miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-34c-5p | ||||
miRNA Stemloop AC | MI0000743 | ||||
miRNA Stemloop ID | hsa-mir-34c | ||||
Sequence | aggcaguguaguuagcugauugc | ||||
TTD Target(s) Regulated by This miRNA | Platelet-derived growth factor receptor alpha (PDGFRA) | Successful Target | Target Info | [1] | |
Cyclin-dependent kinase 4 (CDK4) | Successful Target | Target Info | [2] | ||
Heat shock protein 90 alpha (HSP90A) | Successful Target | Target Info | [3] | ||
Platelet-derived growth factor receptor beta (PDGFRB) | Successful Target | Target Info | [1] | ||
Proto-oncogene c-Met (MET) | Successful Target | Target Info | [2] | ||
Apoptosis regulator Bcl-2 (BCL-2) | Successful Target | Target Info | [4] | ||
GABA(A) receptor alpha-3 (GABRA3) | Successful Target | Target Info | [5] | ||
Retinoic acid receptor gamma (RARG) | Successful Target | Target Info | [6] | ||
Tyrosine-protein kinase UFO (AXL) | Successful Target | Target Info | [7] | ||
Gamma-aminobutyric acid B receptor (GABBR) | Successful Target | Target Info | [5] | ||
ERK activator kinase 1 (MEK1) | Clinical trial Target | Target Info | [8] | ||
Synuclein alpha (SNCA) | Clinical trial Target | Target Info | [9] | ||
Microtubule-associated protein tau (MAPT) | Clinical trial Target | Target Info | [10] | ||
Notch-1 receptor (NOTCH1) | Clinical trial Target | Target Info | [11] | ||
Notch-4 receptor (NOTCH4) | Clinical trial Target | Target Info | [12] | ||
Metabotropic glutamate receptor 7 (mGluR7) | Literature-reported Target | Target Info | [5] | ||
Proto-oncogene c-Myc (MYC) | Literature-reported Target | Target Info | [13] | ||
Tyrosine-protein kinase ZAP-70 (ZAP-70) | Patented-recorded Target | Target Info | [14] | ||
Hepatocyte nuclear factor 4-alpha (HNF4A) | Literature-reported Target | Target Info | [15] | ||
Epithelial cadherin (CDH1) | Literature-reported Target | Target Info | [3] | ||
Fos-related antigen 1 (FOSL1) | Literature-reported Target | Target Info | [16] | ||
IP3 receptor isoform 1 (ITPR1) | Literature-reported Target | Target Info | [8] | ||
N-myc proto-oncogene protein (MYCN) | Literature-reported Target | Target Info | [17] | ||
Transcription factor SOX-2 (SOX2) | Literature-reported Target | Target Info | [17] | ||
G1/S-specific cyclin-E2 (CCNE2) | Literature-reported Target | Target Info | [2] | ||
Runt-related transcription factor 2 (RUNX2) | Literature-reported Target | Target Info | [18] | ||
Protein(s) Regulated by This miRNA | ARF GTPase-activating protein GIT1 | Regulated Protein | [19] | ||
Bcl-2-modifying factor | Regulated Protein | [20] | |||
Homeobox protein NANOG | Regulated Protein | [17] | |||
Homeobox protein TGIF2 | Regulated Protein | [22] | |||
Interleukin-6 receptor subunit alpha | Regulated Protein | [23] | |||
Mucin-2 | Regulated Protein | [24] | |||
Myc-associated zinc finger protein | Regulated Protein | [25] | |||
N-acetylgalactosaminyltransferase 7 | Regulated Protein | [26] | |||
Polyadenylate-binding protein 1 | Regulated Protein | [27] | |||
Tight junction protein ZO-1 | Regulated Protein | [28] | |||
Transcriptional repressor protein YY1 | Regulated Protein | [29] | |||
UL16-binding protein 2 | Regulated Protein | [30] | |||
Uracil-DNA glycosylase | Regulated Protein | [31] | |||
Vezatin | Regulated Protein | [32] | |||
Zinc finger protein SNAI1 | Regulated Protein | [33] | |||
References | |||||
REF 1 | MiR-34a/c-Dependent PDGFR-/ Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PLoS One. 2013 Jun 21;8(6):e67581. | ||||
REF 2 | The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010 Feb;17(2):193-9. | ||||
REF 3 | Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing. PLoS One. 2013 Dec 19;8(12):e84486. | ||||
REF 4 | Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer. 2008 Sep 21;8:266. | ||||
REF 5 | SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients. Neurobiol Dis. 2015 May;77:127-40. | ||||
REF 6 | MIR-34c regulates mouse embryonic stem cells differentiation into male germ-like cells through RARg. Cell Biochem Funct. 2012 Dec;30(8):623-32. | ||||
REF 7 | The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels. PLoS One. 2015 Aug 19;10(8):e0135991. | ||||
REF 8 | The changes of miRNA expression in rat hippocampus following chronic lead exposure. Toxicol Lett. 2014 Aug 17;229(1):158-66. | ||||
REF 9 | Inhibition of miR-34b and miR-34c enhances -synuclein expression in Parkinson's disease. FEBS Lett. 2015 Jan 30;589(3):319-25. | ||||
REF 10 | Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxel. Cancer Chemother Pharmacol. 2013 May;71(5):1159-71. | ||||
REF 11 | miRNA-34c regulates Notch signaling during bone development. Hum Mol Genet. 2012 Jul 1;21(13):2991-3000. | ||||
REF 12 | MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells. J Biol Chem. 2012 Jan 2;287(1):465-73. | ||||
REF 13 | Prediction and preliminary validation of oncogene regulation by miRNAs. BMC Mol Biol. 2007 Sep 18;8:79. | ||||
REF 14 | Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. Genes Dev. 2013 Jul 15;27(14):1624-32. | ||||
REF 15 | The role of microRNAs in hepatocyte nuclear factor-4alpha expression and transactivation. Biochim Biophys Acta. 2013 May;1829(5):436-42. | ||||
REF 16 | MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1. Oncogene. 2013 Sep 5;32(36):4294-303. | ||||
REF 17 | miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 2011 Oct 23;13(11):1353-60. | ||||
REF 18 | MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. J Biol Chem. 2013 Jul 19;288(29):21307-19. | ||||
REF 19 | MicroRNA-34c Suppresses Breast Cancer Migration and Invasion by Targeting GIT1. J Cancer. 2016 Jul 25;7(12):1653-1662. | ||||
REF 20 | miR-34c may protect lung cancer cells from paclitaxel-induced apoptosis.Oncogene. 2013 Jan 17;32(3):341-51. | ||||
REF 21 | miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 2011 Oct 23;13(11):1353-60. | ||||
REF 22 | MicroRNA-34c targets TGFB-induced factor homeobox 2, represses cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular... Oncol Lett. 2015 Nov;10(5):3095-3102. | ||||
REF 23 | IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.J Clin Invest. 2014 Apr;124(4):1853-67. | ||||
REF 24 | Helicobacter pylori infection related long noncoding RNA (lncRNA) AF147447 inhibits gastric cancer proliferation and invasion by targeting MUC2 and up-regulating miR-34c.Oncotarget. 2016 Dec 13;7(50):82770-82782. | ||||
REF 25 | miR-34c regulates the permeability of blood-tumor barrier via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5.J Cell Physiol. 2015 Mar;230(3):716-31. | ||||
REF 26 | MicroRNA 4a/c function as tumor suppressors in Hep laryngeal carcinoma cells and may reduce GALNT7 expression.Mol Med Rep. 2014 Apr;9(4):1293-8. | ||||
REF 27 | PABPC1 exerts carcinogenesis in gastric carcinoma by targeting miR-34c. Int J Clin Exp Pathol. 2015 Apr 1;8(4):3794-802. | ||||
REF 28 | MiR-34c and PlncRNA1 mediated the function of intestinal epithelial barrier by regulating tight junction proteins in inflammatory bowel disease.Biochem Biophys Res Commun. 2017 Apr 22;486(1):6-13. | ||||
REF 29 | Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis.Oncotarget. 2014 Jul 15;5(13):5002-16. | ||||
REF 30 | Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D.Cancer Res. 2012 Jan 15;72(2):460-71. | ||||
REF 31 | Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase.DNA Repair (Amst). 2013 Jan 1;12(1):80-6. | ||||
REF 32 | Down-regulation of VEZT gene expression in human gastric cancer involves promoter methylation and miR-43c.Biochem Biophys Res Commun. 2011 Jan 14;404(2):622-7. | ||||
REF 33 | miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions.Cell Cycle. 2011 Dec 15;10(24):4256-71. |
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