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Target General Information |
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Target ID |
T01575 |
Target Info
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Target Name |
Sphingosine-1-phosphate lyase 1 (SGPL1) |
Synonyms |
hSPL; Sphingosine-1-phosphate aldolase; SPL 1; SP-lyase 1; S1PL; KIAA1252 |
Target Type |
Clinical trial Target |
Gene Name |
SGPL1 |
Biochemical Class |
Carbon-carbon lyase |
UniProt ID |
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The microRNAs (miRNAs) Regulating This Target |
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miRNA Mature ID |
hsa-miR-125b-1-3p |
miRNA Info
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miRNA Mature AC |
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Sequence |
acggguuaggcucuugggagcu
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miRNA Species |
Homo sapiens |
Regulation Mechanism |
Overexpression of miR-125b significantly reduced SGPL1 expression. |
[1] |
Evidence Score (E-score) |
1 |
+ |
1 |
ELISA; Luciferase Reporter Assay; Western Blot |
[1] |
Representative Target(s) Regulated by This miRNA |
Cellular tumor antigen p53 (TP53)
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Target Info
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ERK activator kinase 7 (MAP2K7)
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Target Info
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References |
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REF 1 |
miR-125b Enhances IL-8 Production in Early-Onset Severe Preeclampsia by Targeting Sphingosine-1-Phosphate Lyase 1. PLoS One. 2016 Dec 9;11(12):e0166940.
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