Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95605 | Target Info | |||
| Target Name | Neurotensin receptor type 2 (NTSR2) | ||||
| Synonyms |
NTR2; NT-R-2; Levocabastine-sensitive neurotensin receptor
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | NTSR2 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 47 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Cyclobutyl-6-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431125; SCHEMBL15819562; BDBM50440773; MLS-0463325.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6-Ethoxy-7-methoxy-4-[4-(3-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431236; BDBM50440766
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Ethyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431115; 2-ethyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline; SCHEMBL15818947; BDBM50440753; MLS-0471479.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
4-[4-(2-Fluorophenyl)piperazin-1-yl]-6,7-dimethoxy-2-phenylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431135; SCHEMBL15819199; ZINC2300876; BDBM50440746; STL334993; AKOS022115924; MCULE-1408919683; MLS-0454783.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
4-[4-(2-Chlorophenyl)piperazin-1-yl]-2-cyclopropyl-6,7-dimethoxyquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431131; SCHEMBL15818963; BDBM50440762; MLS-0471515.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
[4-(2-Cyclopropyl-6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl]-phenylmethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431108; SCHEMBL15821063; BDBM50440752; MLS-0471512.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclobutyl-4-[4-(2-fluorophenyl)piperazin-1-yl]-6,7-dimethoxyquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431233; SCHEMBL15819832; BDBM50440764; MLS-0463026.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6,7-Dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431124; SCHEMBL15819169; BDBM50440757; MLS-0471470.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclopropyl-6,7-dimethoxy-4-piperazin-1-ylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431110; SCHEMBL19773006; BDBM50440739; MLS-0471510.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6,7-Dimethoxy-2-phenyl-4-(4-phenylpiperazin-1-yl)quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431134; SCHEMBL15819480; ZINC2338076; BDBM50440747; STL333910; AKOS022115923; MCULE-5431182931; MLS-0454790.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6-Cyclobutyl-8-[4-(2-methoxyphenyl)piperazin-1-yl]-[1,3]dioxolo[4,5-g]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431128; SCHEMBL15824812; BDBM50440755; MLS-0463414.0001
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|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclopropyl-6,7-dimethoxy-4-[4-[(4-methylphenyl)methyl]piperazin-1-yl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431106; SCHEMBL15819681; BDBM50440759; MLS-0471513.0001
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|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
4-[4-(4-Fluorophenyl)piperazin-1-yl]-6,7-dimethoxy-2-phenylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431136; SCHEMBL15821039; ZINC2326665; BDBM50440745; STK606031; AKOS005542119; MCULE-2879453052; MLS-0454796.0001
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|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclobutyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431127; SCHEMBL15821056; BDBM50440760; MLS-0463112.0001
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|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclopropyl-4-[4-(2-ethoxyphenyl)piperazin-1-yl]-6,7-dimethoxyquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431130; SCHEMBL15819068; BDBM50440776; MLS-0469655.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
1-(2-Cyclopropyl-6,7-dimethoxyquinazolin-4-yl)-4-(phenylsulfonyl)piperazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431132; MLS004254801; SCHEMBL15818954; BDBM50440740; SMR003080914; MLS-0469656.0001; 4-[4-(benzenesulfonyl)piperazin-1-yl]-2-cyclopropyl-6,7-dimethoxyquinazoline
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
ML314; ML-314; CHEMBL2431120; 2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline; MLS004254796; SCHEMBL15819587; AOB4170; BCP09261; BDBM50440737; ML 314; ZINC96284476; AKOS030526548; ML 314;ML-314; NCGC00378708-04; AS-16787; HY-16639; SMR003080910; A13570; MLS-0463110.0001; MLS-0463110.0002; 1-[4-(2-cyclopropyl-6,7-dimethoxyquinazolin-4-yl)piperazinyl]-2-methoxybenzene
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6,7-Dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-(2-methylpropyl)quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431118; SCHEMBL15819842; BDBM50440767; MLS-0471511.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Ethenyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431119; SCHEMBL15819549; BDBM50440775; MLS-0471471.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
4-[4-(2,4-Dimethoxyphenyl)piperazin-1-yl]-6-ethoxy-7-methoxy-2-phenylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431238; BDBM50440761
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6-Ethoxy-7-methoxy-4-[4-(2-nitrophenyl)piperazin-1-yl]-2-phenylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431235; BDBM50440748
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclobutyl-6,7-dimethoxy-4-[4-(2-methylphenyl)piperazin-1-yl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431232; SCHEMBL15821073; BDBM50440768; MLS-0454701.0001
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6,7-Dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431112; BDBM50440780; STK940146; ZINC32544286; AKOS002365198; MCULE-6262182369; MLS-0454797.0001
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|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Benzyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431114; SCHEMBL15818670; BDBM50440770; MLS-0463341.0001
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclobutyl-6,7-dimethoxy-4-(4-phenylpiperazin-1-yl)quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431231; SCHEMBL15818972; BDBM50440772; MLS-0454700.0001
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|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6-Ethoxy-7-methoxy-4-[4-(4-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431237; BDBM50440751
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6-Ethoxy-7-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431138; SCHEMBL15818605; BDBM50440743
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
[4-(2-Cyclopropyl-6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl]-(2-methoxyphenyl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431109; SCHEMBL15818659; BDBM50440749; MLS-0469657.0001
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
4-[4-(2-Chlorophenyl)piperazin-1-yl]-6,7-dimethoxy-2-phenylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431137; SCHEMBL15819570; BDBM50440744
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclobutyl-7-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431126; SCHEMBL15819273; BDBM50440756; MLS-0463326.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclobutyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)-1-piperazinyl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
MLS000699290; SMR000229280; 2-cyclobutyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline; MLS004254798; CHEMBL1446377; SCHEMBL15819858; BDBM79557; cid_1230852; HMS2527K18; ZINC1010444; MLS-0233108.0001; MLS-0233108.0002; 2-cyclobutyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazino]quinazoline
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-[6,7-Dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazolin-2-yl]-N,N-dimethylethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431123; SCHEMBL15819631; BDBM50440781; MLS-0471472.0001
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclobutyl-6,7-dimethoxy-4-(4-pyridin-2-ylpiperazin-1-yl)quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1417160; MLS000699291; SCHEMBL15819960; BDBM50440758; ZINC33293658; SMR000229279; MLS-0232587.0001; 2-cyclobutyl-6,7-dimethoxy-4-[4-(2-pyridinyl)-1-piperazinyl]quinazoline
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[1-(7-Chloroquinolin-4-yl)-2-(2,6-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099773; ML301; MLS004254788; BDBM50444943; NCGC00386838-01; SMR003080904; MLS-0437331.0001; MLS-0437331.0002
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|
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| Activity |
EC50 ~ 80000 nM
|
[2] | |||
| Compound Name |
6,7-Dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-propylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431116; SCHEMBL15818970; BDBM50440765; MLS-0469652.0001
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
4-[4-(2,6-Dimethylphenyl)piperazin-1-yl]-6-ethoxy-7-methoxy-2-phenylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431111; BDBM50440750
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclopropyl-6-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431129; SCHEMBL15818754; BDBM50440778; MLS-0471516.0001
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
4-[4-(2-Chlorophenyl)piperazin-1-yl]-2-cyclobutyl-6,7-dimethoxyquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431234; SCHEMBL15819396; BDBM50440771; MLS-0463025.0001
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyclopropyl-6,7-dimethoxy-4-[4-[(2-methoxyphenyl)methyl]piperazin-1-yl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431107; SCHEMBL15818571; BDBM50440754; MLS-0471514.0001
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-(Cyclopropylmethyl)-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431122; SCHEMBL15819774; BDBM50440769; MLS-0469654.0001
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6,7-Dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-methylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431113; SCHEMBL15818823; BDBM50440779; MLS-0463029.0001
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL508044; ML 301 analog; MLS004254795; BDBM50248035; ZINC40848549; AKOS025147327; NCGC00387458-01; SMR003080909; MLS-0437103.0001; MLS-0437103.0002
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[2] | |||
| Compound Name |
6-Ethoxy-7-methoxy-2-phenyl-4-(4-phenylpiperazin-1-yl)quinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431139; SCHEMBL15819912; BDBM50440742
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6,7-Dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431133; MLS004254797; SCHEMBL15819136; ZINC8738178; BDBM50440763; STK613295; AKOS005547874; MCULE-6614147969; SMR003080911; MLS-0454791.0001; MLS-0454791.0002; 1-[4-(2-phenyl-6,7-dimethoxyquinazolin-4-yl)piperazinyl]-2-methoxybenzene
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
1-{4-[6,7-Dimethoxy-2-(methylethyl)quinazolin-4-yl]piperazinyl}-2-methoxybenzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431117; MLS004254799; SCHEMBL15818556; BDBM50440774; SMR003080912; MLS-0469653.0001; 6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-propan-2-ylquinazoline
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|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
6-Ethoxy-4-[4-(2-fluorophenyl)piperazin-1-yl]-7-methoxy-2-phenylquinazoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431140; SCHEMBL15821238; BDBM50440741
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
1-[4-(2-Cyclopentyl-6,7-dimethoxyquinazolin-4-yl)piperazinyl]-2-methoxybenzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431121; MLS004254800; SCHEMBL15818966; BDBM50440777; SMR003080913; MLS-0463111.0001; 2-cyclopentyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
Click to Show/Hide
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| Activity |
EC50 ~ 80000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of ML314, a Brain Penetrant Non-Peptidic -Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. ACS Med Chem Lett. 2013 Jul 20;4(9):846-851. | ||||
| REF 2 | Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg Med Chem Lett. 2014 Jan 1;24(1):262-7. | ||||
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