Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T16340 Target Info
Target Name Interleukin-1 alpha (IL1A)
Synonyms IL1F1; IL-1 alpha; Hematopoietin-1
Target Type Clinical trial Target
Gene Name IL1A
Biochemical Class Cytokine: interleukin
UniProt ID
P01583
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-122-5p miRNA Info
miRNA Mature AC
MIMAT0000421
Sequence uggagugugacaaugguguuug
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay; Western Blot [2]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-W (BCL-W) Target Info
B2CL2_HUMAN
Apoptosis regulator Bcl-xL (BCL-xL) Target Info
B2CL1_HUMAN
miRNA Mature ID hsa-miR-142-3p miRNA Info
miRNA Mature AC
MIMAT0000434
Sequence uguaguguuuccuacuuuaugga
miRNA Species Homo sapiens
Regulation Mechanism IL1A 39-UTR is a bona fide target of this miR-142-3p. [3]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA ATP-binding cassette transporter G2 (ABCG2) Target Info
ABCG2_HUMAN
High mobility group protein B1 (HMGB1) Target Info
HMGB1_HUMAN
miRNA Mature ID hsa-miR-191-5p miRNA Info
miRNA Mature AC
MIMAT0000440
Sequence caacggaaucccaaaagcagcug
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [4]
Representative Target(s) Regulated by This miRNA CCAAT/enhancer binding protein beta (CEBPB) Target Info
CEBPB_HUMAN
Cyclin-dependent kinase 6 (CDK6) Target Info
CDK6_HUMAN
miRNA Mature ID hsa-miR-92a-1-5p miRNA Info
miRNA Mature AC
MIMAT0004507
Sequence agguugggaucgguugcaaugcu
miRNA Species Homo sapiens
Regulation Mechanism miR-92a downregulates mRNA expression of IL-1b. [5]
Evidence Score (E-score) 1 +
1 Microarray [5]
Representative Target(s) Regulated by This miRNA Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
References  Top
REF 1 A functional polymorphism in interleukin-1 (IL1A) gene is associated with risk of alopecia areata in Chinese populations. Gene. 2013 Jun 1;521(2):282-6.
REF 2 An insertion/deletion polymorphism at the microRNA-122 binding site in the interleukin-1 3'-untranslated region is associated with a risk for osteoarthritis. Mol Med Rep. 2015 Oct;12(4):6199-206.
REF 3 MicroRNA profiling of Epstein-Barr virus-associated NK/T-cell lymphomas by deep sequencing. PLoS One. 2012;7(8):e42193.
REF 4 hsa-miR-191 is a candidate oncogene target for hepatocellular carcinoma therapy. Cancer Res. 2010 Oct 15;70(20):8077-87.
REF 5 miR-92a Corrects CD34+ Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation. Diabetes. 2015 Dec;64(12):4226-37.

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