[[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]methyl]benzonitrile; 4-{[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]methyl}benzonitrile
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
4-Bromo-5-(2,4-difluorobenzyloxy)-2-(2,6-difluorophenyl)pyridazin-3(2H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1099098; BDBM50318047
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|
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| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
1-Benzyl-4-(benzyloxy)-3-methylpyridin-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078303; SCHEMBL4476593; BDBM50310958; DB-087511; 1-benzyl-3-methyl-4-phenylmethoxypyridin-2-one
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-Bromo-4-(2,4-difluorobenzyloxy)-1-(5-(hydroxymethyl)pyrazin-2-yl)-6-methylpyridin-2(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081678; BDBM50310978
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|
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
1-(3-(Aminomethyl)benzyl)-3-bromo-4-(2,4-difluorobenzyloxy)-6-methylpyridin-2(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079309; SCHEMBL4374089; BDBM50310981; 1-[3-(aminomethyl)benzyl]-3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methylpyridin-2(1H)-one; 1-[[3-(aminomethyl)phenyl]methyl]-3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methylpyridin-2-one
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-Bromo-4-(2,4-difluorobenzyloxy)-1-(3-((dimethylamino)methyl)benzyl)-6-methylpyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078101; SCHEMBL4377132; BDBM50310983
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-Bromo-1-(3-fluorobenzyl)-4-(4-fluorobenzyloxy)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078024; SCHEMBL4379163; BDBM50310954; 3-bromo-4-[(4-fluorophenyl)methoxy]-1-[(3-fluorophenyl)methyl]pyridin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
2-((3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1077406; SCHEMBL4376687; BDBM50310964; 2-[[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]methyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-1-(pyridin-3-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081675; BDBM50310975
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-1-(4-(2-(methylimino)acetyl)benzyl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080218; BDBM50310971
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
4-Bromo-5-(2,4-difluorobenzyloxy)-2-phenylpyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094476; BDBM50318034
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
3-((3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078585; SCHEMBL4384361; BDBM50310962; 3-[[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-Bromo-4-(2,4-difluorobenzyloxy)-1-(3-fluorobenzyl)-1H-pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078301; SCHEMBL4373903; BDBM50310955; 3-bromo-4-[(2,4-difluorophenyl)methoxy]-1-[(3-fluorophenyl)methyl]pyridin-2-one; 3-bromo-4-(2,4-difluorobenzyloxy)-1-(3-fluorobenzyl)pyridin-2(1H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
1-Benzyl-4-(benzyloxy)-3-ethylpyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078302; SCHEMBL4390048; BDBM50310957; DB-087501; 1-benzyl-3-ethyl-4-phenylmethoxypyridin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
1-(2-(Aminomethyl)benzyl)-3-bromo-4-(2,4-difluorobenzyloxy)-6-methylpyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079308; SCHEMBL4381369; BDBM50310980; 1-[2-(aminomethyl)benzyl]-3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methylpyridin-2(1H)-one; 1-[[2-(aminomethyl)phenyl]methyl]-3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methylpyridin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
5-(Benzyloxy)-4-bromo-2-(2,6-dichlorophenyl)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094983; SCHEMBL6288420; BDBM50318035; 4-bromo-2-(2,6-dichlorophenyl)-5-phenylmethoxypyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
1-Benzyl-4-(benzyloxy)-3-bromopyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095447; SC-25028; SCHEMBL4470415; BDBM50318050; DB-087510; 1-benzyl-3-bromo-4-phenylmethoxypyridin-2-one; 1-Benzyl-4-(benzyloxy)-3-bromopyridine-2(1H)-one; Q27464253
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
2-((3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078584; SCHEMBL4382919; BDBM50310961; 2-[[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]methyl]benzonitrile; 2-{[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]methyl}benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-[4-[(2,4-Difluorophenyl)methoxy]-5-methyl-6-oxopyrimidin-1-yl]-N-(2-hydroxyethyl)-4-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795685; BDBM50346919
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[11] | |||
| Compound Name |
3-Bromo-4-(4-chlorobenzyloxy)-1-(4-fluorobenzyl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078023; SCHEMBL4466494; BDBM50310953; 3-bromo-4-[(4-chlorophenyl)methoxy]-1-[(4-fluorophenyl)methyl]pyridin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
4-Bromo-5-(4-chloro-2-fluorobenzyloxy)-2-(2,6-dichlorophenyl)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098756; BDBM50318045
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
4-Bromo-2-(2,6-dichlorophenyl)-5-(2,3,4-trifluorobenzyloxy)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096438; SCHEMBL6371137; BDBM50318044; 4-bromo-2-(2,6-dichlorophenyl)-5-[(2,3,4-trifluorophenyl)methoxy]pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
N-(4-((3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)benzyl)-2-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078666; SCHEMBL5862552; BDBM50310985
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
4-((3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078859; SCHEMBL4386924; BDBM50310966; 4-[[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]methyl]benzamide; 4-{[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]methyl}benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
7-Methoxy-3,4,5,10-tetrahydro-1H-2,5-methanoazepino[3,4-b]indole-1-carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392876; SCHEMBL1655459; BDBM50215481
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[12] | |||
| Compound Name |
1-Benzyl-4-(benzyloxy)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265448; SCHEMBL2177074; 1-Benzyl-4-benzyloxy-2-pyridone; BDBM50240029; ZINC29048294; 1-benzyl-4-phenylmethoxypyridin-2-one; DB-084277; 1-Benzyl-4-(benzyloxy)pyridine-2(1H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
4-Bromo-2-(2,6-dichlorophenyl)-5-(4-fluorobenzyloxy)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096092; SCHEMBL6234554; BDBM50318039; 4-bromo-2-(2,6-dichlorophenyl)-5-[(4-fluorophenyl)methoxy]pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
4-Bromo-2-(2,6-dichlorophenyl)-5-(4-fluorobenzylamino)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095142; SCHEMBL6376415; BDBM50318040; 4-bromo-2-(2,6-dichlorophenyl)-5-[(4-fluorophenyl)methylamino]pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
4-Bromo-2-(2,6-dichlorophenyl)-5-[(2,4-difluorophenyl)methoxy]pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096436; SCHEMBL4475346; BDBM50318041; 4-bromo-2-(2,6-dichlorophenyl)-5-(2,4-difluorobenzyloxy)pyridazin-3(2H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
4-(2,4-Difluorobenzyloxy)-1-(3-fluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078583; SCHEMBL4382826; BDBM50310960; 4-[(2,4-difluorophenyl)methoxy]-1-[(3-fluorophenyl)methyl]-2-oxopyridine-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-1-(3-(2-(methylimino)acetyl)benzyl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079184; BDBM50310970
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
4-Bromo-2-(2,6-dichlorophenyl)-5-[(3,4-difluorophenyl)methoxy]pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095304; SCHEMBL6369774; BDBM50318043; 4-bromo-2-(2,6-dichlorophenyl)-5-(3,4-difluorobenzyloxy)pyridazin-3(2H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
3-Bromo-4-(4-fluorobenzyloxy)-6-methyl-1-(pyridin-2-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080219; BDBM50310972
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
Methyl 3-(5-bromo-4-(2,4-difluorobenzyloxy)-6-oxopyridazin-1(6H)-yl)-4-methylbenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1099099; SCHEMBL6383419; BDBM50318048; methyl 3-[5-bromo-4-[(2,4-difluorophenyl)methoxy]-6-oxopyridazin-1-yl]-4-methylbenzoate
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
3-(5-Bromo-4-(2,4-difluorobenzyloxy)-6-oxopyridazin-1(6H)-yl)-N,4-dimethylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097021; SCHEMBL6387888; BDBM50318049; 3-[5-bromo-4-[(2,4-difluorophenyl)methoxy]-6-oxopyridazin-1-yl]-N,4-dimethylbenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
4-((3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)-N,N-dimethylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078804; SCHEMBL4381925; BDBM50310968
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
4-((3-Chloro-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)-N,N-dimethylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079110; SCHEMBL4377038; BDBM50310969
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
4-Bromo-2-(2,6-dichlorophenyl)-5-(phenethylamino)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096091; SCHEMBL6370862; BDBM50318038; 4-bromo-2-(2,6-dichlorophenyl)-5-(2-phenylethylamino)pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-1-(2-methylpyrimidin-5-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080771; BDBM50310979
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395157; 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid; 6-METHOXY-1H,2H,3H,4H,9H-PYRIDO[3,4-B]INDOLE-1-CARBOXYLIC ACID; SCHEMBL608164; SCHEMBL12660570; CTK0H2172; DTXSID00397280; BDBM50215483; MFCD00010826; STL525685; AKOS015894383; MCULE-5714246217; ST065834; 952M635; J-011460; Z2216905627; 6-methoxy-1,2,3,4-tetrahydrobeta-carbolinecarboxylic acid; 6-Methoxy-1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acid; 6-methoxy-2,3,4,9-tetrahydro-1h-beta-carboline-1-carboxylic acid; 1H-Pyrido[3,4-b]indole-1-carboxylic acid, 2,3,4,9-tetrahydro-6-methoxy-; 1H-Pyrido[3,4-b]indole-1-carboxylicacid, 2,3,4,9-tetrahydro-6-methoxy-; 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-2-ium-1-carboxylate; 6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid, 97%
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[12] | |||
| Compound Name |
5-(Benzyloxy)-4-bromo-2-phenylpyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094167; SCHEMBL6370909; CTK1F4499; DTXSID90677008; BDBM50318033; 4-bromo-2-phenyl-5-phenylmethoxypyridazin-3-one; 3(2H)-Pyridazinone, 4-bromo-2-phenyl-5-(phenylmethoxy)-
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
1-Benzyl-4-(benzyloxy)-3-iodopyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078022; SCHEMBL3049936; BDBM50310952; 1-Benzyl-4-benzyloxy-3-iodo-2-pyridone; DB-087403; 1-benzyl-4-benzyloxy-3-iodo-1H-pyridin-2-one; 1-Benzyl-3-iodo-4-(benzyloxy)pyridine-2(1H)-one; 1-benzyl-4-(benzyloxy)-3-iodopyridin-2 (1H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-Bromo-4-(4-fluorobenzyloxy)-6-methyl-1-(pyridin-4-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081674; BDBM50310974
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-1-(5-methylpyrazin-2-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081677; BDBM50310977
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
1-Benzyl-4-(benzyloxy)-3-vinylpyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1077396; SCHEMBL4385439; BDBM50310956; DB-087500; 1-benzyl-3-ethenyl-4-phenylmethoxypyridin-2-one; 1-Benzyl-4-(benzyloxy)-3-vinylpyridine-2(1H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
5-(Benzylamino)-4-bromo-2-(2,6-dichlorophenyl)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095775; SCHEMBL6348612; BDBM50318036; 5-(benzylamino)-4-bromo-2-(2,6-dichlorophenyl)pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
4-Bromo-2-(2,6-dichlorophenyl)-5-(2,4,6-trifluorobenzyloxy)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096437; SCHEMBL6371592; BDBM50318042; 4-bromo-2-(2,6-dichlorophenyl)-5-[(2,4,6-trifluorophenyl)methoxy]pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
4-Bromo-2-(2,6-dichlorophenyl)-5-phenethoxypyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096090; SCHEMBL6370740; BDBM50318037; 4-bromo-2-(2,6-dichlorophenyl)-5-(2-phenylethoxy)pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
3-((3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)-N,N-dimethylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078961; SCHEMBL4392642; BDBM50310967
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
3-[4-[(2,4-Difluorobenzyl)oxy]-5-ethyl-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795686; SCHEMBL3527137; BDBM50346920
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[11] | |||
| Compound Name |
3-Bromo-4-(4-fluorobenzyloxy)-6-methyl-1-(pyridin-3-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080220; BDBM50310973
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
4-(Benzyloxy)-1-(3-fluorobenzyl)-3-(trifluoromethyl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078404; SCHEMBL4381953; BDBM50310959; 1-[(3-fluorophenyl)methyl]-4-phenylmethoxy-3-(trifluoromethyl)pyridin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
1-(4-(Aminomethyl)benzyl)-3-bromo-4-(2,4-difluorobenzyloxy)-6-methylpyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079310; SCHEMBL4375992; BDBM50310982; 1-[[4-(aminomethyl)phenyl]methyl]-3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methylpyridin-2-one
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
2-Benzyl-5-(benzyloxy)-4-bromopyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094166; SCHEMBL6232624; CTK1F4502; DTXSID30677007; BDBM50318051; 2-benzyl-4-bromo-5-phenylmethoxypyridazin-3-one; 3(2H)-Pyridazinone, 4-bromo-5-(phenylmethoxy)-2-(phenylmethyl)-
Click to Show/Hide
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| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
4-Bromo-2-(3,5-dichloropyridin-4-yl)-5-(2,4-difluorobenzyloxy)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098757; SCHEMBL6368744; BDBM50318046; 4-bromo-2-(3,5-dichloropyridin-4-yl)-5-[(2,4-difluorophenyl)methoxy]pyridazin-3-one
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-1-(pyridin-4-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081676; BDBM50310976
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
N-(3-((3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)methyl)benzyl)-2-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078594; SCHEMBL4489172; BDBM50310987
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
N-Methyl-4-(2-(piperidin-4-yl)-5-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489344; SCHEMBL4936886; BDBM50260228; N-methyl-4-[2-piperidin-4-yl-4-[3-(trifluoromethyl)phenyl]-1H-imidazol-5-yl]pyrimidin-2-amine
Click to Show/Hide
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||||
| Activity |
IC50 = 404000 nM
|
[7] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis, and biological evaluation of potent c-Met inhibitors. J Med Chem. 2008 Sep 25;51(18):5766-79. | ||||
| REF 2 | Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3726-9. | ||||
| REF 3 | Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7303-7. | ||||
| REF 4 | Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1838-43. | ||||
| REF 5 | Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series. J Med Chem. 2012 Mar 8;55(5):1868-97. | ||||
| REF 6 | Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity. Bioorg Med Chem Lett. 2006 Jan 15;16(2):262-6. | ||||
| REF 7 | Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors. J Biol Chem. 2007 Feb 23;282(8):5536-44. | ||||
| REF 8 | Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5851-6. | ||||
| REF 9 | Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett. 2010 May 15;20(10):3146-9. | ||||
| REF 10 | Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54. | ||||
| REF 11 | Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3856-60. | ||||
| REF 12 | Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett. 2007 Aug 15;17(16):4657-63. | ||||
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