Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83369 | Target Info | |||
| Target Name | Coagulation factor IX (F9) | ||||
| Synonyms |
Plasma thromboplastin component; PTC protein; Factor IX; Christmas factor
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| Target Type | Successful Target | ||||
| Gene Name | F9 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 26 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[2-(6-Carbamimidoyl-1H-benzimidazol-2-yl)ethyl]-4-(1,2,4-triazol-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423031
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| Activity |
Ki = 54200 nM
|
[1] | |||
| Compound Name |
2-Chloro-N-[(2S)-1-(5,6-dimethyl-1H-benzimidazol-2-yl)propan-2-yl]-4-(1,2,4-triazol-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423055
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| Activity |
Ki = 55400 nM
|
[1] | |||
| Compound Name |
Methyl N-[4-[2-[(1S)-1-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-2-phenylethyl]-1H-imidazol-5-yl]phenyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398642; SCHEMBL1196451; SCHEMBL1196454; BDBM50063582
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| Activity |
Ki ~ 60000 nM
|
[2] | |||
| Compound Name |
N-[(1s)-1-Benzyl-2-[2-[5-Chloro-2-(Tetrazol-1-Yl)phenyl]ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2-Oxo-1h-Quinoline-6-Carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754781; SCHEMBL3012551; BDBM50136579; Q27456753
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| Activity |
Ki ~ 73000 nM
|
[3] | |||
| Compound Name |
4-[(N-{(2e)-3-[5-Chloro-2-(1h-Tetrazol-1-Yl)phenyl]prop-2-Enoyl}-L-Phenylalanyl)amino]benzoic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754069; SCHEMBL3004773; SCHEMBL3004779; BDBM50136608; Q27455801
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| Activity |
Ki ~ 73000 nM
|
[3] | |||
| Compound Name |
Chembl4227743
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL10264235; BDBM50460457
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| Activity |
Ki ~ 73700 nM
|
[4] | |||
| Compound Name |
N-[2-(6-Methoxy-1H-benzimidazol-2-yl)ethyl]-4-(1,2,4-triazol-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423029
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|
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| Activity |
Ki = 86600 nM
|
[1] | |||
| Compound Name |
(17S,20R)-20-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,10,19-trioxo-2,5,8,11,18-pentazatetracyclo[20.2.2.25,8.212,15]triaconta-1(25),12,14,22(26),23,27-hexaene-17-carboxamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2315239
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| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[[(3S,3Ar)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzothiazin-3-yl]methyl]-5-chlorothiophene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330482; BDBM50024529
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-({(1S,2S)-1-[(S)-1-(4-Carbamimidoyl-benzylcarbamoyl)-3-carbamoyl-propylcarbamoyl]-2-methyl-butylsulfamoyl}-methyl)-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL505986; BDBM50272538
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[[(3S)-1-Oxo-7-(3-oxomorpholino)-3abeta,4-dihydro-1H,3H-2,5-dioxa-9b-aza-2H-benzo[e]indene-3beta-yl]methyl]-5-chlorothiophene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330442; SCHEMBL16609922; BDBM50024356
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-({(1S,2R)-1-[(S)-1-(4-Carbamimidoyl-benzylcarbamoyl)-3-methylsulfanyl-propylcarbamoyl]-2-hydroxy-propylsulfamoyl}-methyl)-benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL506769; BDBM50272560
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|
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
5-Chloro-N-(((3S,3aS)-1-oxo-7-(3-oxomorpholino)-3,3a,4,5-tetrahydro-1H-oxazolo[3,4-a]quinolin-3-yl)methyl)thiophene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330490; DJT06001; BDBM50024538
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3,3a,4,5-tetrahydro-[1,3]oxazolo[3,4-a]quinoxalin-3-yl]methyl]-5-chlorothiophene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330493; BDBM50024536
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-(1H-Imidazo[4,5-c]pyridin-2-yl)-5-phenyl-1H-pyrazol-4-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL379243; SCHEMBL7972894; BDBM50182960
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|
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| Activity |
Ki = 110000 nM
|
[8] | |||
| Compound Name |
N-[2-(1H-Benzimidazol-2-yl)ethyl]-4-(1,2,4-triazol-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423025
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|
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| Activity |
Ki = 114000 nM
|
[1] | |||
| Compound Name |
4-Hydroxy-5-phenyl-1H-pyrazole-3-carboxylic acid (4-carbamimidoyl-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL207219; BDBM50182958
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|
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| Activity |
Ki = 120000 nM
|
[8] | |||
| Compound Name |
2-Chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-4-(triazol-1-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423042
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|
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| Activity |
Ki = 130000 nM
|
[1] | |||
| Compound Name |
2-Chloro-N-[2-(7-hydroxy-4-methyl-1H-benzimidazol-2-yl)ethyl]-4-(1,2,4-triazol-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423032
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|
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| Activity |
Ki = 131000 nM
|
[1] | |||
| Compound Name |
2-Chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-4-(triazol-2-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423043
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|
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| Activity |
Ki ~ 145000 nM
|
[1] | |||
| Compound Name |
N-[2-(5,6-Dimethyl-1H-benzimidazol-2-yl)ethyl]-2-(1,2,4-triazol-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423034
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|
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| Activity |
Ki ~ 145000 nM
|
[1] | |||
| Compound Name |
2-Chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423039
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|
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| Activity |
Ki ~ 145000 nM
|
[1] | |||
| Compound Name |
N-[2-(4-Methyl-1H-benzimidazol-2-yl)ethyl]-4-(1,2,4-triazol-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423030
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|
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| Activity |
Ki ~ 145000 nM
|
[1] | |||
| Compound Name |
4-Cyano-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-2-fluorobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423036
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|
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| Activity |
Ki ~ 145000 nM
|
[1] | |||
| Compound Name |
N-[2-(5,6-Dimethyl-1H-benzimidazol-2-yl)ethyl]-3-(1,2,4-triazol-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423035; BDBM50083243
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|
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| Activity |
Ki ~ 145000 nM
|
[1] | |||
| Compound Name |
N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536972
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|
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| Activity |
Ki ~ 150000 nM
|
[9] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(3R)-2-[2-(4-Chlorophenyl)acetyl]-N-[4-(3-oxomorpholin-4-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040983; BDBM50386271
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|
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| Activity |
IC50 > 1000000 nM
|
[10] | |||
| Compound Name |
Octasodium;[2-(3,4-disulfonatooxyphenyl)-5-[[4-[[2-(3,4-disulfonatooxyphenyl)-4-oxo-3,7-disulfonatooxychromen-5-yl]oxymethyl]phenyl]methoxy]-4-oxo-3-sulfonatooxychromen-7-yl] sulfate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084933; BDBM50260048
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|
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| Activity |
IC50 > 2000000 nM
|
[11] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Rapid development of two factor IXa inhibitors from hit to lead. Bioorg Med Chem Lett. 2015 Jun 1;25(11):2321-5. | ||||
| REF 2 | Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1635-42. | ||||
| REF 3 | Novel phenylalanine derived diamides as Factor XIa inhibitors. Bioorg Med Chem Lett. 2016 Jan 15;26(2):472-478. | ||||
| REF 4 | Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors. Bioorg Med Chem Lett. 2018 Apr 1;28(6):987-992. | ||||
| REF 5 | Development of new cyclic plasmin inhibitors with excellent potency and selectivity. J Med Chem. 2013 Feb 14;56(3):820-31. | ||||
| REF 6 | Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor. J Med Chem. 2014 Sep 25;57(18):7770-91. | ||||
| REF 7 | Factor VIIa inhibitors: target hopping in the serine protease family using X-ray structure determination. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4533-7. | ||||
| REF 8 | Discovery of novel hydroxy pyrazole based factor IXa inhibitor. Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. | ||||
| REF 9 | Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3434-9. | ||||
| REF 10 | Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold. Eur J Med Chem. 2012 Aug;54:771-83. | ||||
| REF 11 | Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics. J Med Chem. 2017 Jan 26;60(2):641-657. | ||||
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