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| Target General Information |
Top |
| Target ID |
T01575 |
Target Info
|
| Target Name |
Sphingosine-1-phosphate lyase 1 (SGPL1) |
| Synonyms |
hSPL; Sphingosine-1-phosphate aldolase; SPL 1; SP-lyase 1; S1PL; KIAA1252 |
| Target Type |
Clinical trial Target |
| Gene Name |
SGPL1 |
| Biochemical Class |
Carbon-carbon lyase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Epidermal growth factor receptor (EGFR) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III |
| Evidence Score (E-score) |
1 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| References |
Top |
| REF 1 |
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Mol Syst Biol. 2013 Nov 5;9:705.
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