Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46849 | Target Info | |||
| Target Name | DNA mismatch repair protein MSH2 (MSH2) | ||||
| Synonyms | hMSH2; MutS protein homolog 2; Mismatch repair gene Msh2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | MSH2 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: adenosine diphosphate | Ligand Info | |||||
| Structure Description | Human MutSbeta complexed with an IDL of 3 bases (Loop3) and ADP | PDB:3THX | ||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [1] |
| PDB Sequence |
ESAAEVGFVR
21 FFQGMPEKPT31 TTVRLFDRGD41 FYTAHGEDAL51 LAAREVFKTQ61 GVIKYMGPAG 71 AKNLQSVVLS81 KMNFESFVKD91 LLLVRQYRVE101 VYKNRASKEN115 DWYLAYKASP 125 GNLSQFEDIL135 FIGVVGVKMS153 AVDGQRQVGV163 GYVDSIQRKL173 GLCEFPDNDQ 183 FSNLEALLIQ193 IGPKECVLPG203 GETAGDMGKL213 RQIIQRGGIL223 ITERKKADFS 233 TKDIYQDLNR243 LLKGKKGEQM253 NSAVLPEMEN263 QVAVSSLSAV273 IKFLELLSDD 283 SNFGQFELTT293 FDFSQYMKLD303 IAAVRALNLF313 QQSLAALLNK332 CKTPQGQRLV 342 NQWIKQPLMD352 KNRIEERLNL362 VEAFVEDAEL372 RQTLQEDLLR382 RFPDLNRLAK 392 KFQRQAANLQ402 DCYRLYQGIN412 QLPNVIQALE422 KHEGKHQKLL432 LAVFVTPLTD 442 LRSDFSKFQE452 MIETTLDMDQ462 VENHEFLVKP472 SFDPNLSELR482 EIMNDLEKKM 492 QSTLISAARD502 LGLDPGKQIK512 LDSSAGYYFR524 VTCKEEKVLR534 NNKNFSTVDI 544 QGVKFTNSKL556 TSLNEEYTKN566 KTEYEEAQDA576 IVKEIVNISS586 GYVEPMQTLN 596 DVLAQLDAVV606 SFAHVSNGAP616 VPYVRPAILE626 KGQGRIILKA636 SRHACVEVQI 648 AFIPNDVYFE658 KDKQMFHIIT668 GPNMGGKSTY678 IRQTGVIVLM688 AQIGCFVPCE 698 SAEVSIVDCI708 LARVGSTFMA727 EMLETASILR737 SATKDSLIII747 DELGRGTSTY 757 DGFGLAWAIS767 EYIATKIGAF777 CMFATHFHEL787 TALANQIPTV797 NNLHVTALTT 807 EETLTMLYQV817 KKGVCDQSFG827 IHVAELANFP837 KHVIECAKQK847 ALELEEFQYK 872 CYLEREQGEK882 IIQEFLSKVK892 QMPFTEMSEE902 NITIKLKQLK912 AEVIAKNNSF 922 VNEIISRI
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops. Nat Struct Mol Biol. 2011 Dec 18;19(1):72-8. | ||||
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