Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81735 | Target Info | |||
| Target Name | DNA-dependent protein kinase catalytic (PRKDC) | ||||
| Synonyms |
p460; HYRC1; HYRC; DNPK1; DNA-dependent protein kinase catalytic subunit; DNA-PKcs; DNA-PK catalytic subunit
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| Target Type | Clinical trial Target | ||||
| Gene Name | PRKDC | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 28 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dasatinib
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Approved | Compound Info | ||
| Synonyms |
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Sorafenib
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Approved | Compound Info | ||
| Synonyms |
Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor)
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Trifluoperazine
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Approved | Compound Info | ||
| Synonyms |
Calmazine; Eskazine; Fluoperazine; Flurazine; Modalina; Stelazine; Stellazine; TFP; Trifluoperazin; Trifluoperazina; Trifluoperazinum; Trifluoromethylperazine; Trifluoroperazine; Trifluperazine; Triflurin; Trifluroperizine; Triftazin; Triftazine; Triperazine; Triphtazin; Triphtazine; Triphthasine; PMS Trifluoperazine; Stelazine Concentrate; Trifluoperazina [Italian]; Trifluoperazine HCl; Trifluoperazine dihydrochloride; Trifluoroperazine dihydrochloride; Tripfluoperazine Hydrochloride; NCI17474; RP 7623; SKF 5019; Apo-Trifluoperazine; Eskazine (TN); Eskazinyl (TN); Jatroneural (TN); Modalina (TN); Novo-Trifluzine; Stelazine (TN); Terfluzine (TN); Trifluoperaz (TN); Trifluoperazina [INN-Spanish]; Trifluoperazine (INN); Trifluoperazine [INN:BAN]; Trifluoperazinum [INN-Latin]; Apo-trifluoperazine (TN); Stelazine (*Dihydrochloride*); Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine; 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)phenothiazine; 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine; 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-phenothiazine; 10-(gamma-(N'-Methylpiperazino)propyl)-2-trifluoromethylphenothiazine; 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE; 10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine; 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine; 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine; 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine dihydrochloride; 2-Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
PMID28460551-Compound-2
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Patented | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
8-(3-Aminophenyl)-2-morpholin-4-yl-1,3-benzoxazin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765681; BDBM50147687
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| Activity |
IC50 = 63500 nM
|
[3] | |||
| Compound Name |
2-Morpholin-4-yl-8-pyridin-3-yl-1,3-benzoxazin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765523; BDBM50147682
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| Activity |
IC50 = 78400 nM
|
[3] | |||
| Compound Name |
3-Methyl-2-morpholin-4-yl-6-phenylpyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221893; BDBM50208560
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-(4-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1320032; CHEMBL1241358; 3-(4-nitrophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-[4-(4-Amino-2H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242116
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-(4-Chlorophenyl)-2-morpholin-4-yl-4-ethoxypyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223320; BDBM50208541
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4H-Thiopyran-4-one, 2-methyl-6-(4-morpholinyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223251; BDBM50208544; 6-methyl-2-morpholin-4-yl-4H-thiopyran-4-one
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2,6-difluorobenzaldehyde
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3614988; CHEMBL1241861; 4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2,6-difluorobenzaldehyde
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4H-Thiopyran-4-one, 2-methyl-6-(1-pyrrolidinyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL225517; BDBM50208514; 6-methyl-2-pyrrolidin-1-yl-4H-thiopyran-4-one
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241864
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-(4-Methoxyphenyl)-2-morpholin-4-yl-4-methoxypyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL376878; BDBM50208547
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Benzylamino-6-methyl-4H-thiopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL384668; BDBM50208506; ZINC101122154
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-(4-Chlorophenyl)-2-morpholin-4-yl-4-methoxypyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375937; BDBM50208559
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-(3-(2,6-Dichlorobenzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242292; 3-[3-[(2,6-dichlorophenyl)methoxy]phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-Bromo-6-(4-chlorophenyl)-2-morpholin-4-yl-thiopyran-4-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222324; BDBM50208525
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-(4-Bromophenyl)-3-chloro-2-morpholin-4-yl-4H-thiopyran-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221350; BDBM50208536
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-(4-Methoxyphenyl)-2-morpholin-4-ylpyridin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL427096; BDBM50208535
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(3-Phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242205
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|
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-(4-Chlorophenyl)-3-methyl-2-morpholin-4-yl-pyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222524; BDBM50208550
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Morpholin-4-yl-6-(4-morpholin-4-yl-phenyl)-4H-thiopyran-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222977; BDBM50208498
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-Methyl-2-thiomorpholin-4-yl-4H-thiopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223526; BDBM50208549
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Amino-5-(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241487
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Biphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5065122; CHEMBL1242850; 3-(4-phenylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Click to Show/Hide
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Compound Info | |||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
T83193
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|
Patented | Compound Info | ||
| Synonyms |
vanillin; 4-Hydroxy-3-methoxybenzaldehyde; 121-33-5; Vanillaldehyde; Vanillic aldehyde; Vanilla; p-Vanillin; 2-Methoxy-4-formylphenol; Vanilline; Lioxin; 4-Hydroxy-m-anisaldehyde; 3-Methoxy-4-hydroxybenzaldehyde; Zimco; Benzaldehyde, 4-hydroxy-3-methoxy-; 4-Hydroxy-3-methoxy-benzaldehyde; Vanilin; p-Hydroxy-m-methoxybenzaldehyde; 4-Formyl-2-methoxyphenol; Methylprotocatechuic aldehyde; Vanillin (natural); 4-Hydroxy-5-methoxybenzaldehyde; m-Anisaldehyde, 4-hydroxy-; Protocatechualdehyde, methyl-; Vanillin [USAN]; Vanillin (NF)
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| Activity |
IC50 = 1500000 nM
|
[2] | |||
| Compound Name |
PMID28870136-Compound-52
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Patented | Compound Info | ||
| Activity |
IC50 = 10000000 nM
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[5] | |||
| Compound Name |
2-Oxo-5-(4-pyridyl)-6-(4-methoxybenzyloxymethyl)-1,2-dihydropyridine-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL94874; BDBM50105674; 2-(4-Methoxy-benzyloxymethyl)-6-oxo-1,6-dihydro-[3,4'']bipyridinyl-5-carbonitrile
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| Activity |
IC50 > 500000 nM
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[6] | |||
| Compound Name |
6-(Hydroxymethyl)-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL329643
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
Schisandrin B
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Investigative | Compound Info | ||
| Synonyms |
Schizandrin B; CHEMBL479488; Schizandrin-B;Wuweizisu-B;gamma-Schisandrin; Schizandrin-B; Gamma-Schisandrin ,(S); SCHEMBL3380716; CTK8D7637; DTXSID60976772; HMS3652I13; BCP30085; HY-N0089; BDBM50341711; AKOS015897166; CCG-208607; CS-3659; MCULE-2402982355; NCGC00163663-01; SC-49964; DB-050290; DB-055235; FT-0775855; V1533; Schisandrin B; Wuweizisu-B; gamma-Schisandrin; 281S376; SR-05000002175; Q-100707; SR-05000002175-2
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| Activity |
IC50 > 1000000000 nM
|
[5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. | ||||
| REF 2 | Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5352-9. | ||||
| REF 3 | Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39. | ||||
| REF 4 | Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. | ||||
| REF 5 | Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem. 2011 Apr 14;54(7):2320-30. | ||||
| REF 6 | Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035). Bioorg Med Chem Lett. 2001 Nov 5;11(21):2837-41. | ||||
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