Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77400 | Target Info | |||
| Target Name | Phosphodiesterase 2A (PDE2A) | ||||
| Synonyms |
cGMP-dependent 3',5'-cyclic phosphodiesterase; PDE-II; Cyclic-GMP phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase; Cyclic GMP stimulated phosphodiesterase; CGSPDE; CGS-PDE
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| Target Type | Clinical trial Target | ||||
| Gene Name | PDE2A | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 103 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Rhucin
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Approved | Compound Info | ||
| Synonyms |
sildenafil; 139755-83-2; VIAGRA; Sildenafil [INN:BAN]; UK-92480; UNII-3M7OB98Y7H; UK-92,480-10; C22H30N6O4S; HSDB 7305; CHEMBL192; UK 92480-10; CHEBI:9139; 3M7OB98Y7H; 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine; BNRNXUUZRGQAQC-UHFFFAOYSA-N; 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one; Sildenafil
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| Activity |
IC50 = 63000 nM
|
[1] | |||
| Compound Name |
Milrinone
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Approved | Compound Info | ||
| Synonyms |
Corotrop; Corotrope; Milrila; Milrinona; Milrinonum; Primacor; Milrinona [Spanish]; Milrinonum [Latin]; M 4659; M1663; YM 018; MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER; Milrila (TN); PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER; Primacor (TN); WIN 47203-2; Win-47203; Milrinone [USAN:BAN:INN]; Win-47203-2; Milrinone (JAN/USAN/INN); 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile; 111GE027; 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile; 3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone; 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
ROLIPRAM
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Phase 2 | Compound Info | ||
| Synonyms |
61413-54-5; ZK 62711; Rolipramum; Rolipramum [Latin]; 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; Adeo; Rolipram [USAN:INN]; 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone; (R,S)-rolipram; ZK-62711; CHEMBL63; EINECS 262-771-1; BRN 1588548; MLS000069691; CHEBI:104872; HJORMJIFDVBMOB-UHFFFAOYSA-N; 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone; [3H]rolipram
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
US9388139, 12
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Patented | Compound Info | ||
| Synonyms |
SCHEMBL12493454; CHEMBL3899621; BDBM236643; US9388139, 12
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
BC11-28
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Patented | Compound Info | ||
| Synonyms |
BDBM86641; 7-(4-fluorophenyl)-N-(2-methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; AC1MM8WN; Oprea1_524381; CHEMBL2132713; SCHEMBL14998917; BDBM60812; HMS1911I05; ZINC2713985; STK859438; AKOS002104616; MCULE-7713625102; BC11-28; NCGC00138975-01; ST50069829; EU-0095146; US9173884, BC11-28; SR-01000567887; SR-01000567887-1; K405-0344; 7-(4-fluorophenyl)-N-(2-methylphenyl)-5-phenylpyrrolo[2,3-d]pyrimidin-4-amine; [7-(4-fluorophenyl)-5-phenylpyrrolo[3,2-e]pyrimidin-4-yl](2-methylphenyl)amine
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
AC1M1SP5
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Patented | Compound Info | ||
| Synonyms |
3-(2-methoxyphenyl)-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one; 850915-31-0; AC1M1SP5; SCHEMBL16200721; CHEMBL3913943; BDBM86646; ZINC2719834; AKOS024584906; MCULE-4663000139; BC11-38-4; SR-01000120201; SR-01000120201-1; F0579-0260; 3-(2-methoxyphenyl)-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
ZAPRINAST
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Terminated | Compound Info | ||
| Activity |
IC50 = 90200 nM
|
[2] | |||
| Compound Name |
1,3-Dihydro-imidazo[4,5-b]quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL98604; 1,3-Dihydro-imidazo[4,5-b]quinolin-2-one; SCHEMBL2014813; BDBM50007220; 1H-Imidazo[4,5-b]quinolin-2(3H)-one
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| Activity |
IC50 = 80000 nM
|
[5] | |||
| Compound Name |
BUFROLIN
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Investigative | Compound Info | ||
| Synonyms |
Bufrolin; 54867-56-0; UNII-46C1PX266N; ICI-74917; CHEMBL150764; 46C1PX266N; Bufrolinum; Bufroline; Bufrolino; Bufrolin [INN:BAN]; Bufrolinum [INN-Latin]; Bufroline [INN-French]; Bufrolino [INN-Spanish]; AC1Q5RDE; AC1L2HFD; SCHEMBL2109492; CTK1H2392; DTXSID60203353; ZINC4215124; 6-butyl-4,10-dihydroxy-1,7-phenanthroline-2,8-dicarboxylic acid; BDBM50020876; 6-Butyl-1,4,7,10-tetrahydro-4,10-dioxo-1,7-phenanthroline-2,8-dicarbonsaeure; 6-butyl-4,10-dioxo-1,7-dihydro-1,7-phenanthroline-2,8-dicarboxylic acid
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| Activity |
IC50 = 80000 nM
|
[6] | |||
| Compound Name |
7-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL98738; 7-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one; SCHEMBL10758549
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL323071; 7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one; SCHEMBL10757077; 2H-Imidazo[4,5-b]quinolin-2-one, 7-fluoro-1,3-dihydro-; BDBM50007234
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL98851; 7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one; SCHEMBL10758208; 2H-Imidazo[4,5-b]quinolin-2-one, 7-chloro-1,3-dihydro-; BDBM50007221
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
1,3-Dihydro-naphtho[2,3-d]imidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
1H-Naphtho[2,3-d]imidazol-2(3H)-one; 5649-76-3; CHEMBL316599; 1,3-Dihydro-naphtho[2,3-d]imidazol-2-one; SCHEMBL17206226; SCHEMBL11357960; ZINC13824637; BDBM50007236; FCH995480; AKOS024262366; 1H-Naphth[2,3-d]imidazol-2(3H)-one; AJ-64431; AX8292028; 1,3-Dihydro-2H-naphth[2,3-d]imidazol-2-one
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
1-[4-Methoxy-3-(tetrahydropyran-4-yloxy)phenyl]butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456368; BDBM50273333
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(2S)-2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3360413; BDBM50034649
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
1-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-1-quinolin-3-ylbutan-1-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL514277; BDBM50273983
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2-(Methoxymethyl)-7-methyl-5-(2-methylpropyl)-1H-imidazo[4,5-g]quinazoline-6,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL367083; BDBM50405452
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
(1R,4As,6aR,6aS,6bR,8aR,10S,11R,12aR,14bS)-11-hydroxy-10-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy-1,6a,6b,9,9,12a-hexamethyl-2-methylidene-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793675; BDBM50162702
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
4-(3-Chloro-4-methoxy-benzylamino)-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41950; SCHEMBL7159513; BDBM50141581
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin-3-ylbutan-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL457216; BDBM50273601
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2-Tert-butyl-7-methyl-5-(2-methylpropyl)-1H-imidazo[4,5-g]quinazoline-6,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL175132; BDBM50405451
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
7-(3-Hydroxy-propoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL330677; 1,3-dihydro-7-(3-hydroxypropoxy)-2H-imidazo[4,5-b]quinolin-2-one; 1,3-Dihydro-7-[3-hydroxypropoxy]-2H-imidazo[4,5-b]quinolin-2-one; SCHEMBL10660842; BDBM50000882; 7-(3-hydroxypropoxy)-1,3-dihydroimidazo[4,5-b]quinolin-2-one
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| Activity |
IC50 = 50000 nM
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[12] | |||
| Compound Name |
Acetic acid, [(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88525; ACMC-20mh3t; SCHEMBL10658552; CTK0D0867; DTXSID40558419; 2-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]acetic acid; BDBM50000937; (2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-acetic acid; [(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yl)oxy]acetic acid; 2-((2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yl)oxy)acetic acid; 2-[[(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]acetic acid
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| Activity |
IC50 = 50000 nM
|
[12] | |||
| Compound Name |
2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178115; SCHEMBL16981747; BDBM50398649
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| Activity |
IC50 ~ 50000 nM
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[13] | |||
| Compound Name |
1-[4-(Difluoromethoxy)-3-(oxolan-3-yloxy)phenyl]-3-methylbutan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL458298; 1-(4-(difluoromethoxy)-3-((tetrahydrofuran-3-yl)oxy)phenyl)-3-methylbutan-1-one; Roflupram; Zl-n-91; Roflupram, >=98% (HPLC); GTPL10691; BDBM50273512; 1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)phenyl]-3-methylbutan-1-one
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2,7-Dimethyl-5-(2-methylpropyl)-1H-imidazo[4,5-g]quinazoline-6,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL366822; BDBM50405446
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| Activity |
IC50 ~ 50000 nM
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[9] | |||
| Compound Name |
N-[(4-Methoxyphenyl)methyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103591; BDBM50258259
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| Activity |
IC50 = 52000 nM
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[14] | |||
| Compound Name |
4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221434; BDBM50325786; NCGC00249759; NCGC00249759-01; NCGC00249759-02
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| Activity |
IC50 ~ 57000 nM
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[15] | |||
| Compound Name |
1H-Imidazo(4,5-b)pyridine, 2-(2,4-dimethoxyphenyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43406; 2-(2,4-Dimethoxyphenyl)-1H-imidazo(4,5-b)pyridine; 2-(2,4-dimethoxyphenyl)-1H-imidazo[4,5-b]pyridine; 2-(2,4-Dimethoxy-phenyl)-3H-imidazo[4,5-b]pyridine; AR-L 57BS; 2-(2,4-dimethoxyphenyl)-3H-imidazo[4,5-b]pyridine; SCHEMBL6040494; SCHEMBL11770981; AR-L-57; DTXSID50228055; ZINC5115747; BDBM50020868; AKOS011056149; MCULE-1037524258; AM20061499; 2-(2,4-Dimethoxy-phenyl)-1H-imidazo[4,5-b]pyridine; 2-(2,4-dimethoxy-phenyl)-3H-imidazo[5,4-b]pyridine
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| Activity |
IC50 = 57000 nM
|
[6] | |||
| Compound Name |
8-Tert-butyl-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL177336; SCHEMBL9121409; BDBM50405454
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| Activity |
IC50 = 58000 nM
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[9] | |||
| Compound Name |
1-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319166; 2H-Imidazo[4,5-b]quinolin-2-one, 1,3-dihydro-1-methyl-; BDBM50007227; 1-methyl-3H-imidazo[4,5-b]quinolin-2-one
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| Activity |
IC50 = 60000 nM
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[5] | |||
| Compound Name |
1-Methyl-1,3-dihydro-7-[4-oxo-4-piperidinobutoxy]-2H-imidazo[4,5-b]quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313282; SCHEMBL10656343; BDBM50000883; 1-Methyl-7-(4-oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one; 1-methyl-7-(4-oxo-4-piperidin-1-ylbutoxy)-3H-imidazo[4,5-b]quinolin-2-one; 1-[4-[(2,3-Dihydro-1-methyl-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]piperidine
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| Activity |
IC50 = 60000 nM
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[12] | |||
| Compound Name |
1,3-Dihydro-1,8-dimethyl-2H-imidazo[4,5-b]quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99820; SCHEMBL10754575; BDBM50007248; 1,8-dimethyl-3H-imidazo[4,5-b]quinolin-2-one; 1,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
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| Activity |
IC50 = 60000 nM
|
[5] | |||
| Compound Name |
N-Cyclohexyl-N-methyl-5-[(1-methyl-2-oxo-3H-imidazo[4,5-b]quinolin-7-yl)oxy]pentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL91044; SCHEMBL10656444; BDBM50000928
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| Activity |
IC50 = 60000 nM
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[12] | |||
| Compound Name |
2-(Methoxymethyl)-8-methyl-6-(2-methylpropyl)-3H-imidazo[4,5-f]quinazoline-7,9-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL175958; BDBM50405449
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| Activity |
IC50 = 66000 nM
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[9] | |||
| Compound Name |
Chembl4226493
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Investigative | Compound Info | ||
| Synonyms |
BDBM50460668
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| Activity |
IC50 = 66879 nM
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[16] | |||
| Compound Name |
1,8-Dimethyl-3-isobutylxanthine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL277529; D 4160; Xanthine, 1,8-dimethyl-3-isobutyl-; BRN 1132431; 1,8-dimethyl-3-(2-methylpropyl)-7H-purine-2,6-dione; 1H-Purine-2,6-dione, 3,7-dihydro-1,8-dimethyl-3-(2-methylpropyl)-; SCHEMBL897036; CTK5C0166; 1-methyl-3-isobutylmethylxanthine; DTXSID90213607; BDBM50405458; 1H-Purine-2,6-dione,3,9-dihydro-1,8-dimethyl-3-(2-methylpropyl)-
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| Activity |
IC50 = 68000 nM
|
[9] | |||
| Compound Name |
2H-Imidazo[4,5-b]quinolin-2-one, 1,3-dihydro-1,7-dimethyl-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99144; SCHEMBL10757829; BDBM50007235; 1,7-dimethyl-3H-imidazo[4,5-b]quinolin-2-one; 1,7-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
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| Activity |
IC50 = 70000 nM
|
[5] | |||
| Compound Name |
3-Oxo-N-[1-[4-(trifluoromethoxy)phenyl]propyl]-2,4-dihydroquinoxaline-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092061; BDBM50258901
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| Activity |
IC50 = 70000 nM
|
[17] | |||
| Compound Name |
3(2H)-Pyridazinone, 5-ethyl-4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30362; ACMC-20l9l5; SCHEMBL11206290; CTK3B1886; DTXSID00530655; BDBM50018614; 4-ethyl-3-(4-imidazol-1-ylphenyl)-4,5-dihydro-1H-pyridazin-6-one; 3-[4-(1H-Imidazole-1-yl)phenyl]-4-ethyl-4,5-dihydropyridazine-6(1H)-one; 5-Ethyl-6-(4-imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one; 5-Ethyl-6-[4-(1H-imidazol-1-yl)phenyl]-4,5-dihydropyridazin-3(2H)-one
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| Activity |
IC50 = 71000 nM
|
[18] | |||
| Compound Name |
4-Amino-6-(4-imidazol-1-ylphenyl)-2H-pyridazin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL448467; SCHEMBL10668965; BDBM50018611; AKOS015906124; 5-amino-3-(4-imidazol-1-ylphenyl)-1H-pyridazin-6-one; 4-Amino-6-(4-imidazol-1-yl-phenyl)-2H-pyridazin-3-one; 4-amino-6-[4-(1H-imidazol-1-yl)-phenyl]-2H-pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[18] | |||
| Compound Name |
5-Isobutyl-7-methyl-1,5-dihydro-imidazo[4,5-g]quinazoline-6,8-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306389; BDBM50018571
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[9] | |||
| Compound Name |
4,5-Dihydro-6-[4-(2-ethyl-4-methyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30908; SCHEMBL7288026; BDBM50018615; 3-[4-(2-ethyl-4-methylimidazol-1-yl)phenyl]-4,5-dihydro-1H-pyridazin-6-one; 4,5-dihydro-6-[4-(2-ethyl-4-methyl-1H-imidazol-1-yl)-phenyl]-3(2H)-pyridazinone; 6-[4-(2-Ethyl-4-methyl-imidazol-1-yl)-phenyl]-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 92000 nM
|
[18] | |||
| Compound Name |
N-[(3-Methoxyphenyl)methyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079320; BDBM50258260
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-(4-Methoxybenzyl)-3-(cyclopentyloxy)-4-(difluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628685; BDBM50129817
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-[(2-Methoxyphenyl)methyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095833; BDBM50258310
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
6-Methyl-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080230; BDBM50258267
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1,3-Dihydro-7-[4-oxo-4-piperidinobutoxy]-2H-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90414; SCHEMBL10657958; BDBM50000897; 7-(4-oxo-4-piperidin-1-ylbutoxy)-1,3-dihydroimidazo[4,5-b]quinolin-2-one; 1-[4-[(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]piperidine; 7-(4-Oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyryl]-piperidine-4-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328149; SCHEMBL10656229; BDBM50000875; ethyl 1-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]butanoyl]piperidine-4-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883753; BDBM50208310
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
1-(3-Chloro-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26348; BDBM50075705
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-[1-(4-Methoxyphenyl)propyl]-N,6-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074901; BDBM50258296
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-pentanoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91843; SCHEMBL10661338; BDBM50000885; methyl 5-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]pentanoate; 5-[[(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]valeric acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1,3-Dihydro-7-[3-(phenylsulfonyl)propoxy]-2H-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90677; SCHEMBL10655539; BDBM50000870; 7-(3-Benzenesulfonyl-propoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one; 7-[3-(benzenesulfonyl)propoxy]-1,3-dihydroimidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MY-5445; 1-(3-Chloroanilino)-4-phenylphthalazine; MY 5445; 1-(3-chlorophenylamino)-4-phenylphthalazine; n-(3-chlorophenyl)-4-phenylphthalazin-1-amine; UNII-F8CSS73B6A; F8CSS73B6A; CHEMBL332898; Tocris-0432; SpecPlus_000807; Spectrum2_001820; Spectrum3_001763; BSPBio_001360; BSPBio_003225; KBioGR_000080; KBioSS_000080; DivK1c_006903; SPBio_001839; SCHEMBL1752920; CTK2H7315; KBio1_001847; KBio2_000080; KBio2_002648; KBio2_005216; KBio3_000159; KBio3_000160; KBio3_002725; DTXSID70229009; Bio2_000080; Bio2_000560; HMS1361D22; HMS1791D22; HMS1989D22; HMS3266O13; HMS3402D22; HMS3411K15; HMS3675K15; ZINC2557949; BDBM50020874; MFCD00209838; AKOS024458091; IDI1_033830; SMP2_000185; NCGC00024587-01; NCGC00024587-02; NCGC00024587-03; NCGC00024587-04; NCGC00024587-05; HY-100933; 1-(3-Chlorophenyl)amino-4-phenylphthalazine; B6301; CS-0020604; (3-chlorophenyl)-(4-phenylphthalazin-1-yl)amine; SR-01000597645; SR-01000597645-1; (3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine; BRD-K90524085-001-05-2; BRD-K90524085-001-06-0; Q15634077
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
N-[5-(1H-Benzimidazol-2-yl)-1,3-thiazol-2-yl]-3-cyanobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746208; BDBM50500497
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
Chembl4206423
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455384
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283360; BDBM50075684
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-pentanoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88395; SCHEMBL10657815; BDBM50000942; methyl 5-[(1-methyl-2-oxo-3H-imidazo[4,5-b]quinolin-7-yl)oxy]pentanoate; 5-[[(1-Methyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]valeric acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
Chembl4215772
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
4-[[(1,3-Benzodioxol-5-yl)methyl]amino]quinazoline-6-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL67243; SCHEMBL7503578; BDBM50038992; 4-(3,4-Methylenedioxybenzyl)amino-6-cyanoquinazoline; 4-(1,3-benzodioxol-5-ylmethylamino)quinazoline-6-carbonitrile; 4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-quinazoline-6-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
N-Cyclohexyl-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91356; SCHEMBL10657758; BDBM50000893; N-cyclohexyl-4-[(1-methyl-2-oxo-3H-imidazo[4,5-b]quinolin-7-yl)oxy]butanamide; N-Cyclohexyl-4-[(2,3-dihydro-1-methyl-2-oxo 1H-imidazo[4,5-b]quinolin-7-yl)oxy]butanamide; N-Cyclohexyl-4-[[(1-methyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyramide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Methyl 4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88136; SCHEMBL10658185; BDBM50000869; methyl 4-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]butanoate; 4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid methyl ester; 4-[[(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyric acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[5-(1H-Benzimidazol-2-yl)-1H-pyrazol-3-yl]-3-chloro-2-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746615; BDBM50500503
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-[1-(4-Methoxyphenyl)propyl]pyrazolo[1,5-a]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066287; BDBM50258257
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884224; BDBM50208315
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-5-chloro-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24752; SCHEMBL19197655; BDBM50075691
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
1-(3,4,5-Trimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24385; BDBM50075687
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N,N-Diethyl-3-methyl-1-(2-methylphenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972355; SCHEMBL14999000; BDBM86639; HMS1786A16; ZINC3293408; AKOS034464439; BC11-15; MCULE-3880495348; Z56898051
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[1-(4-Methoxyphenyl)propyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087643; BDBM50258311
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1,3-Dihydro-7-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-2H-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89679; SCHEMBL10654720; BDBM50000879; 7-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one; 7-[4-(1-cyclohexyltetrazol-5-yl)butoxy]-1,3-dihydroimidazo[4,5-b]quinolin-2-one; 7-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1,3-dihydro-imidazo[4,5-b]quinolin-2-one(HCl)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(11R,15S)-5-Anilino-8-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770107; SCHEMBL8238925; BDBM50150238
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[26] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24715; BDBM50075693
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
Benzo[1,3]dioxol-5-ylmethyl-(6-methyl-quinazolin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL67276; SCHEMBL7493988; BDBM50038973; N-(1,3-benzodioxol-5-ylmethyl)-6-methylquinazolin-4-amine; N-[(1,3-Benzodioxol-5-yl)methyl]-6-methylquinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
1,7,8-Trimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317604; SCHEMBL10754646; BDBM50007247; ZINC13824609; 1,7,8-trimethyl-3H-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-6-methoxy-4-quinazolinamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66323; N-(1,3-benzodioxol-5-ylmethyl)-6-methoxyquinazolin-4-amine; 4-{[3',4'-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline; 4-Quinazolinamine, N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-; 4-[[3',4'-(methylenedioxy)benzyl]amino]-6-methoxyquinazoline; ACMC-20ekrl; SCHEMBL678438; CTK0B1658; DTXSID20274327; BDBM50038982; HSCI1_000355; J-008706; BRD-K76263570-001-01-6; Q27195180; Benzo[1,3]dioxol-5-ylmethyl-(6-methoxy-quinazolin-4-yl)-amine; N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-methoxyquinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91634; SCHEMBL10658068; BDBM50000901; methyl 4-[(1-methyl-2-oxo-3H-imidazo[4,5-b]quinolin-7-yl)oxy]butanoate; 4-[[(1-Methyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyric acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-6-chloro-4-quinazolinamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66620; N-(1,3-benzodioxol-5-ylmethyl)-6-chloroquinazolin-4-amine; 4-Quinazolinamine, N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-; Bio2_000664; ACMC-20ejrz; UPCMLD-DP008; BSPBio_001464; KBioGR_000184; KBioSS_000184; SCHEMBL2458882; UPCMLD-DP008:001; UPCMLD-DP008:002; CTK0E8522; KBio2_000184; KBio2_002752; KBio2_005320; KBio3_000367; KBio3_000368; 4-[[3,4-(methylenedioxy)benzyl]amino]-6-chloroquinazoline; DTXSID60425013; Bio2_000184; HMS1361J06; HMS1791J06; HMS1989J06; HMS3402J06; MBCQ, >=98% (HPLC); ZINC2568241; BDBM50038991; IDI1_033934; NCGC00161596-01; NCGC00161596-02; NCGC00161596-03; NCGC00161596-04; J-008707; 4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline; BRD-K64746805-001-02-9; Q27164854; Benzo[1,3]dioxol-5-ylmethyl-(6-chloro-quinazolin-4-yl)-amine; N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-chloroquinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-hexanoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91837; BDBM50000890; 6-[[(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]hexanoic acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-Adamantan-1-yl-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL92264; BDBM50000933; N-(1-adamantyl)-4-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]butanamide; N-(1-Adamantyl)-4-[[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyramide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
7-(4-(Phenylsulfonyl)butoxy)-1,3-dihydro-2H-imidazo(4,5-b)quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Bmy 21638; UNII-ZC0V0RZ3CB; ZC0V0RZ3CB; CHEMBL88245; 7-[4-(benzenesulfonyl)butoxy]-1,3-dihydroimidazo[4,5-b]quinolin-2-one; Bmy-21638; 7-[4-(phenylsulfonyl)butoxy]-1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one; SCHEMBL7385083; DTXSID40150194; BDBM50000909; 1,3-Dihydro-7-[4-(phenylsulfonyl)butoxy]-2H-imidazo[4,5-b]quinolin-2-one; 7-(4-Benzenesulfonyl-butoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one; 2H-Imidazo(4,5-b)quinolin-2-one, 1,3-dihydro-7-(4-(phenylsulfonyl)butoxy)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
7-(2-Hydroxy-ethoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90195; BDBM50000880; 1,3-Dihydro-7-[2-hydroxyethoxy]-2H-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-Chloro-2-methyl-N-[5-(1-methylbenzimidazol-2-yl)-1,3-thiazol-2-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746786; BDBM50500500
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330280; BDBM50000919; 4-[[(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyramide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-ethoxy-7-methoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24495; BDBM50075698
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3950652; SCHEMBL16200731; BDBM86645; ZINC2459466; AKOS024584842; MCULE-6274932978; BC11-38-3; EU-0088907; SR-01000120189; SR-01000120189-1; F0579-0160
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM86640; Maybridge4_000373; Oprea1_392751; CHEMBL3974407; SCHEMBL14998934; BDBM60808; HMS1522A21; ZINC134330; CCG-51916; BC11-19; MCULE-1137806289; IDI1_030955; NCGC00177650-01; US9173884, BC11-19; SR-01000641186-1; BRD-K04557143-001-01-6
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(4-Methoxyphenyl)-N-[(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]propan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095339; BDBM50258295
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-methoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25192; BDBM50075686
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885161; BDBM50208311
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(2-Chlorophenyl)-3(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884788; BDBM50208314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-Cyclohexyl-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88218; SCHEMBL10658515; BDBM50000920; N-Cyclohexyl-4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butanamide; N-cyclohexyl-4-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]butanamide; N-Cyclohexyl-4-[[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyramide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Benzo[1,3]dioxol-5-ylmethyl-(6-methylsulfanyl-quinazolin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304927; SCHEMBL7494566; BDBM50038975; 4-(3,4-Methylenedioxybenzyl)amino-6-methylthioquinazoline; N-(1,3-benzodioxol-5-ylmethyl)-6-methylsulfanylquinazolin-4-amine; N-[(1,3-Benzodioxol-5-yl)methyl]-6-(methylthio)quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
CCC(NC(=O)N1CC(=O)Nc2cccnc12)c1ccc(OC(F)(F)F)cc1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064344; SCHEMBL16563313; BDBM50258898
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-7-(phenylmethyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26606; BRN 1229021; Xanthine, 7-benzyl-3-isobutyl-1-methyl-; DTXSID30207181; BDBM50014255; 7-benzyl-3-isobutyl-1-methylxanthine; 1-Methyl-3-isobutyl-7-benzylxanthine; 7-Benzyl-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione; 7-Benzyl-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione(7-benzyl-IBMX)
Click to Show/Hide
|
||||
| Activity |
IC50 = 108000 nM
|
[9] | |||
| Compound Name |
5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61692; BDBM50018627
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[27] | |||
| Compound Name |
9-[(2-Fluorophenyl)methyl]-N-methylpurin-6-amine;methanesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445098
Click to Show/Hide
|
||||
| Activity |
Ki = 122000 nM
|
[28] | |||
| Compound Name |
4-(4-Imidazol-1-yl-phenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30358; BDBM50018612
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[18] | |||
| Compound Name |
6-(4-(1H-Imidazol-1-yl)phenyl)-5-methylpyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL31105; 6-[4-(1H-Imidazol-1-yl)phenyl]-5-methylpyridazin-3(2H)-one; SCHEMBL7290528; CTK2I3158; DTXSID10555899; BDBM50018613; ZINC29213003; 3-(4-imidazol-1-ylphenyl)-4-methyl-1H-pyridazin-6-one; 6-(4-Imidazol-1-yl-phenyl)-5-methyl-2H-pyridazin-3-one; 3(2H)-Pyridazinone, 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[27] | |||
| Compound Name |
6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL58728; BDBM50018620; ZINC29569665
Click to Show/Hide
|
||||
| Activity |
IC50 = 180000 nM
|
[27] | |||
| Compound Name |
6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL287398; SCHEMBL7280366; BDBM50018617; ZINC26420394; AKOS005207362; 3-(4-imidazol-1-ylphenyl)-1H-pyridazin-6-one; 6-[4-(1{H}-imidazol-1-yl)phenyl]pyridazin-3-ol; 6-[4-(1H-Imidazol-1-yl)phenyl]pyridazin-3(2H)-one; F1967-0319
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[27] | |||
| Compound Name |
Sulmazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
sulmazol; Sulmazolum; 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine; Vardax; CHEMBL286020; NCGC00016924-02; 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-1H-imidazo(4,5-b)pyridine; Sulmazole [INN]; Sulmazol [INN-Spanish]; Sulmazolum [INN-Latin]; 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-3H-imidazo(4,5-b)pyridine; 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-3H-imidazo[4,5-b]pyridine; 2-(2-Methoxy-4-[methylsulfinyl]phenyl)-1H-imidazo(4,5-b)pyridine; 2-[2-methoxy-4-(methylsulfinyl)phenyl]-3H-imidazo[4,5-b]pyridine; AR-L 115BS; AR-L 115-BS; SR-01000841215; EINECS 277-406-1; BRN 0818370; 2-(2-methoxy-4-(methylsulfinyl)phenyl)-1H-imidazo[4,5-b]pyridine; Prestwick_1012; Spectrum_001155; Prestwick0_000641; Prestwick1_000641; Prestwick2_000641; Prestwick3_000641; Spectrum3_000733; Spectrum4_001246; Spectrum5_002074; 1H-Imidazo(4,5-b)pyridine, 2-(2-methoxy-4-(methylsulfinyl)phenyl)-; DSSTox_CID_20617; DSSTox_RID_79513; DSSTox_GSID_40617; BSPBio_000641; BSPBio_002286; KBioGR_001772; KBioSS_001635; MLS002153927; DivK1c_000276; SCHEMBL187165; SPECTRUM1501159; SPBio_002562; BPBio1_000707; DTXSID1040617; AR-L-115-BS; CTK5D7914; CTK9A2962; HMS500N18; KBio1_000276; KBio2_001635; KBio2_004203; KBio2_006771; KBio3_001506; NINDS_000276; HMS1570A03; HMS2097A03; HMS2230O09; HMS3371L17; HMS3714A03; Pharmakon1600-01501159; Tox21_110685; BDBM50000056; BDBM50225309; CCG-38446; NSC757867; CCG-220641; NSC-757867; IDI1_000276; NCGC00016924-01; NCGC00095999-01; DA-03205; SMR001233271; SBI-0051668.P002; AB00052230; FT-0748740; C13749; SR-01000841215-2; SR-01000841215-3; BRD-A22081593-001-04-6; BRD-A22081593-001-06-1; Q27116354; 2-methoxy-4-(methylsulfinyl)-phenylimidazo[4,5-b]pyridine; 2-(2-methoxy-4-methylsulfinyl-phenyl)-1H-imidazo[4,5-b]pyridine; 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine; 2-(4-Methanesulfinyl-2-methoxy-phenyl)-3H-imidazo[4,5-b]pyridine; 2-Methyl-6-oxo-1,6-dihydro-[3,4'']bipyridinyl-5-carbonitrile; 3H-Imidazo[4,5-b]pyridine,2-[2-methoxy-4-(methylsulfinyl)phenyl]-; (sulmazole)2-(4-Methanesulfinyl-2-methoxy-phenyl)-3H-imidazo[4,5-b]pyridine; 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine (sulmazole); 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine(sulmazole)
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 16 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Enoximone
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
ENOXIMONE; Perfan; 77671-31-9; Fenoximone; Enoximonum [Latin]; MDL-17043; Enoximona [Spanish]; MDL 17,043; UNII-C7Z4ITI7L7; MDL-17,043; RMI-17043; 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one; C7Z4ITI7L7; 4-Methyl-5-(p-(methylthio)benzoyl)-4-imidazolin-2-one; CHEMBL249856; 2H-Imidazol-2-one, 1,3-dihydro-4-methyl-5-(4-(methylthio)benzoyl)-; NCGC00015400-02; Enoximonum; Enoximona; 1,3-Dihydro-4-methyl-5-[4-methylthiobenzoyl]-2H-imidazol-2-one; DSSTox_RID_80702; DSSTox_CID_25147; DSSTox_GSID_45147; Perfane; Enoximona; E 1279; Perfan (TN); Enoximone (USAN/INN); Enoximone [USAN:BAN:INN]; 1,3-Dihydro-4-methyl-5-(4-methylthiobenzoyl)-2H-imidazol-2-one; FENOXIMONE
Click to Show/Hide
|
||||
| Activity |
IC50 = 520000 nM
|
[6] | |||
| Compound Name |
Inamrinone Lactate
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|
Approved | Compound Info | ||
| Synonyms |
Amrinone; inamrinone; 60719-84-8; Wincoram; Inocor; Cordemcura; Cartonic; 5-Amino-[3,4'-bipyridin]-6(1H)-one; Amrinonum [INN-Latin]; Amrinonum; Amrinona; Amrinona [INN-Spanish]; 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone; Win-40680; Amcoral; 5-Amino-(3,4'-bipyridin)-6(1H)-one; WIN 40680; AWD 08-250; 3-amino-5-pyridin-4-yl-1H-pyridin-2-one; UNII-JUT23379TN; CCRIS 3794; Amrinone lactate; MLS000069829; EINECS 262-390-0; 5-amino-3,4'-bipyridin-6(1H)-one; BRN 0744819; 5-Amino(3,4'-bipyridin)-6(1H)-one; SMR000058850; CHEMBL12856; JUT23379TN; Amrinone Lactate
Click to Show/Hide
|
||||
| Activity |
IC50 = 580000 nM
|
[27] | |||
| Compound Name |
PMID28870136-Compound-48
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 = 210000 nM
|
[6] | |||
| Compound Name |
CI-930
Click to Show/Hide
|
Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
CI-930; CI 930; 86798-59-6; 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone; 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-(1H-imidazol-1-yl)phenyl)-5-methyl-; AC1MIBTH; CHEMBL440593; SCHEMBL6052113; CTK5F7194; BDBM14362; AEZZPAQOEUQNBB-UHFFFAOYSA-N; 90791-23-4 (hydrochloride); BDBM50225945; LS-187480; LS-186812; 6-[4-(1-Imidazolyl)phenyl]-5-methyl-3-oxo-2,3,4,5-tetrahydropyridazine; 3-(4-imidazol-1-ylphenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 380000 nM
|
[27] | |||
| Compound Name |
Ro 20-1724
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|
Terminated | Compound Info | ||
| Synonyms |
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; RO 20-1724; 29925-17-5; 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one; ro-20-1724; Ro 201724; CHEMBL18701; 4-[(3-butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one; 2-Imidazolidinone, 4-((3-butoxy-4-methoxyphenyl)methyl)-; RO-201724; 2-Imidazolidinone, 4-((3-butoxy-4-methoxyphenyl)methyl)-, (+-)-; 4-(3-butoxy-4-methoxy-benzyl)imidazolidin-2-one; 34185-37-0; 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone; SR-01000075647; keratan sulfate I; Keratan sulphate I; Naphthoquinone analogs
Click to Show/Hide
|
||||
| Activity |
IC50 = 390000 nM
|
[6] | |||
| Compound Name |
8-Methoxymethyl-3-isobutyl-1-methylxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-Methoxymethyl-IBMX; 3-Isobutyl-8-(methoxymethyl)-1-methyl-1H-purine-2,6(3H,7H)-dione; 8-METHOXYMETHYL-1-METHYL-3-(2-METHYLPROPYL)XANTHINE; 8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione; CHEMBL307639; MI-methylxanthine; 8MM-IBMX; 3-isobutyl-8-methoxymethyl-1-methylxanthine; SR-01000075985; Tocris-0552; Lopac-M-2547; Lopac0_000764; BSPBio_001462; KBioGR_000182; KBioSS_000182; MLS002153423; SCHEMBL782824; SCHEMBL9927457; CTK7B2646; KBio2_000182; KBio2_002750; KBio2_005318; KBio3_000363; KBio3_000364; DTXSID30228679; Bio2_000182; Bio2_000662; HMS1361J04; HMS1791J04; HMS1989J04; HMS2230A04; HMS3262I10; HMS3266K14; HMS3373L09; HMS3402J04; HMS3411E06; HMS3675E06; Tox21_500764; 2228AC; ANW-54494; BDBM50059035; HSCI1_000291; MFCD00211081; ZINC14806781; AKOS016001307; AKOS024458560; CCG-204849; LP00764; SDCCGSBI-0050742.P002; 1H-Purine-2,6-dione, 3,7-dihydro-8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-; 3,7-Dihydro-8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione; IDI1_033932; NCGC00015658-01; NCGC00015658-02; NCGC00015658-03; NCGC00015658-04; NCGC00015658-05; NCGC00015658-06; NCGC00015658-07; NCGC00015658-08; NCGC00015658-11; NCGC00024647-01; NCGC00024647-02; NCGC00024647-03; NCGC00024647-04; NCGC00024647-05; NCGC00261449-01; SMR001230798; 8-Methoxymethyl-isobutyryl-1-methylxanthine; DB-056279; B6348; EU-0100764; FT-0641660; M 2547; A839315; SR-01000075985-1; SR-01000075985-3; 8-Methoxymethyl-3-isobutyl-1-methylxanthine, >=98%; BRD-K53878242-001-02-4; BRD-K56077740-001-03-5; Q15634072; 8-Methoxymethyl-1-Methyl-1-3-(2-Methylpropyl)Xanthine; 3-Isobutyl-8-methoxymethyl-1-methyl-3,7-dihydro-purine-2,6-dione; 3-Isobutyl-8-methoxymethyl-1-methyl-3,9-dihydro-purine-2,6-dione; 8-Methoxymethyl-3-isobutyl-1-methylxanthine - CAS 78033-08-6
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|
||||
| Activity |
IC50 = 212000 nM
|
[9] | |||
| Compound Name |
6-(4-Imidazol-1-yl-phenyl)-4-methyl-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL31762; SCHEMBL11099239; BDBM50018621; 3-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-1H-pyridazin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 260000 nM
|
[18] | |||
| Compound Name |
Chembl4228423
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50460669
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|
||||
| Activity |
IC50 > 278000 nM
|
[16] | |||
| Compound Name |
6-(4-Imidazol-1-yl-phenyl)-2-methyl-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL31112; SCHEMBL7280036; BDBM50018616; 6-(4-imidazol-1-ylphenyl)-2-methyl-4,5-dihydropyridazin-3-one; 4,5-dihydro-2-methyl-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone
Click to Show/Hide
|
||||
| Activity |
IC50 = 280000 nM
|
[18] | |||
| Compound Name |
6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30367; SCHEMBL7278112; BDBM50018622; 3-(3-imidazol-1-ylphenyl)-4,5-dihydro-1H-pyridazin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 330000 nM
|
[27] | |||
| Compound Name |
4,5-Dihydro-6-[4-(4-hydroxymethyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL286502; SCHEMBL7277863; BDBM50018623; 3-[4-[4-(hydroxymethyl)imidazol-1-yl]phenyl]-4,5-dihydro-1H-pyridazin-6-one; 6-[4-(4-Hydroxymethyl-imidazol-1-yl)-phenyl]-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000 nM
|
[18] | |||
| Compound Name |
4,5-Dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30368; SCHEMBL7280962; BDBM50018619; 3-[4-(2-methylimidazol-1-yl)phenyl]-4,5-dihydro-1H-pyridazin-6-one; 6-[4-(2-Methyl-imidazol-1-yl)-phenyl]-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 380000 nM
|
[18] | |||
| Compound Name |
Imazodan
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|
Investigative | Compound Info | ||
| Synonyms |
6-(4-(1H-imidazol-1-yl)phenyl)-4,5-dihydropyridazin-3(2H)-one; UNII-6PVQ5VQW24; CI 914; Cl 914; 3-(4-imidazol-1-ylphenyl)-4,5-dihydro-1H-pyridazin-6-one; 6PVQ5VQW24; CHEMBL12831; MFCD00867109; NCGC00015547-02; 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone; 3(2H)-Pyridazinone, 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-; Imazodan [INN]; Imazodanum [Latin]; Imazodanum; 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-(1H-imidazol-1-yl)phenyl)-; Lopac-I-0782; DSSTox_CID_25160; DSSTox_RID_80710; DSSTox_GSID_45160; Lopac0_000639; MLS000862182; SCHEMBL148436; ZINC1553; Imazodan, >=99% (HPLC); DTXSID1045160; CTK8G0276; HMS2233L24; HMS3261P20; HMS3369I22; KS-000001DA; Tox21_110171; Tox21_500639; BDBM50000315; AKOS027327583; CCG-204726; LP00639; QC-1573; SDCCGSBI-0050619.P002; NCGC00015547-01; NCGC00015547-03; NCGC00015547-04; NCGC00015547-05; NCGC00094006-01; NCGC00094006-02; NCGC00261324-01; AK326183; DS-11856; SMR000326945; DB-056777; EU-0100639; FT-0630925; I 0782; 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-; SR-01000075931; SR-01000075931-1; Q27265291; 6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one; (CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one; 6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one(CI-914); 6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one(Imazodan)
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| Activity |
IC50 = 500000 nM
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[27] | |||
| Compound Name |
Proxyphylline
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Investigative | Compound Info | ||
| Synonyms |
Proxiphylline; Purophyllin; Monophylline; Spasmolysin; Brontyl; Sanwaphyllin; Sigophyl; Theoden; Thean; Theon; Oxypropyltheophylline; 7-(2-Hydroxypropyl)theophylline; Proxy-Retardoral; Hydroxypropyltheophylline; 7-(beta-Hydroxypropyl)theophylline; 2-Hydroxypropyl-7-theophylline; Theophylline, 7-(2-hydroxypropyl)-; Proxylphylline; 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine; NSC 163343; CHEMBL37390; MLS000069521; .beta.-Hydroxypropyltheophylline; 7-(.beta.-Hydroxypropyl)theophylline; Proxiphyllinum; SMR000058629; DSSTox_CID_3536; 7-(.beta.-Hydroxypropyl)-1,3-dimethylxanthine; DSSTox_RID_77068; DSSTox_GSID_23536; Proxifilina; Proxyphyllinum; beta-Oxypropyltheophyllin; UNII-13G1DMN4P0; Proxifilina [INN-Spanish]; Proxyphyllinum [INN-Latin]; Proxyphylline [INN:BAN:JAN]; EINECS 210-028-7; Proxyfylline; Proxyphyllin; Spantin; 7-(-Hydroxypropyl)theophylline; 7-(beta-Hydroxypropyl)-1,3-dimethylxanthine; 13G1DMN4P0; Monophyllin (TN); NCGC00016521-01; Opera_ID_1170; Prestwick0_000890; Prestwick1_000890; Prestwick2_000890; Prestwick3_000890; Proxyphylline (JAN/INN); SCHEMBL35569; BSPBio_000680; 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione; SPBio_002899; BPBio1_000748; 7-(b-Hydroxypropyl)theophylline; DTXSID5023536; HMS1570B22; HMS2097B22; HMS2233E08; HMS3371A07; HMS3886C07; Pharmakon1600-01505915; HY-B1742; KS-000017UY; Tox21_110471; BDBM50028190; KM0393; MFCD00022833; NSC163343; NSC759279; PDSP1_001132; PDSP2_001116; s4932; SBB058155; 3,3-dimethyl-1H-purine-2,6-dione; AKOS015967318; Tox21_110471_1; CCG-213993; CS-7727; DB13449; MCULE-2304226036; NSC-163343; NSC-759279; Proxyphylline; Monophylline, Spasmolysin; NCGC00018121-02; NCGC00018121-03; NCGC00018121-07; NCGC00179479-01; AS-11774; 7-(2-hydroxypropyl)-1,3-dimethylxanthine; SBI-0207057.P001; DB-053586; AB00513948; FT-0603485; ST50409303; D01771; AB00384297_13; SR-01000003009; Q7252904; SR-01000003009-2; W-105265; BRD-A28887267-001-03-7; 1,3-DIMETHYL-7-(2-HYDROXYPROPYL)-2,6-DIOXOPURINE
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| Activity |
Ki = 600000 nM
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[29] | |||
| Compound Name |
1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (R)-
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Investigative | Compound Info | ||
| Synonyms |
UNII-S0ELR18QO5; S0ELR18QO5; CHEMBL37019; Proxyphylline, (R)-; (R)-PROXYPHYLLINE; 7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; ZINC57348; DTXSID60235654; BDBM50028191; (R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
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| Activity |
Ki = 600000 nM
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[29] | |||
| Compound Name |
1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (S)-
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Investigative | Compound Info | ||
| Synonyms |
UNII-YV88341QW3; CHEMBL290644; YV88341QW3; NCGC00016521-01; Proxyphylline, (S)-; (S)-PROXYPHYLLINE; SCHEMBL35570; 7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; ZINC57347; DTXSID00235653; BDBM50028192; NCGC00018121-01; NCGC00018121-04; A16821; UNII-13G1DMN4P0 component KYHQZNGJUGFTGR-LURJTMIESA-N; UNII-13G1DMN4P0 component KYHQZNGJUGFTGR-ZCFIWIBFSA-N; (S)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
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| Activity |
Ki = 700000 nM
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[29] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 1 | Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5. Bioorg Med Chem. 2015 May 1;23(9):2121-8. | ||||
| REF 2 | 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. J Med Chem. 2000 Jun 29;43(13):2523-9. | ||||
| REF 3 | US patent application no. 9388139B2, Derivatives of celeboxib, use thereof and preparation thereof | ||||
| REF 4 | US patent application no. 9173884B2, Inhibitors of phosphodiesterase 11 (PDE11) | ||||
| REF 5 | 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. | ||||
| REF 6 | A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45. | ||||
| REF 7 | Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors. J Med Chem. 2008 Dec 25;51(24):7673-88. | ||||
| REF 8 | Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent. J Med Chem. 2014 Dec 26;57(24):10304-13. | ||||
| REF 9 | Inhibition of cyclic nucleotide phosphodiesterases from pig coronary artery by benzo-separated analogues of 3-isobutyl-1-methylxanthine. J Med Chem. 1986 Jun;29(6):972-8. | ||||
| REF 10 | Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4. Eur J Med Chem. 2016 May 23;114:134-40. | ||||
| REF 11 | Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1577-80. | ||||
| REF 12 | Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains. J Med Chem. 1992 Jul 10;35(14):2672-87. | ||||
| REF 13 | Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design. J Med Chem. 2012 Oct 11;55(19):8549-58. | ||||
| REF 14 | Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders. J Med Chem. 2017 Sep 28;60(18):7658-7676. | ||||
| REF 15 | The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5502-5. | ||||
| REF 16 | Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species. Bioorg Med Chem Lett. 2018 Apr 1;28(6):1122-1126. | ||||
| REF 17 | Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders. J Med Chem. 2017 Sep 28;60(18):7677-7702. | ||||
| REF 18 | Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity. J Med Chem. 1987 Nov;30(11):1955-62. | ||||
| REF 19 | Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships. Bioorg Med Chem. 2015 Nov 15;23(22):7332-9. | ||||
| REF 20 | Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings. Eur J Med Chem. 2016 Nov 29;124:372-379. | ||||
| REF 21 | 1-Arylnaphthalene lignan: a novel scaffold for type 5 phosphodiesterase inhibitor. J Med Chem. 1999 Apr 8;42(7):1293-305. | ||||
| REF 22 | Cyclic GMP phosphodiesterase inhibitors. 1. The discovery of a novel potent inhibitor, 4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline. J Med Chem. 1993 Nov 26;36(24):3765-70. | ||||
| REF 23 | Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors. Bioorg Med Chem Lett. 2016 Jan 1;26(1):197-202. | ||||
| REF 24 | Structure-based design and structure-activity relationships of 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1188-1193. | ||||
| REF 25 | Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11. | ||||
| REF 26 | Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. J Med Chem. 2016 Feb 11;59(3):1149-64. | ||||
| REF 27 | Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity. J Med Chem. 1987 Nov;30(11):1963-72. | ||||
| REF 28 | 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors. J Med Chem. 1997 Jun 6;40(12):1768-70. | ||||
| REF 29 | Optical resolution, absolute configuration, and activity of the enantiomers of proxyphylline. J Med Chem. 1983 Oct;26(10):1514-8. | ||||
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