Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T15068 Target Info
Target Name Focal adhesion kinase 1 (FAK)
Synonyms pp125FAK; p125FAK; Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Focal adhesion kinase-related nonkinase; FRNK; FAK1; FADK 1; FADK
Target Type Clinical trial Target
Gene Name PTK2
Biochemical Class Kinase
UniProt ID
Q05397
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-379-5p miRNA Info
miRNA Mature AC
MIMAT0000733
Sequence ugguagacuauggaacguagg
miRNA Species Homo sapiens
Regulation Mechanism miR-379-5p exerted this function by directly targeting focal adhesion kinase (FAK) 3'UTR and repressing FAK expression, thus leading to suppression of AKT signaling. [2]
Evidence Score (E-score) 2 +
1 Immunohistochemical Staining [1]
2 Immunohistochemistry; Luciferase Reporter Assay; Western Blot [2]
Representative Target(s) Regulated by This miRNA Focal adhesion kinase 1 (FAK) Target Info
FAK1_HUMAN
Interleukin-11 (IL11) Target Info
IL11_HUMAN
miRNA Mature ID hsa-miR-193a-3p miRNA Info
miRNA Mature AC
MIMAT0000459
Sequence aacuggccuacaaagucccagu
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-193a-3p by mature miRNA precursor transfection resulted in the decreased protein level of target PTK2. [3]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; qRT-PCR; Western Blot [3]
Representative Target(s) Regulated by This miRNA E2F transcription factor 1 (E2F1) Target Info
E2F1_HUMAN
Erbb2 tyrosine kinase receptor (HER2) Target Info
ERBB2_HUMAN
miRNA Mature ID hsa-miR-543 miRNA Info
miRNA Mature AC
MIMAT0004954
Sequence aaacauucgcggugcacuucuu
miRNA Species Homo sapiens
Regulation Mechanism FAK is a direct target of miR-543. [4]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [4]
Representative Target(s) Regulated by This miRNA Focal adhesion kinase 1 (FAK) Target Info
FAK1_HUMAN
High mobility group protein HMGI-C (HMGA2) Target Info
HMGA2_HUMAN
References  Top
REF 1 MicroRNA-379 inhibits metastasis and epithelial-mesenchymal transition via targeting FAK/AKT signaling in gastric cancer. Int J Oncol. 2017 Sep;51(3):867-876.
REF 2 MicroRNA-379-5p inhibits tumor invasion and metastasis by targeting FAK/AKT signaling in hepatocellular carcinoma. Cancer Lett. 2016 May 28;375(1):73-83.
REF 3 Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res. 2008 Apr 1;68(7):2094-105.
REF 4 MicroRNA-543 suppresses endometrial cancer oncogenicity via targeting FAK and TWIST1 expression. Arch Gynecol Obstet. 2014 Sep;290(3):533-41.

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