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| Target General Information |
Top |
| Target ID |
T61243 |
Target Info
|
| Target Name |
Metabotropic glutamate receptor 7 (mGluR7) |
| Synonyms |
mGluR7; GPRC1G |
| Target Type |
Literature-reported Target |
| Gene Name |
GRM7 |
| Biochemical Class |
GPCR glutamate |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
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| miRNA Mature ID |
hsa-miR-34a-5p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
uggcagugucuuagcugguugu
|
| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
Mood stabilizers might upregulate GRM7 levels via miR-34a. |
[1] |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
qRT-PCR |
[1] |
| 2 |
Reporter Assay; Proteomics |
[2] |
| Representative Target(s) Regulated by This miRNA |
Amphiregulin (AREG)
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Target Info
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Androgen receptor (AR)
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Target Info
|
|
| miRNA Mature ID |
hsa-miR-34c-5p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
aggcaguguaguuagcugauugc
|
| miRNA Species |
Homo sapiens |
| Evidence Score (E-score) |
1 |
+ |
| 1 |
Luciferase Reporter Assay |
[3] |
| Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
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Target Info
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Cyclin-dependent kinase 4 (CDK4)
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Target Info
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| References |
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| REF 1 |
MicroRNAs in psychiatric and neurodevelopmental disorders. Brain Res. 2010 Jun 18;1338:78-88.
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| REF 2 |
Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. Mol Cell Proteomics. 2011 Aug;10(8):M111.010462.
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| REF 3 |
SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients. Neurobiol Dis. 2015 May;77:127-40.
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