Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78932 | Target Info | |||
| Target Name | TYK2 tyrosine kinase (TYK2) | ||||
| Synonyms |
Non-receptor tyrosine-protein kinase TYK2
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|
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| Target Type | Successful Target | ||||
| Gene Name | TYK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 17 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Chloro-N-(3-quinoxalin-2-ylphenyl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463405; CHEMBL3645538; BDBM107121; US8592415, 5; 4-chloro-N-[3-(quinoxalin-2-yl)phenyl]butanamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(Dimethylamino)-N-(3-quinoxalin-2-ylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463296; CHEMBL3645535; BDBM107118; US8592415, 2; N2,N2-dimethyl-N1-(3-quinoxalin-2-ylphenyl)glycinamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-Chloro-N-(3-quinoxalin-2-ylphenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463291; CHEMBL3645548; BDBM107134; US8592415, 19; 3-chloro-N-[3-(quinoxalin-2-yl)phenyl]propanamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[3-(2-Quinoxalinyl)phenyl]methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
N-[3-(quinoxalin-2-yl)phenyl]methanesulfonamide; N-(3-quinoxalin-2-ylphenyl)methanesulfonamide; MLS001165982; SCHEMBL1463425; CHEMBL1553519; KS-00001ZVU; BDBM107130; HMS2855A24; ZINC1399325; MFCD03617716; AKOS005099938; MCULE-3207290219; SMR000550249; US8592415, 15; 7T-0022
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(3-Quinoxalin-2-ylphenyl)-2-(1,2,4-triazol-1-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1464125; CHEMBL3645539; BDBM107123; US8592415, 7; N-[3-(quinoxalin-2-yl)phenyl]-2-(1H-1,2,4-triazol-1-yl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[3-(2-Quinoxalinyl)phenyl]-2-furamide
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Investigative | Compound Info | ||
| Synonyms |
N-[3-(quinoxalin-2-yl)phenyl]furan-2-carboxamide; MLS000100130; regid4258715; N-(3-quinoxalin-2-ylphenyl)furan-2-carboxamide; SCHEMBL1462285; CHEMBL1572928; KS-00003DPA; BDBM107127; HMS2167I24; HMS3320K16; ZINC1399317; AKOS005099816; MCULE-1007454916; SMR000081936; US8592415, 12; 7T-0013
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4285755
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(4-Methylpiperazin-1-yl)-N-(3-quinoxalin-2-ylphenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1464066; CHEMBL3645546; BDBM107132; US8592415, 17; 2-(4-methylpiperazin-1-yl)-N-[3-(quinoxalin-2-yl)phenyl]acetamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[4-(2-Quinoxalinyl)phenyl]cyclopropanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
N-[3-(quinoxalin-2-yl)phenyl]cyclopropanecarboxamide; N-(3-quinoxalin-2-ylphenyl)cyclopropanecarboxamide; SCHEMBL1463399; CHEMBL3645544; KS-00003DPB; BDBM107129; MFCD12910763; ZINC43796862; AKOS005099847; MCULE-7559936835; US8592415, 14; 7T-0015
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Methyl-N'-[3-(2-quinoxalinyl)phenyl]thiourea
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|
Investigative | Compound Info | ||
| Synonyms |
1-methyl-3-(3-quinoxalin-2-ylphenyl)thiourea; MLS001165984; SMR000550248; 3-methyl-1-[3-(quinoxalin-2-yl)phenyl]thiourea; SCHEMBL1462401; CHEMBL1537091; REGID_for_CID_409246; BDBM67663; cid_1485416; KS-00001ZVR; REGID_for_CID_1485416; HMS2852P03; ZINC1399314; AKOS005099784; MCULE-4454820641; 1-methyl-3-[3-(2-quinoxalinyl)phenyl]thiourea; 1-methyl-3-[3-(quinoxalin-2-yl)phenyl]thiourea; 7T-0009
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[3-(2-Quinoxalinyl)phenyl]-2-thiophenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
n-[3-(quinoxalin-2-yl)phenyl]thiophene-2-sulfonamide; N-(3-quinoxalin-2-ylphenyl)thiophene-2-sulfonamide; SCHEMBL1462283; CHEMBL3645543; KS-00001ZVS; BDBM107128; ZINC1399318; AKOS005099846; MCULE-1175160761; US8592415, 13; 7T-0014
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Morpholino-N-(3-(quinoxalin-2-yl)phenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463453; CHEMBL3645549; BDBM107135; US8592415, 20; 2-morpholin-4-yl-N-(3-quinoxalin-2-ylphenyl)acetamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4289149
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|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-Chloro-N-(3-quinoxalin-2-ylphenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463360; CHEMBL3645550; BDBM107136; US8592415, 21; 2-chloro-N-(3-(quinoxalin-2-yl)phenyl)propanamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(3-Quinoxalin-2-ylphenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
MLS000537362; SCHEMBL1462316; CHEMBL1446198; BDBM107122; HMS1599D07; HMS2400O23; ZINC555918; AKOS003653098; MCULE-9745117709; N-[3-(2-quinoxalinyl)phenyl]propanamide; SMR000143800; N-[3-(quinoxalin-2-yl)phenyl]propionamide; ST45104659; US8592415, 6; SR-01000287574; SR-01000287574-1
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Methoxyphenyl)-N'-[3-(2-quinoxalinyl)phenyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
1-(4-methoxyphenyl)-3-[3-(quinoxalin-2-yl)phenyl]urea; 1-(4-methoxyphenyl)-3-(3-quinoxalin-2-ylphenyl)urea; SCHEMBL1463272; CHEMBL3645542; KS-00001ZVQ; BDBM107126; ZINC1399313; AKOS005099783; MCULE-4650809137; US8592415, 10; 7T-0007
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(2-Methoxy-4-morpholinophenyl)-N'-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076767; SCHEMBL17731732; BDBM50264841; J3.639.761F
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|
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| Activity |
IC50 = 132000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 43 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ruxolitinib
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|
Approved | Compound Info | ||
| Synonyms |
Ruxolitinib (JAK inhibitor)
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Tofacitinib
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Approved | Compound Info | ||
| Synonyms |
Tasocitinib; 477600-75-2; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; CP-690550; CP 690550; racemic-tofacitinib; 1259404-17-5; tofacitinibum; CP-690,550; UNII-87LA6FU830; 3-((3R,4R)-rel-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile; Tofacitinib (CP-690550,Tasocitinib); CHEMBL221959; CHEBI:71200; Xeljanz (TN)
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Baricitinib
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|
Approved | Compound Info | ||
| Synonyms |
Baricitinib (LY3009104, INCB028050); Baricitinib [USAN:INN]; C16H17N7O2S; INCB 028050; INCB-028050; INCB028050; ISP4442I3Y; J-503551; LY-3009104; LY3009104; Olumiant (TN); UNII-ISP4442I3Y; olumiant
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
2-Methoxy-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065613; BDBM50243838
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
4-[[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]sulfamoylamino]butanenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082035; BDBM50243871
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
1-Cyclopropyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3655091; CHEMBL3655095; SCHEMBL15970215; SCHEMBL15970218; SCHEMBL15970267; BDBM159758; BDBM159762; US9035074, 10; US9035074, 14
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
4-[[3-[[Ethyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085264; BDBM50243840
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
3-N-(Cyclopropylmethylsulfamoyl)-1-N-methyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3655097; SCHEMBL15970095; SCHEMBL15970305; BDBM159764; US9035074, 16
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
3-Methoxy-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087044; BDBM50243905
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Schembl21615478
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101374; SCHEMBL21615574; SCHEMBL21615575; BDBM50243869
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
1-Cyclobutyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068319; BDBM50243813
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]piperidine-1-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077614; BDBM50243841
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
3,3,3-Trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103435; BDBM50243904
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-Methyl-N-[3-(propylsulfonylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090590; CHEMBL3658861; SCHEMBL15970239; SCHEMBL15970241; BDBM159780; BDBM50243858; US9035074, 31
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
3-N-(Cyclopropylsulfamoyl)-1-N-methyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078655; BDBM50243907
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
3-N-(Ethylsulfamoyl)-1-N-methyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071850; BDBM50243870
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-(Cyclopropylmethyl)-N-methyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093955; BDBM50243810
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
1-N-Methyl-3-N-(propylsulfamoyl)-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098094; BDBM50243856
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092805; BDBM50243851
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
4,4,4-Trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]butane-1-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079179; BDBM50243837
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-(Cyclopropylmethyl)-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066876; BDBM50243909
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
2-Methyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3655082; SCHEMBL15970302; SCHEMBL15970304; BDBM159749; US9035074, 3
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-Methyl-N-[3-(pyrrolidin-1-ylsulfonylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104105; BDBM50243843
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]cyclopropanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059667; BDBM50243812
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-1-phenylmethanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085011; BDBM50243855
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|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-Butyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093643; BDBM50243903
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]butane-1-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087961; BDBM50243811
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-[3-(Benzenesulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103586; SCHEMBL17500740; SCHEMBL17500741; BDBM50243908
Click to Show/Hide
|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
4-Fluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103698; BDBM50243852
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
4-[[3-[[2-Cyanoethyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3655104; SCHEMBL15970258; SCHEMBL15970259; BDBM159771; US9035074, 22
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-1-(oxetan-3-yl)methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3655086; SCHEMBL15970477; SCHEMBL15970478; BDBM159753; US9035074, 6
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-[3-(Butylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3658860; SCHEMBL15970256; SCHEMBL15970257; BDBM159779; US9035074, 30
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
4-[[3-[[Cyclopropyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063642; BDBM50243906
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
3-Cyano-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099048; BDBM50243839
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|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Abrocitinib
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|
Investigative | Compound Info | ||
| Synonyms |
PF-04965842; UNII-73SM5SF3OR; 73SM5SF3OR; CHEMBL4101725; 1622902-68-4 (cis-isomer); Abrocitinib [USAN]; Abrocitinib (JAN/USAN); GTPL9991; CHEMBL3655081; SCHEMBL15970412; SCHEMBL15970413; BDBM159748; PF-04965842 (Abrocitinib); BCP30441; EX-A3037; BDBM50243847; MFCD30187577; s8765; ZB1566; ZINC261115849; DB14973; SB18849; compound 25 [PMID: 29298069]; SY248874; HY-107429; CS-0028460; PF04965842; D11400; US9035074, 2; PF-04965842, >=98% (HPLC); PF-04965842; PF 04965842; PF04965842
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| Activity |
IC50 > 200000 nM
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[4] | |||
| Compound Name |
N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100431; BDBM50243850; 6TE
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| Activity |
IC50 > 200000 nM
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[4] | |||
| Compound Name |
2,2,2-Trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3655080; SCHEMBL15970461; SCHEMBL15970462; BDBM159747; US9035074, 1
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| Activity |
IC50 > 200000 nM
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[4] | |||
| Compound Name |
N-Ethyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089286; BDBM50243899
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| Activity |
IC50 > 200000 nM
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[4] | |||
| Compound Name |
N-Butyl-N-methyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066404; SCHEMBL17500613; BDBM50243842
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| Activity |
IC50 > 200000 nM
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[4] | |||
| Compound Name |
1-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-N-propylmethanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059894; BDBM50243902
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| Activity |
IC50 > 200000 nM
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[4] | |||
| Compound Name |
N-[3-(Cyclopropylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075575; BDBM50243898
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| Activity |
IC50 > 200000 nM
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[4] | |||
| Compound Name |
N-[3-(Ethylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100048; BDBM50243857
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| Activity |
IC50 > 200000 nM
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[4] | |||
| Compound Name |
1-(2-Aminoethyl)-2-(4-piperidinyl)-1H-benzoimidazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622826; BDBM50124147
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| Activity |
IC50 = 759500 nM
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[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 8592415B2, Selective kinase inhibitors | ||||
| REF 2 | Identification of imidazo[1,2- b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm. 2016 Dec 15;8(4):700-712. | ||||
| REF 3 | Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer. Bioorg Med Chem. 2017 Apr 1;25(7):2156-2166. | ||||
| REF 4 | Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. J Med Chem. 2018 Feb 8;61(3):1130-1152. | ||||
| REF 5 | Benzimidazole Derivatives as Potent JAK1-Selective Inhibitors. J Med Chem. 2015 Sep 24;58(18):7596-602. | ||||
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