Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82739 | Target Info | |||
| Target Name | Plasma kallikrein (KLKB1) | ||||
| Synonyms |
Plasma prekallikrein; Plasma kallikrein light chain; Plasma kallikrein heavy chain; PKK; Kininogenin; KLK3; Fletcher factor
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| Target Type | Successful Target | ||||
| Gene Name | KLKB1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 53 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Hexamethylene amiloride
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|
Preclinical | Compound Info | ||
| Synonyms |
5-(N,N-Hexamethylene)amiloride; 5-HMA; BIDD; BSPBio_003443; C12H18ClN7O; DivK1c_006875; HMA; HMA-5; Hexamethyleneamiloride; KBioGR_001206; KBioSS_002076; Lopac-A-9561; Lopac0_000104; MLS002153208; N,N-HEXAMETHYLENEAMILORIDE; SPECTRUM1504215; SpecPlus_000779; Spectrum2_001669; Spectrum3_001662; Spectrum4_000623; Spectrum5_001388; Spectrum_001596
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
NSC-622445
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Investigative | Compound Info | ||
| Synonyms |
5,5'-Methylenedisalicylic acid; 122-25-8; 5,5'-Methylenebis(2-hydroxybenzoic acid); Methylenebis(salicylic acid); 5,5-Methylenebis(salicylic acid); UNII-2KF4FVV76N; 5,5-Methylenedisalicylic acid; 5-(3-Carboxy-4-hydroxybenzyl)salicylic acid; 4,4'-Dihydroxy-3,3'-dicarboxydiphenylmethane; 3,3'-Dicarboxy-4,4'-dihydroxydiphenylmethane; NSC 14778; NSC-622445; 2KF4FVV76N; 4,4'-Dihydroxydiphenylmethane-3,3'-dicarboxylic acid; 3,3'-Methylenebis(6-hydroxybenzoic acid); CHEMBL115145; Benzoic acid, 3,3'-methylenebis[6-hydroxy-
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| Activity |
IC50 = 67900 nM
|
[2] | |||
| Compound Name |
Chembl4217043
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Investigative | Compound Info | ||
| Synonyms |
3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide; BDBM50459059; 30I
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(3S)-N-[1-[[(2R)-Butan-2-yl]amino]-1,2-dioxohexan-3-yl]-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184715; BDBM50152748
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
8-Methoxy-2-oxo-N-phenylchromene-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
8-methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide; Oprea1_190668; Oprea1_689234; SCHEMBL981812; CHEMBL493603; IFLab1_000844; BDBM23550; 8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid phenylamide; HMS1414G08; ZINC208754; 3-Carboxamide-coumarin deriv., 40; AKOS000421085; MCULE-6503315868; (8-methoxy-2-oxochromen-3-yl)-N-benzamide; ST50102332; SR-01000520069; SR-01000520069-1; F0249-0129
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6,8-Dichloro-2-oxo-N-phenyl-2H-chromene-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
Oprea1_016779; Oprea1_846562; CHEMBL494799; BDBM23547; ZINC180530; 3-Carboxamide-coumarin deriv., 41; STK825389; AKOS000511890; MCULE-1619511199; ST50006279; (6,8-dichloro-2-oxochromen-3-yl)-N-benzamide; SR-01000424840; SR-01000424840-1; F0341-0308
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Carboxamide-coumarin deriv., 43
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL521526; BDBM23566; 6,8-dichloro-N-(3,5-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Carboxamide-coumarin deriv., 46
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL495155; BDBM23568; 8-bromo-6-chloro-N-(3,5-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
US8598206, Table 6, 19
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660186; SCHEMBL12044908; BDBM108110
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
Chembl365415
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371797; BDBM50152752
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(2-{2-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-acetylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid (1-cyclopropylaminooxalyl-3,3-difluoro-propyl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL414805; BDBM50152750
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
US8598206, Table 6, 7
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660174; SCHEMBL12044903; BDBM108098
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
3-Carboxamide-coumarin deriv., 19
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL493198; BDBM23534; ZINC40952850; 6-methyl-2-oxo-N-(propan-2-yl)-2H-chromene-3-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Oxo-N-phenyl-3H-benzo[f]chromene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
Oprea1_332334; Oprea1_401977; CHEMBL495038; 3-Oxo-3H-benzo[f]chromene-2-carboxylic acid phenylamide; BDBM23551; 3-Carboxamide-coumarin deriv., 48; STK042072; ZINC12062408; AKOS000511888; CCG-311417; MCULE-4505918310; EU-0036469; SR-01000416840; SR-01000416840-1
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Chembl364471
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371795; BDBM50152753
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
3-Carboxamide-coumarin deriv., 20
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL495466; BDBM23538; ZINC38816294; 6-methyl-2-oxo-N-phenyl-2H-chromene-3-carboxamide; 2-Oxo-N-phenyl-6-methyl-2H-1-benzopyran-3-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(3S)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]hexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184035; BDBM50152751
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(3S,3As,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
VX-950, Telaprevir; CHEMBL443336; CYC142; SCHEMBL1709083; SCHEMBL16556602; CTK5A5985; DTXSID00389004; AKOS015896277; AC-5241; AB01566825_01
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
Chembl184525
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371796; BDBM50152755
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
7-Hydroxy-2-oxo-N-phenyl-2H-1-benzopyran-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
7-hydroxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide; EINECS 302-422-3; 7-hydroxy-2-oxo-N-phenylchromene-3-carboxamide; Oprea1_567475; Oprea1_613532; CHEMBL508427; SCHEMBL10980649; BDBM23552; CTK5H5054; DTXSID10240591; ZINC193181; 3-Carboxamide-coumarin deriv., 37; STK057369; AKOS000511885; MCULE-8391530313; NCGC00343225-01; EU-0034812; AB00124768-02; SR-01000400262; SR-01000400262-1
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(3S,3As,6aR)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-2-[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(pyrazine-2-carbonylamino)butanoyl]amino]butanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL315390; SCHEMBL13091808; BDBM50137739
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
7-Diethylamino-3-phenylcarbamoylcoumarin
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Investigative | Compound Info | ||
| Synonyms |
Oprea1_189437; Oprea1_469671; CHEMBL446851; IFLab1_001173; BDBM23554; HMS1415F07; ZINC192817; 3-Carboxamide-coumarin deriv., 39; AKOS000511887; IDI1_009040; EU-0001503; SR-01000399888; SR-01000399888-1; 7-(diethylamino)-2-oxo-N-phenyl-2H-chromene-3-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
US8598206, Table 6, 6
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660173; SCHEMBL12044904; BDBM108097
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| Activity |
Ki ~ 50000 nM
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[5] | |||
| Compound Name |
7-Methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
Oprea1_813820; CHEMBL447503; BDBM23553; ZINC192815; 3-Carboxamide-coumarin deriv., 38; STL376493; AKOS000415407; MCULE-1646989031; ST066313; (7-methoxy-2-oxochromen-3-yl)-N-benzamide; SR-01000399886; SR-01000399886-1
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[(6-Amino-2,4-dimethylpyridin-3-yl)methyl]-1-benzyl-5-methyltriazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL554554; CHEMBL3898179; BDBM212145; US9290485, 177
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| Activity |
IC50 = 52100 nM
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[6] | |||
| Compound Name |
(12E)-19-Amino-21-methyl-6-(pyrazol-1-ylmethyl)-9,16-dioxa-1,18,24,28-tetrazatetracyclo[24.2.1.03,8.017,22]nonacosa-3(8),4,6,12,17(22),18,20,26(29),27-nonaen-25-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883550; BDBM50210077
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| Activity |
IC50 = 53200 nM
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[7] | |||
| Compound Name |
(S)-5-Guanidino-2-[[N-(N-acetyl-L-isoleucyl)-L-leucyl]amino]pentanal
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2373047; BDBM50046897; 2-Acetylamino-3-methyl-pentanoic acid [1-(1-formyl-4-guanidino-butylcarbamoyl)-3-methyl-butyl]-amide
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| Activity |
IC50 = 54000 nM
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[8] | |||
| Compound Name |
2-Chloro-5-[4-(4-isopropylbenzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL379315; ZINC4471247; STL431912; AKOS000112847; ST020488; AG-690/12698020; 2-chloro-5-(3-methyl-4-{[4-(methylethyl)phenyl]methylene}-5-oxo(1,2-diazolinyl ))benzoic acid
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| Activity |
IC50 = 54200 nM
|
[2] | |||
| Compound Name |
3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107392; BDBM50060017
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| Activity |
Ki = 58000 nM
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[9] | |||
| Compound Name |
US8598206, Table 6, 8
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660175; SCHEMBL12044443; BDBM108099
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| Activity |
Ki ~ 60000 nM
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[5] | |||
| Compound Name |
[4-(2,5-Dimethyl-pyrrol-1-yl)-phenyl]-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
2-[4-(2,5-dimethylpyrrol-1-yl)phenyl]acetic acid; [4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]acetic acid; Benzeneacetic acid, 4-(2,5-dimethyl-1H-pyrrol-1-yl)-; 2-(4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)acetic acid; 2-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]acetic acid; Interchim compound 58; CBMicro_005721; ChemDiv2_000574; Oprea1_430537; Oprea1_575327; CHEMBL209974; BDBM11996; CTK0I6316; DTXSID40354236; HMS1370K02; ZINC244546; [4-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL]-ACETIC ACID; ALBB-033052; SMSF0010529; 8620AD; MFCD01874280; STK095503; AKOS000142329; CB07852; MCULE-5377071735; NE11987; BS-16752; BIM-0005448.P001; BB 0217844; ST50008602; EN300-51017; 2-[4-(2,5-dimethylpyrrolyl)phenyl]acetic acid; N-(4-Carboxymethene)phenyl-2,5-dimethylpyrrole; AG-690/13508196; SR-01000430218; SR-01000430218-1; 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-phenyl acetic acid; BRD-K22150193-001-01-7; [4-(2,5-Dimethyl-1H-pyrrol-1-yl)phenyl]acetic acid, AldrichCPR
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| Activity |
IC50 = 60500 nM
|
[2] | |||
| Compound Name |
N-[(6-Amino-4-methylpyridin-3-yl)methyl]-1-benzylpyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL554512; CHEMBL3981586; BDBM212106; US9290485, 138
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| Activity |
IC50 = 62700 nM
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[6] | |||
| Compound Name |
N-[(6-Amino-2,4-dimethylpyridin-3-yl)methyl]-1-(pyrimidin-2-ylmethyl)triazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL555122; CHEMBL3913738; BDBM212146; US9290485, 178
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| Activity |
IC50 = 67300 nM
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[6] | |||
| Compound Name |
(1E,6E)-4-(1,3-Dithian-2-ylidene)-1,7-bis(furan-2-yl)hepta-1,6-diene-3,5-dione
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Investigative | Compound Info | ||
| Synonyms |
(1E,6E)-4-(1,3-dithian-2-ylidene)-1,7-di(2-furyl)hepta-1,6-diene-3,5-dione; CHEMBL383943; BDBM11978; ZINC1083132; chemical diversity library compound 3; AKOS024351668; ST025295; ST50976463
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| Activity |
IC50 = 67400 nM
|
[2] | |||
| Compound Name |
2-Chloro-5-[(4Z)-4-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-3,5-dioxopyrazolidin-1-yl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL385899
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| Activity |
IC50 = 75000 nM
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[2] | |||
| Compound Name |
(S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 5-chloro-2-cyclopropylcarbamoylmethoxy-benzylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL108202; BDBM50066333; N-[2-(Cyclopropylcarbamoylmethoxy)-5-chlorobenzyl]-1-[(R)-2-cyclohexylglycyl]-L-prolinamide
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| Activity |
Ki = 79000 nM
|
[10] | |||
| Compound Name |
US8598206, Table 6, 2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660191; SCHEMBL12044865; BDBM108117
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| Activity |
Ki ~ 80000 nM
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[5] | |||
| Compound Name |
N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536972
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| Activity |
Ki = 83000 nM
|
[11] | |||
| Compound Name |
N-[(6-Amino-2,4-dimethylpyridin-3-yl)methyl]-1-benzyl-2-methylpyrrole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL554752; CHEMBL3983542; BDBM212147; US9290485, 179
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| Activity |
IC50 = 85800 nM
|
[6] | |||
| Compound Name |
4-(5-{(Z)-[1-(4-Chlorophenyl)-3,5-dioxopyrazolidin-4-ylidene]methyl}-2-furyl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL386614; ZINC6221909; CCG-14524; AKOS000112721; BIM-0016047.P001; SR-01000110231; SR-01000110231-1
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| Activity |
IC50 = 96200 nM
|
[2] | |||
| Compound Name |
3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-3-oxo-2-(2,2,5,7,8-pentamethyl-chroman-6-sulfonylamino)-propyl]-benzamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107743; BDBM50060019
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| Activity |
Ki = 97000 nM
|
[9] | |||
| Compound Name |
N-[(6-Amino-2,4-dimethylpyridin-3-yl)methyl]-1-(benzenesulfonyl)-2,4,5-trimethylpyrrole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL553469; CHEMBL3973359; BDBM212151; US9290485, 183
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
US8598206, Table 6, 24
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660189; SCHEMBL12044460; BDBM108115
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| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[[6-Amino-4-(difluoromethoxy)-2-methylpyridin-3-yl]methyl]-1-benzylpyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL554568; CHEMBL3900526; BDBM212148; US9290485, 180
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-[(6-Aminopyridin-3-yl)methyl]-1-benzylpyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL553827; CHEMBL3943842; BDBM212150; US9290485, 182
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-Butyl-3-[[4-(diaminomethylideneamino)phenyl]methylamino]imidazo[1,2-a]pyridine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740183; BDBM50499900
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
US8598206, Table 6, 11
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660178; SCHEMBL12044915; BDBM108102
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| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
US8598206, Table 6, 10
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660177; SCHEMBL12044438; BDBM108101
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S)-2-[[(2R)-2-(Benzylsulfonylamino)-4-(1-oxidopyridin-1-ium-4-yl)butanoyl]amino]-N-[(4-carbamimidoylphenyl)methyl]-4-piperidin-4-ylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660188
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl2332610
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448530; BDBM50431220
Click to Show/Hide
|
||||
| Activity |
Ki ~ 120000 nM
|
[13] | |||
| Compound Name |
Chembl2332604
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448529; BDBM50431213
Click to Show/Hide
|
||||
| Activity |
Ki ~ 120000 nM
|
[13] | |||
| Compound Name |
(5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-2-sulfanylideneimidazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378575; BDBM11980; BHT102866; chemical diversity library compound 5; AKOS027461626; ST003272; 2-Thioxo-5-[(Z)-2,4-dihydroxybenzylidene]imidazolidine-4-one; 5-[(2,4-dihydroxyphenyl)methylene]-2-thioxo-1,3-diazolidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 120100 nM
|
[2] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3,3-dicyclohexylpropanoyl)pyrrolidine-2-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555333
Click to Show/Hide
|
||||
| Activity |
Ki = 170000 nM
|
[14] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 49 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-[[(2R)-2-(Benzylsulfonylamino)-4-[1-(2-methylpropanoyl)piperidin-4-yl]butanoyl]amino]-N-[(4-carbamimidoylphenyl)methyl]-4-piperidin-4-ylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
US8598206, 122; CHEMBL3660185; SCHEMBL12044746; BDBM108109; BDBM108113; US8598206, 118
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[5] | |||
| Compound Name |
US8598206, Table 6, 13
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660180; SCHEMBL12044437; BDBM108104
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[5] | |||
| Compound Name |
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[(4-carbamimidoylphenyl)methylamino]-1-oxo-4-piperidin-4-ylbutan-2-yl]-5-(1-oxidopyridin-1-ium-4-yl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660184
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[5] | |||
| Compound Name |
US8598206, Table 6, 14
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660181; SCHEMBL12044882; BDBM108105
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[5] | |||
| Compound Name |
US8598206, Table 6, 12
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM108103; CHEMBL3660179; SCHEMBL12044751; BDBM47178
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[5] | |||
| Compound Name |
US8598206, Table 6, 16
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660183; SCHEMBL12044875; BDBM108107
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[5] | |||
| Compound Name |
US8598206, Table 6, 1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3660192; SCHEMBL12044907; BDBM108118
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[5] | |||
| Compound Name |
[Amino-[[4-[(4-nitrophenoxy)sulfonylmethyl]phenyl]methylsulfanyl]methylidene]azanium;bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3250026; BDBM50009926
Click to Show/Hide
|
||||
| Activity |
Ki = 320000 nM
|
[15] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-3-[(2-naphthalen-2-ylacetyl)amino]-4-(pyridin-4-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910638; BDBM50355956
Click to Show/Hide
|
||||
| Activity |
IC50 = 380000 nM
|
[16] | |||
| Compound Name |
(S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-amino)-acetyl]-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441468; BDBM50066331; N-(2,5-Dichlorobenzyl)-1-[(R)-N-[(diethylcarbamoyl)methyl]-2-cyclohexylglycyl]-L-prolinamide
Click to Show/Hide
|
||||
| Activity |
Ki = 399000 nM
|
[10] | |||
| Compound Name |
Methyl (2S,4S)-4-amino-2-[[(2S,4S)-4-amino-2-[3-[(1R,3R)-3-[[(2S,4S)-4-amino-2-[[(2S,4S)-4-amino-5-(1H-indol-3-yl)-3-oxo-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-(1H-indol-3-yl)-3-oxopentanoyl]amino]-2-oxocyclohexyl]propanoylamino]-5-(1H-indol-3-yl)-3-oxopentanoyl]amino]-5-(4-hydroxyphenyl)-3-oxopentanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265127; BDBM50292271
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[17] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-3-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333238
Click to Show/Hide
|
||||
| Activity |
Ki = 476000 nM
|
[14] | |||
| Compound Name |
US8598206, Table 6, 9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM108100; CHEMBL3660176; SCHEMBL12044748; BDBM47177
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[5] | |||
| Compound Name |
(S)-1-(2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42495; BDBM50066336; (S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide
Click to Show/Hide
|
||||
| Activity |
Ki = 586000 nM
|
[10] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-3-[(2-naphthalen-1-ylacetyl)amino]-4-(pyridin-4-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910639; BDBM50355957
Click to Show/Hide
|
||||
| Activity |
IC50 = 680000 nM
|
[16] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238362; BDBM50009171
Click to Show/Hide
|
||||
| Activity |
IC50 = 740000 nM
|
[18] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-2-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332870
Click to Show/Hide
|
||||
| Activity |
Ki = 767000 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)acetyl]pyrrolidine-2-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555753
Click to Show/Hide
|
||||
| Activity |
Ki = 775000 nM
|
[14] | |||
| Compound Name |
(S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2-carbamoylmethoxy-5-chloro-benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108717; BDBM50066332; N-[2-(Carbamoylmethoxy)-5-chlorobenzyl]-1-[(R)-2-cyclohexylglycyl]-L-prolinamide
Click to Show/Hide
|
||||
| Activity |
Ki = 816000 nM
|
[10] | |||
| Compound Name |
Tert-butyl 3-[3-[5-[[(1S)-5-amino-1-cyanopentyl]carbamoyl]-2-(pyridin-4-ylmethoxy)anilino]-3-oxopropyl]indole-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910640; BDBM50355958
Click to Show/Hide
|
||||
| Activity |
IC50 = 910000 nM
|
[16] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-sulfamoylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238365; BDBM50009174
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
Mupain-1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734777; BDBM50499239
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(cyanomethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238373; BDBM50009199
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-[4-(2-oxopropoxy)phenyl]imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238371; BDBM50009188
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-fluorophenyl)-5-oxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233151; BDBM50009208
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-cyanophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238367; BDBM50009176
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3,3-diphenylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122894
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[14] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-4-(4-phenoxyphenyl)piperazin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233153; BDBM50009210
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(2-carbamoylphenoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238378; BDBM50009204
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(4-methoxyphenoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238375; BDBM50009201
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-4-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431675
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[14] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(3-sulfamoylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238368; BDBM50009177
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[[5-oxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233152; BDBM50009209
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-quinolin-6-yloxyphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238377; BDBM50009203
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-carbamoyl-4-phenoxyphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238379; BDBM50009205
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[3-(1,3-benzodioxol-5-yl)-3-pyridin-3-ylpropanoyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330791
Click to Show/Hide
|
||||
| Activity |
Ki = 1000000 nM
|
[14] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-carbamoylphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238369; BDBM50009178
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[3-carbamoyl-4-(pyridin-4-ylmethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233150; BDBM50009206
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238363; BDBM50009172
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-carbamoylphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238366; BDBM50009175
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238374; BDBM50009200
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-propylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238364; BDBM50009173
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-[4-(pyridin-4-ylmethoxy)phenyl]imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238376; BDBM50009202
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(2-amino-2-oxoethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238372; BDBM50009197
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-cyanophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238370; BDBM50009179
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[(3-methyl-2,5-dioxoimidazolidin-1-yl)methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238361; BDBM50009170
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[18] | |||
| Compound Name |
6-Amino-N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927450; BDBM50359553
Click to Show/Hide
|
||||
| Activity |
Ki = 2000000 nM
|
[20] | |||
| Compound Name |
(12Z)-19-Amino-21-methyl-6-(pyrazol-1-ylmethyl)-9,16-dioxa-1,18,24,28-tetrazatetracyclo[24.2.1.03,8.017,22]nonacosa-3(8),4,6,12,17(22),18,20,26(29),27-nonaen-25-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884218; BDBM50210128
Click to Show/Hide
|
||||
| Activity |
IC50 > 3000000 nM
|
[7] | |||
| Compound Name |
N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(Aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927307; BDBM50359552
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| Activity |
Ki = 3300000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. J Med Chem. 2018 Sep 27;61(18):8299-8320. | ||||
| REF 2 | Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. J Med Chem. 2006 Aug 24;49(17):5232-44. | ||||
| REF 3 | P4 and P1' optimization of bicycloproline P2 bearing tetrapeptidyl alpha-ketoamides as HCV protease inhibitors. Bioorg Med Chem Lett. 2004 Oct 4;14(19):5007-11. | ||||
| REF 4 | Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. J Med Chem. 2008 Jun 12;51(11):3077-80. | ||||
| REF 5 | US patent application no. 8598206B2, Trypsin-like serine protease inhibitors, and their preparation and use | ||||
| REF 6 | US patent application no. 9290485B2, N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides | ||||
| REF 7 | Structure-Guided Design of Novel, Potent, and Selective Macrocyclic Plasma Kallikrein Inhibitors. ACS Med Chem Lett. 2016 Dec 6;8(2):185-190. | ||||
| REF 8 | Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9. | ||||
| REF 9 | Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine. J Med Chem. 1997 Sep 12;40(19):3091-9. | ||||
| REF 10 | Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position. J Med Chem. 1998 Aug 13;41(17):3210-9. | ||||
| REF 11 | Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3434-9. | ||||
| REF 12 | Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold. J Med Chem. 2015 Dec 10;58(23):9238-57. | ||||
| REF 13 | Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy. J Med Chem. 2013 May 9;56(9):3742-6. | ||||
| REF 14 | Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position. J Med Chem. 1997 Oct 24;40(22):3687-93. | ||||
| REF 15 | Inactivation of trypsin-like proteases by sulfonylation. Variation of positively charged group and inhibitor length. J Med Chem. 1978 May;21(5):456-9. | ||||
| REF 16 | Identification of novel plasmin inhibitors possessing nitrile moiety as warhead. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6305-9. | ||||
| REF 17 | Selective inhibitors of the serine protease plasmin: probing the S3 and S3' subsites using a combinatorial library. J Med Chem. 2005 Nov 3;48(22):6908-17. | ||||
| REF 18 | Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin. Bioorg Med Chem. 2014 Apr 1;22(7):2339-52. | ||||
| REF 19 | Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor. J Med Chem. 2015 Nov 25;58(22):8868-76. | ||||
| REF 20 | The arginine mimicking -amino acid hPhe(3-H1 -CH1 as S1 ligand in cyclotheonamide-based -tryptase inhibitors. Bioorg Med Chem. 2011 Dec 1;19(23):7236-43. | ||||
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