Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T26203 Target Info
Target Name Intercellular adhesion molecule ICAM-1 (ICAM1)
Synonyms Major group rhinovirus receptor; Intercellular adhesion molecule 1; ICAM-1; CD54
Target Type Successful Target
Gene Name ICAM1
Biochemical Class Immunoglobulin
UniProt ID
ICAM1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Myo-inositol hexaphosphate Ligand Info
Structure Description The DBLb domain of PF11_0521 PfEMP1 bound to human ICAM-1 PDB:5MZA
Method X-ray diffraction Resolution 2.78 Å Mutation No [1]
PDB Sequence
QTSVSPSKVI
10
LPRGGSVLVT
20
CSTSCDQPKL
30
LGIETPLPKK
40
ELLLPGNNRK
50

VYELSNVQED
60
SQPMCYSNCP
70
DGQSTAKTFL
80
TVYWTPERVE
90
LAPLPSWQPV
100

GKNLTLRCQV
110
EGGAPRANLT
120
VVLLRGEKEL
130
KREPAVGEPA
140
EVTTTVLVRR
150

DHHGANFSCR
160
TELDLRPQGL
170
ELFENTSAPY
180
QLQTFG
Residue
Distance (Å)
ARG125
2.843
LYS128
2.755
Residue
Distance (Å)
ARG149
2.835
HIS152
3.207
References  Top
REF 1 Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria. Cell Host Microbe. 2017 Mar 8;21(3):403-414.

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