Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95913 | Target Info | |||
| Target Name | PI3-kinase gamma (PIK3CG) | ||||
| Synonyms |
p120-PI3K; p110gamma; Serine/threonine protein kinase PIK3CG; PtdIns-3-kinase subunit p110-gamma; PtdIns-3-kinase subunit gamma; PtdIns-3-kinase p110; Phosphoinositol-3 kinase; Phosphoinositide-3-kinase catalytic gamma polypeptide; Phosphoinositide 3-Kinase gamma; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; PI3Kgamma; PI3K-gamma; PI3K; PI3-kinase subunit gamma; PI3-kinase p110 subunit gamma
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | PIK3CG | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 103 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dasatinib
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Sorafenib
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
IC87114
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
IC-87114; 371242-69-2; IC87114; 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one; IC 87114; UNII-9HC746B1KF; 2-[(6-AMINO-9H-PURIN-9-YL)METHYL]-5-METHYL-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE; 9HC746B1KF; CHEMBL1213082; CHEBI:90686; D-030; 2-[(6-aminopurin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one; 2-[(6-Amino-9h-Purin-9-Yl)methyl]-5-Methyl-3-(2-Methylphenyl)quinazolin-4(3h)-One; BiomolKI2_000002; GNWHRHGTIBRNSM-UHFFFAOYSA-N; PubChem22453; MLS006011148; SCHEMBL360745; GTPL9376; EX-A326
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[2] | |||
| Compound Name |
AMA37
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
arylmorpholine analog 37
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
(R)-2-(3-Benzylmorpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477787; BDBM50262406
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-[(4-Fluoro-2-methylphenoxy)methyl]-N-(2-hydroxyethyl)-6-morpholin-4-ylpyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469981
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
10-(4-Methoxyphenyl)-2-morpholin-4-ylbenzo[g]chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915703; BDBM50200519
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-Morpholin-4-yl-10-phenylbenzo[g]chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3945937; BDBM50200518
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-Acetyl-N-[5-(4-morpholin-4-ylpyrido[3,2-d]pyrimidin-2-yl)pyrimidin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109136; BDBM50495508
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(S)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469059; BDBM50262359
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[5-[3-(2-Hydroxyethylsulfamoyl)-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785694; BDBM50160073
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenol; CHEMBL1241355; J-002258; (6Z)-6-(4-amino-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-ylidene)cyclohexa-2,4-dien-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine; Ibrutinib N-2; Ibrutinib deacryloylpiperidine; MFCD20270360; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-; C17H13N5O; SCHEMBL200349; CHEMBL1242204; BCP08092; CS-M2418; KS-00000A8A; 3209AH; ABP001124; ZINC64527573; AKOS024464512; AKOS032949962; CM11014; DS-7365; AC-28742; AK161694; DA-25126; HY-78727; SC-01281; SY032999; FT-0696694; 4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyri; Z2753057767; 3-(4-phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
(R)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512470; BDBM50262358
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
[3-(4-Morpholin-4-ylpyrido[2,3-d]pyrimidin-2-yl)phenyl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109138; BDBM50495495
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-(1,2,3,4-Tetrahydronaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241440; 3-(1,2,3,4-tetrahydronaphthalen-2-yl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-(4-Morpholin-4-ylpyrido[3,2-d]pyrimidin-2-yl)aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109129; BDBM50495502
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
4-[2-(3-Methoxyphenyl)pyrido[3,2-d]pyrimidin-4-yl]morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109124; BDBM50495503
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-Benzyl-5-morpholin-4-ylthieno[3,2-b]pyran-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322230; SCHEMBL13000064; BDBM50427466
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
4-(2-Pyridin-3-ylpyrido[3,2-d]pyrimidin-4-yl)morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109130; BDBM50495496
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
8-[(2R)-1-(3,5-Difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060768; SCHEMBL13276616; HY-101517; CS-0021620
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
3-(4-Thiomorpholin-4-ylpyrido[3,2-d]pyrimidin-2-yl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109117; BDBM50495506
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-[4-(4,4-Difluoropiperidin-1-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109120; BDBM50495511
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
4-[2-(4-Methoxyphenyl)pyrido[3,2-d]pyrimidin-4-yl]morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109125; BDBM50495493
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-[4-(4-Methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109119; BDBM50495515
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-[4-(1,1-Dioxo-1,4-thiazinan-4-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109118; BDBM50495513
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
5-Morpholin-4-ylthieno[3,2-b]pyran-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322246; SCHEMBL13000098; BDBM50427490
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-[6-[4-(Methylsulfamoyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064488; BDBM50389423
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50118.72 nM
|
[11] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[(1,1-dioxothian-4-yl)methylamino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600784; BDBM50107256
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118.72 nM
|
[12] | |||
| Compound Name |
6-[6-(Methylaminomethyl)pyridin-3-yl]-1,3-benzothiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600686; BDBM50107262
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118.72 nM
|
[12] | |||
| Compound Name |
3-[2-Amino-7-(3-hydroxyphenyl)-4-{[3-(morpholin-4-yl)propyl]amino}pteridin-6-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
aminopteridine derivative, 15; CHEMBL244770; BDBM25092
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[13] | |||
| Compound Name |
3-Amino-7-chloro-1,2,4-benzotriazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-chloro-1,2,4-benzotriazin-3-amine; 1,2,4-Benzotriazine, 3-amino-7-chloro-; MLS002638305; CHEMBL1728139; 7-chlorobenzo[e][1,2,4]triazin-3-amine; NSC13204; LEADIVPROPIONATE; SCHEMBL6366137; CTK8B8932; DTXSID80202580; TQP0605; HMS3078A05; ZINC1683312; 7798AB; ANW-61609; BDBM50356937; MFCD00024044; NSC-13204; AKOS006271763; MB00343; KS-00000I23; AK-38589; DS-12941; SMR001547793; DB-071814; FT-0746900; 1,2,4-BENZOTRIAZIN-3-AMINE, 7-CHLORO-
Click to Show/Hide
|
||||
| Activity |
IC50 = 53000 nM
|
[14] | |||
| Compound Name |
5-(Pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645098; BDBM50333213
Click to Show/Hide
|
||||
| Activity |
IC50 = 55400 nM
|
[15] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[[(1R)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600782; BDBM50107254
Click to Show/Hide
|
||||
| Activity |
IC50 = 63095.73 nM
|
[12] | |||
| Compound Name |
N-[6-(5-Methylsulfonylpyridin-3-Yl)-[1,2,4]triazolo[1,5-A]pyridin-2-Yl]ethanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059907; N-(6-(5-(Methylsulfonyl)pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)acetamide; SCHEMBL3101726; BDBM50387545; Q27456741; N-[6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide; N-{6-[5-(methylsulfonyl)pyridin-3-yl][1,2,4]triazolo[1,5-a]pyridin-2-yl}acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 63095.73 nM
|
[11] | |||
| Compound Name |
5-(Pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645094; 1H-Pyrrolo[2,3-b]pyridine, 5-(4-pyridinyl)-; 5-Pyridin-4-yl-1H-pyrrolo[2,3-b]pyridine; SCHEMBL416750; CTK3C9693; DTXSID10693427; BDBM50333210; ZINC66259733; 5-(4-Pyridinyl)-1H-pyrrolo[2,3-b]pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[15] | |||
| Compound Name |
5-(Pyridin-4-yl)benzo[d]thiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645106; BDBM50333220
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[15] | |||
| Compound Name |
N-(2-Hydroxyethyl)-N-methyl-2-morpholin-4-yl-4-oxo-9-[(1R)-1-phenoxyethyl]pyrido[1,2-a]pyrimidine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318728; BDBM50052809
Click to Show/Hide
|
||||
| Activity |
IC50 = 83000 nM
|
[16] | |||
| Compound Name |
6-Oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-9V1XHG6QRM; 9V1XHG6QRM; 2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile; CHEMBL58782; 1,2-dihydro-2-oxo-5-(4-pyridinyl)-nicotinonitrile; 6-Odbcn; Inamrinone nitrile [USP]; SCHEMBL7281879; DTXSID70159918; (N-(1,6-Dihydro-6-oxo-(3,4'-bipyridine)-5-carbonitrile); ZINC155538; BDBM50024966; Inamrinone related compound C [USP]; AKOS022645570; MCULE-1980235207; 5-cyano[3,4'-bipyridin]-6(1H)-one; Inamrinone related compound C [USP-RS]; 5-cyano-[3,4'-bipyridin]-6(1H)-one; ST50999862; 2-oxo-5-(4-pyridyl)hydropyridine-3-carbonitrile; 1,6-Dihydro-6-oxo-3,4'-bipyridine-5-carbonitrile; 6-Oxo-1,6-dihydro-(3,4'-bipyridine)-5-carbonitrile; 6-Oxo-1,6-dihydro-[3,4'']bipyridinyl-5-carbonitrile; [3,4'-Bipyridine]-5-carbonitrile,1,6-dihydro-6-oxo-, hydrobromide (1:1)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[15] | |||
| Compound Name |
2-(Pyridin-4-yl)benzo[d]oxazol-5-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645096; BDBM50333212; ZINC16431343; AKOS003232867; 2-(PYRIDIN-4-YL)-1,3-BENZOXAZOL-5-OL
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[15] | |||
| Compound Name |
7-(4-Morpholinyl)pyrimido[4,5-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645103; Maybridge4_002088; HMS1526O20; ZINC129802; BDBM50333218; CCG-239477; MCULE-3865101773; NCGC00176934-01; 7-morpholinopyrimido[4,5-d]pyrimidin-4-amine; AO-476/43362687; SR-01000003667; SR-01000003667-1; BRD-K34291222-001-01-0
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[15] | |||
| Compound Name |
4-(1H-Pyrazolo[3,4-b]pyridin-4-yl)morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645101; BDBM50333216
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[15] | |||
| Compound Name |
2-Pyridin-4-yl-benzooxazol-5-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(pyridin-4-yl)-1,3-benzoxazol-5-amine; 2-(pyridin-4-yl)benzo[d]oxazol-5-amine; 2-pyridin-4-yl-1,3-benzoxazol-5-amine; CHEMBL1645099; 2-(4-pyridyl)benzoxazole-5-ylamine; Oprea1_262137; CBDivE_012963; SCHEMBL4076162; CTK4H3354; DTXSID90352904; ZINC155043; ALBB-006224; 2-(4-Pyridinyl)-5-benzoxazolamine; 1121AE; BBL012052; BDBM50333214; MFCD00448006; SBB007305; STK026134; 2-Pyridin-4-ylbenzooxazol-5-yl amine; AKOS000108388; CCG-109259; MCULE-8999136327; VS-03182; 5-amino-2-(pyridine-4-yl)benzo[d]oxazole; 5-amino-2-(pyridine-4-yl) benzo[d]oxazole; BB 0245215; EU-0041953; H2652; ST50024827; SR-01000465976; SR-01000465976-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[15] | |||
| Compound Name |
7-(Morpholin-4-yl)quinazolin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645100; 7-morpholin-4-yl-3H-quinazolin-4-one; SCHEMBL2426171; SCHEMBL14481463; 7-morpholinoquinazolin-4(3H)-one; BDBM50333215; ZINC66252202; 7-morpholin-4-yl-1H-quinazolin-4-one; AS-64125; 4(3H)-Quinazolinone,7-(4-morpholinyl)-; 7-(morpholin-4-yl)-3,4-dihydroquinazolin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[15] | |||
| Compound Name |
4-Methyl-2-morpholin-4-yl-thiazole-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-methyl-2-morpholin-4-yl-1,3-thiazole-5-carboxylic acid; CHEMBL1645102; 4-methyl-2-(morpholin-4-yl)-1,3-thiazole-5-carboxylic acid; 4-methyl-2-morpholinothiazole-5-carboxylic acid; SCHEMBL3328268; CTK7J1372; HMS1700N14; ALBB-010713; ZINC4384363; 1357AF; BBL011825; BDBM50333217; MFCD07643242; SBB050515; STK727317; AKOS000303070; MCULE-7841098545; VS-03060; ST50289548; 5-thiazolecarboxylic acid, 4-methyl-2-(4-morpholinyl)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[15] | |||
| Compound Name |
(9,10-Dihydroxy-4,4,11c-trimethyl-1,2,3,4a,5,6-hexahydronaphtho[2,1-b][1]benzofuran-8-yl)boronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959396; SCHEMBL15278021; BDBM196114; US9206201, AZ
Click to Show/Hide
|
||||
| Activity |
IC50 = 85390 nM
|
[17] | |||
| Compound Name |
8-Ethyl-11-(3-methoxyphenyl)-13-morpholin-4-yl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589320; BDBM50094951
Click to Show/Hide
|
||||
| Activity |
IC50 = 91560 nM
|
[18] | |||
| Compound Name |
6-[2-Hydroxyethyl(naphthalen-1-ylmethyl)amino]-4-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165189; SCHEMBL20288011; BDBM50395802
Click to Show/Hide
|
||||
| Activity |
IC50 = 97400 nM
|
[19] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-morpholinoisonicotinaldehyde
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512311; BDBM50278544
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
6-Methyl-8-(2-methylphenoxy)-2-morpholin-4-yl-1H-quinolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218572
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(3-hydroxypyrrolidin-1-yl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471046; BDBM50278576
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-Morpholinoisonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Morpholin-4-yl-isonicotinic acid; 2-morpholin-4-ylisonicotinic acid; 2-morpholin-4-ylpyridine-4-carboxylic acid; 2-(morpholin-4-yl)pyridine-4-carboxylic acid; 2-(Morpholin-4-yl)isonicotinic Acid; 2-Morpholinopyridine-4-carboxylic acid; 4-PYRIDINECARBOXYLIC ACID, 2-(4-MORPHOLINYL)-; CHEMBL449172; MFCD03411666; 2-(4-morpholinyl)-4-pyridinecarboxylic acid; 2-(4-Morpholinyl)-pyridine-4-carboxylic acid; SCHEMBL1255470; CTK1A1409; DTXSID90376246; 2-(4-Morpholinyl)-isonitinic acid; ALBB-005463; ZINC2524958; 2-(Morpholin-4-yl)isonicotinic aci; ANW-57773; BBL009991; BDBM50278659; SBB014934; STK500353; AKOS000215606; AB14195; AC-2988; MCULE-3415512892; PS-4962; NCGC00337035-01; SC-27349; SY003500; AB0040922; DB-025915; ST4143478; FT-0608684; Y8591; 4-Pyridinecarboxylicacid, 2-(4-morpholinyl)-; 2-morpholin-4-yl-isonicotinic acid, AldrichCPR; Y-0356; AB01330387-02; 349M643; A819950; (PYRROLIDIN-1-YLCARBONOTHIOYL)THIO]ACETICACID; J-510137
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
7-Methyl-9-[(2-methylphenyl)methylamino]-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218574; SCHEMBL3206304; BDBM50093493; ZINC34554298
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
1-Isopropyl-3-(pyrido[3,2-b]pyrazin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241775
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1320032; CHEMBL1241358; 3-(4-nitrophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Tert-Butyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1231371; 1-tert-butyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; NA-PP2; SCHEMBL1964558; 1-tert-butyl-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine; BDBM50345704; NCGC00167637-01; Q27458432; 1-tert-butyl-3-(2-naphthyl)pyrazolo[3,4-d]pyrimidin-4-amine; 4-Amino-1-tert-butyl-3-(2-naphthyl)pyrazolo[3,4-d]pyrimidine; 1-(tert-butyl)-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3)
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616915; CHEMBL1241391; US9765037, Compound 18; BDBM340891; 1-propan-2-yl-3-pyrimidin-5-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-((1H-Indazol-3-yl)ethynyl)aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631888; SCHEMBL12269728; BDBM50333031; ZINC66263421
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
1-Isopropyl-3-(isoquinolin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242207
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(2-Chloroquinolin-3-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242663
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Methyl-3-(4-phenylmethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL130425; CHEMBL1242206
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Ethyl 2-morpholinoisonicotinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450243; 2-(4-morpholinyl)-4-Pyridinecarboxylic acid ethyl ester; Ethyl 2-morpholin-4-ylpyridine-4-carboxylate; Ethyl 2-morpholinopyridine-4-carboxylate; DTXSID20376597; BDBM50278660; MFCD04114261; ZINC33369609; AS-31386; DB-077243; FT-0747321; 2-morpholin-4-ylisonicotinic acid ethyl ester; 2-morpholin-4-yl-isonicotinic acid ethyl ester; A-2241; 2-(4-morpholinyl)pyridine-4-carboxylic acid ethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(Bis(2-hydroxyethyl)amino)-6-((4-fluoro-2-methylphenylamino)methyl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469807; BDBM50278579
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-(1-Isopropyl-4-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241942
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242660; SCHEMBL3602391; BDBM50345734; 1-propan-2-yl-3-(3,4,5-trimethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(piperazin-1-yl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469797; BDBM50278546
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241864
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(H-Imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242665
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(2,3-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3613209; CHEMBL1242751; 3-(2,3-dimethoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Methyl-3-(3-phenylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242849
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(2-hydroxyethylamino)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469806; BDBM50278578
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[7-Methyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064566; BDBM50389416
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(piperidin-1-yl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470001; BDBM50278547
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-((2-hydroxyethyl)(methyl)amino)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512487; BDBM50278577
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenylamino)propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3605044; CHEMBL1241486; 2-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyanilino]propan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-Chloro-6-((4-fluoro-2-methylphenylamino)methyl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502174; BDBM50278656
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(4-hydroxyphenyl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470639; BDBM50278615
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
(2-((4-Fluoro-2-methylphenylamino)methyl)-6-morpholinopyridin-4-yl)methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512309; BDBM50278543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-(3-(2,6-Dichlorobenzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242292; 3-[3-[(2,6-dichlorophenyl)methoxy]phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
8-Methyl-7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-morpholin-4-yl-1,3-benzoxazin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL244672; BDBM50401468
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(pyrrolidin-1-yl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471045; BDBM50278575
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241863
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-N-(2-hydroxyethyl)-6-(2-hydroxyethylamino)isonicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470855; BDBM50278657
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[6-[3-(Benzylsulfamoyl)-4-methoxyphenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062546; BDBM50389402
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
3-(3-Phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242205
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-((4-Fluoro-2-methylphenylamino)methyl)-2,3''-bipyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470638; BDBM50278614
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(S)-2-Amino-1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-3-phenylpropan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322664; MIPS-9922; SCHEMBL15582980; BDBM50426450
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[22] | |||
| Compound Name |
N-[6-(4-Methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064487; BDBM50389399
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2-((4-Fluoro-2-methylphenylamino)methyl)-6-(3-hydroxypyrrolidin-1-yl)pyridin-4-yl)(3-hydroxypyrrolidin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471057; BDBM50278658
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-((1H-Indazol-3-yl)ethynyl)aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631895; SCHEMBL12269751; BDBM50333024; ZINC66263695
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
3-(4-Biphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5065122; CHEMBL1242850; 3-(4-phenylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-(5-Methylsulfonylpyridin-3-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064568; BDBM50389418
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241482
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(2-hydroxyphenyl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470853; BDBM50278617
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
6-(Benzyloxy)-5-methoxy-1H-indole-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-Benzyloxy-5-methoxyindole-2-carboxylic acid; CHEMBL37880; 6-Benzyloxy-5-methoxy-1H-indole-2-carboxylic acid; MFCD00055977; 5-methoxy-6-phenylmethoxy-1H-indole-2-carboxylic acid; 1H-Indole-2-carboxylicacid, 5-methoxy-6-(phenylmethoxy)-; NSC92530; SCHEMBL3243291; CTK1A3591; DTXSID80293832; ZINC402728; BDBM50407310; NSC 92530; NSC-92530; 6-Benzyloxy-5-methoxy-2-carboxyindole; Indole, 6-benzyloxy-2-carboxy-5-methoxy-; FT-0620960; J-015750; 5-Methoxy-6-(benzyloxy)-1H-indole-2-carboxylic acid; 6-(Benzyloxy)-5-methoxy-1H-indole-2-carboxylic acid #; 6-Benzyloxy-5-methoxy-2-carboxyindole, >=99%, powder; 1H-Indole-2-carboxylic acid, 5-methoxy-6-(phenylmethoxy)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[23] | |||
| Compound Name |
8-Ethyl-11-(4-methoxyphenyl)-13-morpholin-4-yl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589321; BDBM50094952
Click to Show/Hide
|
||||
| Activity |
IC50 = 125800 nM
|
[18] | |||
| Compound Name |
3-(4-Butoxy-3-methoxyphenyl)pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325885; NSC55853; NCIOpen2_007659; CTK5C4166; DTXSID60288443; ZINC1686407; BDBM50054880; NSC-55853
Click to Show/Hide
|
||||
| Activity |
IC50 = 134000 nM
|
[23] | |||
| Compound Name |
3-Morpholin-4-yl-2-(7H-purin-6-ylsulfanylmethyl)quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3326779; SCHEMBL735069; BDBM50054923
Click to Show/Hide
|
||||
| Activity |
IC50 = 137900 nM
|
[23] | |||
| Compound Name |
3-(2-Chlorophenyl)-7-fluoro-2-(7H-purin-6-ylsulfanylmethyl)quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3326774; SCHEMBL732732; BDBM50054942; 3-(2-Chlorophenyl)-7-fluoro-2-(9H-purin-6-ylsulfanylmethyl)-3H-quinazolin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 145200 nM
|
[23] | |||
| Compound Name |
6-Bromoimidazo[1,2-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Amino-6-bromoimidazo[1,2-a]pyridine; 6-BROMO-IMIDAZO[1,2-A]PYRIDIN-2-AMINE; CHEMBL1916042; MFCD09864902; SCHEMBL1303123; CTK5I8290; DTXSID20657131; KS-00000A4X; ANW-66519; BDBM50356931; SBB052070; ZINC54957303; AKOS015899232; PS-4827; SB10149; AK-40992; CS-11263; SY012618; 6-bromo-imidazo[1,2-a]pyridin-2-ylamine; AB0051758; DB-080008; CS-0040344; FT-0723504; V9459; W-4268; 6-bromo-4-hydroimidazo[1,2-a]pyridine-2-ylamine; F1967-5697
Click to Show/Hide
|
||||
| Activity |
IC50 = 156000 nM
|
[14] | |||
| Compound Name |
2,2'-((3-Chlorophenyl)methylene)bis(sulfanediyl)dibenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325886; NSC73890; ZINC1699348; BDBM50054900; NSC-73890
Click to Show/Hide
|
||||
| Activity |
IC50 = 187000 nM
|
[23] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[[(1S)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600783; BDBM50107255
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 199526.23 nM
|
[12] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 30 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID28870136-Compound-48
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 = 800000 nM
|
[3] | |||
| Compound Name |
PMID28870136-Compound-52
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 = 1000000 nM
|
[3] | |||
| Compound Name |
CGP-029482
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CGP-029482; CHEMBL92361; (5-OXO-5,6-DIHYDRO-INDOLO[1,2-A]QUINAZOLIN-7-YL)-ACETIC ACID; (5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid; IQA; 1om1; AC1L9L3Y; SCHEMBL263731; BDBM11319; MolPort-006-167-937; HMS3229D05; ZINC2047511; CGP029482; AKOS005266257; DB01765; {5-oxo-6H-indolo[1,2-a]quinazolin-7-yl}acetic acid; 2-(5-oxo-6H-indolo[1,2-a]quinazolin-7-yl)acetic acid; [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[24] | |||
| Compound Name |
3-Butyl-2-(7H-purin-6-ylsulfanylmethyl)quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3326778; SCHEMBL735091; SCHEMBL18526813; BDBM50054929
Click to Show/Hide
|
||||
| Activity |
IC50 = 217800 nM
|
[23] | |||
| Compound Name |
4-(1,3-Benzodioxol-5-yl)-2-(3,4-dimethoxyphenyl)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC157111; MLS003106453; CHEMBL3325887; NSC 157111; CTK1D7400; BDBM50054901; NSC-157111; SMR001821356; 4-(Benzo[d][1,4-dimethoxyphenyl)-4-oxobutanoic acid; 4-(1,3-benzodioxol-5-yl)-2-(3,4-dimethoxyphenyl)-4-oxo-butanoic acid; 4-(Benzo[d][1,3]dioxol-5-yl)-2-(3,4-dimethoxyphenyl)-4-oxobutanoic acid; 4-benzo[1,3]dioxol-5-yl-2-(3,4-dimethoxyphenyl)-4-oxo-butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 234000 nM
|
[23] | |||
| Compound Name |
4-{5-Oxo-3-pentadecyl-4-[(e)-phenyldiazenyl]-4,5-dihydro-1h-pyrazol-1-yl}benzenesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945352; NSC119884; CTK6D9534; BDBM50054902; NSC-119884
Click to Show/Hide
|
||||
| Activity |
IC50 = 241000 nM
|
[23] | |||
| Compound Name |
n,o-Bis[(benzyloxy)carbonyl]tyrosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325888; NSC97954; N,O-BIS(BENZYLOXYCARBONYL)-L-TYROSINE; CBMicro_012863; Oprea1_308568; SCHEMBL9636970; DTXSID40294764; SMSF0010709; BDBM50054913; NSC-97954; NSC333725; AKOS000287891; AKOS024431630; CB01575; MCULE-4309791482; NSC-333725; N,O-BIS(CARBOBENZYLOXY)DL-TYROSINE; BIM-0012998.P001; DS-004364; 2-phenylmethoxycarbonylamino-3-(4-phenylmethoxycarbonyloxyphenyl)propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 324000 nM
|
[23] | |||
| Compound Name |
11-(4-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589323; BDBM50094954
Click to Show/Hide
|
||||
| Activity |
IC50 = 345900 nM
|
[18] | |||
| Compound Name |
2-Amino-6-chlorobenzoxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-Chlorobenzo[d]oxazol-2-amine; 6-chloro-1,3-benzoxazol-2-amine; 2-Benzoxazolamine, 6-chloro-; 6-Chloro-2-benzoxazolamine; BENZOXAZOLE, 2-AMINO-6-CHLORO-; MLS002639031; CHEMBL1889525; MFCD01664218; NSC 24991; NSC24991; PubChem21894; cid_40237; SCHEMBL9896463; 6-Chloro-benzooxazol-2-ylamine; CTK3I9341; 2-Amino-6-chlorobenzo[d]oxazole; DTXSID60200125; Ethyl7-Bromoindole-2-Carboxylate; HMS3093D21; ALBB-016547; EBD35906; KS-00000A1Z; ZINC8614805; ANW-58324; BBL000397; BDBM50356932; NSC-24991; STK802945; 6-chloranyl-1,3-benzoxazol-2-amine; 2-Benzoxazolamine, 6-chloro- (9CI); AKOS000114286; AB09701; MCULE-1635125426; AK-82490; AS-31528; SC-29268; SMR001548487; SY005591; AB0057092; DB-027791; BB 0244038; FT-0655153; V6371; K-9543; A828931
Click to Show/Hide
|
||||
| Activity |
IC50 = 380000 nM
|
[14] | |||
| Compound Name |
2-Propan-2-ylpyrazolo[1,5-a]pyrimidine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916044; BDBM50356935
Click to Show/Hide
|
||||
| Activity |
IC50 = 395000 nM
|
[14] | |||
| Compound Name |
11-(3-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589322; BDBM50094953
Click to Show/Hide
|
||||
| Activity |
IC50 = 465500 nM
|
[18] | |||
| Compound Name |
(2S)-4-(1,3-Benzodioxol-5-yl)-4-oxo-2-[(3,4,5-trimethoxyphenyl)methyl]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325972; ZINC2048231; BDBM50054916
Click to Show/Hide
|
||||
| Activity |
IC50 = 575000 nM
|
[23] | |||
| Compound Name |
{2-[(3-Ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-4-nitrophenoxy}acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325973; DTXSID40421811; ZINC8618735; BDBM50055037
Click to Show/Hide
|
||||
| Activity |
IC50 = 612000 nM
|
[23] | |||
| Compound Name |
2-Methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916045; SCHEMBL10556141; BDBM50356936
Click to Show/Hide
|
||||
| Activity |
IC50 = 773000 nM
|
[14] | |||
| Compound Name |
13-Morpholin-4-yl-11-(morpholin-4-ylmethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589373; BDBM50094944
Click to Show/Hide
|
||||
| Activity |
IC50 = 781500 nM
|
[18] | |||
| Compound Name |
5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916048; 5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-2-ylamine; 5,7-dimethyl-8-hydropyrazolo[1,5-a]pyrimidine-2-ylamine; SCHEMBL10002464; CTK8C2221; DTXSID10650873; 8098AA; ANW-68037; BDBM50356938; MFCD09055316; SBB027008; STK510379; ZINC19089919; AKOS005169056; HR-0333; MCULE-2873219020; DA-18696; CS-0080336; FT-0744206; ST45055050; Y-5140; Pyrazolo[1,5-a]pyrimidin-2-amine, 5,7-dimethyl-; Q27467503; 5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-amine, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 = 915000 nM
|
[14] | |||
| Compound Name |
13-Morpholin-4-yl-11-(1-morpholin-4-ylethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589374; BDBM50094945
Click to Show/Hide
|
||||
| Activity |
IC50 = 967700 nM
|
[18] | |||
| Compound Name |
7-(4-Ethoxyanilino)-4-hydroxynaphthalene-2-sulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325974; NSC37190; CTK6G2135; ZINC1669808; BDBM50055038; NSC-37190; 7-(4-Ethoxyphenylamino)-4-hydroxynaphthalene-2-sulfonic acid; 7-[(4-ethoxyphenyl)amino]-4-hydroxynaphthalene-2-sulfonic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 992000 nM
|
[23] | |||
| Compound Name |
4-[(4-Carboxy-2,5-dimethyl-phenyl)disulfanyl]-2,5-dimethyl-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC-121513; NSC121513; CHEMBL332892; CTK7I6682; ZINC1710868; BDBM50055039; 4,4'-Dithiobis(2,5-dimethylbenzoic acid); benzoic acid, 4,4'-dithiobis[2,5-dimethyl-
Click to Show/Hide
|
||||
| Activity |
IC50 = 1460000 nM
|
[23] | |||
| Compound Name |
5-(2-Chlorophenylazo)-6-hydroxy-2-naphthalenesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2008490; ZINC4804124; BDBM50055040; ZINC104366654; NCI60_004057; 1-(4'-chloro-phenylazo)-2-naphthol-6-sulfonic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 1498000 nM
|
[23] | |||
| Compound Name |
2-(7-Oxobenzo[a]phenalen-3-yl)sulfinylacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC16211; NSC-16211; CHEMBL1162521; ((7-oxo-7H-benzo[de]anthracen-3-yl)sulfinyl)acetic acid; [(7-oxo-7h-benzo[de]anthracen-3-yl)sulfinyl]acetic acid; NCIStruc1_001245; NCIStruc2_000746; BDBM25460; CTK7J5612; benzanthrone-3-sulphinylacetic acid; NCI16211; BDBM50055034; NCGC00013211; NCGC00013211-02; NCGC00096332-01; NCI60_001208; 2-[(4-oxo-4H-triphenylene-11-)sulfinyl]acetic acid; 2-(7-Oxo-7H-benzo[de]anthracen-3-ylsulfinyl)acetic acid; Acetic acid, [(7-oxo-7H-benz[de]anthracen-3-yl)sulfinyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 = 1570000 nM
|
[23] | |||
| Compound Name |
5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine; 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine; 5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine; MLS002703920; CHEMBL1887078; 5,7-dimethyl-8-hydro-1,2,4-triazolo[1,5-a]pyrimidine-2-ylamine; NSC106484; Cambridge id 5140662; Oprea1_451097; Oprea1_482759; SCHEMBL10558826; CTK2I0074; DTXSID60295950; ALBB-005408; 8586AE; BBL009835; BDBM50356933; MFCD00227025; SBB015167; STK249780; ZINC17420493; AKOS000271018; CA-0724; MCULE-4378413433; NSC-106484; SDCCGMLS-0065574.P001; KS-000023M7; SMR001330305; ST063243; BB 0237715; EU-0083594; EN300-04541; W-6715; SR-01000388967; 2-Amino-5,7-dimethyl-S-triazolo[1,5-a]pyrimidine; J-516566; SR-01000388967-1; Z57039689; 2-Amino-5,7-dimethyl-1,2,4-triazolo(1,5-a)pyrimidine; 5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidine-2-amine; F1415-0068; [1,2,4]Triazolo[1,5-a]pyrimidine, 2-amino-5,7-dimethyl-; 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2 -ylamine; 5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine #; 2,4-dimethyl-1,5,7,9-tetrazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-amine; 5-chloro-N-(3-fluoro-4-methoxyphenyl)-3-methoxy-1-benzothiophene-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1600000 nM
|
[14] | |||
| Compound Name |
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-chloro-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine; [1,2,4]Triazolo[1,5-a]pyrimidine, 7-chloro-5-methyl-; CHEMBL1916043; 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE; 7-chloro-5-methyl-8-hydro-1,2,4-triazolo[1,5-a]pyrimidine; SCHEMBL864946; CS-WAA0102; CTK4F3624; DTXSID00334256; HMS1729H08; ZINC390840; S-2-N-BOC-propane-1,2-diamine; ANW-50608; BDBM50356934; MFCD00227619; SBB078190; STK387226; AKOS000122956; AB04989; CS-W022537; MCULE-1390492801; WT82306; AK-25032; BR-25032; BS-13379; AB0023686; 4-Chloro-6-methyl-1,3,3a,7-tetrazaindene; AM20090272; FT-0647833; ST50544458; W4797; EN300-12045; S-5783; A817293; 5-Methyl-7-chloro[1,2,4]triazolo[1,5-a]pyrimidine; [1,2,4]Triazolo[1,5-a]pyrimidine,7-chloro-5-methyl-; 5-methyl-7-chloro-1,2,4-triazolo[ 1,5-a]pyrimidine; 7-chloranyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine; F1904-0010
Click to Show/Hide
|
||||
| Activity |
IC50 > 1670000 nM
|
[14] | |||
| Compound Name |
6-Hydroxy-5-[[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]diazenyl]naphthalene-2-sulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325975; ZINC4758272; BDBM50055035; ZINC18125463; ZINC104389113; ZINC104389118
Click to Show/Hide
|
||||
| Activity |
IC50 = 2415000 nM
|
[23] | |||
| Compound Name |
6-Hydroxy-5-[[2-methoxy-4-[(4-sulfophenyl)diazenyl]phenyl]diazenyl]naphthalene-2-sulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325976; SCHEMBL14418550; ZINC4758269; BDBM50055036; ZINC104389068; ZINC104389073; ZINC104389077
Click to Show/Hide
|
||||
| Activity |
IC50 = 2437000 nM
|
[23] | |||
| Compound Name |
6-(6-Methoxynaphthalen-2-yl)-2-methyl-6-oxohexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325977; NSC61898; CTK7A8170; BDBM50055027; NSC-61898
Click to Show/Hide
|
||||
| Activity |
IC50 = 5184000 nM
|
[23] | |||
| Compound Name |
3-[4-(Benzyloxy)-3-methoxyphenyl]pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325978; NSC405857; CTK2I0956; DTXSID10324143; ZINC1598799; BDBM50054950; NSC-405857; Pentanedioic acid, 3-[3-methoxy-4-(phenylmethoxy)phenyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 = 5876000 nM
|
[23] | |||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS002706500; CHEMBL1885254; NSC113039; SCHEMBL12635172; CTK7A7233; BDBM50054954; AKOS024428611; MCULE-1359806428; NSC-113039; SMR001573905
Click to Show/Hide
|
||||
| Activity |
IC50 = 6074000 nM
|
[23] | |||
| Compound Name |
3-(2,3,10,11-Tetramethoxyisoquinolino[2,1-b]isoquinolin-7-ium-8-yl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325979; ZINC1732790; BDBM50054956
Click to Show/Hide
|
||||
| Activity |
IC50 = 7333000 nM
|
[23] | |||
| Compound Name |
5-Chloro-2-[2-[3-[(3-fluorosulfonylphenyl)carbamoylamino]anilino]-2-oxoethoxy]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325980; NSC211899; DTXSID80309402; BDBM50054958; ZINC104170663; NSC-211899
Click to Show/Hide
|
||||
| Activity |
IC50 = 9157000 nM
|
[23] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. | ||||
| REF 2 | PI3K and PI3K as targets for autoimmune and inflammatory diseases. J Med Chem. 2012 Oct 25;55(20):8559-81. | ||||
| REF 3 | Small molecules targeting phosphoinositide 3-kinases. Medchemcomm. 2012;3:1337-55. | ||||
| REF 4 | 4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4316-20. | ||||
| REF 5 | Exploring the PI3K alpha and gamma binding sites with 2,6-disubstituted isonicotinic derivatives. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2215-9. | ||||
| REF 6 | Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5534-5538. | ||||
| REF 7 | Design, synthesis, and biological activity of pyridopyrimidine scaffolds as novel PI3K/mTOR dual inhibitors. J Med Chem. 2014 Feb 13;57(3):613-31. | ||||
| REF 8 | Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III. J Med Chem. 2016 Mar 10;59(5):1830-9. | ||||
| REF 9 | Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors. J Med Chem. 2013 Mar 14;56(5):1922-39. | ||||
| REF 10 | Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3K/ inhibitors for the treatment of PTEN-deficient tumours. Bioorg Med Chem Lett. 2017 May 1;27(9):1949-1954. | ||||
| REF 11 | SAR studies around a series of triazolopyridines as potent and selective PI3K inhibitors. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5257-63. | ||||
| REF 12 | Discovery of potent, selective small molecule inhibitors of alpha-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIalpha). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3189-93. | ||||
| REF 13 | Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. J Med Chem. 2007 Sep 6;50(18):4279-94. | ||||
| REF 14 | Fragment based discovery of a novel and selective PI3 kinase inhibitor. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6586-90. | ||||
| REF 15 | Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening. Bioorg Med Chem Lett. 2011 Jan 15;21(2):829-35. | ||||
| REF 16 | Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as oral PI3K inhibitors, useful as antiplatelet agents. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3936-43. | ||||
| REF 17 | US patent application no. 9206201B2, Boronic acid bearing liphagane compounds as inhibitors of P13K-alpha and/or beta | ||||
| REF 18 | Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kalpha inhibitors. Eur J Med Chem. 2015 Jun 24;99:1-13. | ||||
| REF 19 | Discovery of phosphoinositide 3-kinases (PI3K) p110 isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6671-6. | ||||
| REF 20 | Design, synthesis, and structure-activity relationships of 3-ethynyl-1H-indazoles as inhibitors of the phosphatidylinositol 3-kinase signaling pathway. J Med Chem. 2010 Dec 9;53(23):8368-75. | ||||
| REF 21 | Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines. Eur J Med Chem. 2012 Nov;57:85-101. | ||||
| REF 22 | L-Aminoacyl-triazine derivatives are isoform-selective PI3K inhibitors that target non-conserved Asp862 of PI3K. ACS Med Chem Lett. 2013 Feb 14;4(2):206-210. | ||||
| REF 23 | Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3K) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis. Eur J Med Chem. 2014 Sep 12;84:454-65. | ||||
| REF 24 | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). Biochem J. 2003 Sep 15;374(Pt 3):639-46. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.