Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T02259 Target Info
Target Name Runt-related transcription factor 2 (RUNX2)
Synonyms SL3/AKV core-binding factor alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha Asubunit; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2A; PEBP2-alpha A; PEA2-alpha A; Osteoblast-specific transcription factor 2; Oncogene AML-3; OSF2; OSF-2; Core-binding factor subunit alpha-1; CBFA1; CBF-alpha-1; Acute myeloid leukemia 3 protein; AML3
Target Type Literature-reported Target
Gene Name RUNX2
UniProt ID
RUNX2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Plicamycin Ligand Info
Structure Description Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC PDB:6VGG
Method X-ray diffraction Resolution 4.31 Å Mutation No [1]
PDB Sequence
AELVRTDSPN
120
FLCSVLPSHW
130
RCNKTLPVAF
140
KVVALGEVPD
150
GTVVTVMAGN
160

DENYSAELRN
170
ASAVMKNQVA
180
RFNDLRFVGR
190
SGRGKSFTLT
200
ITVFTNPPQV
210

ATYHRAIKVT
220
VDGPREP
Residue
Distance (Å)
THR135
3.002
ASP184
3.401
Residue
Distance (Å)
ARG186
3.059
References  Top
REF 1 Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure. 2021 May 6;29(5):404-412.e4.

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