Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32247 | Target Info | |||
| Target Name | Calcitonin receptor (CALCR) | ||||
| Synonyms | CT-R | ||||
| Target Type | Successful Target | ||||
| Gene Name | CALCR | ||||
| Biochemical Class | GPCR secretin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (2s)-2-{[(1r)-1-Hydroxyhexadecyl]oxy}-3-{[(1r)-1-Hydroxyoctadecyl]oxy}propyl 2-(Trimethylammonio)ethyl Phosphate | Ligand Info | |||||
| Structure Description | Calcitonin Receptor in complex with Gs and salmon calcitonin peptide | PDB:7TYN | ||||
| Method | Electron microscopy | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
KPFLYVVGRK
46 KMMDAQYKCY56 DRMQQLPAYQ66 GEGPYCNRTW76 DGWLCWDDTP86 AGVLSYQFCP 96 DYFPDFDPSE106 KVTKYCDEKG116 VWFKHPENNR126 TWSNYTMCNA136 FTPEKLKNAY 146 VLYYLAIVGH156 SLSIFTLVIS166 LGIFVFFRSL176 GCQRVTLHKN186 MFLTYILNSM 196 IIIIHLVEVV206 PNGELVRRDP216 VSCKILHFFH226 QYMMACNYFW236 MLCEGIYLHT 246 LIVVAVFTEK256 QRLRWYYLLG266 WGFPLVPTTI276 HAITRAVYFN286 DNCWLSVETH 296 LLYIIHGPVM306 AALVVNFFFL316 LNIVRVLVTK326 MRETHEAESH336 MYLKAVKATM 346 ILVPLLGIQF356 VVFPWRPSNK366 MLGKIYDYVM376 HSLIHFQGFF386 VATIYCFCNN 396 EVQTTVKRQW406 AQF
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| Ligand Name: Cholesterol hemisuccinate | Ligand Info | |||||
| Structure Description | Calcitonin Receptor in complex with Gs and salmon calcitonin peptide | PDB:7TYN | ||||
| Method | Electron microscopy | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
KPFLYVVGRK
46 KMMDAQYKCY56 DRMQQLPAYQ66 GEGPYCNRTW76 DGWLCWDDTP86 AGVLSYQFCP 96 DYFPDFDPSE106 KVTKYCDEKG116 VWFKHPENNR126 TWSNYTMCNA136 FTPEKLKNAY 146 VLYYLAIVGH156 SLSIFTLVIS166 LGIFVFFRSL176 GCQRVTLHKN186 MFLTYILNSM 196 IIIIHLVEVV206 PNGELVRRDP216 VSCKILHFFH226 QYMMACNYFW236 MLCEGIYLHT 246 LIVVAVFTEK256 QRLRWYYLLG266 WGFPLVPTTI276 HAITRAVYFN286 DNCWLSVETH 296 LLYIIHGPVM306 AALVVNFFFL316 LNIVRVLVTK326 MRETHEAESH336 MYLKAVKATM 346 ILVPLLGIQF356 VVFPWRPSNK366 MLGKIYDYVM376 HSLIHFQGFF386 VATIYCFCNN 396 EVQTTVKRQW406 AQF
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 4-Bromo-L-phenylalanine | Ligand Info | |||||
| Structure Description | Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue | PDB:5II0 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [2] |
| PDB Sequence |
LYVVGRKKMM
49 DAQYKCYDRM59 QQLPAYQGEG69 PYCNRTWDGW79 LCWDDTPAGV89 LSYQFCPDYF 99 PDFDPSEKVT109 KYCDEKGVWF119 KHPENNRTWS129 NYTMCNAFT
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .4BF or .4BF2 or .4BF3 or :34BF;style chemicals stick;color identity;select .A:40 or .A:41 or .A:100 or .A:101; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: L-prolinamide | Ligand Info | |||||
| Structure Description | Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue | PDB:5II0 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [2] |
| PDB Sequence |
LYVVGRKKMM
49 DAQYKCYDRM59 QQLPAYQGEG69 PYCNRTWDGW79 LCWDDTPAGV89 LSYQFCPDYF 99 PDFDPSEKVT109 KYCDEKGVWF119 KHPENNRTWS129 NYTMCNAFT
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LPD or .LPD2 or .LPD3 or :3LPD;style chemicals stick;color identity;select .A:77 or .A:78 or .A:79 or .A:110 or .A:127 or .A:128 or .A:129 or .A:131; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A structural basis for amylin receptor phenotype. Science. 2022 Mar 25;375(6587):eabm9609. | ||||
| REF 2 | Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography. J Biol Chem. 2016 Jun 24;291(26):13689-98. | ||||
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