Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T02259 Target Info
Target Name Runt-related transcription factor 2 (RUNX2)
Synonyms SL3/AKV core-binding factor alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha Asubunit; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2A; PEBP2-alpha A; PEA2-alpha A; Osteoblast-specific transcription factor 2; Oncogene AML-3; OSF2; OSF-2; Core-binding factor subunit alpha-1; CBFA1; CBF-alpha-1; Acute myeloid leukemia 3 protein; AML3
Target Type Literature-reported Target
Gene Name RUNX2
UniProt ID
RUNX2_HUMAN 
Target Interacting Proteins  Top
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Transcription regulators [+] 5 Transcription regulators +
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
5 Yeast two hybrid [4]
Interacting Target Name Proto-oncogene c-Fos (c-Fos) Literature-reported Target Interacting Protein Info
UniProt ID
FOS_HUMAN 
Synonyms Proto-oncogene c-Fos; G0S7; G0/G1 switch regulatory protein 7; C-fos; Cellular oncogene fos
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
5 Yeast two hybrid [4]
Interacting Protein Name Mad-related protein 1 (SMAD1) Interacting Protein Interacting Protein Info
UniProt ID
SMAD1_HUMAN 
Synonyms Transforming growth factor-beta-signaling protein 1; Smad1; SMAD family member 1; SMAD 1; Mothers against DPP homolog 1; Mothers against decapentaplegic homolog 1; Mad-related protein 1; MADR1; MADH1; MAD homolog 1; JV4-1; BSP-1; BSP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Co-localization [7]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [5]
Interacting Target Name Yes-associated protein 1 (YAP1) Literature-reported Target Interacting Protein Info
UniProt ID
YAP1_HUMAN 
Synonyms Yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; 65 kDa Yes-associated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Reconstituted Complex [9]
References  Top
REF 1 Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells. Gene. 2008 Apr 30;413(1-2):8-17.
REF 2 Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem. 2004 Oct 1;279(40):41998-2007.
REF 3 AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. J Biol Chem. 2001 Jun 8;276(23):20029-38.
REF 4 Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J Biol Chem. 2002 Jan 4;277(1):816-22.
REF 5 A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10549-54.
REF 6 BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity. J Biol Chem. 2010 Nov 19;285(47):36410-9.
REF 7 Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. J Biol Chem. 2007 Apr 6;282(14):10742-8.
REF 8 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 9 A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J. 1999 May 4;18(9):2551-62.

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