Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84780 | Target Info | |||
| Target Name | Cellular inhibitor of apoptosis 1 (BIRC2) | ||||
| Synonyms |
hIAP2; hIAP-2; TNFR2TRAFsignaling complex protein 2; TNFR2-TRAF-signaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; CIAP1; C-IAP1; Baculoviral IAP repeatcontaining protein 2; Baculoviral IAP repeat-containing protein 2; API1
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| Target Type | Clinical trial Target | ||||
| Gene Name | BIRC2 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 17 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Nvp-cgm097
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Investigative | Compound Info | ||
| Synonyms |
CGM097; CGM-097; CGM 097; NVP-CGM-097; NVP CGM097; UNII-4UF6MSL0ZH; 4UF6MSL0ZH; C38H47ClN4O4; SCHEMBL2391192; SCHEMBL2391196; CHEMBL3601398; SCHEMBL18458199; KS-00000TSY; BDBM162123; BCP18308; EX-A1059; MFCD28144684; s7875; NVP-CGM097 (CGM-097); AKOS030526402; ZINC253387855; CCG-270337; CS-3138; NCGC00390552-01; AC-32967; AS-75288; HY-15954; W5747; J3.509.326E; A16326; US9051279, 106; Q27454942
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
(3S,6S,10As)-N-[(S)-[1-[4-[4-[4-[4-[(S)-[[(3S,6S,10aS)-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carbonyl]amino]-phenylmethyl]triazol-1-yl]butyl]phenyl]butyl]triazol-4-yl]-phenylmethyl]-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1774155; BDBM50343514
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
(S)-N-((3S,4S)-5-Acetyl-7-cyano-4-methyl-1-((2-methylnaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1, 4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436226; SCHEMBL15621755
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| Activity |
IC50 ~ 54800 nM
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[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[[2-Cyano-1-(2-cyanophenyl)indol-3-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431755
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| Activity |
IC50 ~ 55000 nM
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[4] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-(2-oxo-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-6-yl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892789; SCHEMBL13826404; BDBM184613; US9155743, 44
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| Activity |
IC50 = 55000 nM
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[5] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-(2-oxo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-6-yl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3890929; SCHEMBL13734507; BDBM184587; US9155743, 16
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| Activity |
IC50 = 55000 nM
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[5] | |||
| Compound Name |
(2S)-N-(1,3-Dimethyl-2-oxobenzimidazol-5-yl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3920196; SCHEMBL15474185; BDBM184588; US9155743, 17
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| Activity |
IC50 = 55000 nM
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[5] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-3-methyl-2-oxo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-6-yl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922505; SCHEMBL13734315; BDBM184586; US9155743, 15
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| Activity |
IC50 = 55000 nM
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[5] | |||
| Compound Name |
(2S)-N-(3-Benzyl-2-oxo-1H-imidazo[4,5-b]pyridin-5-yl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917272; SCHEMBL13826401; BDBM184612; US9155743, 43
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| Activity |
IC50 = 55000 nM
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[5] | |||
| Compound Name |
N,N-Dimethyl-1-[2-[(3R)-3-methylpiperazin-1-yl]acetyl]-2,3-dihydroindole-6-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696501; SCHEMBL15812258; BDBM155981; US9018214, 32
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| Activity |
IC50 = 57000 nM
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[6] | |||
| Compound Name |
N-Methyl-1-[2-[(3R)-3-methylpiperazin-1-yl]acetyl]-2,3-dihydroindole-6-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696498; SCHEMBL15811934; BDBM155976; US9018214, 27; 1-[2-((R)-3-Methyl-piperazin-1-yl)-acetyl]-2,3-dihydro-1H-indole-6-sulfonic acid methylamide
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| Activity |
IC50 = 59000 nM
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[6] | |||
| Compound Name |
5-Bromo-N-methyl-1-[2-[(3R)-3-methylpiperazin-1-yl]acetyl]-2,3-dihydroindole-6-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696496; SCHEMBL15841253; BDBM155974; US9018214, 25
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| Activity |
IC50 = 60000 nM
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[6] | |||
| Compound Name |
1-(6-Isopropylindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600726; SCHEMBL15837638; BDBM155962; US9018214, 13; 2-[(3R)-3-methylpiperazin-1-yl]-1-(6-propan-2-yl-2,3-dihydroindol-1-yl)ethanone
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| Activity |
IC50 = 63000 nM
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[6] | |||
| Compound Name |
1-(6-Methoxyindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600724; SCHEMBL15841254; BDBM155954; US9018214, 5; 1-(6-methoxy-2,3-dihydroindol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone
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| Activity |
IC50 = 78000 nM
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[6] | |||
| Compound Name |
1-[6-(N-Methylanilino)-2,3-dihydroindol-1-yl]-2-[(3R)-3-methylpiperazin-1-yl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696486; SCHEMBL13733036; BDBM155951; US9018214, 2
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| Activity |
IC50 = 79000 nM
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[6] | |||
| Compound Name |
1-(6-Methylindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600725; SCHEMBL15837631; BDBM155955; US9018214, 6; 1-(6-methyl-2,3-dihydroindol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone
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| Activity |
IC50 = 95000 nM
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[6] | |||
| Compound Name |
1-(5-Fluoro-2,3-dihydroindol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696488; SCHEMBL15837633; BDBM155958; US9018214, 9
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| Activity |
IC50 = 170000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(1-Pyrrolidinyl)-2-((3R)-3-methylpiperazine-1-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600721; BDBM50109044
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| Activity |
IC50 = 410000 nM
|
[7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J Med Chem. 2015 Aug 27;58(16):6348-58. | ||||
| REF 2 | Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. J Med Chem. 2011 May 12;54(9):3306-18. | ||||
| REF 3 | Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain. J Med Chem. 2013 Oct 24;56(20):7788-803. | ||||
| REF 4 | Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain. J Med Chem. 2013 Oct 24;56(20):7772-87. | ||||
| REF 5 | US patent application no. 9155743B2, Bicyclic heterocycle compounds and their uses in therapy | ||||
| REF 6 | US patent application no. 9018214B2, Bicyclic heterocycle compounds and their uses in therapy | ||||
| REF 7 | Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP. J Med Chem. 2015 Aug 27;58(16):6574-88. | ||||
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