Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T06671 Target Info
Target Name Interleukin-18 (IL18)
Synonyms Interleukin-1 gamma; Interferon-gamma inducing factor; Interferon gamma-inducing factor; Iboctadekin; IL1F4; IL-18; IL-1 gamma; IGIF; IFN-gamma-inducing factor
Target Type Clinical trial Target
Gene Name IL18
Biochemical Class Cytokine: interleukin
UniProt ID
IL18_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Chaps Ligand Info
Structure Description Crystal structure of human interleukin-18 PDB:3WO2
Method X-ray diffraction Resolution 2.33 Å Mutation No [1]
PDB Sequence
YFGKLESKLS
10
VIRNLNDQVL
20
FIDQGNRPLF
30
EDMTDSDCRD
40
NAPRTIFIIS
50

MYKDSQPRGM
60
AVTISVKCEK
70
ISTLSCENKI
80
ISFKEMNPPD
90
NIKDTKSDII
100

FFQRSVPGHD
110
NKMQFESSSY
120
EGYFLACEKE
130
RDLFKLILKK
140
EDELGDRSIM
150

FTVQNED
Residue
Distance (Å)
LYS4
3.698
SER7
3.383
LYS8
4.595
LEU9
3.804
SER10
4.369
VAL11
3.874
ARG13
4.359
ASP35
3.508
CYS38
3.739
ARG39
4.024
ASP40
4.978
ALA42
3.913
Residue
Distance (Å)
PRO43
3.692
THR45
4.590
ILE46
3.858
ILE48
3.678
LYS67
3.302
ILE71
3.088
ASN87
3.728
PRO88
3.722
GLN154
3.000
ASN155
3.432
GLU156
3.319
ASP157
4.142
References  Top
REF 1 The structural basis for receptor recognition of human interleukin-18. Nat Commun. 2014 Dec 15;5:5340.

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