Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66538 | Target Info | |||
| Target Name | Calcium-activated potassium channel KCa1.1 (KCNMA1) | ||||
| Synonyms | hSlo; Slowpoke homolog; Slo1; Slo-alpha; Slo homolog; SLO; MaxiK; Maxi K channel; KCa1.1; KCNMA; K(VCA)alpha; Calcium-activated potassium channel, subfamily M subunit alpha-1; Calcium-activated potassium channel subunit alpha-1; BKCA alpha; BK channel | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | KCNMA1 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C | ||||
| InChI | 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 | ||||
| InChIKey | HVYWMOMLDIMFJA-DPAQBDIFSA-N | ||||
| PubChem Compound ID | 5997 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6V22 Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex | ||||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
SRGQRMWWAF
25 LASSMVTFFG35 GLFIILLWRT45 LKYLWTVCCV91 GWMTSVKDWA101 GVMISAQTLT 111 GRVLVVLVFA121 LSIGALVIYF131 IDSSNPIESC141 QNFYKDFTLQ151 IDMAFNVFFL 161 LYFGLRFIAA171 NDKLWFWLEV181 NSVVDFFTVP191 PVFVSVYLNR201 SWLGLRFLRA 211 LRLIQFSEIL221 QFLNILKTSN231 SIKLVNLLSI241 FISTWLTAAG251 FIHLVENSGD 261 PWENFQNNQA271 LTYWECVYLL281 MVTMSTVGYG291 DVYAKTTLGR301 LFMVFFILGG 311 LAMFASYVPE321 IIELIGNRKK331 YGGSYSAVSG341 RKHIVVCGHI351 TLESVSNFLK 361 DFLHKDRDDV371 NVEIVFLHNI381 SPNLELEALF391 KRHFTQVEFY401 QGSVLNPHDL 411 ARVKIESADA421 CLILANKYCA431 DPDAEDASNI441 MRVISIKNYH451 PKIRIITQML 461 QYHNKAHLLN471 IPSWNWKEGD481 DAICLAELKL491 GFIAQSCLAQ501 GLSTMLANLF 511 SMRSFIKIEE521 DTWQKYYLEG531 VSNEMYTEYL541 SSAFVGLSFP551 TVCELCFVKL 561 KLLMIAIESR578 ILINPGNHLK588 IQEGTLGFFI598 ASDAKEVKRA608 FFYCKACSNV 683 KKYDSTGMFH693 WCAPKEIEKV703 ILTRSEAAMT713 VLSGHVVVCI723 FGDVSSALIG 733 LRNLVMPLRA743 SNFHYHELKH753 IVFVGSIEYL763 KREWETLHNF773 PKVSILPGTP 783 LSRADLRAVN793 INLCDMCVIL803 SANQNNIDDT813 SLQDKECILA823 SLNIKSMQFD 833 TTGVNIPIIT880 ELVNDTNVQF890 LDQDDDDDPD900 TELYLTQPFA910 CGTAFAVSVL 920 DSLMSATYFN930 DNILTLIRTL940 VTGGATPELE950 ALIAEENALR960 GGYSTPQTLA 970 NRDRCRVAQL980 ALLDGPFADL990 GDGGCYGDLF1000 CKALKTYNML1010 CFGIYRLRDA 1020 HLSTPSQCTK1030 RYVITNPPYE1040 FELVPTDLIF1050 CLMQFD
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MET21
3.703
TRP22
4.146
TRP23
3.764
ALA24
3.658
LEU26
4.662
ALA27
4.757
SER28
3.434
MET30
4.586
VAL31
4.130
THR32
1.375
GLY36
3.747
ILE39
3.749
ILE40
4.006
TRP43
3.795
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| PDB ID: 6V35 Cryo-EM structure of Ca2+-free hsSlo1-beta4 channel complex | ||||||
| Method | Electron microscopy | Resolution | 3.50 Å | Mutation | No | [1] |
| PDB Sequence |
QRMWWAFLAS
28 SMVTFFGGLF38 IILLWRTLKY48 LWTVCWMTSV97 KDWAGVMISA107 QTLTGRVLVV 117 LVFALSIGAL127 VIYFIDSSNP137 IESCQNFYKD147 FTLQIDMAFN157 VFFLLYFGLR 167 FIAANDKLWF177 WLEVNSVVDF187 FTVPPVFVSV197 YLNRSWLGLR207 FLRALRLIQF 217 SEILQFLNIL227 KTSNSIKLVN237 LLSIFISTWL247 TAAGFIHLVE257 NSGDPWENFQ 267 NNQALTYWEC277 VYLLMVTMST287 VGYGDVYAKT297 TLGRLFMVFF307 ILGGLAMFAS 317 YVPEIIELIG327 NRKKYGGSYS337 AVSGRKHIVV347 CGHITLESVS357 NFLKDFLHKD 367 RDDVNVEIVF377 LHNISPNLEL387 EALFKRHFTQ397 VEFYQGSVLN407 PHDLARVKIE 417 SADACLILAN427 KYCADPDAED437 ASNIMRVISI447 KNYHPKIRII457 TQMLQYHNKA 467 HLLNIPSWNW477 KEGDDAICLA487 ELKLGFIAQS497 CLAQGLSTML507 ANLFSMRSFI 517 KIEEDTWQKY527 YLEGVSNEMY537 TEYLSSAFVG547 LSFPTVCELC557 FVKLKLLMIA 567 IEYKSANRES577 RILINPGNHL587 KIQEGTLGFF597 IASDAKEVKR607 AFFYCKACHD 617 DITDPKRIKK627 CGCKSNVKKY686 DSTGMFHWCA696 PKEIEKVILT706 RSEAAMTVLS 716 GHVVVCIFGD726 VSSALIGLRN736 LVMPLRASNF746 HYHELKHIVF756 VGSIEYLKRE 766 WETLHNFPKV776 SILPGTPLSR786 ADLRAVNINL796 CDMCVILSAN806 QNNIDDTSLQ 816 DKECILASLN826 IKSMQFDDTT872 GVNIPIITEL882 VNDTNVQFLD892 QDDDDDPDTE 902 LYLTQPFACG912 TAFAVSVLDS922 LMSATYFNDN932 ILTLIRTLVT942 GGATPELEAL 952 IAEENALRGG962 YSTPQTLANR972 DRCRVAQLAL982 LDGPFADLGD992 GGCYGDLFCK 1002 ALKTYNMLCF1012 GIYRLRDAHL1022 STPSQCTKRY1032 VITNPPYEFE1042 LVPTDLIFCL 1052 MQFD
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| PDB ID: 6V38 Cryo-EM structure of Ca2+-bound hsSlo1 channel | ||||||
| Method | Electron microscopy | Resolution | 3.80 Å | Mutation | No | [1] |
| PDB Sequence |
QRMWWAFLAS
28 SMVTFFGGLF38 IILLWRTLKY48 LWTWMTSVKD99 WAGVMISAQT109 LTGRVLVVLV 119 FALSIGALVI129 YFIDSSNPIE139 SCQNFYKDFT149 LQIDMAFNVF159 FLLYFGLRFI 169 AANDKLWFWL179 EVNSVVDFFT189 VPPVFVSVYL199 NRSWLGLRFL209 RALRLIQFSE 219 ILQFLNILKT229 SNSIKLVNLL239 SIFISTWLTA249 AGFIHLVENS259 GDPWENFQNN 269 QALTYWECVY279 LLMVTMSTVG289 YGDVYAKTTL299 GRLFMVFFIL309 GGLAMFASYV 319 PEIIELIGNR329 KKYGGSYSAV339 SGRKHIVVCG349 HITLESVSNF359 LKDFLHKDRD 369 DVNVEIVFLH379 NISPNLELEA389 LFKRHFTQVE399 FYQGSVLNPH409 DLARVKIESA 419 DACLILANKY429 CADPDAEDAS439 NIMRVISIKN449 YHPKIRIITQ459 MLQYHNKAHL 469 LNIPSWNWKE479 GDDAICLAEL489 KLGFIAQSCL499 AQGLSTMLAN509 LFSMRSFIKI 519 EEDTWQKYYL529 EGVSNEMYTE539 YLSSAFVGLS549 FPTVCELCFV559 KLKLLMISRI 579 LINPGNGTLG595 FFIASDAKEV605 KRAFFYCKKK685 YDSTGMFHWC695 APKEIEKVIL 705 TRSEAAMTVL715 SGHVVVCIFG725 DVSSALIGLR735 NLVMPLRASN745 FHYHELKHIV 755 FVGSIEYLKR765 EWETLHNFPK775 VSILPGTPLS785 RADLRAVNIN795 LCDMCVILSA 805 NQNNIDDTSL815 QDKECILASL825 NIKSMQFDTT872 GVNIPIITEL882 VNDTNVQFLD 892 QDDDDDPDTE902 LYLTQPFACG912 TAFAVSVLDS922 LMSATYFNDN932 ILTLIRTLVT 942 GGATPELEAL952 IAEENALRGG962 YSTPQTLANR972 DRCRVAQLAL982 LDGPFADLGD 992 GGCYGDLFCK1002 ALKTYNMLCF1012 GIYRLRDAHL1022 STPSQCTKRY1032 VITNPPYEFE 1042 LVPTDLIFCL1052 MQFD
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular structures of the human Slo1 K(+) channel in complex with beta4. Elife. 2019 Dec 9;8:e51409. | ||||
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