Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T52921 | Target Info | |||
| Target Name | Nociceptin receptor (OPRL1) | ||||
| Synonyms | Orphanin FQ receptor; Opioid-receptor-like 1; Opioid receptor like-1 receptor; Opioid receptor 4; ORL-1 receptor; ORL-1; OPRL1; OP(4); Kappa-type 3 opioid receptor; KOR-3 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | OPRL1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Oleic acid | Ligand Info | |||||
| Structure Description | The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with C-35 (PSI Community Target) | PDB:5DHG | ||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
PLGLKVTIVG
56 LYLAVCVGGL66 LGNCLVMYVI76 LRHTKMKTAT86 NIYIFNLALA96 DTLVLLTLPF 106 QGTDILLGFW116 PFGNALCKTV126 IAIDYYNMFT136 STFTLTAMSV146 DRYVAICHPI 156 VRTSSKAQAV170 NVAIWALASV180 VGVPVAIMGS190 AQVEDEEIEC200 LVEIPTPQDY 210 WGPVFAICIF220 LFSFIVPVLV230 ISVCYSLMIR240 RLRGVRLLSG250 SREKDRNLRR 260 ITRLVLVVVA270 VFVGCWTPVQ280 VFVLAQGLGV290 QPSSETAVAI300 LRFCTALGYV 310 NSCLNPILYA320 FLDENFKACF330 R
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: SB-612111 | Ligand Info | |||||
| Structure Description | The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with SB-612111 (PSI Community Target) | PDB:5DHH | ||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
FLPLGLKVTI
54 VGLYLAVCVG64 GLLGNCLVMY74 VILRHTKMKT84 ATNIYIFNLA94 LADTLVLLTL 104 PFQGTDILLG114 FWPFGNALCK124 TVIAIDYYNM134 FTSTFTLTAM144 SVDRYVAICH 154 PRTSSKAQAV170 NVAIWALASV180 VGVPVAIMGS190 AQVEDEEIEC200 LVEIPTPQDY 210 WGPVFAICIF220 LFSFIVPVLV230 ISVCYSLMIR240 RLRGVRLLSG250 SREKDRNLRR 260 ITRLVLVVVA270 VFVGCWTPVQ280 VFVLAQGLGV290 QPSSETAVAI300 LRFCTALGYV 310 NSCLNPILYA320 FLDENFKACF330 RK
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| Ligand Name: Banyu Compound-24 | Ligand Info | |||||
| Structure Description | Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic | PDB:4EA3 | ||||
| Method | X-ray diffraction | Resolution | 3.01 Å | Mutation | Yes | [2] |
| PDB Sequence |
PLGLKVTIVG
56 LYLAVCVGGL66 LGNCLVMYVI76 LRHTKMKTAT86 NIYIFNLALA96 DTLVLLTLPF 106 QGTDILLGFW116 PFGNALCKTV126 IAIDYYNMFT136 STFTLTAMSV146 DRYVAICHPT 163 SSKAQAVNVA173 IWALASVVGV183 PVAIMGSAQV193 EDEEIECLVE203 IPTPQDYWGP 213 VFAICIFLFS223 FIVPVLVISV233 CYSLMIRRLR243 GVRLLSGSRE253 KDRNLRRITR 263 LVLVVVAVFV273 GCWTPVQVFV283 LAQGLGVQPS293 SETAVAILRF303 CTALGYVNSC 313 LNPILYAFLD323 ENFKACFR
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0NN or .0NN2 or .0NN3 or :30NN;style chemicals stick;color identity;select .A:107 or .A:110 or .A:116 or .A:126 or .A:127 or .A:130 or .A:131 or .A:134 or .A:135 or .A:200 or .A:201 or .A:202 or .A:219 or .A:223 or .A:276 or .A:279 or .A:280 or .A:283 or .A:302 or .A:305 or .A:309; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLN107
3.154
ASP110
3.929
TRP116
4.171
VAL126
4.174
ILE127
3.798
ASP130
2.722
TYR131
3.466
MET134
3.212
PHE135
3.660
CYS200
3.727
LEU201
3.639
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| Ligand Name: 1-Benzyl-N-{3-[4-(2,6-Dichlorophenyl)piperidin-1-Yl]propyl}-D-Prolinamide | Ligand Info | |||||
| Structure Description | The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with C-35 (PSI Community Target) | PDB:5DHG | ||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
PLGLKVTIVG
56 LYLAVCVGGL66 LGNCLVMYVI76 LRHTKMKTAT86 NIYIFNLALA96 DTLVLLTLPF 106 QGTDILLGFW116 PFGNALCKTV126 IAIDYYNMFT136 STFTLTAMSV146 DRYVAICHPI 156 VRTSSKAQAV170 NVAIWALASV180 VGVPVAIMGS190 AQVEDEEIEC200 LVEIPTPQDY 210 WGPVFAICIF220 LFSFIVPVLV230 ISVCYSLMIR240 RLRGVRLLSG250 SREKDRNLRR 260 ITRLVLVVVA270 VFVGCWTPVQ280 VFVLAQGLGV290 QPSSETAVAI300 LRFCTALGYV 310 NSCLNPILYA320 FLDENFKACF330 R
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DGV or .DGV2 or .DGV3 or :3DGV;style chemicals stick;color identity;select .A:107 or .A:110 or .A:116 or .A:126 or .A:127 or .A:130 or .A:131 or .A:134 or .A:135 or .A:200 or .A:202 or .A:219 or .A:223 or .A:276 or .A:279 or .A:280 or .A:283 or .A:302 or .A:305 or .A:309; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLN107
3.176
ASP110
3.630
TRP116
3.410
VAL126
4.042
ILE127
3.725
ASP130
2.584
TYR131
3.213
MET134
3.456
PHE135
4.121
CYS200
3.472
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor. Structure. 2015 Dec 1;23(12):2291-2299. | ||||
| REF 2 | Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature. 2012 May 16;485(7398):395-9. | ||||
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