Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T19579 | Target Info | |||
| Target Name | Interleukin 2 receptor beta (IL2RB) | ||||
| Synonyms | P70-75; Interleukin-2 receptor subunit beta; Interleukin-15 receptor subunit beta; IL15RB; IL-2RB; IL-2R subunit beta; IL-2 receptor subunit beta; IL-2 receptor; High affinity IL-2 receptor subunit beta; CD122 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | IL2RB | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Alpha-D-Mannose | Ligand Info | |||||
| Structure Description | Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor | PDB:5M5E | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
SQFTCFYNSR
15 ANISCVWSQD25 GALQDTSCQV35 HAWPDRRRWN45 QTCELLPVSQ55 ASWACNLILG 65 APDSQKLTTV75 DIVTLRVLCR85 EGVRWRVMAI95 QDFKPFENLR105 LMAPISLQVV 115 HVETHRCNIS125 WEISQASHYF135 ERHLEFEART145 LSPGHTWEEA155 PLLTLKQKQE 165 WICLETLTPD175 TQYEFQVRVK185 PLQGEFTTWS195 PWSQPLAFRT205 KPA |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines. Oncoimmunology. 2017 Jan 11;6(3):e1277306. | ||||
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