Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T00724 Target Info
Target Name Transcription factor SOX-2 (SOX2)
Synonyms SRY-box 2; MCOPS3; ANOP3
Target Type Literature-reported Target
Gene Name SOX2
UniProt ID
SOX2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Chromodomain-helicase-DNA-binding protein 7 (CHD7) Interacting Protein Interacting Protein Info
UniProt ID
CHD7_HUMAN 
Synonyms CRG; HH5; IS3; KAL5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Histone-binding protein RBBP4 (RBBP4) Interacting Protein Interacting Protein Info
UniProt ID
RBBP4_HUMAN 
Synonyms NURF55; RBAP48; lin.53
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Transcription regulators [+] 5 Transcription regulators +
Interacting Target Name Metastasis associated gene-1 (MTA1) Literature-reported Target Interacting Protein Info
UniProt ID
MTA1_HUMAN 
Synonyms Metastasis-associated protein MTA1; Metastasisassociated protein MTA1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Homeobox protein cut-like 1 (CUX1) Interacting Protein Interacting Protein Info
UniProt ID
CUX1_HUMAN 
Synonyms CASP; CDP; CDP/Cut; CDP1; COY1; CUTL1; CUX; Clox; Cux/CDP; GOLIM6; Nbla10317; p100; p110; p200; p75
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Myelin expression factor 2 (MYEF2) Interacting Protein Interacting Protein Info
UniProt ID
MYEF2_HUMAN 
Synonyms HsT18564; MEF.2; MST156; MSTP156; myEF.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Transcriptional repressor p66-alpha (GATAD2A) Interacting Protein Interacting Protein Info
UniProt ID
P66A_HUMAN 
Synonyms p66alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Other proteins [+] 5 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [3]
Interacting Protein Name AT-rich interactive domain-containing protein 1A (ARID1A) Interacting Protein Interacting Protein Info
UniProt ID
ARI1A_HUMAN 
Synonyms B120; BAF250; BAF250a; BM029; C1orf4; ELD; MRD14; OSA1; P270; SMARCF1; hELD; hOSA1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Cell cycle and apoptosis regulator protein 2 (CCAR2) Interacting Protein Interacting Protein Info
UniProt ID
CCAR2_HUMAN 
Synonyms DBC.1; DBC1; KIAA1967; NET35; p30 DBC; p30DBC
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [1]
Interacting Protein Name DnaJ homolog subfamily A member 2 (DNAJA2) Interacting Protein Interacting Protein Info
UniProt ID
DNJA2_HUMAN 
Synonyms CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4; PRO3015; RDJ2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Integrase interactor 1 protein (SMARCB1) Interacting Protein Interacting Protein Info
UniProt ID
SNF5_HUMAN 
Synonyms BAF47; INI1; MRD15; PPP1R144; RDT; RTPS1; SNF5; SNF5L1; SWNTS1; Sfh1p; Snr1; hSNFS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
References  Top
REF 1 Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat Genet. 2011 Jun;43(6):607-11.
REF 2 The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. PLoS One. 2013 May 7;8(5):e62857.
REF 3 -Catenin/POU5F1/SOX2 transcription factor complex mediates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinoma. Cancer Res. 2013 May 15;73(10):3181-9.

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