Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T23673 | Target Info | |||
| Target Name | Proto-oncogene c-RAF (c-RAF) | ||||
| Synonyms | cRaf; Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | RAF1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cystein-S-Yl Cacodylate | Ligand Info | |||
| Canonical SMILES | C[As](=O)(C)SCC(C(=O)O)N | ||||
| InChI | 1S/C5H12AsNO3S/c1-6(2,10)11-3-4(7)5(8)9/h4H,3,7H2,1-2H3,(H,8,9)/t4-/m0/s1 | ||||
| InChIKey | HBKZDQYWGRUTJX-BYPYZUCNSA-N | ||||
| PubChem Compound ID | 17753879 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6XGV Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | ||||||
| Method | X-ray diffraction | Resolution | 2.11 Å | Mutation | Yes | [1] |
| PDB Sequence |
SNTIRVFLPN
64 KQRTVVNVRN74 GMSLHDCLMK84 ALKVRGLQPE94 CAVFRLLHEH105 KGKKARLDWN 115 TDAASLIGEE125 LQVDFLDHVP135 LTTHNFARKT145 FLKLAFCDIC155 QKFLLNGFRC 165 QTCGYKFHEH175 CSTKVPTMCV185 DWS
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| PDB ID: 6XHB Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II) | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
SNTIRVFLPN
64 KQRTVVNVRN74 GMSLHDCLMK84 ALKVRGLQPE94 CAVFRLLHEH105 KGKKARLDWN 115 TDAASLIGEE125 LQVDFLDHVP135 LTTHNFARKT145 FLKLAFCDIC155 QKFLLNGFRC 165 QTCGYKFHEH175 CSTKVPTMCV185 DWS
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| PDB ID: 6XGU Crystal Structure of KRAS-Q61R (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
SNTIRVFLPN
64 KQRTVVNVRN74 GMSLHDCLMK84 ALKVRGLQPE94 CAVFRLLHEH105 KGKKARLDWN 115 TDAASLIGEE125 LQVDFLDHVP135 LTTHNFARKT145 FLKLAFCDIC155 QKFLLNGFRC 165 QTCGYKFHEH175 CSTKVPTMCV185 DWS
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| PDB ID: 6XHA Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | ||||||
| Method | X-ray diffraction | Resolution | 2.87 Å | Mutation | Yes | [1] |
| PDB Sequence |
SNTIRVFLPN
64 KQRTVVNVRN74 GMSLHDCLMK84 ALKVRGLQPE94 CAVFRLLHEH105 KGKKARLDWN 115 TDAASLIGEE125 LQVDFLDHVP135 LTTHNFARKT145 FLKLAFCDIC155 QKFLLNGFRC 165 QTCGYKFHEH175 CSTKVPTMCV185 DWS
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun. 2021 Feb 19;12(1):1176. | ||||
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