Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T50594 | Target Info | |||
| Target Name | Serine/threonine-protein kinase pim-1 (PIM1) | ||||
| Synonyms | Pim-1 proto-oncogene, serine/threonine kinase; PIM | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PIM1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-serine-O-phosphate | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 | ||||
| InChIKey | BZQFBWGGLXLEPQ-REOHCLBHSA-N | ||||
| PubChem Compound ID | 68841 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 2BIK Human Pim1 phosphorylated on Ser261 | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIGGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
|
||||||
| PDB ID: 2BZI CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU2 | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [2] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIGGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
|
||||||
| PDB ID: 5N5L Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and [2-oxo-2-(1H-pyrrol-2-yl)ethyl] 5-bromo-1H-indole-3-carboxylate | ||||||
| Method | X-ray diffraction | Resolution | 1.97 Å | Mutation | Yes | [3] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELNG83 TRVPMEVVLL 93 KKVSSGFSGV103 IRLLDWFERP113 DSFVLILERP123 EPVQDLFDFI133 TERGALQEEL 143 ARSFFWQVLE153 AVRHCHNCGV163 LHRDIKDENI173 LIDLNRGELK183 LIDFGSGALL 193 KDTVYTDFDG203 TRVYSPPEWI213 RYHRYHGRSA223 AVWSLGILLY233 DMVCGDIPFE 243 HDEEIIGGQV253 FFRQRVSECQ264 HLIRWCLALR274 PSDRPTFEEI284 QNHPWMQDVL 294 LPQETAEIHL304 H
|
|||||
|
|
||||||
| PDB ID: 5N51 Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule 3,4-Dibromothiophene-2-carboxylic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.12 Å | Mutation | Yes | [4] |
| PDB Sequence |
PLESQYQVGP
42 LLGSSVYSGI56 RVSDNLPVAI66 KHVEKDRISD76 WGELPNGTRV86 PMEVVLLKKV 96 SSGFSGVIRL106 LDWFERPDSF116 VLILERPEPV126 QDLFDFITER136 GALQEELARS 146 FFWQVLEAVR156 HCHNCGVLHR166 DIKDENILID176 LNRGELKLID186 FGSGALLKDT 196 VYTDFDGTRV206 YSPPEWIRYH216 RYHGRSAAVW226 SLGILLYDMV236 CGDIPFEHDE 246 EIIGGQVFFR256 QRVSECQHLI267 RWCLALRPSD277 RPTFEEIQNH287 PWMQDVLLPQ 297 ETAEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5N5M Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and (R)-3-(2-((isoquinolin-5-ylmethyl)(methyl)carbamoyl)phenyl)pyrrolidin-1-ium | ||||||
| Method | X-ray diffraction | Resolution | 2.21 Å | Mutation | Yes | [5] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIGGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 3MA3 Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a naphtho-difuran ligand | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [6] |
| PDB Sequence |
QYQVGPLLGG
48 FGSVYSGIRV58 SDNLPVAIKH68 VEKDRISDWG78 ELPNGTRVPM88 EVVLLKKVSS 98 GFSGVIRLLD108 WFERPDSFVL118 ILERPEPVQD128 LFDFITERGA138 LQEELARSFF 148 WQVLEAVRHC158 HNCGVLHRDI168 KDENILIDLN178 RGELKLIDFG188 SGALLKDTVY 198 TDFDGTRVYS208 PPEWIRYHRY218 HGRSAAVWSL228 GILLYDMVCG238 DIPFEHDEEI 248 IGGQVFFRQR258 VSECQHLIRW269 CLALRPSDRP279 TFEEIQNHPW289 MQDVLLPQET 299 AEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6PDN Human PIM1 bound to benzothiophene inhibitor 292 | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [7] |
| PDB Sequence |
EPLESQYQVG
41 PLLGSSVYSG55 IRVSDNLPVA65 IKHVEKDRIS75 DWGELPNGTR85 VPMEVVLLKK 95 VSSGFSGVIR105 LLDWFERPDS115 FVLILERPEP125 VQDLFDFITE135 RGALQEELAR 145 SFFWQVLEAV155 RHCHNCGVLH165 RDIKDENILI175 DLNRGELKLI185 DFGSGALLKD 195 TVYTDFDGTR205 VYSPPEWIRY215 HRYHGRSAAV225 WSLGILLYDM235 VCGDIPFEHD 245 EEIIGGQVFF255 RQRVSECQHL266 IRWCLALRPS276 DRPTFEEIQN286 HPWMQDVLLP 296 QETAEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4BZN Crystal structure of PIM1 in complex with a Pyrrolo(1,2-a)Pyrazinone inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [8] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4BZO Crystal structure of PIM1 in complex with a Pyrrolo-Pyrazinone inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [8] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 3CY3 Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | Yes | [9] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPT84 RVPMEVVLLK 94 KVSSGFSGVI104 RLLDWFERPD114 SFVLILERPE124 PVQDLFDFIT134 ERGALQEELA 144 RSFFWQVLEA154 VRHCHNCGVL164 HRDIKDENIL174 IDLNRGELKL184 IDFGSGALLK 194 DTVYTDFDGT204 RVYSPPEWIR214 YHRYHGRSAA224 VWSLGILLYD234 MVCGDIPFEH 244 DEEIIGGQVF254 FRQRVSECQH265 LIRWCLALRP275 SDRPTFEEIQ285 NHPWMQDVLL 295 PQETAEIHLH305
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4XHK PIM1 kinase in complex with Compound 1s | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [10] |
| PDB Sequence |
EPLESQYQVG
41 PLLGSGGFGS51 VYSGIRVSDN61 LPVAIKHVEK71 DRISDWGELR85 VPMEVVLLKK 95 VSSGFSGVIR105 LLDWFERPDS115 FVLILERPEP125 VQDLFDFITE135 RGALQEELAR 145 SFFWQVLEAV155 RHCHNCGVLH165 RDIKDENILI175 DLNRGELKLI185 DFGSGALLKD 195 TVYTDFDGTR205 VYSPPEWIRY215 HRYHGRSAAV225 WSLGILLYDM235 VCGDIPFEHD 245 EEIIRGQVFF255 RQRVSECQHL266 IRWCLALRPS276 DRPTFEEIQN286 HPWMQDVLLP 296 QETAEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .B:258 or .B:259 or .B:260 or .B:262 or .B:263 or .B:264 or .B:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4A7C Crystal structure of PIM1 kinase with ETP46546 | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [11] |
| PDB Sequence |
EPLESQYQVG
41 PLLGSGGFGS51 VYSGIRVSDN61 LPVAIKHVEK71 DRISDWGELP81 NGTRVPMEVV 91 LLKKVSSGFS101 GVIRLLDWFE111 RPDSFVLILE121 RPEPVQDLFD131 FITERGALQE 141 ELARSFFWQV151 LEAVRHCHNC161 GVLHRDIKDE171 NILIDLNRGE181 LKLIDFGSGA 191 LLKDTVYTDF201 DGTRVYSPPE211 WIRYHRYHGR221 SAAVWSLGIL231 LYDMVCGDIP 241 FEHDEEIIRG251 QVFFRQRVSE262 CQHLIRWCLA272 LRPSDRPTFE282 EIQNHPWMQD 292 VLLPQETAEI302 HLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 2XJ1 Protein kinase Pim-1 in complex with small molecule inibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.13 Å | Mutation | No | [12] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LHS
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 2XIY Protein kinase Pim-1 in complex with fragment-2 from crystallographic fragment screen | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [12] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LHS
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 2XJ2 Protein kinase Pim-1 in complex with small molecule inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [12] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LHS
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 2XIZ Protein kinase Pim-1 in complex with fragment-3 from crystallographic fragment screen | ||||||
| Method | X-ray diffraction | Resolution | 2.21 Å | Mutation | No | [12] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LHS
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 2XIX Protein kinase Pim-1 in complex with fragment-1 from crystallographic fragment screen | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [12] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPDRPTFEEI284 QNHPWMQDVL 294 LPQETAEIHL304 HS
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265 or .A:274 or .A:275 or .A:277 or .A:278; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 3F2A Crystal structure of human Pim-1 in complex with DAPPA | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [13] |
| PDB Sequence |
EPLESQYQVG
41 PLLGSGGFGS51 VYSGIRVSDN61 LPVAIKHVEK71 DRISDWGELP81 NGTRVPMEVV 91 LLKKVSSGFS101 GVIRLLDWFE111 RPDSFVLILE121 RPEPVQDLFD131 FITERGALQE 141 ELARSFFWQV151 LEAVRHCHNC161 GVLHRDIKDE171 NILIDLNRGE181 LKLIDFGSGA 191 LLKDTVYTDF201 DGTRVYSPPE211 WIRYHRYHGR221 SAAVWSLGIL231 LYDMVCGDIP 241 FEHDEEIIRG251 QVFFRQRVSE262 CQHLIRWCLA272 LRPSDRPTFE282 EIQNHPWMQD 292 VLLPQETAEI302 HLHSLS
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5DWR Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [14] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LHS
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4N70 Pim1 Complexed with a pyridylcarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [15] |
| PDB Sequence |
EPLESQYQVG
41 PLLGSGGFGS51 VYSGIRVSDN61 LPVAIKHVEK71 DRISDWGELP81 NGTRVPMEVV 91 LLKKVSSGFS101 GVIRLLDWFE111 RPDSFVLILE121 RPEPVQDLFD131 FITERGALQE 141 ELARSFFWQV151 LEAVRHCHNC161 GVLHRDIKDE171 NILIDLNRGE181 LKLIDFGSGA 191 LLKDTVYTDF201 DGTRVYSPPE211 WIRYHRYHGR221 SAAVWSLGIL231 LYDMVCGDIP 241 FEHDEEIIRG251 QVFFRQRVSE262 CQHLIRWCLA272 LRPSDRPTFE282 EIQNHPWMQD 292 VLLPQETAEI302 HLHS
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4N6Z Pim1 Complexed with a pyridylcarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [15] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5O11 Crystal structure of PIM1 kinase in complex with small-molecule inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [16] |
| PDB Sequence |
LESQYQVGPL
43 LGSGGSVYSG55 IRVSDNLPVA65 IKHVEKDRIS75 DWGELPNGTR85 VPMEVVLLKK 95 VSSGFSGVIR105 LLDWFERPDS115 FVLILERPEP125 VQDLFDFITE135 RGALQEELAR 145 SFFWQVLEAV155 RHCHNGVLHR166 DIKDENILID176 LNRGELKLID186 FGSGALLKDT 196 VYTDFDGTRV206 YSPPEWIRYH216 RYHGRSAAVW226 SLGILLYDMV236 CGDIPFEHDE 246 EIIRGQVFFR256 QRVSECQHLI267 RWCLALRPSD277 RPTFEEIQNH287 PWMQDVLLPQ 297 ETAEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5O12 Crystal structure of PIM1 kinase in complex with small-molecule inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [16] |
| PDB Sequence |
LESQYQVGPL
43 LGSSVYSGIR57 VSDNLPVAIK67 HVEKDRISDW77 GELPTRVPME89 VVLLKKVSSG 99 FSGVIRLLDW109 FERPDSFVLI119 LERPEPVQDL129 FDFITERGAL139 QEELARSFFW 149 QVLEAVRHCH159 NGVLHRDIKD170 ENILIDLNRG180 ELKLIDFGSG190 ALLKDTVYTD 200 FDGTRVYSPP210 EWIRYHRYHG220 RSAAVWSLGI230 LLYDMVCGDI240 PFEHDEEIIR 250 GQVFFRQRVS260 ECQHLIRWCL271 ALRPSDRPTF281 EEIQNHPWMQ291 DVLLPQETAE 301 IHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5O13 Crystal structure of PIM1 kinase in complex with small-molecule inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.44 Å | Mutation | No | [16] |
| PDB Sequence |
LESQYQVGPL
43 LGSGGFGSVY53 SGIRVSDNLP63 VAIKHVEKDR73 ISDWGELPNG83 TRVPMEVVLL 93 KKVSSGFSGV103 IRLLDWFERP113 DSFVLILERP123 EPVQDLFDFI133 TERGALQEEL 143 ARSFFWQVLE153 AVRHCHNGVL164 HRDIKDENIL174 IDLNRGELKL184 IDFGSGALLK 194 DTVYTDFDGT204 RVYSPPEWIR214 YHRYHGRSAA224 VWSLGILLYD234 MVCGDIPFEH 244 DEEIIRGQVF254 FRQRVSECQH265 LIRWCLALRP275 SDRPTFEEIQ285 NHPWMQDVLL 295 PQETAEIHLH305
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265 or .A:266; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 3T9I Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [17] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LHS
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4N6Y Pim1 Complexed with a phenylcarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [15] |
| PDB Sequence |
EPLESQYQVG
41 PLLGSGGFGS51 VYSGIRVSDN61 LPVAIKHVEK71 DRISDWGELP81 NGTRVPMEVV 91 LLKKVSSGFS101 GVIRLLDWFE111 RPDSFVLILE121 RPEPVQDLFD131 FITERGALQE 141 ELARSFFWQV151 LEAVRHCHNC161 GVLHRDIKDE171 NILIDLNRGE181 LKLIDFGSGA 191 LLKDTVYTDF201 DGTRVYSPPE211 WIRYHRYHGR221 SAAVWSLGIL231 LYDMVCGDIP 241 FEHDEEIIRG251 QVFFRQRVSE262 CQHLIRWCLA272 LRPSDRPTFE282 EIQNHPWMQD 292 VLLPQETAEI302 HLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 3DCV Crystal structure of human Pim1 kinase complexed with 4-(4-hydroxy-3-methyl-phenyl)-6-phenylpyrimidin-2(1H)-one | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [18] |
| PDB Sequence |
EPLESQYQVG
41 PLLGSGGFGS51 VYSGIRVSDN61 LPVAIKHVEK71 DRISDWGELP81 NGTRVPMEVV 91 LLKKVSSGFS101 GVIRLLDWFE111 RPDSFVLILE121 RPEPVQDLFD131 FITERGALQE 141 ELARSFFWQV151 LEAVRHCHNC161 GVLHRDIKDE171 NILIDLNRGE181 LKLIDFGSGA 191 LLKDTVYTDF201 DGTRVYSPPE211 WIRYHRYHGR221 SAAVWSLGIL231 LYDMVCGDIP 241 FEHDEEIIRG251 QVFFRQRVSE262 CQHLIRWCLA272 LRPSDRPTFE282 EIQNHPWMQD 292 VLLPQETAEI302 HLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6YKD Human Pim-1 kinase in complex with an inhibitor identified by virtual screening | ||||||
| Method | X-ray diffraction | Resolution | 1.86 Å | Mutation | No | [19] |
| PDB Sequence |
HHHHPLESQY
38 QVGPLLGSGG48 FGSVYSGIRV58 SDNLPVAIKH68 VEKDRISDWG78 ELPNGTRVPM 88 EVVLLKKVSS98 GFSGVIRLLD108 WFERPDSFVL118 ILERPEPVQD128 LFDFITERGA 138 LQEELARSFF148 WQVLEAVRHC158 HNCGVLHRDI168 KDENILIDLN178 RGELKLIDFG 188 SGALLKDTVY198 TDFDGTRVYS208 PPEWIRYHRY218 HGRSAAVWSL228 GILLYDMVCG 238 DIPFEHDEEI248 IRGQVFFRQR258 VSECQHLIRW269 CLALRPSDRP279 TFEEIQNHPW 289 MQDVLLPQET299 AEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 3BGQ Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2 | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [20] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 3BGZ Human Pim-1 kinase in complex with diphenyl indole inhibitor VX3 | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [20] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGERVP87 MEVVLLKKVS 97 SGFSGVIRLL107 DWFERPDSFV117 LILERPEPVQ127 DLFDFITERG137 ALQEELARSF 147 FWQVLEAVRH157 CHNCGVLHRD167 IKDENILIDL177 NRGELKLIDF187 GSGALLKDTV 197 YTDFDGTRVY207 SPPEWIRYHR217 YHGRSAAVWS227 LGILLYDMVC237 GDIPFEHDEE 247 IIRGQVFFRQ257 RVSECQHLIR268 WCLALRPSDR278 PTFEEIQNHP288 WMQDVLLPQE 298 TAEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 2OBJ Crystal structure of human PIM-1 Kinase in complex with inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | Yes | [21] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 3BGP Human Pim-1 complexed with a benzoisoxazole inhibitor VX1 | ||||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [20] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6L17 Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [22] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6L12 Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives | ||||||
| Method | X-ray diffraction | Resolution | 1.87 Å | Mutation | No | [22] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6L14 Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [22] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPT84 RVPMEVVLLK 94 KVSSGFSGVI104 RLLDWFERPD114 SFVLILERPE124 PVQDLFDFIT134 ERGALQEELA 144 RSFFWQVLEA154 VRHCHNCGVL164 HRDIKDENIL174 IDLNRGELKL184 IDFGSGALLK 194 DTVYTDFDGT204 RVYSPPEWIR214 YHRYHGRSAA224 VWSLGILLYD234 MVCGDIPFEH 244 DEEIIRGQVF254 FRQRVSECQH265 LIRWCLALRP275 SDRPTFEEIQ285 NHPWMQDVLL 295 PQETAEIHLH305
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6L11 Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [22] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4RC2 Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [23] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6L16 Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [22] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELTR85 VPMEVVLLKK 95 VSSGFSGVIR105 LLDWFERPDS115 FVLILERPEP125 VQDLFDFITE135 RGALQEELAR 145 SFFWQVLEAV155 RHCHNCGVLH165 RDIKDENILI175 DLNRGELKLI185 DFGSGALLKD 195 TVYTDFDGTR205 VYSPPEWIRY215 HRYHGRSAAV225 WSLGILLYDM235 VCGDIPFEHD 245 EEIIRGQVFF255 RQRVSECQHL266 IRWCLALRPS276 DRPTFEEIQN286 HPWMQDVLLP 296 QETAEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6L13 Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives | ||||||
| Method | X-ray diffraction | Resolution | 2.24 Å | Mutation | No | [22] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4RC3 Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | ||||||
| Method | X-ray diffraction | Resolution | 2.34 Å | Mutation | No | [24] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGFGSVY53 SGIRVSDNLP63 VAIKHVEKDR73 ISDWGELPNG83 TRVPMEVVLL 93 KKVSSGFSGV103 IRLLDWFERP113 DSFVLILERP123 EPVQDLFDFI133 TERGALQEEL 143 ARSFFWQVLE153 AVRHCHNCGV163 LHRDIKDENI173 LIDLNRGELK183 LIDFGSGALL 193 KDTVYTDFDG203 TRVYSPPEWI213 RYHRYHGRSA223 AVWSLGILLY233 DMVCGDIPFE 243 HDEEIIRGQV253 FFRQRVSECQ264 HLIRWCLALR274 PSDRPTFEEI284 QNHPWMQDVL 294 LPQETAEIHL304 H
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4RBL Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | ||||||
| Method | X-ray diffraction | Resolution | 2.55 Å | Mutation | No | [25] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGFGSVY53 SGIRVSDNLP63 VAIKHVEKDR73 ISDWGELPNG83 TRVPMEVVLL 93 KKVSSGFSGV103 IRLLDWFERP113 DSFVLILERP123 EPVQDLFDFI133 TERGALQEEL 143 ARSFFWQVLE153 AVRHCHNCGV163 LHRDIKDENI173 LIDLNRGELK183 LIDFGSGALL 193 KDTVYTDFDG203 TRVYSPPEWI213 RYHRYHGRSA223 AVWSLGILLY233 DMVCGDIPFE 243 HDEEIIRGQV253 FFRQRVSECQ264 HLIRWCLALR274 PSDRPTFEEI284 QNHPWMQDVL 294 LPQETAEIHL304 H
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6L15 Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [22] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELTR85 VPMEVVLLKK 95 VSSGFSGVIR105 LLDWFERPDS115 FVLILERPEP125 VQDLFDFITE135 RGALQEELAR 145 SFFWQVLEAV155 RHCHNCGVLH165 RDIKDENILI175 DLNRGELKLI185 DFGSGALLKD 195 TVYTDFDGTR205 VYSPPEWIRY215 HRYHGRSAAV225 WSLGILLYDM235 VCGDIPFEHD 245 EEIIRGQVFF255 RQRVSECQHL266 IRWCLALRPS276 DRPTFEEIQN286 HPWMQDVLLP 296 QETAEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4RC4 Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | ||||||
| Method | X-ray diffraction | Resolution | 2.65 Å | Mutation | No | [26] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 7XSV Crystal Structures of PIM1 in Complex with Macrocyclic Compound H3 | ||||||
| Method | X-ray diffraction | Resolution | 2.66 Å | Mutation | No | [27] |
| PDB Sequence |
EPLESQYQVG
41 PLLGSGGFGS51 VYSGIRVSDN61 LPVAIKHVEK71 DRISDWGELP81 NGTRVPMEVV 91 LLKKVSSGFS101 GVIRLLDWFE111 RPDSFVLILE121 RPEPVQDLFD131 FITERGALQE 141 ELARSFFWQV151 LEAVRHCHNC161 GVLHRDIKDE171 NILIDLNRGE181 LKLIDFGSGA 191 LLKDTVYTDF201 DGTRVYSPPE211 WIRYHRYHGR221 SAAVWSLGIL231 LYDMVCGDIP 241 FEHDEEIIRG251 QVFFRQRVSE262 CQHLIRWCLA272 LRPSDRPTFE282 EIQNHPWMQD 292 VLLPQETAEI302 HLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6KZI Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine derivatives | ||||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [22] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4IAA Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine | ||||||
| Method | X-ray diffraction | Resolution | 2.85 Å | Mutation | No | [28] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 4I41 Crystal Structure of human Ser/Thr kinase Pim1 in complex with mitoxantrone | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [29] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGELPN82 GTRVPMEVVL 92 LKKVSSGFSG102 VIRLLDWFER112 PDSFVLILER122 PEPVQDLFDF132 ITERGALQEE 142 LARSFFWQVL152 EAVRHCHNCG162 VLHRDIKDEN172 ILIDLNRGEL182 KLIDFGSGAL 192 LKDTVYTDFD202 GTRVYSPPEW212 IRYHRYHGRS222 AAVWSLGILL232 YDMVCGDIPF 242 EHDEEIIRGQ252 VFFRQRVSEC263 QHLIRWCLAL273 RPSDRPTFEE283 IQNHPWMQDV 293 LLPQETAEIH303 LH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5IIS Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl-amide scaffold | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [30] |
| PDB Sequence |
EPLESQYQVG
41 PLLGSGGFGS51 VYSGIRVSDN61 LPVAIKHVEK71 DRISDWGELP81 NGTRVPMEVV 91 LLKKVSSGFS101 GVIRLLDWFE111 RPDSFVLILE121 RPEPVQDLFD131 FITERGALQE 141 ELARSFFWQV151 LEAVRHCHNC161 GVLHRDIKDE171 NILIDLNRGE181 LKLIDFGSGA 191 LLKDTVYTDF201 DGTRVYSPPE211 WIRYHRYHGR221 SAAVWSLGIL231 LYDMVCGDIP 241 FEHDEEIIRG251 QVFFRQRVSE262 CQHLIRWCLA272 LRPSDRPTFE282 EIQNHPWMQD 292 VLLPQETAEI302 HLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 1YHS Crystal structure of Pim-1 bound to staurosporine | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | Yes | [31] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGETRV86 PMEVVLLKKV 96 SSGFSGVIRL106 LDWFERPDSF116 VLILERPEPV126 QDLFDFITER136 GALQEELARS 146 FFWQVLEAVR156 HCHNGVLHRD167 IKDENILIDL177 NRGELKLIDF187 GSGALLKDTV 197 YTDFDGTRVY207 SPPEWIRYHR217 YHGRSAAVWS227 LGILLYDMVC237 GDIPFEHDEE 247 IIRGQVFFRQ257 RVSECQHLIR268 WCLALRPSDR278 PTFEEIQNHP288 WMQDVLLPQE 298 TAEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 1YI4 Structure of Pim-1 bound to adenosine | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [31] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGETRV86 PMEVVLLKKV 96 SSGFSGVIRL106 LDWFERPDSF116 VLILERPEPV126 QDLFDFITER136 GALQEELARS 146 FFWQVLEAVR156 HCHNGVLHRD167 IKDENILIDL177 NRGELKLIDF187 GSGALLKDTV 197 YTDFDGTRVY207 SPPEWIRYHR217 YHGRSAAVWS227 LGILLYDMVC237 GDIPFEHDEE 247 IIRGQVFFRQ257 RVSECQHLIR268 WCLALRPSDR278 PTFEEIQNHP288 WMQDVLLPQE 298 TAEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 1YI3 Crystal Structure of Pim-1 bound to LY294002 | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | Yes | [31] |
| PDB Sequence |
PLESQYQVGP
42 LLGSGGFGSV52 YSGIRVSDNL62 PVAIKHVEKD72 RISDWGETRV86 PMEVVLLKKV 96 SSGFSGVIRL106 LDWFERPDSF116 VLILERPEPV126 QDLFDFITER136 GALQEELARS 146 FFWQVLEAVR156 HCHNGVLHRD167 IKDENILIDL177 NRGELKLIDF187 GSGALLKDTV 197 YTDFDGTRVY207 SPPEWIRYHR217 YHGRSAAVWS227 LGILLYDMVC237 GDIPFEHDEE 247 IIRGQVFFRQ257 RVSECQHLIR268 WCLALRPSDR278 PTFEEIQNHP288 WMQDVLLPQE 298 TAEIHLH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:262 or .A:263 or .A:264 or .A:265; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Human Pim1 Phosphorylated on Ser261 | ||||
| REF 2 | Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands | ||||
| REF 3 | A crystallographic fragment study with human Pim-1 kinase | ||||
| REF 4 | A crystallographic fragment study with human Pim-1 kinase | ||||
| REF 5 | A crystallographic fragment study with human Pim-1 kinase | ||||
| REF 6 | New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. FASEB J. 2010 Sep;24(9):3171-85. | ||||
| REF 7 | Human PIM1 | ||||
| REF 8 | Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases. Bioorg Med Chem. 2013 Dec 1;21(23):7364-80. | ||||
| REF 9 | Proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V. | ||||
| REF 10 | Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25(3):474-80. | ||||
| REF 11 | Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1591-7. | ||||
| REF 12 | A crystallographic fragment screen identifies cinnamic acid derivatives as starting points for potent Pim-1 inhibitors. Acta Crystallogr D Biol Crystallogr. 2011 Mar;67(Pt 3):156-66. | ||||
| REF 13 | Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. J Med Chem. 2009 Apr 9;52(7):1814-27. | ||||
| REF 14 | Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. J Med Chem. 2015 Nov 12;58(21):8373-86. | ||||
| REF 15 | Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett. 2013 Oct 15;4(12):1193-7. | ||||
| REF 16 | Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors. Sci Rep. 2017 Oct 17;7(1):13399. | ||||
| REF 17 | Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6366-9. | ||||
| REF 18 | 4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4482-5. | ||||
| REF 19 | Virtual Screening and Design with Machine Intelligence Applied to Pim-1 Kinase Inhibitors. Mol Inform. 2020 Sep;39(9):e2000109. | ||||
| REF 20 | Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J Med Chem. 2008 Mar 27;51(6):1972-5. | ||||
| REF 21 | Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1679-83. | ||||
| REF 22 | Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J Chem Inf Model. 2020 Jun 22;60(6):3287-3294. | ||||
| REF 23 | Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | ||||
| REF 24 | Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | ||||
| REF 25 | Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | ||||
| REF 26 | Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | ||||
| REF 27 | Design, synthesis, and bioactivity evaluation of macrocyclic benzo[b]pyrido[4,3-e][1,4]oxazine derivatives as novel Pim-1 kinase inhibitors. Bioorg Med Chem Lett. 2022 Sep 15;72:128874. | ||||
| REF 28 | Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine | ||||
| REF 29 | A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J Med Chem. 2013 Mar 28;56(6):2619-29. | ||||
| REF 30 | Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold. Bioorg Med Chem Lett. 2016 May 1;26(9):2328-32. | ||||
| REF 31 | Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002. J Biol Chem. 2005 Apr 8;280(14):13728-34. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.