Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97196 | Target Info | |||
| Target Name | ATM serine/threonine kinase (ATM) | ||||
| Synonyms |
Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
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| Target Type | Clinical trial Target | ||||
| Gene Name | ATM | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 18 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
LY294002
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Phase 1 | Compound Info | ||
| Synonyms |
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 154447-36-6; LY 294002; LY-294002; 2-morpholino-8-phenyl-4H-chromen-4-one; 2-morpholin-4-yl-8-phenyl-4H-chromen-4-one; UNII-31M2U1DVID; LY-294,002; 2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one; 31M2U1DVID; 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE; CHEMBL98350; 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-; CHEBI:65329; 2-morpholino-8-phenyl-chromen-4-one; AK162301; 2-(morpholin-4-yl)-8-phenylchromen-4-one; LY2; 15447-36-6; IN1266; IN1268; Lys 294002; BMK1-D5; H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI); 2-(4-Morpholino)-8-phenyl-4H-1-benzopyran-4-one; 2-morpholin-4-yl-8-phenylchromen-4-one; 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl; 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI); 8-Phenyl-2-(morpholin-4-yl)-chromen-4-one; 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
PMID28870136-Compound-52
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Patented | Compound Info | ||
| Activity |
IC50 = 200000 nM
|
[2] | |||
| Compound Name |
2-(2-aminophenyl)-6-morpholino-4H-pyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL375346; 2-(2-aminophenyl)-6-morpholino-4H-pyran-4-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222180; 3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzoic acid; SCHEMBL13435565
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-morpholino-6-(naphthalen-1-yl)-4H-pyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL225608; 2-morpholino-6-(naphthalen-1-yl)-4H-pyran-4-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
Compound 401; 168425-64-7; 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one; 2-(morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one; CHEMBL179242; 2-(4-MORPHOLINYL)-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE; Compound401; 2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one; SCHEMBL10092321; KS-00001DEG; CTK4D2994; DTXSID20434626; MolPort-023-276-726; HMS3229D15; EX-A1016; BCP04303; BDBM50159620; ZINC13608047; AKOS016369524; CS-5624; NCGC00378805-02; HY-19341; KB-224235; M2537; B7337; S-7713; J-010456
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
2-(Morpholin-4-yl)-benzo[h]chromen-4-one; 154447-35-5; NU7026; NU 7026; DNA-PK Inhibitor II; NU-7026; 2-morpholino-4H-benzo[h]chromen-4-one; LY293646; LY-293646; 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one; 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one; CHEMBL104468; AK186905; DNA-Dependent Protein Kinase Inhibitor II; 2-morpholin-4-ylbenzo[h]chromen-4-one; SCHEMBL610237; ZINC9230; GTPL5959; KS-00000XHI; CTK0E7833; CHEBI:92165; DTXSID10432010; AOB2835; MolPort-009-019-548; HMS3229C11; EX-A1100; BCP04736; IN1364; s2893
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL435507; 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one; SCHEMBL3545107
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
NU-7432
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Investigative | Compound Info | ||
| Synonyms |
NU-7441
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
2-Morpholino-6-(4-(trifluoromethoxy)phenyl)-4H-pyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221412; BDBM50208546
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(3-(6-Morpholino-4-oxo-4H-pyran-2-yl)benzyl)isoindoline-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL373699; BDBM50208532
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl 3-amino-4-(6-morpholino-4-oxo-4H-pyran-2-yl)benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL224782; BDBM50208497
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(6-Morpholino-4-oxo-4H-pyran-2-yl)-1-naphthaldehyde
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223382; BDBM50208503
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(4-(Benzyloxy)phenyl)-6-morpholino-4H-pyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL225796; SCHEMBL9200525; BDBM50208533; 2-morpholin-4-yl-6-(4-phenylmethoxyphenyl)pyran-4-one
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
Benzyl 4-(6-morpholino-4-oxo-4H-pyran-2-yl)phenylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222179; BDBM50208537
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-Morpholino-6-(3-(trifluoromethoxy)phenyl)-4H-pyran-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL222766; BDBM50208502
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Benzyl 4-(6-morpholino-4-oxo-4H-pyran-2-yl)benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL222815; BDBM50208515
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(4-(6-Morpholino-4-oxo-4H-pyran-2-yl)benzyl)isoindoline-1,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374290; BDBM50208494
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Schisandrin B
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|
Investigative | Compound Info | ||
| Synonyms |
Schizandrin B; CHEMBL479488; Schizandrin-B;Wuweizisu-B;gamma-Schisandrin; Schizandrin-B; Gamma-Schisandrin ,(S); SCHEMBL3380716; CTK8D7637; DTXSID60976772; HMS3652I13; BCP30085; HY-N0089; BDBM50341711; AKOS015897166; CCG-208607; CS-3659; MCULE-2402982355; NCGC00163663-01; SC-49964; DB-050290; DB-055235; FT-0775855; V1533; Schisandrin B; Wuweizisu-B; gamma-Schisandrin; 281S376; SR-05000002175; Q-100707; SR-05000002175-2
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| Activity |
IC50 = 1740000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. | ||||
| REF 2 | Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem. 2011 Apr 14;54(7):2320-30. | ||||
| REF 3 | Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. | ||||
| REF 4 | Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7. | ||||
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