Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81735 | Target Info | |||
| Target Name | DNA-dependent protein kinase catalytic (PRKDC) | ||||
| Synonyms | p460; HYRC1; HYRC; DNPK1; DNA-dependent protein kinase catalytic subunit; DNA-PKcs; DNA-PK catalytic subunit | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PRKDC | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Adenosine triphosphate | Ligand Info | |||
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N | ||||
| InChI | 1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 | ||||
| InChIKey | ZKHQWZAMYRWXGA-KQYNXXCUSA-N | ||||
| PubChem Compound ID | 5957 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7SGL DNA-PK complex of DNA end processing | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
MAGSGAGVRC
10 SLLRLQETLS20 AADRCGAALA30 GHQLIRGLGQ40 ECVLSSSPAV50 LALQTSLVFS 60 RDFGLLVFVR70 KSLNSIEFRE80 CREEILKFLC90 IFLEKMGQKI100 APYSVEIKNT 110 CTSVYTKDRA120 AKCKIPALDL130 LIKLLQTFRS140 SRLMDEFKIG150 ELFSKFYGEL 160 ALKKKIPDTV170 LEKVYELLGL180 LGEVHPSEMI190 NNAENLFRAF200 LGELKTQMTS 210 AVREPKLPVL220 AGCLKGLSSL230 LCNFTKSMEE240 DPQTSREIFN250 FVLKAIRPQI 260 DLKRYAVPSA270 GLRLFALHAS280 QFSTCLLDNY290 VSLFEVLLKW300 CAHTNVELKK 310 AALSALESFL320 KQVSNMVAKN330 AEMHKNKLQY340 FMEQFYGIIR350 NVDSNNKELS 360 IAIRGYGLFA370 GPCKVINAKD380 VDFMYVELIQ390 RCKQMFLTQT400 DTGDDRVYQM 410 PSFLQSVASV420 LLYLDTVPEV430 YTPVLEHLVV440 MQIDSFPQYS450 PKMQLVCCRA 460 IVKVFLALAA470 KGPVLRNCIS480 TVVHQGLIRI490 CSKPVVLPKG500 PESESEDHRA 510 SGEVRTGKWK520 VPTYKDYVDL530 FRHLLSSDQM540 MDSILADEAF550 FSVNSSSESL 560 NHLLYDEFVK570 SVLKIVEKLD580 LTLEIDPAAN611 LHPAKPKDFS621 AFINLVEFCR 631 EILPEKQAEF641 FEPWVYSFSY651 ELILQSTRLP661 LISGFYKLLS671 ITVRNAKKIK 681 YFEGVSDPEK700 YSCFALFVKF710 GKEVAVKMKQ720 YKDELLASCL730 TFLLSLPHNI 740 IELDVRAYVP750 ALQMAFKLGL760 SYTPLAEVGL770 NALEEWSIYI780 DRHVMQPYYK 790 DILPCLDGYL800 KTNWEVSALS819 RAAAISLEEI851 RIRVVQMLGS861 LGGQINKNLL 871 TVTSSDEMMK881 SYVAWDREKR891 LSFAVPFREM901 KPVIFLDVFL911 PRVTELALTA 921 SDRQTKVAAC931 ELLHSMVMFM941 LGKATQMPEG951 GQGAPPMYQL961 YKRTFPVLLR 971 LACDVDQVTR981 QLYEPLVMQL991 IHWFTNNKKF1001 ESQDTVALLE1011 AILDGIVDPV 1021 DSTLRDFCGR1031 CIREFLKWSI1041 KQITPQQQEK1051 SPVNTKSLFK1061 RLYSLALHPN 1071 AFKRLGASLA1081 FNNIYREFRE1091 EESLVEQFVF1101 EALVIYMESL1111 ALAHADEKSL 1121 GTIQQCCDAI1131 DHLCRIIEKK1141 HVSLNKAKKR1151 RLPRGFPPSA1161 SLCLLDLVKW 1171 LLAHCGRPQT1181 ECRHKSIELF1191 YKFVPLLPGN1201 RSPNLWLKDV1211 LKEEGVSFLI 1221 NTFEGGGCGQ1231 PSGILAQPTL1241 LYLRGPFSLQ1251 ATLCWLDLLL1261 AALECYNTFI 1271 GERTVGALQV1281 LGTEAQSSLL1291 KAVAFFLESI1301 AMHDIIAAEK1311 CFGTGAAGNR 1321 TSPQEGERYN1331 YSKCTVVVRI1341 MEFTTTLLNT1351 SPEGWKLLKK1361 DLCNTHLMRV 1371 LVQTLCEPAS1381 IGFNIGDVQV1391 MAHLPDVCVN1401 LMKALKMSPY1411 KDILETHLRE 1421 KITAQSIEEL1431 CAVNLYGPDA1441 QVDRSRLAAV1451 VSACKQLHRA1461 GLLHNILPSQ 1471 STDLHHSVGT1481 ELLSLVYKGI1491 APGDERQCLP1501 SLDLSCKQLA1511 SGLLELAFAF 1521 GGLCERLVSL1531 LLNPAVLSTS1549 VIHFSHGEYF1559 YSLFSETINT1569 ELLKNLDLAV 1579 LELMQSSVDN1589 TKMVSAVLNG1599 MLDQSFRERA1609 NQKHQGLKLA1619 TTILQHWKKC 1629 DSWWAKDSPL1639 ETKMAVLALL1649 AKILQIDSSV1659 SFNTSHGSFP1669 EVFTTYISLL 1679 ADTKLDLHLK1689 GQAVTLLPFF1699 TSLTGGSLEE1709 LRRVLEQLIV1719 AHFPMQSREF 1729 PPGTPRFNNY1739 VDCMKKFLDA1749 LELSQSPMLL1759 ELMTEVLCRE1769 QQHVMEELFQ 1779 SSFRRIARRG1789 SCVTQVGLLE1799 SVYEMFRKDD1809 PRLSFTRQSF1819 VDRSLLTLLW 1829 HCSLDALREF1839 FSTIVVDAID1849 VLKSRFTKLN1859 ESTFDTQITK1869 KMGYYKILDV 1879 MYSRLPKDDV1889 HAKESKINQV1899 FHGSCITEGN1909 ELTKTLIKLC1919 YDAFTENMAG 1929 ENQLLERRRL1939 YHCAAYNCAI1949 SVICCVFNEL1959 KFYQGFLFSE1969 KPEKNLLIFE 1979 NLIDLKRRYN1989 FPVEVEVPME1999 RKKKYIEIRK2009 EAREAANGDS2019 DGPSYMSSLS 2029 YLADSTLSEE2039 MSQFDFSTGV2049 QSYSYSSQLE2084 MDELNRHECM2094 APLTALVKHM 2104 HRSPRDLPSW2125 MKFLHGKLGN2135 PIVPLNIRLF2145 LAKLVINTEE2155 VFRPYAKHWL 2165 SPLLQLAASE2175 NNGGEGIHYM2185 VVEIVATILS2195 WTGLATPTGV2205 PKDEVLANRL 2215 LNFLMKHVFH2225 PKRAVFRHNL2235 EIIKTLVECW2245 KDCLSIPYRL2255 IFEKFSGKDP 2265 NSKDNSVGIQ2275 LLGIVMANDL2285 PPYDPQCGIQ2295 SSEYFQALVN2305 NMSFVRYKEV 2315 YAAAAEVLGL2325 ILRYVMERKN2335 ILEESLCELV2345 AKQLKQHQNT2355 MEDKFIVCLN 2365 KVTKSFPPLA2375 DRFMNAVFFL2385 LPKFHGVLKT2395 LCLEVVLCRV2405 EGMTELYFQL 2415 KSKDFVQVMR2425 HRDDERQKVC2435 LDIIYKMMPK2445 LKPVELRELL2455 NPVVEFVSHP 2465 STTCREQMYN2475 ILMWIHDNYR2485 DPESETDNDS2495 QEIFKLAKDV2505 LIQGLIDENP 2515 GLQLIIRNFW2525 SHETRLPSNT2535 LDRLLALNSL2545 YSPKIEVHFL2555 SLATNFLLEM 2565 TSMSPDYPNP2575 MFEHPLSECE2585 FQEYTIDSDW2595 RFRSTVLTPM2605 FVEQASQGPV 2631 AGQIRAQQQH2642 DFLQTQVVLY2772 RSYRHGDLPD2782 IQIKHSSLIT2792 PLQAVAQRDP 2802 IIAKQLFSSL2812 FSGILKEMDK2822 FKTLSEKNNI2832 TQKLLQDFNR2842 FLNTTFSFFP 2852 PFVSCIQDIS2862 CQHAALLSLD2872 PAAVSAGCLA2882 SLQQPVGIRL2892 LEEALLRLLP 2902 ALPPDVLRWV2924 ELAKLYRSIG2934 EYDVLRGIFT2944 SEIGTKQITQ2954 SALLAEARSD 2964 YSEAAKQYDE2974 ALNKQDWVDG2984 EPTEAEKDFW2994 ELASLDCYNH3004 LAEWKSLEYC 3014 STASIDSENP3024 PDLNKIWSEP3034 FYQETYLPYM3044 IRSKLKLLLQ3054 GEADQSLLTF 3064 IDKAMHGELQ3074 KAILELHYSQ3084 ELSLLYLLQD3094 DVDRAKYYIQ3104 NGIQSFMQNY 3114 SSIDVLLHQS3124 RLTKLQSVQA3134 LTEIQEFISF3144 ISKQGNLSSQ3154 VPLKRLLNTW 3164 TNRYPDAKMD3174 PMNIWDDIIT3184 NRCFFLSKIE3194 EKLTEDISSL3230 IRSCKFSMKM 3240 KMIDSARKQN3250 NFSLAMKLLK3260 ELHKESKTRD3270 DWLVSWVQSY3280 CRLSHCRSRS 3290 QGCSEQVLTV3300 LKTVSLLDEN3310 NVSSYLSKNI3320 LAFRDQNILL3330 GTTYRIIANA 3340 LSSEPACLAE3350 IEEDKARRIL3360 ELSGSSSEDS3370 EKVIAGLYQR3380 AFQHLSEAVQ 3390 AAEEEAQPPS3400 WSCGPAAGVI3410 DAYMTLADFC3420 DQQLRKEEEN3430 ASVIDSAELQ 3440 AYPALVVEKM3450 LKALKLNSNE3460 ARLKFPRLLQ3470 IIERYPEETL3480 SLMTKEISSV 3490 PCWQFISWIS3500 HMVALLDKDQ3510 AVAVQHSVEE3520 ITDNYPQAIV3530 YPFIISSESY 3540 SFKDTSTGHK3550 NKEFVARIKS3560 KLDQGGVIQD3570 FINALDQLSN3580 PELLFKDWSN 3590 DVRAELAKTP3600 VNKKNIEKMY3610 ERMYAALGDP3620 KAPGLGAFRR3630 KFIQTFGKEF 3640 DKHFGKGGSK3650 LLRMKLSDFN3660 DITNMLLLKM3670 NKDSKPPGNL3680 KECSPWMSDF 3690 KVEFLRNELE3700 IPGQYDGRGK3710 PLPEYHVRIA3720 GFDERVTVMA3730 SLRRPKRIII 3740 RGHDEREHPF3750 LVKGGEDLRQ3760 DQRVEQLFQV3770 MNGILAQDSA3780 CSQRALQLRT 3790 YSVVPMTSRL3800 GLIEWLENTV3810 TLKDLLLNTM3820 SQEEKAAYLS3830 DPRAPPCEYK 3840 DWLTKMSGKH3850 DVGAYMLMYK3860 GANRTETVTS3870 FRKRESKVPA3880 DLLKRAFVRM 3890 STSPEAFLAL3900 RSHFASSHAL3910 ICISHWILGI3920 GDRHLNNFMV3930 AMETGGVIGI 3940 DFGHAFGSAT3950 QFLPVPELMP3960 FRLTRQFINL3970 MLPMKETGLM3980 YSIMVHALRA 3990 FRSDPGLLTN4000 TMDVFVKEPS4010 FDWKNFEQKM4020 LKKGGSWIQE4030 INVAEKNWYP 4040 RQKICYAKRK4050 LAGANPAVIT4060 CDELLLGHEK4070 APAFRDYVAV4080 ARGSKDHNIR 4090 AQEPESGLSE4100 ETQVKCLMDQ4110 ATDPNILGRT4120 WEGWEPWM
|
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|
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PHE2597
4.309
MET3729
3.915
SER3731
3.843
ARG3733
4.969
PRO3735
4.207
LEU3751
3.741
LYS3753
2.920
TYR3791
4.497
ILE3803
3.697
GLU3804
3.160
TRP3805
3.217
|
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| PDB ID: 7SU3 CryoEM structure of DNA-PK complex VII | ||||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
GVRCSLLRLQ
16 ETLSAADRCG26 AALAGHQLIR36 GLGQECVLSS46 SPAVLALQTS56 LVFSRDFGLL 66 VFVRKSLNSI76 EFRECREEIL86 KFLCIFLEKM96 GQKIAPYSVE106 IKNTCTSVYT 116 KDRAAKCKIP126 ALDLLIKLLQ136 TFRSSRLMDE146 FKIGELFSKF156 YGELALKKKI 166 PDTVLEKVYE176 LLGLLGEVHP186 SEMINNAENL196 FRAFLGELKT206 QMTSAVREPK 216 LPVLAGCLKG226 LSSLLCNFTK236 SMEEDPQTSR246 EIFNFVLKAI256 RPQIDLKRYA 266 VPSAGLRLFA276 LHASQFSTCL286 LDNYVSLFEV296 LLKWCAHTNV306 ELKKAALSAL 316 ESFLKQVSNM326 VAKNAEMHKN336 KLQYFMEQFY346 GIIRNVDSNN356 KELSIAIRGY 366 GLFAGPCKVI376 NAKDVDFMYV386 ELIQRCKQMF396 LTQTDTGDDR406 VYQMPSFLQS 416 VASVLLYLDT426 VPEVYTPVLE436 HLVVMQIDSF446 PQYSPKMQLV456 CCRAIVKVFL 466 ALAAKGPVLR476 NCISTVVHQG486 LIRICSKPVV496 WKVPTYKDYV528 DLFRHLLSSD 538 QMMDSILAES559 LNHLLYDEFV569 KSVLKIVEKL579 DLTLEIQAAN611 LHPAKPKDFS 621 AFINLVEFCR631 EILPEKQAEF641 FEPWVYSFSY651 ELILQSTRLP661 LISGFYKLLS 671 ITVRNAKKIK681 YFEGVDPEKY701 SCFALFVKFG711 KEVAVKMKQY721 KDELLASCLT 731 FLLSLPHNII741 ELDVRAYVPA751 LQMAFKLGLS761 YTPLAEVGLN771 ALEEWSIYID 781 RHVMQPYYKD791 ILPCLDGYLK801 TSALSDETKN811 NWEVSALSRA821 AQKGFNKVVL 831 KHLKKTKNLS841 SNEAISLEEI851 RIRVVQMLGS861 LGGQINKNLL871 TVTSSDEMMK 881 SYVAWDREKR891 LSFAVPFREM901 KPVIFLDVFL911 PRVTELALTA921 SDRQTKVAAC 931 ELLHSMVMFM941 LGKATQMPEG951 GQGAPPMYQL961 YKRTFPVLLR971 LACDVDQVTR 981 QLYEPLVMQL991 IHWFTNNKKF1001 ESQDTVALLE1011 AILDGIVDPV1021 DSTLRDFCGR 1031 CIREFLKWSI1041 KQITPQQQEK1051 SPVNTKSLFK1061 RLYSLALHPN1071 AFKRLGASLA 1081 FNNIYREFRE1091 EESLVEQFVF1101 EALVIYMESL1111 ALAHADEKSL1121 GTIQQCCDAI 1131 DHLCRIIEKK1141 HVSLNKAKKR1151 RLPRGFPPSA1161 SLCLLDLVKW1171 LLAHCGRPQT 1181 ECRHKSIELF1191 YKFVPLLPGN1201 RSPNLWLKDV1211 LKEEGVSFLI1221 NTFEGGGCGQ 1231 PSGILAQPTL1241 LYLRGPFSLQ1251 ATLCWLDLLL1261 AALECYNTFI1271 GERTVGALQV 1281 LGTEAQSSLL1291 KAVAFFLESI1301 AMHDIIAAEK1311 CSPQEGERYN1331 YSKCTVVVRI 1341 MEFTTTLLNT1351 SPEGWKLLKK1361 DLCNTHLMRV1371 LVQTLCEPAS1381 IGFNIGDVQV 1391 MAHLPDVCVN1401 LMKALKMSPY1411 KDILETHLRE1421 KITAQSIEEL1431 CAVNLYGPDA 1441 QVDRSRLAAV1451 VSACKQLHRA1461 GLLHNILPSQ1471 STDLHHSVGT1481 ELLSLVYKGI 1491 APGQCLPSLD1504 LSCKQLASGL1514 LELAFAFGGL1524 CERLVSLLLN1534 PAVLSTAVIH 1552 FSHGEYFYSL1562 FSETINTELL1572 KNLDLAVLEL1582 MQSSVDNTKM1592 VSAVLNGMLD 1602 QSFRERANQK1612 HQGLKLATTI1622 LQHWKKCDSW1632 WAKDSPLETK1642 MAVLALLAKI 1652 LQIDSSVSFN1662 TSHGSFPEVF1672 TTYISLLADT1682 KLDLHLKGQA1692 VTLLPFFTSL 1702 TGGSLEELRR1712 VLEQLIVAHF1722 PMQSREFPPG1732 TPRFNNYVDC1742 MKKFLDALEL 1752 SQSPMLLELM1762 TEVLCREQQH1772 VMEELFQSSF1782 RRIARRGSCV1792 TQVGLLESVY 1802 EMFRKDDPRL1812 SFTRQSFVDR1822 SLLTLLWHCS1832 LDALREFFST1842 IVVDAIDVLK 1852 SRFTKLNEST1862 FDTQITKKMG1872 YYKILDVMYS1882 RLPKDDVHAK1892 ESKINQVFHG 1902 SCITEGNELT1912 KTLIKLCYDA1922 FTENMAGENQ1932 LLERRRLYHC1942 AAYNCAISVI 1952 CCVFNELKFY1962 QGFLFSEKPE1972 KNLLIFENLI1982 DLKRRYNFPV1992 EVEVPMERKE 2082 LEMDELNRHE2092 CMAPLTALVK2102 HMHRSLPRDL2122 PSWMKFLHGK2132 LGNPIVPLNI 2142 RLFLAKLVIN2152 TEEVFRPYAK2162 HWLSPLLQLA2172 ASENNGGEGI2182 HYMVVEIVAT 2192 ILSWTGLATP2202 TGVPKDEVLA2212 NRLLNFLMKH2222 VFHPKRAVFR2232 HNLEIIKTLV 2242 ECWKDCLSIP2252 YRLIFEKFSG2262 KDPNSKDNSV2272 GIQLLGIVMA2282 NDLPPYDPQC 2292 GIQSSEYFQA2302 LVNNMSFVRY2312 KEVYAAAAEV2322 LGLILRYVME2332 RKNILEESLC 2342 ELVAKQLKQH2352 QNTMEDKFIV2362 CLNKVTKSFP2372 PLADRFMNAV2382 FFLLPKFHGV 2392 LKTLCLEVVL2402 CRVEGMTELY2412 FQLKSKDFVQ2422 VMRHRDDERQ2432 KVCLDIIYKM 2442 MPKLKPVELR2452 ELLNPVVEFV2462 SHPSTTCREQ2472 MYNILMWIHD2482 NYRDPESETD 2492 NDSQEIFKLA2502 KDVLIQGLID2512 ENPGLQLIIR2522 NFWSHETRLP2532 SNTLDRLLAL 2542 NSLYSPKIEV2552 HFLSLATNFL2562 LEMTSMSPDY2572 PNPMFEHPLS2582 ECEFQEYTID 2592 SDWRFRSTVL2602 TPMFVETQRS2654 SFDWLTGSSS2675 DSLLFAHAAG2721 RTDLLRLRRR 2731 FMRDQEKLSL2741 MYARKGVAEQ2751 KREKEIKSEL2761 KMKQDAQVVL2771 YRSYRHGDLP 2781 DIQIKHSSLI2791 TPLQAVAQRD2801 PIIAKQLFSS2811 LFSGILKEMD2821 KFKTLSEKNN 2831 ITQKLLQDFN2841 RFLNTTFSFF2851 PPFVSCIQDI2861 SCQHAALLSL2871 DPAAVSAGCL 2881 ASLQQPVGIR2891 LLEEALLRPP2918 DVLRWVELAK2928 LYRSIGEYDV2938 LRGIFTSEIG 2948 TKQITQSALL2958 AEARSDYSEA2968 AKQYDEALNK2978 QDWVDGEPTE2988 AEKDFWELAS 2998 LDCYNHLAEW3008 KSLEYCSTAS3018 IDSENPPDLN3028 KIWSEPFYQE3038 TYLPYMIRSK 3048 LKLLLQGEAD3058 QSLLTFIDKA3068 MHGELQKAIL3078 ELHYSQELSL3088 LYLLQDDVDR 3098 AKYYIQNGIQ3108 SFMQNYSSID3118 VLLHQSRLTK3128 LQSVQALTEI3138 QEFISFISKQ 3148 GNLSSQVPLK3158 RLLNTWTNRY3168 PDAKMDPMNI3178 WDDIITNRCF3188 FLSKIEEKLT 3198 DISSLIRSCK3235 FSMKMKMIDS3245 ARKQNNFSLA3255 MKLLKELHKE3265 SKTRDDWLVS 3275 WVQSYCRLSH3285 CRSRSQGCSE3295 QVLTVLKTVS3305 LLDENNVSSY3315 LSKNILAFRD 3325 QNILLGTTYR3335 IIANALSSEP3345 ACLAEIEEDK3355 ARRILELSGS3365 SSEDSEKVIA 3375 GLYQRAFQHL3385 SEAVQAAEEA3406 AGVIDAYMTL3416 ADFCDQQLRK3426 EEENASVIDS 3436 AELQAYPALV3446 VEKMLKALKL3456 NSNEARLKFP3466 RLLQIIERYP3476 EETLSLMTKE 3486 ISSVPCWQFI3496 SWISHMVALL3506 DKDQAVAVQH3516 SVEEITDNYP3526 QAIVYPFIIS 3536 SESYSFKDTS3546 TGHKNKEFVA3556 RIKSKLDQGG3566 VIQDFINALD3576 QLSNPELLFK 3586 DWSNDVRAEL3596 AKTPVNKKNI3606 EKMYERMYAA3616 LGDPKAPGLG3626 AFRRKFIQTF 3636 GKEFDKHFGK3646 GGSKLLRMKL3656 SDFNDITNML3666 LLKMNKDSKP3676 PGNLKECSPW 3686 MSDFKVEFLR3696 NELEIPGQYD3706 GRGKPLPEYH3716 VRIAGFDERV3726 TVMASLRRPK 3736 RIIIRGHDER3746 EHPFLVKGGE3756 DLRQDQRVEQ3766 LFQVMNGILA3776 QDSACSQRAL 3786 QLRTYSVVPM3796 TSRLGLIEWL3806 ENTVTLKDLL3816 LNTMSQEEKA3826 AYLSDPRAPP 3836 CEYKDWLTKM3846 SGKHDVGAYM3856 LMYKGANRTE3866 TVTSFRKRES3876 KVPADLLKRA 3886 FVRMSTSPEA3896 FLALRSHFAS3906 SHALICISHW3916 ILGIGDRHLN3926 NFMVAMETGG 3936 VIGIDFGHAF3946 GSATQFLPVP3956 ELMPFRLTRQ3966 FINLMLPMKE3976 TGLMYSIMVH 3986 ALRAFRSDPG3996 LLTNTMDVFV4006 KEPSFDWKNF4016 EQKMLKKGGS4026 WIQEINVAEK 4036 NWYPRQKICY4046 AKRKLAGANP4056 AVITCDELLL4066 GHEKAPAFRD4076 YVAVARGSKD 4086 HNIRAQEPES4096 GLSEETQVKC4106 LMDQATDPNI4116 LGRTWEGWEP4126 WM |
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MET3729
3.318
SER3731
2.744
ARG3733
4.388
PRO3735
4.512
LEU3751
3.766
LYS3753
3.809
TYR3791
3.499
ILE3803
3.484
GLU3804
3.076
TRP3805
3.409
|
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| PDB ID: 7SUD CryoEM structure of DNA-PK complex VIII | ||||||
| Method | Electron microscopy | Resolution | 3.60 Å | Mutation | No | [1] |
| PDB Sequence |
GVRCSLLRLQ
16 ETLSAADRCG26 AALAGHQLIR36 GLGQECVLSS46 SPAVLALQTS56 LVFSRDFGLL 66 VFVRKSLNSI76 EFRECREEIL86 KFLCIFLEKM96 GQKIAPYSVE106 IKNTCTSVYT 116 KDRAAKCKIP126 ALDLLIKLLQ136 TFRSSRLMDE146 FKIGELFSKF156 YGELALKKKI 166 PDTVLEKVYE176 LLGLLGEVHP186 SEMINNAENL196 FRAFLGELKT206 QMTSAVREPK 216 LPVLAGCLKG226 LSSLLCNFTK236 SMEEDPQTSR246 EIFNFVLKAI256 RPQIDLKRYA 266 VPSAGLRLFA276 LHASQFSTCL286 LDNYVSLFEV296 LLKWCAHTNV306 ELKKAALSAL 316 ESFLKQVSNM326 VAKNAEMHKN336 KLQYFMEQFY346 GIIRNVDSNN356 KELSIAIRGY 366 GLFAGPCKVI376 NAKDVDFMYV386 ELIQRCKQMF396 LTQTDTGDDR406 VYQMPSFLQS 416 VASVLLYLDT426 VPEVYTPVLE436 HLVVMQIDSF446 PQYSPKMQLV456 CCRAIVKVFL 466 ALAAKGPVLR476 NCISTVVHQG486 LIRICSKPVV496 WKVPTYKDYV528 DLFRHLLSSD 538 QMMDSILAES559 LNHLLYDEFV569 KSVLKIVEKL579 DLTLEIQAAN611 LHPAKPKDFS 621 AFINLVEFCR631 EILPEKQAEF641 FEPWVYSFSY651 ELILQSTRLP661 LISGFYKLLS 671 ITVRNAKKIK681 YFEGVPEKYS702 CFALFVKFGK712 EVAVKMKQYK722 DELLASCLTF 732 LLSLPHNIIE742 LDVRAYVPAL752 QMAFKLGLSY762 TPLAEVGLNA772 LEEWSIYIDR 782 HVMQPYYKDI792 LPCLDGYLKT802 TKNNWEVSAL818 SRAAQKGAIS847 LEEIRIRVVQ 857 MLGSLGGQIN867 KNLLTVTSSD877 EMMKSYVAWD887 REKRLSFAVP897 FREMKPVIFL 907 DVFLPRVTEL917 ALTASDRQTK927 VAACELLHSM937 VMFMLGKATQ947 MPEGGQGAPP 957 MYQLYKRTFP967 VLLRLACDVD977 QVTRQLYEPL987 VMQLIHWFTN997 NKKFESQDTV 1007 ALLEAILDGI1017 VDPVDSTLRD1027 FCGRCIREFL1037 KWSIKQITPQ1047 QQEKSPVNTK 1057 SLFKRLYSLA1067 LHPNAFKRLG1077 ASLAFNNIYR1087 EFREEESLVE1097 QFVFEALVIY 1107 MESLALAHAD1117 EKSLGTIQQC1127 CDAIDHLCRI1137 IEKKHVSLNK1147 AKKRRLPRGF 1157 PPSASLCLLD1167 LVKWLLAHCG1177 RPQTECRHKS1187 IELFYKFVPL1197 LPGNRSPNLW 1207 LKDVLKEEGV1217 SFLINTFEGG1227 GCGQPSGILA1237 QPTLLYLRGP1247 FSLQATLCWL 1257 DLLLAALECY1267 NTFIGERTVG1277 ALQVLGTEAQ1287 SSLLKAVAFF1297 LESIAMHDII 1307 AAEKCNRTSP1324 QEGERYNYSK1334 CTVVVRIMEF1344 TTTLLNTSPE1354 GWKLLKKDLC 1364 NTHLMRVLVQ1374 TLCEPASIGF1384 NIGDVQVMAH1394 LPDVCVNLMK1404 ALKMSPYKDI 1414 LETHLREKIT1424 AQSIEELCAV1434 NLYGPDAQVD1444 RSRLAAVVSA1454 CKQLHRAGLL 1464 HNILPSQSTD1474 LHHSVGTELL1484 SLVYKGIAPG1494 QCLPSLDLSC1507 KQLASGLLEL 1517 AFAFGGLCER1527 LVSLLLNPAV1537 LSTAVIHFSH1555 GEYFYSLFSE1565 TINTELLKNL 1575 DLAVLELMQS1585 SVDNTKMVSA1595 VLNGMLDQSF1605 RERANQKHQG1615 LKLATTILQH 1625 WKKCDSWWAK1635 DSPLETKMAV1645 LALLAKILQI1655 DSSVSFNTSH1665 GSFPEVFTTY 1675 ISLLADTKLD1685 LHLKGQAVTL1695 LPFFTSLTGG1705 SLEELRRVLE1715 QLIVAHFPMQ 1725 SREFPPGTPR1735 FNNYVDCMKK1745 FLDALELSQS1755 PMLLELMTEV1765 LCREQQHVME 1775 ELFQSSFRRI1785 ARRGSCVTQV1795 GLLESVYEMF1805 RKDDPRLSFT1815 RQSFVDRSLL 1825 TLLWHCSLDA1835 LREFFSTIVV1845 DAIDVLKSRF1855 TKLNESTFDT1865 QITKKMGYYK 1875 ILDVMYSRLP1885 KDDVHAKESK1895 INQVFHGSCI1905 TEGNELTKTL1915 IKLCYDAFTE 1925 NMAGENQLLE1935 RRRLYHCAAY1945 NCAISVICCV1955 FNELKFYQGF1965 LFSEKPEKNL 1975 LIFENLIDLK1985 RRYNFPVEVE1995 VPMERKKKYI2005 EIRKEAREAA2015 NGDSDGPSYM 2025 DELNRHECMA2095 PLTALVKHMH2105 RSLLPSWMKF2128 LHGKLGNPIV2138 PLNIRLFLAK 2148 LVINTEEVFR2158 PYAKHWLSPL2168 LQLAASENNG2178 GEGIHYMVVE2188 IVATILSWTG 2198 LATPTGVPKD2208 EVLANRLLNF2218 LMKHVFHPKR2228 AVFRHNLEII2238 KTLVECWKDC 2248 LSIPYRLIFE2258 KFSGKDPNSK2268 DNSVGIQLLG2278 IVMANDLPPY2288 DPQCGIQSSE 2298 YFQALVNNMS2308 FVRYKEVYAA2318 AAEVLGLILR2328 YVMERKNILE2338 ESLCELVAKQ 2348 LKQHQNTMED2358 KFIVCLNKVT2368 KSFPPLADRF2378 MNAVFFLLPK2388 FHGVLKTLCL 2398 EVVLCRVEGM2408 TELYFQLKSK2418 DFVQVMRHRD2428 DERQKVCLDI2438 IYKMMPKLKP 2448 VELRELLNPV2458 VEFVSHPSTT2468 CREQMYNILM2478 WIHDNYRDPE2488 SETDNDSQEI 2498 FKLAKDVLIQ2508 GLIDENPGLQ2518 LIIRNFWSHE2528 TRLPSNTLDR2538 LLALNSLYSP 2548 KIEVHFLSLA2558 TNFLLEMTSM2568 SPDYPNPMFE2578 HPLSECEFQE2588 YTIDSDWRFR 2598 STVLTPMFVE2608 QASQGQIRAQ2639 QQHDFLQVVL2771 YRSYRHGDLP2781 DIQIKHSSLI 2791 TPLQAVAQRD2801 PIIAKQLFSS2811 LFSGILKEMD2821 KFKTLSEKNN2831 ITQKLLQDFN 2841 RFLNTTFSFF2851 PPFVSCIQDI2861 SCQHAALLSL2871 DPAAVSAGCL2881 ASLQQPVGIR 2891 LLEEALLRPP2918 DVLRWVELAK2928 LYRSIGEYDV2938 LRGIFTSEIG2948 TKQITQSALL 2958 AEARSDYSEA2968 AKQYDEALNK2978 QDWVDGEPTE2988 AEKDFWELAS2998 LDCYNHLAEW 3008 KSLEYCSTAS3018 IDSENPPDLN3028 KIWSEPFYQE3038 TYLPYMIRSK3048 LKLLLQGEAD 3058 QSLLTFIDKA3068 MHGELQKAIL3078 ELHYSQELSL3088 LYLLQDDVDR3098 AKYYIQNGIQ 3108 SFMQNYSSID3118 VLLHQSRLTK3128 LQSVQALTEI3138 QEFISFISKQ3148 GNLSSQVPLK 3158 RLLNTWTNRY3168 PDAKMDPMNI3178 WDDIITNRCF3188 FLSKIEEKLT3198 DISSLIRSCK 3235 FSMKMKMIDS3245 ARKQNNFSLA3255 MKLLKELHKE3265 SKTRDDWLVS3275 WVQSYCRLSH 3285 CRSRSQGCSE3295 QVLTVLKTVS3305 LLDENNVSSY3315 LSKNILAFRD3325 QNILLGTTYR 3335 IIANALSSEP3345 ACLAEIEEDK3355 ARRILELSGS3365 SSEDSEKVIA3375 GLYQRAFQHL 3385 SEAVQAAEEA3406 AGVIDAYMTL3416 ADFCDQQLRK3426 EEENAELQAY3442 PALVVEKMLK 3452 ALKLNSNEAR3462 LKFPRLLQII3472 ERYPEETLSL3482 MTKEISSVPC3492 WQFISWISHM 3502 VALLDKDQAV3512 AVQHSVEEIT3522 DNYPQAIVYP3532 FIISSESYSF3542 KDTSTGHKNK 3552 EFVARIKSKL3562 DQGGVIQDFI3572 NALDQLSNPE3582 LLFKDWSNDV3592 RAELAKTPVN 3602 KKNIEKMYER3612 MYAALGDPKA3622 PGLGAFRRKF3632 IQTFGKEFDK3642 HFGKGGSKLL 3652 RMKLSDFNDI3662 TNMLLLKMNK3672 DSKPPGNLKE3682 CSPWMSDFKV3692 EFLRNELEIP 3702 GQYDGRGKPL3712 PEYHVRIAGF3722 DERVTVMASL3732 RRPKRIIIRG3742 HDEREHPFLV 3752 KGGEDLRQDQ3762 RVEQLFQVMN3772 GILAQDSACS3782 QRALQLRTYS3792 VVPMTSRLGL 3802 IEWLENTVTL3812 KDLLLNTMSQ3822 EEKAAYLSDP3832 RAPPCEYKDW3842 LTKMSGKHDV 3852 GAYMLMYKGA3862 NRTETVTSFR3872 KRESKVPADL3882 LKRAFVRMST3892 SPEAFLALRS 3902 HFASSHALIC3912 ISHWILGIGD3922 RHLNNFMVAM3932 ETGGVIGIDF3942 GHAFGSATQF 3952 LPVPELMPFR3962 LTRQFINLML3972 PMKETGLMYS3982 IMVHALRAFR3992 SDPGLLTNTM 4002 DVFVKEPSFD4012 WKNFEQKMLK4022 KGGSWIQEIN4032 VAEKNWYPRQ4042 KICYAKRKLA 4052 GANPAVITCD4062 ELLLGHEKAP4072 AFRDYVAVAR4082 GSKDHNIRAQ4092 EPESGLSEET 4102 QVKCLMDQAT4112 DPNILGRTWE4122 GWEPWM
|
|||||
|
|
MET3729
3.893
SER3731
3.516
LEU3732
4.767
ARG3733
4.048
PRO3735
4.089
LEU3751
3.465
LYS3753
2.410
TYR3791
3.842
ILE3803
3.609
GLU3804
3.075
|
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| References | Top | ||||
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| REF 1 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol Cell. 2022 Jan 6;82(1):177-189.e4. | ||||
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